International experts publish guidelines on the administration of gene therapy for hereditary hearing loss
Up to 60% of congenital and early-onset hearing loss is caused by genetic mutations in an inherited gene,…
Disruption of glial circadian rhythms linked to Alzheimer’s disease progression
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during…
New gene-editing method can correct many disease-causing mutations in mammalian cells
Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person’s genome, often…
HMGN1 gene linked to heart problems in people with Down syndrome
Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that…
Genetic inflammatory signature defines depression subtypes and treatment response
Researchers led by Prof. Alessandro Serretti at Kore University of Enna have identified a genetic inflammatory signature that…
Epigenetic editing enables safer and more effective T cell therapies
Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that…
Researchers develop a novel approach to monitor CD8⁺ T cell activity over time
The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key…
Women with isolated REM sleep behavior disorder show lesser brain atrophy than men
A large international study involving nearly 700 participants reveals that women with a precursor condition to Parkinson’s disease…
Genetic and inflammatory factors amplify the link between earlier menopause and cognitive risk
Women are significantly more likely than men to develop Alzheimer’s disease. Earlier age at menopause is associated with…
MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer
By decoding age gaps across the brain, heart, liver, and more, scientists show that no two organs grow…
Study reveals how a microglial mutation increases risk for Alzheimer’s disease
Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead…
New insights reveal persistent genome structure during cell division
Before cells can divide, they first need to replicate all of their chromosomes, so that each of the…