Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…
New chemotherapeutic agent shows remarkable efficacy against multiple tumor types
A research team led by the Medical University of Vienna, the HUN-REN Research Centre for Natural Sciences and…
How COVID mRNA vaccines may make cancer treatments more effective
A new study reveals that SARS-CoV-2 mRNA vaccines can amplify immune checkpoint therapy in lung and skin cancers…
Strong grip strength lowers risk of organ dysfunction in obesity
People with obesity who also have high muscle mass may be less likely to have obesity-related organ damage.…
Engineered Salmonella therapy delivers immune payloads to combat cancer
A new research paper was published in Volume 16 of Oncotarget on October 6, 2025, titled “ACTM-838, a novel systemically delivered…
Researchers identify a central controller of mitochondrial dynamics in disease
A key switch for cellular energy balance has been discovered in cells: it could potentially become the target…
Highly targeted gene therapy could revolutionize treatment for cancers linked to herpesvirus
In a preclinical study, UC Davis Comprehensive Cancer Center scientists developed a highly targeted gene therapy that could…
Mapping the dynamics of complex protein
Discover how the University of Manchester was able to explore the dynamics of complex proteins thanks to Bruker’s groundbreaking…
Genetic modification enhances “living drugs” for blood cancers
CAR T cells are patient-derived, genetically engineered immune cells. They are “living drugs” and constitute a milestone in…
Glucose-fructose mix found in sugary drinks fuels colorectal cancer metastasis
A new study from researchers at The University of Texas MD Anderson Cancer Center shows that the glucose-fructose…
Genetic study shows dual GIPR/GLP1R action curbs binge alcohol use
New genetic evidence suggests that targeting GIPR and GLP1R could reduce harmful drinking patterns while improving liver and…