Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
New gene-editing method can correct many disease-causing mutations in mammalian cells
Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person’s genome, often…
Study reveals acidic conditions as key to pancreatic cancer survival
Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful…
Researchers identify a central controller of mitochondrial dynamics in disease
A key switch for cellular energy balance has been discovered in cells: it could potentially become the target…
Second round of exercise boosts muscle growth in mice
New research offers potential good news for those who’ve lapsed at the gym. The study found that mice…
Scientists “Improve on Mother Nature” To Create Powerful Cancer-Killing Molecule
Researchers discovered that bacteria inside tumors can create a molecule that makes chemotherapy more powerful. This surprising microbial…
Antidepressant fluoxetine alters brain energy use and boosts neural plasticity
A new study shows that the widely used antidepressant fluoxetine does more than boost serotonin levels: it…
Scientists Find a Way to “Bulletproof” T Cells Against Cancer
Researchers at the University of Pittsburgh have discovered that the harsh environment inside tumors, characterized by low oxygen…
Female-specific mechanism enhances heat production in brown fat
Higher activity of PGC-1α enables brown fat cells in females to thermogenic activity and energy expenditure compared to…
Targeting telomere damage offers new path to boost cancer immunotherapy
Tumors are stressful places for cancer-fighting immune cells. Low oxygen, high acid levels, and other stressors put strain…
Rare ABCA7 gene variants linked to Alzheimer’s risk
A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to…
Why One Brain Circuit Collapses First in Alzheimer’s
Researchers suspect energy failures in brain “power plants” may explain why memory pathways collapse so early in Alzheimer’s.…