Could scorpion venom inspire new treatments for liver disease?
From blocking inflammatory immune pathways to disrupting hepatitis viruses, scorpion-derived peptides are attracting attention as potential drug candidates,…
Genetic tool turns soft cancer cells into immune targets
Researchers at the USC Viterbi School of Engineering and Keck School of Medicine of USC have engineered a remarkable genetic tool that…
Exhausted T cells balance graft tolerance and infection risk
A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this…
Wistar scientists develop new bispecific T cell engager to target ovarian cancer
Wistar scientists have developed a new type of bispecific T cell engager, or BTE, that is effective against…
Memory B cells reveal how nasal vaccines could stop respiratory infections earlier
New insights into lung-resident memory B cells show why the next generation of vaccines may need to protect…
New breast cancer classification system predicts immunotherapy response success
The advent of immune checkpoint inhibitors (ICIs) has marked a paradigm shift in cancer treatment, yet a significant…
Engineered CAR-T cells offer potential rheumatoid arthritis cure
For the 18 million people living with rheumatoid arthritis, disease management currently means a lifetime of injections-a reality…
PSMA PET detects high-risk prostate cancer bone metastases
Compared to conventional imaging techniques, prostate specific membrane antigen (PSMA) PET imaging provides superior detection of bone metastases…
Kenyan bat coronavirus uses human CEACAM6 to enter cells, raising spillover concerns
A newly characterized bat coronavirus can latch onto a human cell receptor found in the lung, giving scientists…
Targeting glutamine metabolism enhances CAR-macrophage cancer therapy
Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) exhibit significant metabolic dysregulation, which impairs their antitumor function. Specifically,…
Study outlines principles for using CAR immunotherapies to treat neurodegenerative diseases
A UAB research team defines the criteria that CAR immunotherapies for neurodegenerative diseases must meet to advance both conceptually…
New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…