![The sensing principle of these sensors is straightforward: the molecular target or drug to be monitored (shown in green in the illustration above) can interact with a specific DNA molecule, called aptamer (yellow molecule). Upon binding to the molecular target, this “aptamer” DNA can no longer inhibits another electro-active DNA (red DNA), that can then reach the surface of an electrode and generate an electrochemical current easily detectable with an inexpensive reader. [Jianbin Zhou]](https://www.newsbeep.com/ie/wp-content/uploads/2025/10/Low-Res_Cover-art_JACS-female-character-380x220.jpg)
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