The year is coming to a close, and the editors of C&EN’s Chemistry in Pictures photoblog want to send it out right. Together with our team of designers, we have brought back the Chempics Bracket Challenge, assembled from 2026’s monthly contest winners and reader favorites.

Scroll down to vote on each matchup, and check back every Monday to see which entries advance to the next round. All your voting leads up to Nov. 30, when we will announce the 2026 champion.

And if you feel you’ve snapped a winner recently, submit your entry to the 2027 contest today.