New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
Study finds cockroach allergy often driven by shared proteins across arthropods
A new molecular analysis reveals that many patients labeled as cockroach-allergic may actually be reacting to shared proteins…
Simplified nanoparticles “educate” the immune system to find and destroy disease-causing cells
Johns Hopkins Medicine scientists say they have developed a simplified version of biodegradable nanoparticles that can “educate” the…
Biomimetic platform enhances CAR T therapy for relapsed and refractory leukemia
Chimeric antigen receptor T (CAR T) cell therapy represents a milestone in leukemia treatment. CAR T works by…
Optimized costimulatory domains boost tumor killing in CAR NK cells
Researchers at the Ribeirão Preto Blood Center and the Center for Cell-Based Therapy (CTC) conducted a study using the NK-92…
Genetic mismatch identified as major risk factor in cord blood transplantation
A Japanese study of more than 7,400 patients has identified a genetic mismatch that sharply increases the risk…
Remote-controlled CAR T cells offer safer cancer therapy
Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells…
Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study
A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the possibility that engineered immune…
Dynamic viral markers predict treatment response in hepatitis B
Background and aims The rate of functional cure (HBsAg loss) remains unsatisfactory following pegylated interferon (PEG-IFN) treatment in…
Web-based cytometry atlas reveals immune signatures across pancreatic cancer treatments
Oncologists have achieved some immune system responses in patients with pancreatic cancers using various combinations of vaccines and…
Silica nanomatrix enhances immunotherapy for solid tumors
Cancer has long remained a leading cause of death worldwide and in Hong Kong, accounting for 30% of…