Microbial ecosystems influence success of cancer checkpoint immunotherapy
Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.…
Remote-controlled CAR T cells offer safer cancer therapy
Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells…
Engineered Listeria boosts innate immunity against cancer
After nearly 40 years of research on how Listeria bacteria manipulate our cells and battle our immune system…
Tumor-targeted chimeric drug increases efficacy and limits side effects
Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more…
ERC Proof of Concept grant supports promising CRISPR-based cancer treatment research
Microbiologist John van der Oost of Wageningen University & Research (WUR) has received an ERC Proof of Concept…
Reframing the role of MCL1 in cancer signaling and metabolism
A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD…
AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects
One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through…
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy | Molecular Cancer
Bernadotte A, Mikhelson VM, Spivak IM. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence.…
CRATERs identified as key sites for T cell-mediated tumor destruction
Like the surface of the moon, new research published today in Cell finds the existence of craters on…
New findings show lymph nodes educate T cells to combat disease
A team of researchers, led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute), explored the…