Neurodegeneration

CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder

March 12, 2026

Ayrignac X, Carra-Dalliere C, Codjia P, Mouzat K, Castelnovo G, Ellie E, et al. Evaluation of CSF1R-related adult…

Environmental insults reduce gut resilience and initiate convergent mechanisms that drive Parkinson’s disease. A lifetime of environmental insults (including Western diets and food additives, nano- and microplastics, pesticides and herbicides, industrial solvents, and air pollution) act on the intestinal microbiome and barrier. These exposures promote microbiota dysbiosis, disrupt tight junctions, and erode the mucus layer, collectively reducing gut resilience. Once this peripheral defense is compromised, several mechanistic pathways propagate pathology to the brain: (a) amyloid seeding by bacterial functional amyloids, (b) maladaptive T cell education and autoimmune responses, (c) microbiome-driven metabolic shifts that generate neurotoxic metabolites and reduce short-chain fatty acids, and (d) systemic inflammatory amplification. Together, these processes lower the threshold for α-syn misfolding, neuroinflammation, and neurodegeneration.

March 6, 2026

Scientists propose that Parkinson’s disease may begin far from the brain, where environmental toxins, microbiome disruption, and intestinal…

FFitness

Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia

March 2, 2026

Knopman, D. S. et al. Alzheimer disease. Nat. Rev. Dis. Primers 7, 33 (2021). Article PubMed PubMed Central …

HHealth

Study: Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease. Image Credit: Andrii Vodolazhskyi / Shutterstock

February 12, 2026

A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the possibility that engineered immune…

SScience

Pioneering technology enables scalable production of human kidney organoids

February 10, 2026

Spatial omics is a new generation of technologies that allow scientists to study cells in their original location…

HHealth

Cumulative social advantage linked to slower biological aging and lower inflammation

February 3, 2026

As we age, we begin to lose the connections that wire up our brains-and neuroscientists aren’t sure why. …

HHealth

February 2, 2026

Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s diagnosis. Study: Longitudinal assessment of…

HHealth

Brain stimulation may help people with multiple sclerosis cut back on excessive cannabis use

January 28, 2026

When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, researchers…

HHealth

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

January 27, 2026

Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when…

HHealth

Study: Total and different types of olive oil consumption, gut microbiota, and cognitive function changes in older adults. Image Credit: Mehes Daniel / Shutterstock

January 27, 2026

A large cohort study suggests that not all olive oils are equal, with virgin olive oil showing favorable…

SScience

Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease

January 27, 2026

From protein misfolding to gut–brain signalling, emerging evidence suggests that everyday plastic exposure may intersect with key biological…

SScience

SLIT2 protein levels in the eye and blood linked to cognitive function

January 12, 2026

Researchers at VIB and KU Leuven have identified a molecular process that allows motor neurons to maintain protein…

CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder

Researchers propose that Parkinson’s disease may start in the gut, not the brain

Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia

Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

New spatial omics platform advances biomedical research in Spain

Aging brains struggle to recycle synaptic proteins

Blood gene signals reveal Parkinson’s risk years before diagnosis

Overactive protein cleanup disrupts nuclear pores in neurodegenerative disease

New atlas of brain lysosomes sheds light on neurodegenerative disorders

Olive oil type matters for cognition and gut health in older adults

Tiny plastic particles may interfere with brain processes implicated in Parkinson’s disease

Restoring protein production in motor neuron axons