DNA methylation “fingerprints” identify primary sites in metastatic cancers
A machine learning model analyzing CpG-based DNA methylation accurately predicted the origin of many different cancer types in…
Targeting glutamine metabolism enhances CAR-macrophage cancer therapy
Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) exhibit significant metabolic dysregulation, which impairs their antitumor function. Specifically,…
New study reveals CRISPR enzyme that responds to human DNA methylation
Cancer cells excel at evading detection, but subtle chemical differences set them apart from healthy cells. Now, a…
Scientists find unexpected immune pathways for mRNA cancer vaccines
The advent of mRNA vaccines against SARS-CoV-2 in 2020 changed the course of the COVID-19 pandemic. Now, the…
New imager separates UV and infrared light to find cancerous nodes
Researchers have developed a compact camera that captures ultraviolet, near-infrared and visible images using a single chip. Inspired…
Scientists link poor sleep to decreased chemotherapy response via the gut
Sleep deprivation has long been known to weaken the immune system. Now UF Health Cancer Institute researchers have…
Mitochondrial activity keeps dendritic cells ready to fight disease
Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) show that active mitochondria maintain dendritic cells,…
Targeting senescent fat cells provides new hope for ovarian cancer
Ovarian cancer is the most lethal malignancy of the female reproductive system. Due to its insidious early symptoms…
Lung tumors shift identity making treatment more difficult
A new study co-led by the Institute for Systems Biology (ISB) shows that some lung cancers can change…
Nanomedicine offers targeted solutions for breast cancer treatment
Breast cancer (BCA) is one of the most common cancers worldwide, with high mortality and morbidity in women.…
Targeted diet helps reprogram aggressive neuroblastoma in mice
A new commentary spotlights preclinical evidence that blocking key amino acids, along with a polyamine-blocking drug, may force…
New blood test spots four cancers and other diseases by stripping away healthy DNA noise
By cutting through the overwhelming background of healthy blood DNA, MethylScan gives clinicians a clearer view of cancer,…