Molecular map reveals how Down syndrome alters brain development
Scientists at UCLA have created one of the first cellular-resolution molecular maps detailing how Down syndrome alters human…
Epigenome proteins shape dynamic gene expression beyond simple on-off
A new study finds the proteins responsible for controlling which genes are expressed in a genome do more…
High-resolution study maps molecular differences across six human cortical regions
A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in…
Parents’ intake of sugar substitutes may influence offspring gut biology, study finds
A new mouse study suggests that sweeteners consumed by parents may reshape gut bacteria, microbial metabolites, and metabolic…
Study identifies a common hidden genetic cause of neurodevelopmental disorder in children
A major genetic study has uncovered a surprisingly common recessive cause of neurodevelopmental disorder, revealing how hidden changes…
How could bisphenol A raise depression risk? Study identifies six key molecular targets
Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may…
Alcohol impacts gene expression differently across brain regions
Erica Periandri and Gabor Egervari, from Washington University in St. Louis, led a study to explore how alcohol exposure in male mice influences gene expression…
New AI system maps gene expression across the whole body
Understanding gene expression within the body has been a boon for 21st century biology and therapeutics, but most…
Scientists identify common molecular program across multiple brain tumor types
Research uncovering the origin of pineoblastoma, a rare pediatric brain tumor, has also revealed a dependency across multiple…
Study sheds light on potential therapeutic strategies for post-traumatic osteoarthritis
Post-traumatic osteoarthritis often affects younger, active individuals and progresses quickly following ligament or cartilage injury. Chondrocytes, the sole…
New HIV-seq tool advances understanding of persistent viral reservoirs
For people living with human immunodeficiency virus (HIV), life-saving antiretroviral therapy keeps their HIV-infected immune cells from making…
New method isolates true transcription factor targets in tuberculosis bacteria
Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression.…