Tsai H-M. Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. Am J Med. 2013, Mar;126(3):200–09. https://doi.org/10.1016/j.amjmed.2012.09.006.


Google Scholar 

Arnold DM, Patriquin CJ, Nazy I. Thrombotic microangiopathies: a general approach to diagnosis and management. C Can Med Assoc J = J l’Assoc Medicale Can. 2017, Jan;189(4):E153–59. https://doi.org/10.1503/cmaj.160142.


Google Scholar 

Thomas MR, Scully M. How I treat microangiopathic hemolytic anemia in patients with cancer. Blood. 2021, Mar;137(10):1310–17. https://doi.org/10.1182/blood.2019003810.


Google Scholar 

Scully M, et al. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol. 2012, Aug;158(3):323–35. https://doi.org/10.1111/j.1365-2141.2012.09167.x.


Google Scholar 

Legendre CM, et al.. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013, Jun;368(23):2169–81. https://doi.org/10.1056/NEJMoa1208981.


Google Scholar 

Adil SN, Karim F. Thrombotic microangiopathies: role of ADAMTS-13. JPMA The J Pak Med Assoc. 2012, Feb;62(2. Pakistan, pp. 91–92.


Google Scholar 

Tsai H-M. Autoimmune thrombotic microangiopathy: advances in pathogenesis, diagnosis, and management. Semin Thromb Hemost. 2012, Jul;38(5):469–82. https://doi.org/10.1055/s-0032-1306431.


Google Scholar 

Lämmle B, Kremer Hovinga JA, Alberio L. Thrombotic thrombocytopenic purpura. J Thromb Haemost. 2005, Aug;3(8):1663–75. https://doi.org/10.1111/j.1538-7836.2005.01425.x.


Google Scholar 

Bhandari S, Kumar R. Thrombotic Thrombocytopenic Purpura. N Engl J Med. 2019, Apr;380(16):e23. https://doi.org/10.1056/NEJMicm1813768.


Google Scholar 

Zheng XL, et al. Isth guidelines for treatment of thrombotic thrombocytopenic purpura. J Thromb Haemost. 2020, Oct;18(10):2496–502. https://doi.org/10.1111/jth.15010.


Google Scholar 

Coppo P, et al. A regimen with caplacizumab, immunosuppression, and plasma exchange prevents unfavorable outcomes in immune-mediated TTP. Blood. 2021, Feb;137(6):733–42. https://doi.org/10.1182/blood.2020008021.


Google Scholar 

Tarr PI, Gordon CA, Chandler WL. Shiga-toxin-producing escherichia coli and haemolytic uraemic syndrome. Lancet (lond, Engl). 2005, Mar;365(9464):1073–86. https://doi.org/10.1016/S0140-6736(05)71144-2.


Google Scholar 

Noris M, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol. 2010, Oct;5(10):1844–59. https://doi.org/10.2215/CJN.02210310.


Google Scholar 

Pande A, Kumar A, Krishnani H, Acharya S, Shukla S. Recent advances in the management of microangiopathic hemolytic anemias (MAHA): a narrative review. Cureus. 2023, Oct;15(10):e47196. https://doi.org/10.7759/cureus.47196.


Google Scholar 

Iqbal S, Zaidi SZA, Motabi IH, Alshehry NF, AlGhamdi MS, Tailor IK. Thrombotic thrombocytopenic purpura – analysis of clinical features, laboratory characteristics and therapeutic outcome of 24 patients treated at a tertiary care center in Saudi Arabia. Pak J Med Sci. 2016;32(6):1494–99. https://doi.org/10.12669/pjms.326.11274.


Google Scholar 

Nguyen T, Radhakrishnan SM, Radhakrishnan SJ, Johnson DH. Near-complete vision recovery from bilateral serous retinal detachment associated with thrombotic thrombocytopenic purpura. BMJ Case Rep. 2022, Feb;15(2). https://doi.org/10.1136/bcr-2021-244030.

Sheth KJ, Swick HM, Haworth N. Neurological involvement in hemolytic-uremic syndrome. Ann Neurol. 1986, Jan;19(1):90–93. https://doi.org/10.1002/ana.410190120.


Google Scholar 

Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001, Sep;60(3):831–46. https://doi.org/10.1046/j.1523-1755.2001.060003831.x.


Google Scholar 

Sturm V, Menke MN, Landau K, Laube GF, Neuhaus TJ. Ocular involvement in paediatric haemolytic uraemic syndrome. Acta Ophthalmol. 2010, Nov;88(7):804–07. https://doi.org/10.1111/j.1755-3768.2009.01552.x.


Google Scholar 

Loudon SE, Dorresteijn EM, Catsman-Berrevoets CE, Verdijk RM, Simonsz HJ, Jansen AJG. Blinded by shiga toxin-producing O104 escherichia coli and hemolytic uremic syndrome. J Pediatr. 2014, Aug;165(2):410–410.e1. https://doi.org/10.1016/j.jpeds.2014.04.008.


Google Scholar 

Смирнова ТВ, Козловская НЛ, Шелудченко ВМ. Глазные проявления первичной тромботической микроангиопатии. 2021.

Page MJ, et al. The prisma 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021;10(1):1–11. https://doi.org/10.1186/s13643-021-01626-4.


Google Scholar 

Ma LL, Wang YY, Yang ZH, Huang D, Weng H, Zeng XT. Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Mil Med Res. 2020;7(1):1–11. https://doi.org/10.1186/s40779-020-00238-8.


Google Scholar 

Lo CK-L, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol. 2014, Apr;14:45. https://doi.org/10.1186/1471-2288-14-45.


Google Scholar 

Stefani FH, Brandt F, Pielsticker K. Periarteritis nodosa and thrombotic thrombocytopenic purpura with serous retinal detachment in siblings. Br J Ophthalmol. 1978, Jun;62(6):402–07. https://doi.org/10.1136/bjo.62.6.402.


Google Scholar 

Wyszynski RE, Frank KE, Grossniklaus HE. Bilateral retinal detachments in thrombotic thrombocytopenic purpura. Graefe’s Arch Clin Exp Ophthalmol = Albr von Graefes Arch fur Klin und Exp Ophthalmol. 1988;226(6):501–04. https://doi.org/10.1007/BF02169195.


Google Scholar 

Tajunisah I, Patel DK, Subrayan V. Purtscher retinopathy as an initial presentation of thrombotic thrombocytopenic purpura. J Thromb Thrombolysis. 2010, Jul;30(1):112–13. https://doi.org/10.1007/s11239-009-0399-y.


Google Scholar 

Williams PJ, Pearce WA, Smith JM, Robinson J. Profound visual recovery at 16 months after resolution of serous retinal detachments secondary to thrombotic thrombocytopenic purpura: case report and literature review. Retin Cases Brief Rep. 2021, Jan;15(1):18–21. https://doi.org/10.1097/ICB.0000000000000727.


Google Scholar 

Ustaoğlu M, Önder F, Solmaz N, Öztürk S, Ayer M. Purtscher-like retinopathy associated with atypical hemolytic uremic syndrome. Turk J Ophthalmol. 2017, Dec;47(6):348–50. https://doi.org/10.4274/tjo.66502.


Google Scholar 

Siegler RL, Brewer ED, Swartz M. Ocular involvement in hemolytic-uremic syndrome. J Pediatr. 1988, Apr;112(4):594–97. https://doi.org/10.1016/s0022-3476(88)80178-1.


Google Scholar 

Slusher MM, Pugh HP, Hackel RP. Bilateral serous retinal detachment in thrombotic thrombocytopenic purpura. Arch Ophthalmol (Chic, Ill. 1960), 1990 May;108(5):744–45. https://doi.org/10.1001/archopht.1990.01070070130050.

Sandhu H, Vavvas D. Bilateral tractional retinal detachment in a patient with hemolytic-uremic syndrome. J AAPOS Off Publ Am Assoc Pediatr Ophthalmol Strabismus. 2015, Oct;19(5):484–86. https://doi.org/10.1016/j.jaapos.2015.05.017.


Google Scholar 

Sampo M, Yin GHW, Hoffart L, Denis D, Soler V, Matonti F. Exudative retinal detachment treatment in a patient with thrombotic Thrombocytopenic Purpura. Case Rep Ophthalmol. 2016;7(1):90–95. https://doi.org/10.1159/000444291.


Google Scholar 

Santamaría Álvarez JF, Serret Camps A, Aguayo Alvarez J, García García O. Optic coherence tomography angiography follow-up in a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome. Eur J Ophthalmol. 2020, May;30(3):NP14–17. https://doi.org/10.1177/1120672119833277.


Google Scholar 

Ramos de Carvalho JE, Schlingemann RO, Oranje M, Bemelman FJ, van Schooneveld MJ. Reversal of threatening blindness after initiation of eculizumab in Purtscher-like retinopathy secondary to atypical hemolytic uremic syndrome. Int Ophthalmol. 2018, Feb;38(1):399–407. https://doi.org/10.1007/s10792-017-0470-1.


Google Scholar 

Nagai T, Hasegawa O, Tuji A, Kamiyama Y, Honda M, Ito H. Pituitary hemorrhage in hemolytic uremic syndrome. Pediatr Neurol. 1992;8(1):75–76. https://doi.org/10.1016/0887-8994(92)90059-8.


Google Scholar 

Nanayakkara P, Gans RO, Reichert-Thoen J, Ter W. Pm. Serous retinal detachment as an early presentation of thrombotic thrombocytopenic purpura. Eur J Intern Med. 2000, Oct;11(5):286–88. https://doi.org/10.1016/s0953-6205(00)00109-6.


Google Scholar 

Mishra AV, Cadieux DC, Gjerde H, Lewis DR. Peripheral ulcerative keratitis secondary to atypical hemolytic uremic syndrome. Cornea. 2020, Nov;39(11):1431–32. https://doi.org/10.1097/ICO.0000000000002317.


Google Scholar 

Lin I-H, Chen Y-J, Chang P-Y, Hsiao P-W, Weng T-H, Chang Y-H. Bilateral proliferative retinopathy and ischemic optic neuropathy in a patient with atypical hemolytic-uremic syndrome: a case report. Med (baltim), vol. 2019, Sep;98(39):e17232. https://doi.org/10.1097/MD.0000000000017232.


Google Scholar 

Ong T, Nolan W, Jagger J. Purtscher-like retinopathy as an initial presentation of thrombotic thrombocytopenic purpura: a case report. Eye (lond, Engl). 2005, Mar;19(3. England, pp. 359–61. https://doi.org/10.1038/sj.eye.6701491.


Google Scholar 

Larakeb A, et al. Ocular involvement in hemolytic uremic syndrome due to factor H deficiency–are there therapeutic consequences? Pediatr Nephrol. 2007, Nov;22(11):1967–70. https://doi.org/10.1007/s00467-007-0540-0.


Google Scholar 

Lambert SR, High KA, Cotlier E, Benz EJJ. Serous retinal detachments in thrombotic thrombocytopenic purpura. Arch Ophthalmol (Chic, Ill. 1960 1985, Aug;103(8):1172–74. https://doi.org/10.1001/archopht.1985.01050080084026.

Harris JA, Friedman MT, Varma M. Unilateral serous retinal detachment in a patient with thrombotic thrombocytopenic purpura. J Clin Apher. 2008;23(3):116–17. https://doi.org/10.1002/jca.20165.


Google Scholar 

Geraissate JCÁ, Yamamoto RE, Isaac DLC, de Ávila MP. Hemorrhagic retinopathy in an infant with hemolytic-uremic syndrome. Arq Bras Oftalmol. 2014;77(6):397–99. https://doi.org/10.5935/0004-2749.20140099.


Google Scholar 

Chodnicki KD, Brodsky MC, Olsen TW. Pigmented macular lesion in a child. JAMA Ophthalmol. 2019, Sep;137(9):1076–77. https://doi.org/10.1001/jamaophthalmol.2019.1659.


Google Scholar 

González DP, Iglicki M, Svetitsky S, Bar-On Y, Habot-Wilner Z, Zur D. Occlusive retinal vasculopathy with macular branch retinal artery occlusion as a leading sign of atypical hemolytic uremic syndrome – a case report. BMC Ophthalmol. 2021, Jan;21(1):65. https://doi.org/10.1186/s12886-021-01820-x.


Google Scholar 

Spizzirri AP, et al. Ocular involvement in STEC-associated hemolytic uremic syndrome. Pediatr Nephrol. 2022, Nov;37(11):2699–703. https://doi.org/10.1007/s00467-022-05587-1.


Google Scholar 

Costa JR, Krause M, Friedman E, D’Amico DJ. Central retinal vein occlusion in a patient with thrombotic thrombocytopenic purpura. Am J Ophthalmol. 2001, May;131(5):669–71. https://doi.org/10.1016/s0002-9394(00)00875-8.


Google Scholar 

Corgier-Pattberg A, Beylerian M, Clave S, Cailliez M, Testud B, Desnous B. Threatening blindness in a child with typical hemolytic uremic syndrome. Pediatr Neurol. 2021, Sep;122:35–37. https://doi.org/10.1016/j.pediatrneurol.2021.06.008.


Google Scholar 

Catón B, Díaz de Otazu R, Aldamiz-Echebarria M, Viguri A. Haemolytic-uraemic syndrome with thrombotic microangiopathy of the retina following cytomegalovirus infection: postmortem findings. Postgrad Med J. 1993, Aug;69(814):653–55. https://doi.org/10.1136/pgmj.69.814.653.


Google Scholar 

Benvenuto F, Guillen S, Marchiscio L, Falbo J, Fandiño A. Purtscher-like retinopathy in a paediatric patient with haemolytic uraemic syndrome: a case report and literature review. Arch Soc Esp Oftalmol. 2021, Nov;96(11):607–10. https://doi.org/10.1016/j.oftale.2020.10.007.


Google Scholar 

Power MH, Regillo MC, Custis PH. Thrombotic thrombocytopenic purpura associated with purtscher retinopathy. Arch Ophthalmol (Chic, Ill. 1960), 1997 Jan;115(1):128–29. https://doi.org/10.1001/archopht.1997.01100150130030.

Patel MR, Bains AK, O’Hara JP, Kallab AM, Marcus DM. Purtscher retinopathy as the initial sign of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. Arch Ophthalmol (Chic, Ill. 1960), 2001 Sep;119(9):1388–89. https://doi.org/10.1001/archopht.119.9.1388.

Agarwal A, Ram J. Pan-ocular hemorrhage in thrombotic thrombocytopenic purpura. Int J Hematol. 2014;99(5):527–28. https://doi.org/10.1007/s12185-014-1569-z.


Google Scholar 

Bandara AGNMK, Matthias AT. Retinal involvement in acute thrombotic thrombocytopenic purpura: a case report. BMC Ophthalmol. 2020, Nov;20(1):456. https://doi.org/10.1186/s12886-020-01719-z.


Google Scholar 

Efthymiou M, et al. Comparison of real world and core laboratory lupus anticoagulant results from the Antiphospholipid syndrome Alliance for clinical trials and international networking (aps action) clinical database and repository. J Thromb Haemost. 2019, Dec;17(12):2069–80. https://doi.org/10.1111/jth.14596.


Google Scholar 

Melton RC, Spaide RF. Visual problems as a presenting sign of thrombotic thrombocytopenic purpura. Retina. 1996;16(1):78–80. https://doi.org/10.1097/00006982-199616010-00016.


Google Scholar 

Miguel AIM, Henriques F, Azevedo LFR, Loureiro AJR, Maberley DAL. Systematic review of Purtscher’s and Purtscher-like retinopathies. Eye (Lond), vol. 2013 Jan;27(1):1–13. https://doi.org/10.1038/eye.2012.222.


Google Scholar 

Serhan HA, et al. Purtscher’s and Purtscher-like retinopathy etiology, features, management, and outcomes: a summative systematic review of 168 cases. PLoS One. 2024;19(9):e0306473. https://doi.org/10.1371/journal.pone.0306473.


Google Scholar 

David R, Hochberg-Klein S, Amer R. Resolution of ocular involvement with systemic eculizumab therapy in atypical hemolytic-uremic syndrome. Eye (lond, Engl). 2013, Aug;27(8). England, pp. 997–98. https://doi.org/10.1038/eye.2013.111.


Google Scholar 

Zheng X, Gorovoy IR, Mao J, Jin J, Chen X, Cui QN. Recurrent ocular involvement in pediatric atypical hemolytic uremic syndrome. J Pediatr Ophthalmol Strabismus. 2014 Oct;51:pp. e 62–5. https://doi.org/10.3928/01913913-20140923-03.


Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The prisma 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71.


Google Scholar