Giant-nucleus cells form the foundation of early-stage cancer
Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells…
Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma
Background and aims The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent…
Evolutionary noncoding RNAs reveal new targets for cancer therapy
In cancer research, one person’s junk is increasingly becoming another person’s treasure. Scientists have now uncovered new evidence…
Long-Term Iron Accumulation Strips Neurons of Disease Resilience
Summary: Neurodegenerative conditions like Alzheimer’s and Parkinson’s diseases afflict tens of millions of people worldwide, driven by a…
Melatonin improves skin flap survival by reducing ferroptosis
Random-pattern skin flaps are widely used to repair defects caused by trauma, burns, tumor removal, and other injuries…
Exploiting a new weakness in ‘zombie-like’ cells to treat senescence-associated diseases
A new set of drugs exploit a recently-revealed weakness in ‘zombie-like’ – or senescent – cells that could lead to new treatments for cancer and age-associated diseases. The study from the…
Tumor microenvironment drives resistance to ferroptosis in pancreatic cancer
Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can…
Vitamin B2 metabolism helps cancer cells resist ferroptosis
A lack of vitamin B2 makes tumor cells more susceptible to a unique form of cell death. This…
Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease
From protein misfolding to gut–brain signalling, emerging evidence suggests that everyday plastic exposure may intersect with key biological…
Trojan horse strategy using cesium nanosalts shows powerful anti-cancer effects
Recently, a team led by Academician Hongjie Zhang, Researcher Shuyan Song, Associate Researcher Pengpeng Lei, and Dr. Ran An…
Genetic mutation in some East Asians linked to aldehyde storm and increased liver disease risk
Researchers have identified the mechanism by which a common genetic mutation increases liver disease risk. Their findings suggest…