Combination therapy overcomes ferroptosis resistance in β-catenin-mutant hepatocellular carcinoma
Background and aims The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent…
Review outlines effective approaches to reduce recurrent hepatic encephalopathy
Hepatic encephalopathy (HE) is a neurologic complication of advanced liver disease, causing impaired functioning, reduced quality of life…
Microbial metabolites could help improve functional cure rates for hepatitis B
Chronic hepatitis B (CHB) remains a major global challenge. Current therapies suppress HBV but rarely achieve functional cure…
Novel interventional approach successfully treats rare hepatic myelopathy
Hepatic myelopathy (HM) is a rare neurological complication of decompensated chronic liver disease that profoundly impairs quality of…
Lifestyle changes improve MASLD by suppressing key molecular pathway
A molecular explanation for how lifestyle interventions protect the liver Lifestyle modification is the cornerstone of managing metabolic…
Ireland urged to recognise symptoms of the nation’s ‘hidden condition’
This June, during World Haemochromatosis Awareness Week (1st–7th June 2026 ), the Irish Haemochromatosis Association (IHA ) is…
Hepatitis C infection associated with reduced portal insulin levels
Background and aims Insulin resistance is a common extrahepatic manifestation of hepatitis C virus (HCV) infection (HCVi), but…
Specific intestinal fungi play role in the pathogenesis of MASLD and cardiovascular disease
Background and aims Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for cardiovascular disease (CVD).…
Molecular test shows high sensitivity in detecting bile duct cancer
When patients develop a narrowing or blockage in the bile ducts – the tubes connecting the liver, gallbladder…
New algorithm enables precise subtyping of metabolic liver disease
Metabolic-associated steatotic liver disease (MASLD) is a clinically heterogeneous condition with highly variable outcomes affecting more than 30%…
‘I am not fighting bad science, I am fighting state-sanctioned propaganda’
Dr Cyriac Abby Philips. There have been court injunctions, police summons, a social media ban (later lifted) and…
Dynamic viral markers predict treatment response in hepatitis B
Background and aims The rate of functional cure (HBsAg loss) remains unsatisfactory following pegylated interferon (PEG-IFN) treatment in…