New genomic tools improve detection of rare DNA changes
WashU Medicine researchers have verified the accuracy of genetics tools to correctly identify all the rare DNA changes…
Novel method identifies active tRNAs during cellular protein synthesis
Our cells turn genetic instructions into proteins with great precision. Critical for the translation of this information are…
Vulnerable DNA sites make cancer cells sensitive to PARP inhibitors
A small subset of vulnerable DNA sites can make cancer cells highly sensitive to targeted drugs called PARP…
Graded physical activity prescriptions improve functional outcomes in psychiatry
Most of us have heard the advice so often that it has worn smooth, like a stone in…
CHOP researchers link MAP2K4 variants to a neurodevelopmental disorder
Researchers from Children’s Hospital of Philadelphia (CHOP) have discovered the mechanisms of previously unknown changes in a gene…
An AI-identified biomarker can look accurate and still fail its biggest test
From blood samples to scans and wearables, the review follows what happens after an AI model identifies a…
New prime assembly method enables long and precise DNA insertions
Genomic editing holds great potential yet continues to have its limitations. Most current methods either rely on untargeted gene…
Study identifies DNA loops as essential for tissue regeneration
After an injury, DNA not only alters its activity but also the way it is organized spatially within…
Blood protein profiling could improve rare disease diagnosis
Researchers from Queen Mary University of London, the Berlin Institute of Health at Charité (BIH) and Genomics England…
Paternal sperm epigenetics may help explain early pregnancy loss
When a pregnancy ends early and unexplained, the search for answers usually begins with the mother. Lacey Luense,…
Mitochondrial gene RTN4IP1 drives triple-negative breast cancer metastasis
Triple-negative breast cancer accounts for approximately 15% of all breast cancer cases. It is characterized by the absence…
New human genome benchmark captures both parental copies with near-perfect accuracy
By capturing both inherited chromosome sets and reaching genomic regions missed by conventional benchmarks, T2T-HG002 could help shift…