Cryo-EM reveals NPFFR1 activation and guides novel ligand design
This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of neuropeptide FF receptor 1…
Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch
A microbial metabolite long linked to cardiovascular risk emerges as a surprising ally against metabolic inflammation, revealing how…
WSU researchers discover how a neural circuit drives relapse after opioid use
Washington State University researchers have discovered how a neural circuit – or a connection between two brain regions…
Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease
A phase 2 trial suggests that a drug commonly used for constipation may help preserve kidney function in…
Study shines light on how P2X4 receptor can be inhibited
A study carried out by the University of Bonn and the University Hospital Bonn throws light on how…
Diabetes drugs linked to slower frailty progression in older adults
A new study shows that older adults with type 2 diabetes who start treatment with sodium–glucose cotransporter-2 (SGLT-2)…
Stopping GLP-1 drugs before pregnancy leads to more weight gain
New research shows that women who halt GLP-1 medications near conception face greater gestational weight gain and elevated…
New skin-permeable polymer delivers insulin without needles
A breakthrough zwitterionic polymer slips through the skin’s toughest barriers, carrying insulin deep into tissue and normalizing blood…
Dexamethasone shows potential to fight therapy-resistant breast cancer metastases
The drug dexamethasone supplements cancer treatments to alleviate side effects of chemotherapy such as nausea or inflammation. Researchers…
Searches for “Ozempic face” surge as people look for filler-based solutions
New search data reveal that as interest in “Ozempic face” surges, people increasingly turn to nonsurgical fillers rather…
Study compares GLP-1 drug benefits and finds substantial variation in clinical effects
A new umbrella review reveals how GLP-1 therapies shape cardiovascular, renal, and metabolic outcomes in type 2 diabetes…
Breast cancer cells use a molecular switch to survive stress
Cells are regularly faced with environmental stresses that may damage or destroy them. To survive, they quickly adjust…