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Browsing Tag

Dopaminergic

6 posts
HHealth
Environmental insults reduce gut resilience and initiate convergent mechanisms that drive Parkinson’s disease. A lifetime of environmental insults (including Western diets and food additives, nano- and microplastics, pesticides and herbicides, industrial solvents, and air pollution) act on the intestinal microbiome and barrier. These exposures promote microbiota dysbiosis, disrupt tight junctions, and erode the mucus layer, collectively reducing gut resilience. Once this peripheral defense is compromised, several mechanistic pathways propagate pathology to the brain: (a) amyloid seeding by bacterial functional amyloids, (b) maladaptive T cell education and autoimmune responses, (c) microbiome-driven metabolic shifts that generate neurotoxic metabolites and reduce short-chain fatty acids, and (d) systemic inflammatory amplification. Together, these processes lower the threshold for α-syn misfolding, neuroinflammation, and neurodegeneration.
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Researchers propose that Parkinson’s disease may start in the gut, not the brain

  • March 6, 2026
Scientists propose that Parkinson’s disease may begin far from the brain, where environmental toxins, microbiome disruption, and intestinal…
SScience
Scientists explore how dopamine shapes myelin in social isolation
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Dopamine bursts drive faster movement during happy moments

  • February 28, 2026
New research by engineers at the University of Colorado Boulder aims to get to the bottom of why,…
HHealth
Women with isolated REM sleep behavior disorder show lesser brain atrophy than men
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Regulating microglial phagocytosis through immunotherapy could slow Parkinson’s disease progression

  • February 2, 2026
By analyzing tissue from patients with Parkinson’s disease, and animal and cellular models of the disease, a research…
SScience
Smartphone motor tests can predict dopamine deficiency in Parkinson’s disease without brain scans
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Smartphone motor tests can predict dopamine deficiency in Parkinson’s disease without brain scans

  • December 7, 2025
By pairing everyday smartphone motion data with established clinical scores, researchers demonstrate a promising path toward accessible, radiation-free…
SScience
Mapping the evolutionary trajectory of meningiomas at single-cell resolution
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Scientists create detailed single-cell map of the developing human brain

  • November 4, 2025
Scientists from Duke-NUS Medical School and their collaborators have created one of the most comprehensive single cell maps…
HHealth
Researchers identify a central controller of mitochondrial dynamics in disease
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Researchers identify a central controller of mitochondrial dynamics in disease

  • October 6, 2025
A key switch for cellular energy balance has been discovered in cells: it could potentially become the target…
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