Oncometabolites at the crossroads of genetic, epigenetic and ecological alterations in cancer
Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, et al. Classifying the evolutionary and…
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold
Input embeddings In CellNavi, we use single-cell raw count matrices as the only input. Specifically, the single-cell sequencing…
The Surprising Way Parents Transfer Longevity to Offspring
Research in C. elegans shows that longevity-related changes in lysosomes can be passed from parents to offspring. The…
Researchers Pinpoint Protein That May Halt the Progression of Heart Disease
When cardiac workload rises, the heart’s walls can thicken, an initially adaptive shift that may tip into damaging…
Scientists “Improve on Mother Nature” To Create Powerful Cancer-Killing Molecule
Researchers discovered that bacteria inside tumors can create a molecule that makes chemotherapy more powerful. This surprising microbial…
Tiny Arctic Organisms Are Defying the Rules of Biology
Image of an Arctic diatom, showing the actin filaments that run down its middle and enable its skating…
Study reveals a new oncogenic role of NBL1 in ovarian cancer metastasis
Ovarian cancer (OC), one of the three most common gynecological malignancies, is characterized by low early detection rates…
Understanding how lipids activate LC3-associated phagocytosis
LC3-associated phagocytosis (LAP) is a specialized process for degrading dead cells, microbes or other particles. It plays a…
Scientists Solve Medical Mystery Behind Rare Multi-Organ Disease
Scientists have uncovered the genetic cause of a mysterious multi-organ disease, tracing it to faulty versions of the…
How Physical Stress Pushes Cancer Cells Into Dangerous New States
New research shows that the physical pressure of surrounding tissues can trigger hidden epigenetic changes in cancer cells,…
Study identifies C1orf122 as prognostic marker in liver cancer
Primary liver cancer is the third leading cause of cancer-related deaths, of which hepatocellular carcinoma (HCC) accounts for…
Why One Brain Circuit Collapses First in Alzheimer’s
Researchers suspect energy failures in brain “power plants” may explain why memory pathways collapse so early in Alzheimer’s.…