Taoiseach Micheál Martin is expected to focus on global uncertainty during his address to the UN General Assembly in New York.
It is understood Mr Martin will speak about the need to make the multilateral system stronger and highlight conflicts around the world, including in the Middle East, Ukraine and Sudan.
His speech is scheduled for around 8pm local time (1am tomorrow Irish time), on the final day of his trip.
Israeli Prime Minister Benjamin Netanyahu and Palestinian Authority President Mahmoud Abbas are also scheduled to speak today.
Mr Martin has attended a series of political and cultural events during his three-day visit to New York.
He participated in a meeting about the Gaza peace plan with the leaders of the UK, France and Canada.
The Taoiseach also briefly met with US President Donald Trump on the sidelines of the UNGA, at the annual host country reception, on Tuesday.
Yesterday, he met with New York Governor Kathy Hochul and New York City Mayor Zohran Mamdani at the New York Irish Centre in Queens.
Minister for Foreign Affairs Helen McEntee, who is also in New York for the UNGA, is due to speak at the annual meeting of the Informal Ministerial Network for the International Criminal Court today.
She is also expected to deliver a national statement at a meeting of the Global Alliance for the Implementation of the Two State Solution and will deliver remarks at a high-level ministerial meeting on ensuring accountability for Ukraine.
Netanyahu expected to slate New York mayor Mamdani

Benjamin Netanyahu, Israel’s longest-serving prime minister, is running for re-election next month
Mr Netanyahu, facing a difficult re-election campaign at home, is expected to lash out at both political enemies as well as allies that have crossed him in recent months.
He will also likely raise the case of Israeli ambassador to Washington Yechiel Leiter whose son, a soldier, was badly injured in an alleged Palestinian ramming attack in the occupied West Bank.
Foremost among Mr Netanyahu’s foes in New York is the city’s leftist Mayor Zohran Mamdani, who recently vowed to execute an ICC arrest warrant when the visiting leader arrived in the city for the UN’s signature gathering.
The Hague-based International Criminal Court (ICC) said in 2024 it had reasonable grounds to believe Mr Netanyahu was responsible for alleged war crimes in his Gaza campaign that responded to Hamas’ deadly 7 October, 2023 attacks. Mr Netanyahu denies the ICC claims.
But Mr Mamdani later conceded he did not have the authority for such a manoeuvre, leading to howls of indignation from Mr Netanyahu and his backers.
Ahead of his turn at the UN’s signature diplomatic week, Mr Netanyahu said he was going to “tell the truth about you,” addressing Mamdani and accusing him of “supporting the Hamas terrorist monsters.”
He also baselessly accused Mr Mamdani of “inciting riots against New York Jews.”
Mr Mamdani, who has long supported Palestinian rights and accused Israel of war crimes, fired back on Tuesday, saying “we all know that what the prime minister has said in that video is not true.”
One of Mr Netanyahu’s fiercest critics, Palestinian president Mahmud Abbas, will not be in the room after Washington denied him a visa to attend.
Additional reporting: AFP