Large reasoning models as thinking machines for medicine
Jaech, A. et al. OpenAI o1 system card. Preprint at https://arxiv.org/abs/2412.16720 (2024). Guo, D. et al. DeepSeek-R1 incentivizes…
General-purpose chatbots outperform clinical AI tools on physicians’ real-world questions
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This…
Apitegromab for lean mass preservation during tirzepatide-induced weight loss: a randomized, double-blind, placebo-controlled phase 2 trial
Trial details EMBRAZE was a randomized, double-blind, placebo-controlled, phase 2 trial (NCT06445075) conducted at seven sites in the…
Medically tailored meals receipt and healthcare utilization and costs in Massachusetts’ Medicaid demonstration
Study design and setting We used a propensity score weighted, difference-in-difference analysis of adult MassHealth members with one…
The promise of adaptive health in the United Arab Emirates and beyond
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA Andrew P. Feinberg Department of Biomedical Engineering, Johns Hopkins…
Sensor wide association studies in digital medicine
Data quality and standardization Wearable data can be noisy, incomplete, and inconsistent across devices. Even within a single…
Genetic variation in transgenerational immune priming and its association with fecundity and body mass in the mealworm beetle Tenebrio molitor
Beetle cultures Tenebrio molitor used in this study originated from an outbred stock culture of more than 100,000…
Bioinformatics accelerates discovery of marine-derived bioactive therapeutic peptides
Marine organisms have evolved a remarkable arsenal of host-defense peptides under conditions of extreme variability and constant pathogen…
New malaria vaccine offers long-lasting protection without refrigeration
Malaria is a deadly disease killing more than half a million people every year, but a new vaccine…
Advancing conversational diagnostic AI with multimodal reasoning
This work advances the diagnostic capabilities of the multimodal AMIE system4,5 by integrating multimodal perception, enabling it to…
Anonymization and visualization of health data and biomarkers
Implementation details All DGMs evaluated in this study (CTGAN, CTAB-GAN, DP-CGANS, CopulaGAN, TVAE, TabDDPM, and TabSyn), along with…
AI framework for multidisease detection via retinal imaging
Study population For the model training, we used CFPs from the UKB and three hospital-based centers in China…