Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers
Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and…
precision DNA repair may hold clues for human aging
The bowhead whale’s remarkable lifespan and low cancer risk stem from a finely tuned DNA repair system driven…
Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway
Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.…
New chemotherapeutic agent shows remarkable efficacy against multiple tumor types
A research team led by the Medical University of Vienna, the HUN-REN Research Centre for Natural Sciences and…
Two microbial metabolites compete to control the cells’ protein building machinery
The microbiome-the trillions of bacteria, viruses, and fungi that live quietly in our body-plays a crucial role in…
Targeting myeloid cells to enhance cancer immunotherapy
Mayo Clinic researchers have identified a specific immune cell that can be targeted to give a boost to standard…
Harnessing extracellular vesicles for targeted lung cancer treatment
In the quest for more targeted lung cancer treatments, a researcher at the University of Missouri thinks the…
Two analgesic drugs may one day be repurposed as anti-tumor therapies
Peripheral afferent neurons – nerves that send signals from all areas of the body to the central nervous…
Mitochondria and lysosomes work together to control regulatory T cell activation
Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the…
How COVID mRNA vaccines may make cancer treatments more effective
A new study reveals that SARS-CoV-2 mRNA vaccines can amplify immune checkpoint therapy in lung and skin cancers…
Researchers develop a novel approach to monitor CD8⁺ T cell activity over time
The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key…
Researchers engineer a tool to dismantle cancer’s RNA-built growth hubs
In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form-but instead of…