Targeting lipid enzymes triggers starvation states in aggressive tumor cells
While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for…
Dual targeting strategy may improve treatment for resistant lung cancers
Findings from a study led by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G.…
Tuberculosis bacteria stiffen cell membranes to evade immune destruction
Scientists have uncovered an elegant biophysical trick that tuberculosis-causing bacteria use to survive inside human cells, a discovery…
Grant supports research into how microglia may spread toxic tau in Alzheimer’s
A researcher with the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases at UT Health San Antonio has…
New atlas of brain lysosomes sheds light on neurodegenerative disorders
Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when…
Changes in brain fats play a key role in Alzheimer’s development and progression
More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as “lipoid…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
Lysosomal activity in worms linked to transgenerational extension of lifespan
In the Wang Lab, it’s not unusual for worms to live for a long time. HHMI Janelia Research…
High fat diet impairs memory formation through autophagy dysfunction
Modern lifestyles and dietary changes have significantly increased the consumption of high-fat foods, contributing to a steep rise…