New insights highlight multifaceted roles of CD4+ T cells in tumor immunity
For decades, cancer immunotherapy has focused primarily on CD8+ cytotoxic T lymphocytes as the main executors of tumor…
Gene mutation that aids high-altitude survival could repair myelin sheath damage
A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing…
Pen-strep treatment rewires mechanical sensing in immune cells
Macrophages are central to mechanobiology research: their physical characteristics-stiffness, adhesion, and ECM (extracellular matrix) sensing-are inextricably linked to…
Defining the limits of immunotherapy in early small-cell lung cancer
Immunotherapy given during and after chemoradiation did not improve survival for study participants with limited-stage, small-cell lung cancer…
Scientists uncover unexpected cancer target on tumor cell surfaces
For five decades, scientists have known about a notorious cancer-causing enzyme called SRC. But they always assumed it…
Can eating almonds reduce inflammation in obesity?
A six-week randomized trial shows that adding almonds to the daily diet of adults with obesity can improve…
Simplified nanoparticles “educate” the immune system to find and destroy disease-causing cells
Johns Hopkins Medicine scientists say they have developed a simplified version of biodegradable nanoparticles that can “educate” the…
Dual-positive hybrid cells linked to shorter survival in advanced breast cancer
An enigmatic type of circulating tumor cell called a dual-positive (DP) cell is associated with shorter survival time…
New catalog identifies dozens of plasma membrane repair proteins
In the evolutionary history of life, the ability of a cell to separate its inner world from the…
Boron-assisted reactions overcome solubility barriers in protein synthesis
Chemists from ETH Zurich have found a way to produce poorly soluble proteins by caging a uniquely reactive…
Targeting IGF2BP2 improves anti-angiogenic therapy effectiveness in colorectal cancer
A recent study published in Engineering has shed light on a novel therapeutic target for improving anti-angiogenic treatment…
FOXJ1 gene may drive resistance to taxane chemotherapy in advanced prostate cancer
A gene called FOXJ1 may drive resistance to taxane chemotherapy during treatment for advanced prostate cancer, according to…