Vulnerable DNA sites make cancer cells sensitive to PARP inhibitors
A small subset of vulnerable DNA sites can make cancer cells highly sensitive to targeted drugs called PARP…
Comprehensive genetic map offers new hope for tuberculosis treatments
Rockefeller scientists have created the most comprehensive map to date of how essential genes interact in Mycobacterium tuberculosis…
Piracetam attenuates cyclophosphamide-evoked pulmonary injury in rats; the role of AMPK/NF-κB/NLRP3/caspase-1 and caspase-3 mediated apoptosis signaling cascades
Medications and chemical agents Cyclophosphamide (CP) was procured from Baxter Company, Germany, and was freshly dissolved in sterile…
New model reduces trial and error in mass spectrometry imaging
Andrei Fedorov and his team have found a way to take some of the guesswork out of mass…
Oncogenic mutations in non-small cell lung cancer: from molecular mechanisms to clinical practice
Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers…
Finding Their Sense of Direction: Cell Movement Helps Tissues Establish Polarity
Newswise — From the hairs on our arms to the microscopic sensory structures of the inner ear, many…
RNA modification enzyme FTO shows therapeutic promise in gastrointestinal cancers
A new review in Genes & Diseases highlights FTO, an enzyme involved in RNA modification, as a potentially…
Scientists Discover a “Fire Amoeba” That Defies Life’s Heat Limit
A sulfur pool at Lassen National Park. Credit: Shutterstock A newly identified amoeba from a volcanic region of…
Scientists Look Inside Antarctic Fish Cells to See How They Survive Near-Freezing Water
Antarctic plunderfish pictured near Rothera Station. Credit: Simon Brockington, BAS. Antarctic fish spend their entire lives in water…
Avoiding a Sticky Situation: How Cells Stop Messenger RNAs From Clumping Together
Newswise — Messenger RNA, or mRNA, is best known for carrying genetic instructions from DNA to the cellular…
Itaconate and its derivatives in human health and diseases
Wu, R. et al. ACOD1 in immunometabolism and disease. Cell Mol. Immunol. 17, 822–833 (2020). Article CAS PubMed …
UNC researcher wins major grant to study the role of endoplasmic reticulum in T-cell metabolism
Jessica Thaxton, PhD, MsCR, associate professor in the Department of Cell Biology and Physiology at the UNC School…