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Browsing Tag

Metabolites

23 posts
HHealth
NYU Langone strengthens world-leading GI cancer program with renowned leaders
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Microbial ecosystems influence success of cancer checkpoint immunotherapy

  • March 9, 2026
Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.…
HHealth
Environmental insults reduce gut resilience and initiate convergent mechanisms that drive Parkinson’s disease. A lifetime of environmental insults (including Western diets and food additives, nano- and microplastics, pesticides and herbicides, industrial solvents, and air pollution) act on the intestinal microbiome and barrier. These exposures promote microbiota dysbiosis, disrupt tight junctions, and erode the mucus layer, collectively reducing gut resilience. Once this peripheral defense is compromised, several mechanistic pathways propagate pathology to the brain: (a) amyloid seeding by bacterial functional amyloids, (b) maladaptive T cell education and autoimmune responses, (c) microbiome-driven metabolic shifts that generate neurotoxic metabolites and reduce short-chain fatty acids, and (d) systemic inflammatory amplification. Together, these processes lower the threshold for α-syn misfolding, neuroinflammation, and neurodegeneration.
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Researchers propose that Parkinson’s disease may start in the gut, not the brain

  • March 6, 2026
Scientists propose that Parkinson’s disease may begin far from the brain, where environmental toxins, microbiome disruption, and intestinal…
HHealth
Periodontal bacteria trigger bone density reduction via the gut
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Periodontal bacteria trigger bone density reduction via the gut

  • March 4, 2026
Periodontitis, a chronic inflammatory disease of the gums, affects hundreds of millions of people worldwide and is increasingly…
SScience
Machine learning unlocks blood test secrets for spinal cord injury
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Metabolite-driven AI model accurately estimates time of death

  • February 25, 2026
Artificial intelligence can be used to provide a more precise time of death, which can be crucial in…
HHealth
Raw meat, fish, and eggs.
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Health benefits and risks uncovered

  • February 2, 2026
A new review finds that while the carnivore diet may deliver short-term improvements, weak evidence and emerging risks…
HHealth
Study: Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality. Image Credit: Kateryna Kon / Shutterstock
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How modern lifestyles reprogram the gut microbiome and shape disease risk

  • January 28, 2026
From jet lag and poor sleep to exercise and chronic stress, this review unpacks how everyday lifestyle factors…
HHealth
Study: The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations. Image Credit: Prostock-studio / Shutterstock
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Blood lipid–hormone ratios predict future asthma attacks years in advance

  • January 21, 2026
A large biobank study reveals that subtle imbalances between inflammatory lipids and steroids in the blood can identify…
HHealth
Study: Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control. Image Credit: Ahmet Misirligul / Shutterstock
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Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

  • December 10, 2025
A microbial metabolite long linked to cardiovascular risk emerges as a surprising ally against metabolic inflammation, revealing how…
HHealth
female alcoholic drinking whiskey at home
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Chronic drinking weakens the blood-brain barrier through the gut

  • November 27, 2025
Scientists trace alcohol’s impact from the gut to the brain, uncovering microbial changes that weaken the blood-brain barrier,…
HHealth
Raw beef tenderloin meat
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Eating lean beef as part of MED diet could improve gut diversity

  • November 21, 2025
New clinical trial evidence suggests that replacing an American-style diet with a Mediterranean eating pattern, while still consuming…
HHealth
Woman taking various food supplements and fruit smoothie
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The role of dietary supplements

  • November 10, 2025
New research reveals how everyday supplements like protein, creatine, and vitamin D may help keep muscles strong, but…
HHealth
Gut microbiota characteristics in sleep disorders. The figure shows representative characteristics of gut microbiota changes in patients with sleep disorders and those with sleep disorders combined with psychiatric disorders. F/B: the ratio of Firmicutes/Bacteroidetes.
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New review reveals microbiome clues to insomnia and apnea

  • November 6, 2025
Trillions of gut microbes may hold the key to better rest. A new review reveals how shifts in…
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