There’s a lot of epidemiological data about breastfeeding in particular reducing the risk of triple negative breast cancer. But also just it’s plausible because as you can imagine, there’s a lot of interaction between the baby and the breast during breastfeeding with saliva, with microbes, with viruses, et cetera. And so that’s how we hypothesize that maybe breastfeeding and pregnancy per se can change the immune microenvironment of the breast. And this may be particularly important for the protection against triple negative breast cancer. And indeed that’s what we found. First of all, we looked at healthy cancer unaffected normal breast tissue, both from women who’d had breast reductions as well as women who’d had prophylactic mastectomies because they’re high risk of breast cancer such as germline carriers. And also the data set that we use for the normal breast. One of the data sets had women from all around the world, so from diverse populations, thinking about geo population, African-Americans, Hispanics, Asians, as well as European backgrounds.
