Synthetic DNA molecules enable precise targeting of cancer-linked genes
Researchers have developed a promising new approach that uses synthetic DNA molecules to target cancer-linked genes directly, opening…
New study identifies biological mechanism driving therapy resistance in advanced prostate cancer
A multi-institutional collaborative study led by researchers at the University of Chicago and the Fred Hutchinson Cancer Center…
Researchers uncover molecular pathway controlling bone resorption and tooth eruption
RUNX2 is best known as a master transcription factor of osteoblast differentiation. Mutations in, or haploinsufficiency of RUNX2…
New mathematical method maps gene roles across different species
Background Much of what we know about biology comes from animal models, particularly mice. Applying these insights to…
Amyloid fibers help sperm deliver RNA to mouse embryos
A longstanding mystery about the genetic messages carried by sperm led researchers to investigate an unexpected component of…
Novel gene rejuvenation therapy preserves cell identity while reversing age
Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified “hallmarks…
Researchers improve CRISPR technology for detecting HIV and other RNA viruses
Scientists have long used a powerful gene-editing tool called CRISPR to make precise changes to DNA. But a…
RNA modification enzyme FTO shows therapeutic promise in gastrointestinal cancers
A new review in Genes & Diseases highlights FTO, an enzyme involved in RNA modification, as a potentially…
Advances in chemistry and delivery are taking oligonucleotide medicines beyond rare diseases
Decades of work on RNA targeting, chemical modification, and tissue-specific delivery are reshaping what programmable genetic medicines can…
KAUST researchers develop AI tool to map cell evolution
Publishing in Nature Communications, a KAUST-led team has developed the AI tool Unify to help scientists compare similar…
Microscopic peptide droplets reduce colorectal tumor growth in mice
Scientists from Nanyang Technological University, Singapore (NTU Singapore) have developed microscopic peptide droplets that deliver large amounts of…
DARPA funds project to build wireless yeast DNA printer
The Defense Advanced Research Projects Agency (DARPA) has tasked scientists with developing a system that can receive instructions…