Itaconate and its derivatives in human health and diseases
Wu, R. et al. ACOD1 in immunometabolism and disease. Cell Mol. Immunol. 17, 822–833 (2020). Article CAS PubMed …
Faulty myelin-making brain cells may help drive cognitive decline with age
A rare combination of lifelong cognitive tracking, postmortem brain analysis, and targeted mouse experiments reveals unexpected changes in…
Shared protein pathology redefines treatment for multiple neurodegenerative diseases
On the surface, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) might seem…
Lancet review examines possible amyloid-beta transmission through blood transfusions
A review and opinion piece published in The Lancet and led by UCL (University College London) and UCLH…
Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes
From mitochondrial fragmentation to antioxidant defenses, researchers reveal how the same viruses can drive cellular damage in vertebrates…
AI-based methods help uncover hidden roots of tumor metastasis
A cancerous tumor is not a single enemy. It is made up of many different cell populations that…
A closer look at Parkinson’s brains finds tau where standard tests saw little
By examining six brain regions at single-molecule resolution, researchers identified a layer of tau pathology that conventional tissue…
RNA-based testing can improve detection of key lung cancer biomarkers
New research has shown that RNA-based testing can improve the detection and interpretation of clinically actionable genomic alterations…
Prenatal use of certain medications can harm developing fetal brain
A review article by a University of Nebraska Medical Center/Child Health Research Institute research team underscores and describes…
New tumor organoids strengthen precision oncology research
Significant advances have been made in the development of patient-derived tumor “organoids” for preclinical research, in two new…
Tau buildup in progressive supranuclear palsy alters brain networks linked to thinking and behavior
Researchers at Japan’s National Institutes for Quantum Science and Technology (QST) have found that tau buildup in progressive…
Blood p-tau217 levels signal cognitive impairment risk years before symptoms emerge
A six-cohort analysis links higher baseline p-tau217 to rising 5- and 10-year risks, bringing presymptomatic risk models closer…