Vulnerable DNA sites make cancer cells sensitive to PARP inhibitors
A small subset of vulnerable DNA sites can make cancer cells highly sensitive to targeted drugs called PARP…
African nations seek decision-making power over gene-drive malaria tools
Gene-drive technology, which could stop mosquitoes spreading malaria, is so far confined to laboratories. But as researchers work…
Newly discovered protein helps preserve egg chromosome integrity during aging
Eggs follow a very different developmental path from sperm. Once a male hits puberty, sperm cells are produced…
New human genome benchmark captures both parental copies with near-perfect accuracy
By capturing both inherited chromosome sets and reaching genomic regions missed by conventional benchmarks, T2T-HG002 could help shift…
Smaller tetraploid cells drive more aggressive cancer
Megan Sweet slices tumors. A normal day in the lab finds the Virginia Tech graduate student with hands…
New mechanism to enhance precision in cancer drug development
Researchers at The University of Texas Medical Branch (UTMB) have identified how a key enzyme called ATR protects…
Chromosome abnormalities may help cancer cells resist treatment and spread
A new study led by NYU Langone Health researchers found that cancer cells are better able to resist…
Study proposes genetic basis for autism’s strong sex bias
Autism has a significant and enduring sex bias, with roughly four boys diagnosed for every girl. For many…
Transposable elements cause majority of lethal mutations in fruit flies
Most lethal mutations in wild fruit flies are driven by newly transferred jumping genes, not small DNA errors,…
Scientists simulate complete life cycle of a minimal bacterial cell
By simulating the life cycle of a minimal bacterial cell – from DNA replication to protein translation to…
Study: Ancient Mating Preferences, Not Natural Selection, Helped Shape Human Genome
Prehistoric humans and Neanderthals didn’t just interbreed, they did so with a consistent sex bias, as male Neanderthals…
Embryonic reproductive cells reveal striking genomic architecture before development
Researchers at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have shown for the first…