Researchers uncover new mechanism linking metabolism, immunity, and skeletal health
Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment.…
Study explores racial differences in gastric cancer immunotherapy outcomes
Advanced gastric cancer remains one of the deadliest malignancies, with a 5-year overall survival rate below 10%. In…
Microbial ecosystems influence success of cancer checkpoint immunotherapy
Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies.…
Chronic inflammation shapes cancer progression and immunotherapy response
Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs,…
AI turns routine pathology slides into powerful maps of the tumor immune landscape
By transforming standard H&E slides into virtual multiplex protein maps, GigaTIME reveals how immune activity, tumor invasion, and…
Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Targeting myeloid cells to enhance cancer immunotherapy
Mayo Clinic researchers have identified a specific immune cell that can be targeted to give a boost to standard…
How COVID mRNA vaccines may make cancer treatments more effective
A new study reveals that SARS-CoV-2 mRNA vaccines can amplify immune checkpoint therapy in lung and skin cancers…
Engineered CAR T cells show promise against solid tumors
Chimeric antigen receptor (CAR) T cell therapy, which uses a patient’s own immune cells to fight cancer, has…