LassoESM accelerates discovery of therapeutic peptides
In the hunt for new therapeutics for cancer and infectious diseases, lasso peptides prove to be a catch.…
SMOC1 gene plays a surprising role in the development of type 2 diabetes
Scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in…
COMBINEDBrain and MUSC join forces to launch pediatric CNS biorepository
COMBINEDBrain, a leader in advancing translational neuroscience research, and the Medical University of South Carolina (MUSC), one of…
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold
Input embeddings In CellNavi, we use single-cell raw count matrices as the only input. Specifically, the single-cell sequencing…
Preventing radiation damage with melanin-based material
Radiotherapy for abdominal and pelvic cancers almost always leads to small-intestine injuries that are difficult to heal,…
PROTACs and MGDs role in drug discovery
Stick, tag, destroy: The science of PROTACs and MGDs Traditional drug research has focused on creating inhibitors that…
DeepMind CEO Demis Hassabis: ‘AI could cut drug discovery from years to…’; how it is changing medicine worldwide |
Artificial intelligence (AI) is rapidly transforming industries, and the pharmaceutical sector is poised to be one of its…
Merck & Co. reveals monthly HIV-PrEP pill candidate
Scientists at Merck & Co. have unveiled the structure of the company’s latest candidate for HIV pre-exposure…
AI Model Finds Gene Targets and Drug Combos to Reprogram Diseased Cells
Credit: FlashMovie/Getty Images Traditional drug discovery has often followed the “one drug, one target” paradigm—developing compounds against individual…
Morphological map of under- and overexpression of genes in human cells
Mattiazzi Usaj, M. et al. High-content screening for quantitative cell biology. Trends Cell Biol. 26, 598–611 (2016). CAS …
Preclinical Data Spotlights Gene with Therapeutic Potential for Barth Syndrome
Barth Syndrome is a rare X-linked genetic condition caused by a mutation in the Tafazzin gene, which is…