New atlas of brain lysosomes sheds light on neurodegenerative disorders
Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when…
Study shows DHPS enzyme controls macrophage maturation across multiple organs
A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns…
Suppressing brain immune cells enhances memory recall in young mice
Babies of every species from mouse to human rapidly forget things that happen to them-an effect called infantile…
Blocking microglia can prevent infantile amnesia
Scientists have found that blocking microglia (specialist immune cells in the brain) prevents infant forgetting (“infantile amnesia”) and…
Brain immune cells drive persistent negative emotions after repeated binge drinking
New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying…
Changes in brain fats play a key role in Alzheimer’s development and progression
More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as “lipoid…
Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections
Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new…
Disruption of glial circadian rhythms linked to Alzheimer’s disease progression
Alzheimer’s disease is notorious for scrambling patients’ daily rhythms. Restless nights with little sleep and increased napping during…
Study reveals how a microglial mutation increases risk for Alzheimer’s disease
Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead…
Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease | Journal of Neuroinflammation
Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15(9):545–58. CAS PubMed Google Scholar …
Mount Sinai study maps protein networks driving Alzheimer’s disease pathogenesis
A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most…