Robbie Henshaw will start for Leinster against Cardiff as the Ireland centre completes his comeback from a knee injury.
The Ireland back missed the opening three rounds of the Six Nations as Andy Farrell’s side lost to France and beat Italy and England.
The 32-year-old has been out of action since the Bayonne match in mid-January but takes his place alongside Rieko Ioane in midfield for the URC clash in Cardiff on Friday night (7pm).
Ireland internationals Harry Byrne and Jimmy O’Brien also start for Leo Cullen’s side, who make six changes to the team that beat Edinburgh last month.
Max Deegan captains the team on his 150th appearance for the province as the URC celebrates Origin Round.
Scott Penny, earning his 99th Leinster cap, and James Culhane join Deegan in the back row, with academy second row Alan Spicer partnering Brian Deeny.
Jerry Cahir and Andrew Sparrow pack down either side of John McKee in an unchanged front row.
O’Brien starts at full-back alongside Joshua Kenny and Ruben Moloney on the wings, while Henshaw partners Ioane in the centre.
Byrne starts at out-half, with Fintan Gunne his partner in the half-backs.
Rabah Slimani returns to the matchday 23 for the first time since before Christmas, with Gus McCarthy and Alex Usanov also offering front row cover as RG Snyman and Josh Ericson complete the forward replacements.
Luke McGrath, Charlie Tector and Andrew Osborne round out the matchday squad.
Cullen, whose side are in second in the table, said: “We have a younger cohort but there’s some experienced guys coming back into the mix.
“Robbie Henshaw is back training with the group, as is Jimmy O’Brien. It helps us build depth.
“It looks to the future and all that good stuff.
“We just need to try and produce a better overall performance because we were too standoffish in the first half in our last game.”
Leinster Rugby: Jimmy O’Brien (Newbridge College / Naas RFC); Joshua Kenny (Presentation College Bray / Greystones RFC), Rieko Ioane (Auckland Grammar School / Ponsonby Rugby Club), Robbie Henshaw (Marist College / Buccaneers RFC), Ruben Moloney (Blackrock College / Blackrock College RFC); Harry Byrne (St Michael’s College / Old Belvedere RFC), Fintan Gunne (St Michael’s College / Old Belvedere RFC); Jerry Cahir (Cistercian College Roscrea / Lansdowne FC), John McKee (Campbell College / Ards RFC & Terenure College RFC), Andrew Sparrow (St Mary’s College / St Mary’s College RFC); Alan Spicer (Belvedere College / Malahide RFC), Brian Deeny (St Peter’s College / Wexford Wanderers RFC); Max Deegan (capt) (St Michael’s College / Wanderers FC), Scott Penny (St Michael’s College / UCD RFC), James Culhane (Blackrock College / De La Salle Palmerston FC).
Replacements: Gus McCarthy (Blackrock College / Old Belvedere RFC), Alex Usanov (Belvedere College / Malahide RFC), Rabah Slimani (AAS Sarcelles), RG Snyman (Afrikaanse Hoër Seunskool), Josh Ericson (Skerries Community College / Skerries RFC), Luke McGrath (St Michael’s College / Old Belvedere RFC), Charlie Tector (Kilkenny College / Enniscorthy RFC), Andrew Osborne (Naas CBS / Naas RFC)
Michael Milne scored for Ireland at Stade de France
Elsewhere, Munster have also been boosted by the return of Ireland internationals Tom Farrell, Michael Milne and Edwin Edogbo to their ranks for Saturday’s visit of Zebre to Thomond Park (5.30pm).
Centre Farrell and prop Milne, who scored a try against France in the Six Nations defeat are two of ten changes to the side that lost to Glasgow in the last round, while lock Edogbo is on the bench.
Milne, Niall Scannell and Michael Ala’alatoa pack down in the front row with Jean Kleyn and Fineen Wycherley starting in the second row.
Gavin Coombes, captain Jack O’Donoghue and Brien Gleeson start in the back row.
In the backline, Calvin Nash, Farrell, JJ Hanrahan and Paddy Patterson all come into Clayton McMillan’s side, who are sixth in the table.
Mike Haley, Nash and Shane Daly start in the back three with Nash returning from the shoulder injury he sustained against Toulon last month.
Dan Kelly, who was on Ireland XV duty earlier this month, and Farrell partner up in midfield.
JJ Hanrahan returns from a hamstring injury to start at out-half with scrum-half Paddy Patterson starting on his 50th appearance for the province.
Munster: Mike Haley (Preston Grasshoppers/Hartpury College); Calvin Nash (Young Munster RFC/Crescent College Comp), Tom Farrell (Coolmine RFC/Castleknock College), Dan Kelly (Rochdale Rugby Union/Kirkham Grammar), Shane Daly (Highfield RFC/PBC); JJ Hanrahan (Castleisland RFC/Rockwell College), Paddy Patterson (Blackrock College); Michael Milne (Birr RFC/Cistercian College Roscrea), Niall Scannell (PBC/Dolphin RFC), Michael Ala’alatoa (West Harbour RFC); Jean Kleyn (Hoërskool Linden), Fineen Wycherley (Bantry Bay RFC/Cistercian College Roscrea); Gavin Coombes (Skibbereen RFC/Bandon Grammar), Jack O’Donoghue (capt) (Waterpark RFC), Brian Gleeson (Thurles RFC/Rockwell College).
Replacements: Lee Barron (Lansdowne RFC/St Michael’s College), Josh Wycherley (Bantry Bay RFC/Cistercian College Roscrea), John Ryan (Muskerry RFC/CBC), Edwin Edogbo (Cobh Pirates RFC), Alex Kendellen (PBC), Ethan Coughlan (Ennis RFC), Tom Wood (Ballina Killaloe RFC/St Munchin’s College), Seán O’Brien (Mullingar RFC).