New spatially resolved transcriptomic map reveals how bone and muscle cells communicate
A new study generated one of the most comprehensive spatially resolved transcriptomic maps of cellular communication between bone…
Optibrium introduces graphical interface for QuanSA to enhance ligand-based affinity predictions
Optibrium, a leading developer of software and AI solutions for molecular design, today announced a new QuanSA™ plugin…
Machine learning model predicts chemical reactions to accelerate drug discovery
Drug discovery is like molecular Tetris. Chemists snap atoms together, adjusting the pieces until everything fits and suddenly,…
Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
RNA micelles enable targeted chemotherapy without immune toxicity
A new study in mice hints at the potential to use tiny particles made with RNA molecules to…
Cryo-EM reveals NPFFR1 activation and guides novel ligand design
This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of neuropeptide FF receptor 1…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Immune cell dysregulation and inflammatory mediators shape epilepsy risk
Background and objectives Emerging evidence implicates immune dysregulation and neuroinflammation in the pathogenesis of epilepsy, yet the causal…
Integrating physicochemical laws into future AI models for better drug design
Proteins play a key role not only in the body, but also in medicine: they either serve as…
New fluorescent molecule could be used to generate clearer images of tumors
MIT chemists have designed a new type of fluorescent molecule that they hope could be used for applications…
Engineered CAR T cells show promise against solid tumors
Chimeric antigen receptor (CAR) T cell therapy, which uses a patient’s own immune cells to fight cancer, has…
SLIT2 protein levels in the eye and blood linked to cognitive function
Neurocognitive impairments are classified by pathological changes with potential for destruction of neural tissue. One change known to…