Dinutuximab beta plus chemotherapy shrinks neuroblastoma tumors in children
Children with a rare form of cancer called neuroblastoma which hasn’t responded to initial treatment or that has…
Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes
Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion,…
MIT researchers find new immunotherapeutic targets for glioblastoma | MIT News
Glioblastoma is the most common form of brain cancer in adults, and its consequences are usually quick and…
Dietary restriction boosts antitumour immunity by rewiring T cell metabolism
By elevating ketone-driven energy pathways inside CD8+ T cells, dietary restriction steers them away from exhaustion and toward…
Novel mRNA-based therapy may offer a new path to tackle antibiotic-resistant infections
Researchers at the Icahn School of Medicine at Mount Sinai and collaborators have reported early success with a…
Single-cell study reveals how HPV shapes immune landscape in penile cancer
Although penile cancer represents less than 1% of male malignancies, it carries substantial physical and psychological burden, with…
Innovative research reveals FGD3 as a key player in breast cancer cell death
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the…
Northwestern team develops antibody to expose hidden pancreatic cancer cells
Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Targeting myeloid cells to enhance cancer immunotherapy
Mayo Clinic researchers have identified a specific immune cell that can be targeted to give a boost to standard…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
How COVID mRNA vaccines may make cancer treatments more effective
A new study reveals that SARS-CoV-2 mRNA vaccines can amplify immune checkpoint therapy in lung and skin cancers…