Tumor microenvironment drives resistance to ferroptosis in pancreatic cancer
Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can…
Novel microneedle patch accelerates healing of chronic diabetic wounds using light
Researchers from Nanjing Drum Tower Hospital, Southeast University, and Wenzhou Medical University have developed a novel microneedle patch…
Researchers show red blood cells drive better glucose tolerance at high altitude
New research reveals how hypoxia-driven red blood cell adaptations may reshape glucose regulation, offering fresh insight into diabetes…
Low oxygen turns red blood cells into powerful glucose sinks
Scientists have long known that people living at high altitudes, where oxygen levels are low, have lower rates…
Hypoxia rewires red blood cells to clear excess glucose
In a 2023 paper on hypoxia and glucose metabolism, our lab showed how organisms rewire their metabolism to…
Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
How Do Athletes Train to Avoid Altitude Sickness?
Some athletes go to the gym. Some run long distances across vast terrains. Some even build their fitness…
The caffeine conundrum in rapid depression treatments
Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Hypoxia weakens the body’s infection defense by changing genetic material of neutrophils
Low oxygen levels in the blood can alter the genetic makeup of key immune cells, weakening the body’s…
Chronic hypoxia induces liver injury via PKCδ/ASMase-driven ceramide accumulation and endoplasmic reticulum stress in rats | Lipids in Health and Disease
Ramirez TA, Jourdan-Le SC, Joy A, Zhang J, Dai Q, Mifflin S, et al. Chronic and intermittent hypoxia…