On-premise medical AI agents for reliable clinical decision-making
Ethics statement This study utilized deidentified, retrospective clinical data from the MIMIC-IV (version 2.2) and physician-curated cases from…
Initial lessons from real-world implementation of an AI-agent eye clinic in China
These authors contributed equally: Tao Yan, Di Zhang. Department of Automation, Tsinghua University, Beijing, China Tao Yan, Taizhangtian Ma, Chunyang…
Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health
Ethical approval This study involves data from human participants that have participated in the OFH program and the…
Prospective evaluation of a large language model clinical decision support system in the emergency department
Hoot, N. R. & Aronsky, D. Systematic review of emergency department crowding: causes, effects, and solutions. Ann. Emerg.…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Divergent impacts of explainable AI for dermatological diagnosis on clinicians versus lay people
Study design We designed two complementary large-scale experiments to evaluate human−AI collaborative diagnostic performance across expertise levels (Fig.…
Integrated care pathway in individuals with Long COVID: STIMULATE-ICP, a cluster-randomized, phase 3 trial
Trial design and oversight The STIMULATE-ICP trial aimed to investigate the efficacy of an enhanced ICP for LC,…
Genomas Brasil program: building precision public health within Brazil’s Unified Health System
Patel, H. N. et al. J. Pharm. Bioallied Sci. 17, S1101–S3 (2025). Article PubMed PubMed Central Google Scholar …
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial
Design We conducted a pragmatic, multicenter, parallel-group cluster-randomized controlled trial across a network of 16 primary care facilities…
Evaluating the robustness and readiness of large frontier models in health AI applications
Singhal, K. et al. Large language models encode clinical knowledge. Nature 620, 172–180 (2023). Article CAS PubMed PubMed…
General-purpose chatbots outperform clinical AI tools on physicians’ real-world questions
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This…