Neurons may build their identity after birth, study finds
Neurons – nerve cells that transmit signals throughout the body – may not simply inherit their identity from…
Gene Syntax Determines DNA Supercoiling and Modulates Gene Expression
Digital DNA molecule, structure. Concept binary code human genome. DNA molecule with modified genes, 3D illustration When synthetic…
Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs
Cohorts We used published data (GEO accession no. GSE162632) to study the effect of 12 h of ex vivo…
Is enhancer-driven gene regulation all wrapped up?
Symmons, O. et al. The Shh topological domain facilitates the action of remote enhancers by reducing the effects…