Whilst you may not recognise chlorphenamine, you’ve likely encountered Piriton, Allerief or Pollenase, which all feature it as their primary active component. The majority of adults and children over 12 months can use chlorphenamine, though there are 12 key groups who must exercise particular care.
The NHS states this encompasses anyone experiencing the following conditions, who should consult a doctor or pharmacist beforehand:
Anyone who’s had an allergic reaction to chlorphenamine or any other medicineAnyone with an eye problem called primary angle closure glaucomaAnyone who has taken a type of antidepressant called monoamine oxidase inhibitors in the last 14 daysAnyone with problems peeing or emptying their bladderAnyone with epilepsy or another health problem that can cause fits or seizuresAnyone who has breathing difficulties such as asthma or a lung conditionAnyone who has heart disease or very high blood pressureAnyone with an enlarged prostateAnyone who has liver or kidney problemsAnyone due to have an allergy test, as taking chlorphenamine may affect the results, so you might need to stop taking it a few days before the test – ask a pharmacist or your doctor for adviceAnyone who is unable to have any alcohol – some liquid chlorphenamine products contain a very small amount of alcohol, so check the ingredients and the packaging carefullyAnyone who is a frail, older adult – they may have more side effects, such as confusion
The health service also adds: “If you or your child has been prescribed chlorphenamine, follow your doctor’s instructions about how and when to take it.
“If you’ve bought chlorphenamine or any medicine containing chlorphenamine from a pharmacy, follow the instructions that come with the packet, or ask your pharmacist for advice. If you or your child’s symptoms do not get better within a few days, talk to a doctor.”
People taking chlorphenamine must also exercise caution when mixing it with other medications to prevent adverse reactions. Consult your GP or pharmacist if you’re currently taking medicines such as:
A type of antidepressant called a monoamine oxidase inhibitor, such as phenelzinePhenytoin (an anti-epilepsy medicine)Any medicines for anxiety or to help you sleepAny medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking chlorphenamine might make these side effects worse
Children under six years old should also not take cough or cold medicines containing chlorphenamine along with other ingredients. Nonetheless, NHS guidance warns: “These are not all the medicines that may cause problems if you take them with chlorphenamine. For a full list, see the leaflet inside your medicine packet.”
It continues: “It’s safe to take chlorphenamine with painkillers like paracetamol or ibuprofen that you buy from a pharmacy or shop. But if you take chlorphenamine with painkillers that contain codeine (such as co-codamol) or other prescription painkillers, you’re more likely to have side effects.”
Chlorphenamine typically begins working between 30 minutes and one hour after consumption, with users advised to allow at least four hours between doses. Common adverse effects include feeling sick, dizziness, headaches, drowsiness, impaired vision and poor concentration.
Anyone experiencing dizziness, sleepiness, or blurred vision should avoid riding a bike or driving a car until their symptoms resolve. Alcohol should also be avoided when taking chlorphenamine.
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