{"id":126893,"date":"2025-11-07T13:50:10","date_gmt":"2025-11-07T13:50:10","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/126893\/"},"modified":"2025-11-07T13:50:10","modified_gmt":"2025-11-07T13:50:10","slug":"the-controversial-role-of-senescence-associated-secretory-phenotype-sasp-in-cancer-therapy-molecular-cancer","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/126893\/","title":{"rendered":"The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy | Molecular Cancer"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Bernadotte A, Mikhelson VM, Spivak IM. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence. Aging (Albany NY). 2016;8:3\u201311.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXmtFSnu78%3D\" aria-label=\"CAS reference 1\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26805432\" aria-label=\"PubMed reference 1\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Markers%20of%20cellular%20senescence.%20Telomere%20shortening%20as%20a%20marker%20of%20cellular%20senescence&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=8&amp;pages=3-11&amp;publication_year=2016&amp;author=Bernadotte%2CA&amp;author=Mikhelson%2CVM&amp;author=Spivak%2CIM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">d\u2019Adda di Fagagna F. Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer. 2008;8:512\u201322.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Living%20on%20a%20break%3A%20cellular%20senescence%20as%20a%20DNA-damage%20response&amp;journal=Nat%20Rev%20Cancer&amp;volume=8&amp;pages=512-22&amp;publication_year=2008&amp;author=Fagagna%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Erusalimsky JD. Oxidative stress, telomeres and cellular senescence: what non-drug interventions might break the link? Free Radic Biol Med. 2020;150:87\u201395.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXktlygtbs%3D\" aria-label=\"CAS reference 3\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32061901\" aria-label=\"PubMed reference 3\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Oxidative%20stress%2C%20telomeres%20and%20cellular%20senescence%3A%20what%20non-drug%20interventions%20might%20break%20the%20link%3F&amp;journal=Free%20Radic%20Biol%20Med&amp;volume=150&amp;pages=87-95&amp;publication_year=2020&amp;author=Erusalimsky%2CJD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Liu XL, Ding J, Meng LH. Oncogene-induced senescence: a double edged sword in cancer. Acta Pharmacol Sin. 2018;39:1553\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhvVOjsb3J\" aria-label=\"CAS reference 4\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29620049\" aria-label=\"PubMed reference 4\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6289471\" aria-label=\"PubMed Central reference 4\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Oncogene-induced%20senescence%3A%20a%20double%20edged%20sword%20in%20cancer&amp;journal=Acta%20Pharmacol%20Sin&amp;volume=39&amp;pages=1553-8&amp;publication_year=2018&amp;author=Liu%2CXL&amp;author=Ding%2CJ&amp;author=Meng%2CLH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Kumari R, Jat P. Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol. 2021;9:645593.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33855023\" aria-label=\"PubMed reference 5\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8039141\" aria-label=\"PubMed Central reference 5\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mechanisms%20of%20cellular%20senescence%3A%20cell%20cycle%20arrest%20and%20senescence%20associated%20secretory%20phenotype&amp;journal=Front%20Cell%20Dev%20Biol&amp;volume=9&amp;publication_year=2021&amp;author=Kumari%2CR&amp;author=Jat%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Liu B, Peng Z, Zhang H, Zhang N, Liu Z, Xia Z, et al. Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways. Mol Cancer. 2025;24:106.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40170077\" aria-label=\"PubMed reference 6\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11963325\" aria-label=\"PubMed Central reference 6\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20cellular%20senescence%20in%20tumor%20progression%20and%20therapeutic%20targeting%3A%20mechanisms%20and%20pathways&amp;journal=Mol%20Cancer&amp;volume=24&amp;publication_year=2025&amp;author=Liu%2CB&amp;author=Peng%2CZ&amp;author=Zhang%2CH&amp;author=Zhang%2CN&amp;author=Liu%2CZ&amp;author=Xia%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, et al. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. 2012;149(3):1269\u201383.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XosVaktrk%3D\" aria-label=\"CAS reference 7\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22682249\" aria-label=\"PubMed reference 7\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3688046\" aria-label=\"PubMed Central reference 7\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumor%20suppression%20in%20the%20absence%20of%20p53-mediated%20cell-cycle%20arrest%2C%20apoptosis%2C%20and%20senescence&amp;journal=Cell&amp;volume=149&amp;issue=3&amp;pages=1269-1283&amp;publication_year=2012&amp;author=Li%2CT&amp;author=Kon%2CN&amp;author=Jiang%2CL&amp;author=Tan%2CM&amp;author=Ludwig%2CT&amp;author=Zhao%2CY&amp;author=Baer%2CR&amp;author=Gu%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005;436:725\u201330.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXmvFenu78%3D\" aria-label=\"CAS reference 8\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16079851\" aria-label=\"PubMed reference 8\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1939938\" aria-label=\"PubMed Central reference 8\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Crucial%20role%20of%20p53-dependent%20cellular%20senescence%20in%20suppression%20of%20Pten-deficient%20tumorigenesis&amp;journal=Nature&amp;volume=436&amp;pages=725-30&amp;publication_year=2005&amp;author=Chen%2CZ&amp;author=Trotman%2CLC&amp;author=Shaffer%2CD&amp;author=Lin%2CHK&amp;author=Dotan%2CZA&amp;author=Niki%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, et al. Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol. 2016;18:777\u201389.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhtVSksbrN\" aria-label=\"CAS reference 9\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27323328\" aria-label=\"PubMed reference 9\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6535144\" aria-label=\"PubMed Central reference 9\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chronic%20p53-independent%20p21%20expression%20causes%20genomic%20instability%20by%20deregulating%20replication%20licensing&amp;journal=Nat%20Cell%20Biol&amp;volume=18&amp;pages=777-89&amp;publication_year=2016&amp;author=Galanos%2CP&amp;author=Vougas%2CK&amp;author=Walter%2CD&amp;author=Polyzos%2CA&amp;author=Maya-Mendoza%2CA&amp;author=Haagensen%2CEJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Milanovic M, Fan DNY, Belenki D, Dabritz JHM, Zhao Z, Yu Y, et al. Senescence-associated reprogramming promotes cancer stemness. Nature. 2018;553(2018):96\u2013100.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhvF2gu73M\" aria-label=\"CAS reference 10\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29258294\" aria-label=\"PubMed reference 10\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20reprogramming%20promotes%20cancer%20stemness&amp;journal=Nature&amp;volume=553&amp;issue=2018&amp;pages=96-100&amp;publication_year=2018&amp;author=Milanovic%2CM&amp;author=Fan%2CDNY&amp;author=Belenki%2CD&amp;author=Dabritz%2CJHM&amp;author=Zhao%2CZ&amp;author=Yu%2CY&amp;author=Dorr%2CJR&amp;author=Dimitrova%2CL&amp;author=Lenze%2CD&amp;author=Monteiro%20Barbosa%2CIA&amp;author=Mendoza-Parra%2CMA&amp;author=Kanashova%2CT&amp;author=Metzner%2CM&amp;author=Pardon%2CK&amp;author=Reimann%2CM&amp;author=Trumpp%2CA&amp;author=Dorken%2CB&amp;author=Zuber%2CJ&amp;author=Gronemeyer%2CH&amp;author=Hummel%2CM&amp;author=Dittmar%2CG&amp;author=Lee%2CS&amp;author=Schmitt%2CCA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Zampetidis CP, Galanos P, Angelopoulou A, Zhu Y, Polyzou A, Karamitros T, et al. A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization. Mol Cell. 2021;81:4907-4923 e4908.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXisFWhu7bL\" aria-label=\"CAS reference 11\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34793711\" aria-label=\"PubMed reference 11\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20recurrent%20chromosomal%20inversion%20suffices%20for%20driving%20escape%20from%20oncogene-induced%20senescence%20via%20subTAD%20reorganization&amp;journal=Mol%20Cell.&amp;volume=81&amp;pages=4907-4923%20e4908&amp;publication_year=2021&amp;author=Zampetidis%2CCP&amp;author=Galanos%2CP&amp;author=Angelopoulou%2CA&amp;author=Zhu%2CY&amp;author=Polyzou%2CA&amp;author=Karamitros%2CT&amp;author=Kotsinas%2CA&amp;author=Lagopati%2CN&amp;author=Mourkioti%2CI&amp;author=Mirzazadeh%2CR&amp;author=Polyzos%2CA&amp;author=Garnerone%2CS&amp;author=Mizi%2CA&amp;author=Gusmao%2CEG&amp;author=Sofiadis%2CK&amp;author=Gal%2CZ&amp;author=Larsen%2CDH&amp;author=Pefani%2CDE&amp;author=Demaria%2CM&amp;author=Tsirigos%2CA&amp;author=Crosetto%2CN&amp;author=Maya-Mendoza%2CA&amp;author=Papaspyropoulos%2CA&amp;author=Evangelou%2CK&amp;author=Bartek%2CJ&amp;author=Papantonis%2CA&amp;author=Gorgoulis%2CVG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Herbstein F, Sapochnik M, Attorresi A, Pollak C, Senin S, Gonilski-Pacin D, et al. The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFkappaB intracrine senescent noncanonical pathway. Aging Cell. 2024;23:e14258.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhsFGltb7F\" aria-label=\"CAS reference 12\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39012326\" aria-label=\"PubMed reference 12\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11464112\" aria-label=\"PubMed Central reference 12\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20SASP%20factor%20IL-6%20sustains%20cell-autonomous%20senescent%20cells%20via%20a%20cGAS-STING-NFkappaB%20intracrine%20senescent%20noncanonical%20pathway&amp;journal=Aging%20Cell&amp;volume=23&amp;publication_year=2024&amp;author=Herbstein%2CF&amp;author=Sapochnik%2CM&amp;author=Attorresi%2CA&amp;author=Pollak%2CC&amp;author=Senin%2CS&amp;author=Gonilski-Pacin%2CD&amp;author=Ciancio%20Del%20Giudice%2CN&amp;author=Fiz%2CM&amp;author=Elguero%2CB&amp;author=Fuertes%2CM&amp;author=Muller%2CL&amp;author=Theodoropoulou%2CM&amp;author=Pontel%2CLB&amp;author=Arzt%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Ortiz-Montero P, Londono-Vallejo A, Vernot JP. Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence\/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. Cell Commun Signal. 2017;15:17.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28472950\" aria-label=\"PubMed reference 13\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5418812\" aria-label=\"PubMed Central reference 13\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20IL-6%20and%20IL-8%20cytokines%20induce%20a%20self-%20and%20cross-reinforced%20senescence%2Finflammatory%20milieu%20strengthening%20tumorigenic%20capabilities%20in%20the%20MCF-7%20breast%20cancer%20cell%20line&amp;journal=Cell%20Commun%20Signal&amp;volume=15&amp;publication_year=2017&amp;author=Ortiz-Montero%2CP&amp;author=Londono-Vallejo%2CA&amp;author=Vernot%2CJP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Birch J, Gil J. Senescence and the SASP: many therapeutic avenues. Genes Dev. 2020;34:1565\u201376.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXjvV2lur8%3D\" aria-label=\"CAS reference 14\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33262144\" aria-label=\"PubMed reference 14\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7706700\" aria-label=\"PubMed Central reference 14\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence%20and%20the%20SASP%3A%20many%20therapeutic%20avenues&amp;journal=Genes%20Dev&amp;volume=34&amp;pages=1565-76&amp;publication_year=2020&amp;author=Birch%2CJ&amp;author=Gil%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Young AR, Narita M. SASP reflects senescence. EMBO Rep. 2009;10(2009):228\u201330.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhvFKis70%3D\" aria-label=\"CAS reference 15\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19218920\" aria-label=\"PubMed reference 15\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2658552\" aria-label=\"PubMed Central reference 15\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=SASP%20reflects%20senescence&amp;journal=EMBO%20Rep&amp;volume=10&amp;issue=2009&amp;pages=228-230&amp;publication_year=2009&amp;author=Young%2CAR&amp;author=Narita%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular senescence: defining a path forward. Cell. 2019;179(2019):813\u201327.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXitFSjsrrF\" aria-label=\"CAS reference 16\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31675495\" aria-label=\"PubMed reference 16\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20senescence%3A%20defining%20a%20path%20forward&amp;journal=Cell&amp;volume=179&amp;issue=2019&amp;pages=813-827&amp;publication_year=2019&amp;author=Gorgoulis%2CV&amp;author=Adams%2CPD&amp;author=Alimonti%2CA&amp;author=Bennett%2CDC&amp;author=Bischof%2CO&amp;author=Bishop%2CC&amp;author=Campisi%2CJ&amp;author=Collado%2CM&amp;author=Evangelou%2CK&amp;author=Ferbeyre%2CG&amp;author=Gil%2CJ&amp;author=Hara%2CE&amp;author=Krizhanovsky%2CV&amp;author=Jurk%2CD&amp;author=Maier%2CAB&amp;author=Narita%2CM&amp;author=Niedernhofer%2CL&amp;author=Passos%2CJF&amp;author=Robbins%2CPD&amp;author=Schmitt%2CCA&amp;author=Sedivy%2CJ&amp;author=Vougas%2CK&amp;author=Zglinicki%2CT&amp;author=Zhou%2CD&amp;author=Serrano%2CM&amp;author=Demaria%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Kohli J, Wang B, Brandenburg SM, Basisty N, Evangelou K, Varela-Eirin M, et al. Algorithmic assessment of cellular senescence in experimental and clinical specimens. Nat Protoc. 2021;16(2021):2471\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhtVSrur%2FJ\" aria-label=\"CAS reference 17\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33911261\" aria-label=\"PubMed reference 17\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8710232\" aria-label=\"PubMed Central reference 17\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Algorithmic%20assessment%20of%20cellular%20senescence%20in%20experimental%20and%20clinical%20specimens&amp;journal=Nat%20Protoc&amp;volume=16&amp;issue=2021&amp;pages=2471-2498&amp;publication_year=2021&amp;author=Kohli%2CJ&amp;author=Wang%2CB&amp;author=Brandenburg%2CSM&amp;author=Basisty%2CN&amp;author=Evangelou%2CK&amp;author=Varela-Eirin%2CM&amp;author=Campisi%2CJ&amp;author=Schilling%2CB&amp;author=Gorgoulis%2CV&amp;author=Demaria%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Ogrodnik M, Carlos Acosta J, Adams PD, d&#8217;Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-D\u00fcrr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M. Guidelines for minimal information on cellular senescence experimentation in vivo. Cell. 2024;187:4150-4175.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Magkouta S, Veroutis D, Pousias A, Papaspyropoulos A, Pippa N, Lougiakis N, et al. A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells. Mol Cell. 2023;83:3558-3573 e3557.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitVOrt7rM\" aria-label=\"CAS reference 19\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37802028\" aria-label=\"PubMed reference 19\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20fluorophore-conjugated%20reagent%20enabling%20rapid%20detection%2C%20isolation%20and%20live%20tracking%20of%20senescent%20cells&amp;journal=Mol%20Cell.&amp;volume=83&amp;pages=3558-3573%20e3557&amp;publication_year=2023&amp;author=Magkouta%2CS&amp;author=Veroutis%2CD&amp;author=Pousias%2CA&amp;author=Papaspyropoulos%2CA&amp;author=Pippa%2CN&amp;author=Lougiakis%2CN&amp;author=Kambas%2CK&amp;author=Lagopati%2CN&amp;author=Polyzou%2CA&amp;author=Georgiou%2CM&amp;author=Chountoulesi%2CM&amp;author=Pispas%2CS&amp;author=Foutadakis%2CS&amp;author=Pouli%2CN&amp;author=Marakos%2CP&amp;author=Kotsinas%2CA&amp;author=Verginis%2CP&amp;author=Valakos%2CD&amp;author=Mizi%2CA&amp;author=Papantonis%2CA&amp;author=Vatsellas%2CG&amp;author=Galanos%2CP&amp;author=Bartek%2CJ&amp;author=Petty%2CR&amp;author=Serrano%2CM&amp;author=Thanos%2CD&amp;author=Roussos%2CC&amp;author=Demaria%2CM&amp;author=Evangelou%2CK&amp;author=Gorgoulis%2CVG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Magkouta S, Veroutis D, Pousias A, Papaspyropoulos A, Giannetti K, Pippa N, et al. One-step rapid tracking and isolation of senescent cells in cellular systems, tissues, or animal models via GLF16. STAR Protoc. 2024;5:102929.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXlsFKit7o%3D\" aria-label=\"CAS reference 20\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38460134\" aria-label=\"PubMed reference 20\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10943059\" aria-label=\"PubMed Central reference 20\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=One-step%20rapid%20tracking%20and%20isolation%20of%20senescent%20cells%20in%20cellular%20systems%2C%20tissues%2C%20or%20animal%20models%20via%20GLF16&amp;journal=STAR%20Protoc&amp;volume=5&amp;publication_year=2024&amp;author=Magkouta%2CS&amp;author=Veroutis%2CD&amp;author=Pousias%2CA&amp;author=Papaspyropoulos%2CA&amp;author=Giannetti%2CK&amp;author=Pippa%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Fitsiou E, Soto-Gamez A, Demaria M. Biological functions of therapy-induced senescence in cancer. Semin Cancer Biol. 2022;81:5\u201313.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhtlWqtrjM\" aria-label=\"CAS reference 21\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33775830\" aria-label=\"PubMed reference 21\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Biological%20functions%20of%20therapy-induced%20senescence%20in%20cancer&amp;journal=Semin%20Cancer%20Biol&amp;volume=81&amp;pages=5-13&amp;publication_year=2022&amp;author=Fitsiou%2CE&amp;author=Soto-Gamez%2CA&amp;author=Demaria%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. J Intern Med. 2020;288:518\u201336.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXitFanu7vJ\" aria-label=\"CAS reference 22\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32686219\" aria-label=\"PubMed reference 22\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7405395\" aria-label=\"PubMed Central reference 22\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senolytic%20drugs%3A%20from%20discovery%20to%20translation&amp;journal=J%20Intern%20Med&amp;volume=288&amp;pages=518-36&amp;publication_year=2020&amp;author=Kirkland%2CJL&amp;author=Tchkonia%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Carpenter VJ, Saleh T, Gewirtz DA. Senolytics for cancer therapy: is all that glitters really gold? Cancers (Basel). 2021;13(4):723. <a href=\"https:\/\/doi.org\/10.3390\/cancers13040723\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cancers13040723\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cancers13040723<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/cancers13040723\" data-track-item_id=\"10.3390\/cancers13040723\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fcancers13040723\" aria-label=\"Article reference 23\" data-doi=\"10.3390\/cancers13040723\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34885094\" aria-label=\"PubMed reference 23\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senolytics%20for%20cancer%20therapy%3A%20is%20all%20that%20glitters%20really%20gold%3F%3E&amp;journal=Cancers%20%28Basel%29&amp;doi=10.3390%2Fcancers13040723&amp;publication_year=2021&amp;author=Carpenter%2CVJ&amp;author=Saleh%2CT&amp;author=Gewirtz%2CDA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Vernot JP. Senescence-associated pro-inflammatory cytokines and tumor cell plasticity. Front Mol Biosci. 2020;7:63.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhvFKksb7K\" aria-label=\"CAS reference 24\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32478091\" aria-label=\"PubMed reference 24\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7237636\" aria-label=\"PubMed Central reference 24\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20pro-inflammatory%20cytokines%20and%20tumor%20cell%20plasticity&amp;journal=Front%20Mol%20Biosci&amp;volume=7&amp;publication_year=2020&amp;author=Vernot%2CJP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Faget DV, Ren Q, Stewart SA. Unmasking senescence: context-dependent effects of SASP in cancer. Nat Rev Cancer. 2019;19:439\u201353.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXht1ems7vE\" aria-label=\"CAS reference 25\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31235879\" aria-label=\"PubMed reference 25\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unmasking%20senescence%3A%20context-dependent%20effects%20of%20SASP%20in%20cancer&amp;journal=Nat%20Rev%20Cancer&amp;volume=19&amp;pages=439-453&amp;publication_year=2019&amp;author=Faget%2CDV&amp;author=Ren%2CQ&amp;author=Stewart%2CSA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Pukhalskaia TV, Yurakova TR, Bogdanova DA, Demidov ON. Tumor-associated senescent macrophages, their markers, and their role in tumor microenvironment. Biochemistry (Mosc). 2024;89:839\u201352.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhtlSmsL7L\" aria-label=\"CAS reference 26\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38880645\" aria-label=\"PubMed reference 26\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumor-associated%20senescent%20macrophages%2C%20their%20markers%2C%20and%20their%20role%20in%20tumor%20microenvironment&amp;journal=Biochemistry%20%28Mosc%29&amp;volume=89&amp;pages=839-52&amp;publication_year=2024&amp;author=Pukhalskaia%2CTV&amp;author=Yurakova%2CTR&amp;author=Bogdanova%2CDA&amp;author=Demidov%2CON\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Takasugi M, Yoshida Y, Hara E, Ohtani N. The role of cellular senescence and SASP in tumour microenvironment. FEBS J. 2023;290(1348):1348\u201361.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XksFCitbY%3D\" aria-label=\"CAS reference 27\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35106956\" aria-label=\"PubMed reference 27\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20cellular%20senescence%20and%20SASP%20in%20tumour%20microenvironment&amp;journal=FEBS%20J&amp;volume=290&amp;issue=1348&amp;pages=1348-61&amp;publication_year=2023&amp;author=Takasugi%2CM&amp;author=Yoshida%2CY&amp;author=Hara%2CE&amp;author=Ohtani%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008;6:2853\u201368.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXlsFGhsQ%3D%3D\" aria-label=\"CAS reference 28\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19053174\" aria-label=\"PubMed reference 28\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20secretory%20phenotypes%20reveal%20cell-nonautonomous%20functions%20of%20oncogenic%20RAS%20and%20the%20p53%20tumor%20suppressor&amp;journal=PLoS%20Biol&amp;volume=6&amp;pages=2853-2868&amp;publication_year=2008&amp;author=Coppe%2CJP&amp;author=Patil%2CCK&amp;author=Rodier%2CF&amp;author=Sun%2CY&amp;author=Munoz%2CDP&amp;author=Goldstein%2CJ&amp;author=Nelson%2CPS&amp;author=Desprez%2CPY&amp;author=Campisi%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Silva EM, Mariano VS, Pastrez PRA, Pinto MC, Castro AG, Syrjanen KJ, et al. High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer. PLoS One. 2017;12:e0181125.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28715437\" aria-label=\"PubMed reference 29\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5513446\" aria-label=\"PubMed Central reference 29\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=High%20systemic%20IL-6%20is%20associated%20with%20worse%20prognosis%20in%20patients%20with%20non-small%20cell%20lung%20cancer&amp;journal=PLoS%20One&amp;volume=12&amp;publication_year=2017&amp;author=Silva%2CEM&amp;author=Mariano%2CVS&amp;author=Pastrez%2CPRA&amp;author=Pinto%2CMC&amp;author=Castro%2CAG&amp;author=Syrjanen%2CKJ&amp;author=Longatto-Filho%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Felcher CM, Bogni ES, Kordon EC. Il-6 cytokine family: a putative target for breast cancer prevention and treatment. Int J Mol Sci. 2022;23(3):1809. <a href=\"https:\/\/doi.org\/10.3390\/ijms23031809\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms23031809\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms23031809<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms23031809\" data-track-item_id=\"10.3390\/ijms23031809\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms23031809\" aria-label=\"Article reference 30\" data-doi=\"10.3390\/ijms23031809\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35163731\" aria-label=\"PubMed reference 30\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8836921\" aria-label=\"PubMed Central reference 30\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Il-6%20cytokine%20family%3A%20a%20putative%20target%20for%20breast%20cancer%20prevention%20and%20treatment&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms23031809&amp;publication_year=2022&amp;author=Felcher%2CCM&amp;author=Bogni%2CES&amp;author=Kordon%2CEC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Bent EH, Gilbert LA, Hemann MT. A senescence secretory switch mediated by PI3K\/AKT\/mTOR activation controls chemoprotective endothelial secretory responses. Genes Dev. 2016;30:1811\u201321.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhvV2msbnM\" aria-label=\"CAS reference 31\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27566778\" aria-label=\"PubMed reference 31\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5024680\" aria-label=\"PubMed Central reference 31\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20senescence%20secretory%20switch%20mediated%20by%20PI3K%2FAKT%2FmTOR%20activation%20controls%20chemoprotective%20endothelial%20secretory%20responses&amp;journal=Genes%20Dev&amp;volume=30&amp;pages=1811-1821&amp;publication_year=2016&amp;author=Bent%2CEH&amp;author=Gilbert%2CLA&amp;author=Hemann%2CMT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Drost EM, MacNee W. Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis. Eur J Immunol. 2002;32:393\u2013403.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XhvVeht78%3D\" aria-label=\"CAS reference 32\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11813158\" aria-label=\"PubMed reference 32\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Potential%20role%20of%20IL-8%2C%20platelet-activating%20factor%20and%20TNF-alpha%20in%20the%20sequestration%20of%20neutrophils%20in%20the%20lung%3A%20effects%20on%20neutrophil%20deformability%2C%20adhesion%20receptor%20expression%2C%20and%20chemotaxis&amp;journal=Eur%20J%20Immunol&amp;volume=32&amp;pages=393-403&amp;publication_year=2002&amp;author=Drost%2CEM&amp;author=MacNee%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Lee YS, Choi I, Ning Y, Kim NY, Khatchadourian V, Yang D, et al. Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. Br J Cancer. 2012;106:1833\u201341.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xns1SnsbY%3D\" aria-label=\"CAS reference 33\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22617157\" aria-label=\"PubMed reference 33\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3364111\" aria-label=\"PubMed Central reference 33\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin-8%20and%20its%20receptor%20CXCR2%20in%20the%20tumour%20microenvironment%20promote%20colon%20cancer%20growth%2C%20progression%20and%20metastasis&amp;journal=Br%20J%20Cancer&amp;volume=106&amp;pages=1833-41&amp;publication_year=2012&amp;author=Lee%2CYS&amp;author=Choi%2CI&amp;author=Ning%2CY&amp;author=Kim%2CNY&amp;author=Khatchadourian%2CV&amp;author=Yang%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Chambers CR, Ritchie S, Pereira BA, Timpson P. Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer. Mol Oncol. 2021;15(2):3242\u201355.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34137158\" aria-label=\"PubMed reference 34\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8637570\" aria-label=\"PubMed Central reference 34\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Overcoming%20the%20senescence-associated%20secretory%20phenotype%20%28SASP%29%3A%20a%20complex%20mechanism%20of%20resistance%20in%20the%20treatment%20of%20cancer&amp;journal=Mol%20Oncol&amp;volume=15&amp;issue=2&amp;pages=3242-55&amp;publication_year=2021&amp;author=Chambers%2CCR&amp;author=Ritchie%2CS&amp;author=Pereira%2CBA&amp;author=Timpson%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Jeong Y, Yoon SY, Jung SP, Nam SJ, Lee JE, Kim S. Inhibition of interleukin-8\/C-X-C chemokine receptor 2 signaling axis prevents tumor growth and metastasis in triple-negative breast cancer cells. Pharmacology. 2025;110:178\u201390.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhsFCitb7J\" aria-label=\"CAS reference 35\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40188812\" aria-label=\"PubMed reference 35\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20interleukin-8%2FC-X-C%20chemokine%20receptor%202%20signaling%20axis%20prevents%20tumor%20growth%20and%20metastasis%20in%20triple-negative%20breast%20cancer%20cells&amp;journal=Pharmacology&amp;volume=110&amp;pages=178-90&amp;publication_year=2025&amp;author=Jeong%2CY&amp;author=Yoon%2CSY&amp;author=Jung%2CSP&amp;author=Nam%2CSJ&amp;author=Lee%2CJE&amp;author=Kim%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Prattichizzo F, Giuliani A, Recchioni R, Bonafe M, Marcheselli F, De Carolis S, et al. Anti-TNF-alpha treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells. Oncotarget. 2016;7:11945\u201358.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26943583\" aria-label=\"PubMed reference 36\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4914260\" aria-label=\"PubMed Central reference 36\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Anti-TNF-alpha%20treatment%20modulates%20SASP%20and%20SASP-related%20microRNAs%20in%20endothelial%20cells%20and%20in%20circulating%20angiogenic%20cells&amp;journal=Oncotarget&amp;volume=7&amp;pages=11945-11958&amp;publication_year=2016&amp;author=Prattichizzo%2CF&amp;author=Giuliani%2CA&amp;author=Recchioni%2CR&amp;author=Bonafe%2CM&amp;author=Marcheselli%2CF&amp;author=Carolis%2CS&amp;author=Campanati%2CA&amp;author=Giuliodori%2CK&amp;author=Rippo%2CMR&amp;author=Bruge%2CF&amp;author=Tiano%2CL&amp;author=Micucci%2CC&amp;author=Ceriello%2CA&amp;author=Offidani%2CA&amp;author=Procopio%2CAD&amp;author=Olivieri%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Dong Z, Luo Y, Yuan Z, Tian Y, Jin T, Xu F. Cellular senescence and SASP in tumor progression and therapeutic opportunities. Mol Cancer. 2024;23:181.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39217404\" aria-label=\"PubMed reference 37\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11365203\" aria-label=\"PubMed Central reference 37\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20senescence%20and%20SASP%20in%20tumor%20progression%20and%20therapeutic%20opportunities&amp;journal=Mol%20Cancer&amp;volume=23&amp;publication_year=2024&amp;author=Dong%2CZ&amp;author=Luo%2CY&amp;author=Yuan%2CZ&amp;author=Tian%2CY&amp;author=Jin%2CT&amp;author=Xu%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Parajuli P, Rosati R, Mamdani H, Wright RE 3rd, Hussain Z, Naeem A, et al. Senescence-associated secretory proteins induced in lung adenocarcinoma by extended treatment with dexamethasone enhance migration and activation of lymphocytes. Cancer Immunol Immunother. 2023;72:1273\u201384.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XjtVWlurfN\" aria-label=\"CAS reference 38\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36434273\" aria-label=\"PubMed reference 38\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20secretory%20proteins%20induced%20in%20lung%20adenocarcinoma%20by%20extended%20treatment%20with%20dexamethasone%20enhance%20migration%20and%20activation%20of%20lymphocytes&amp;journal=Cancer%20Immunol%20Immunother&amp;volume=72&amp;pages=1273-84&amp;publication_year=2023&amp;author=Parajuli%2CP&amp;author=Rosati%2CR&amp;author=Mamdani%2CH&amp;author=Wright%2CRE&amp;author=Hussain%2CZ&amp;author=Naeem%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Kawagoe Y, Kawashima I, Sato Y, Okamoto N, Matsubara K, Kawamura K. Cxcl5-Cxcr2 signaling is a senescence-associated secretory phenotype in preimplantation embryos. Aging Cell. 2020;19:e13240.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhvVKltLfP\" aria-label=\"CAS reference 39\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32959976\" aria-label=\"PubMed reference 39\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7576282\" aria-label=\"PubMed Central reference 39\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cxcl5-Cxcr2%20signaling%20is%20a%20senescence-associated%20secretory%20phenotype%20in%20preimplantation%20embryos&amp;journal=Aging%20Cell&amp;volume=19&amp;publication_year=2020&amp;author=Kawagoe%2CY&amp;author=Kawashima%2CI&amp;author=Sato%2CY&amp;author=Okamoto%2CN&amp;author=Matsubara%2CK&amp;author=Kawamura%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Huda N, Khambu B, Liu G, Nakatsumi H, Yan S, Chen X, et al. Senescence connects autophagy deficiency to inflammation and tumor progression in the liver. Cell Mol Gastroenterol Hepatol. 2022;14:333\u201355.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhvVCmtrjN\" aria-label=\"CAS reference 40\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35398596\" aria-label=\"PubMed reference 40\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9233281\" aria-label=\"PubMed Central reference 40\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence%20connects%20autophagy%20deficiency%20to%20inflammation%20and%20tumor%20progression%20in%20the%20liver&amp;journal=Cell%20Mol%20Gastroenterol%20Hepatol&amp;volume=14&amp;pages=333-55&amp;publication_year=2022&amp;author=Huda%2CN&amp;author=Khambu%2CB&amp;author=Liu%2CG&amp;author=Nakatsumi%2CH&amp;author=Yan%2CS&amp;author=Chen%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Soto-Gamez A, van Es M, Hageman E, Serna-Salas SA, Moshage H, Demaria M, et al. Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation. Radiother Oncol. 2024;190:109984.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXisVeltbfK\" aria-label=\"CAS reference 41\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37926332\" aria-label=\"PubMed reference 41\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mesenchymal%20stem%20cell-derived%20HGF%20attenuates%20radiation-induced%20senescence%20in%20salivary%20glands%20via%20compensatory%20proliferation&amp;journal=Radiother%20Oncol&amp;volume=190&amp;publication_year=2024&amp;author=Soto-Gamez%2CA&amp;author=Es%2CM&amp;author=Hageman%2CE&amp;author=Serna-Salas%2CSA&amp;author=Moshage%2CH&amp;author=Demaria%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Siraj Y, Aprile D, Alessio N, Peluso G, Di Bernardo G, Galderisi U. IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin IGF, and activin A pathways. Cell Commun Signal. 2024;22:540.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXisV2ls7zP\" aria-label=\"CAS reference 42\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39533382\" aria-label=\"PubMed reference 42\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11558980\" aria-label=\"PubMed Central reference 42\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IGFBP7%20is%20a%20key%20component%20of%20the%20senescence-associated%20secretory%20phenotype%20%28SASP%29%20that%20induces%20senescence%20in%20healthy%20cells%20by%20modulating%20the%20insulin%20IGF%2C%20and%20activin%20A%20pathways&amp;journal=Cell%20Commun%20Signal&amp;volume=22&amp;publication_year=2024&amp;author=Siraj%2CY&amp;author=Aprile%2CD&amp;author=Alessio%2CN&amp;author=Peluso%2CG&amp;author=Di%20Bernardo%2CG&amp;author=Galderisi%2CU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">von Joest M, Chen C, Douche T, Chantrel J, Chiche A, Gianetto QG, et al. Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming. Cell Rep. 2022;40:111074.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Amphiregulin%20mediates%20non-cell-autonomous%20effect%20of%20senescence%20on%20reprogramming&amp;journal=Cell%20Rep&amp;volume=40&amp;publication_year=2022&amp;author=Joest%2CM&amp;author=Chen%2CC&amp;author=Douche%2CT&amp;author=Chantrel%2CJ&amp;author=Chiche%2CA&amp;author=Gianetto%2CQG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Wang C, Long Q, Fu Q, Xu Q, Fu D, Li Y, et al. Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance. Oncogene. 2022;41:4941\u201359.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XisFOmsrjL\" aria-label=\"CAS reference 44\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36202915\" aria-label=\"PubMed reference 44\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9630100\" aria-label=\"PubMed Central reference 44\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20epiregulin%20in%20the%20treatment-damaged%20tumor%20microenvironment%20restrains%20therapeutic%20resistance&amp;journal=Oncogene&amp;volume=41&amp;pages=4941-59&amp;publication_year=2022&amp;author=Wang%2CC&amp;author=Long%2CQ&amp;author=Fu%2CQ&amp;author=Xu%2CQ&amp;author=Fu%2CD&amp;author=Li%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Guo Y, Ayers JL, Carter KT, Wang T, Maden SK, Edmond D, et al. Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. Aging Cell. 2019;18:e13013.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhsFWqtbfK\" aria-label=\"CAS reference 45\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31389184\" aria-label=\"PubMed reference 45\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6826139\" aria-label=\"PubMed Central reference 45\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20tissue%20microenvironment%20promotes%20colon%20cancer%20formation%20through%20the%20secretory%20factor%20GDF15&amp;journal=Aging%20Cell&amp;volume=18&amp;publication_year=2019&amp;author=Guo%2CY&amp;author=Ayers%2CJL&amp;author=Carter%2CKT&amp;author=Wang%2CT&amp;author=Maden%2CSK&amp;author=Edmond%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Tominaga K, Suzuki HI. TGF-beta signaling in cellular senescence and aging-related pathology. Int J Mol Sci. 2019;20(20):5002. <a href=\"https:\/\/doi.org\/10.3390\/ijms20205002\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms20205002\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms20205002<\/a> .<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Wang N, Fang Y, Hou Y, Cheng D, Dressler EV, Wang H, et al. Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway. Cell Commun Signal. 2024;22:478.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39375718\" aria-label=\"PubMed reference 47\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11457416\" aria-label=\"PubMed Central reference 47\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20cells%20promote%20breast%20cancer%20cells%20motility%20by%20secreting%20GM-CSF%20and%20bFGF%20that%20activate%20the%20JNK%20signaling%20pathway&amp;journal=Cell%20Commun%20Signal&amp;volume=22&amp;publication_year=2024&amp;author=Wang%2CN&amp;author=Fang%2CY&amp;author=Hou%2CY&amp;author=Cheng%2CD&amp;author=Dressler%2CEV&amp;author=Wang%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Alessio N, Squillaro T, Di Bernardo G, Galano G, De Rosa R, Melone MAB, et al. Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence. Elife. 2020;9:e54523. <a href=\"https:\/\/doi.org\/10.7554\/eLife.54523\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.7554\/eLife.54523\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.7554\/eLife.54523<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.7554\/eLife.54523\" data-track-item_id=\"10.7554\/eLife.54523\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.7554%2FeLife.54523\" aria-label=\"Article reference 48\" data-doi=\"10.7554\/eLife.54523\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32223893\" aria-label=\"PubMed reference 48\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7136022\" aria-label=\"PubMed Central reference 48\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Increase%20of%20circulating%20IGFBP-4%20following%20genotoxic%20stress%20and%20its%20implication%20for%20senescence&amp;journal=Elife&amp;doi=10.7554%2FeLife.54523&amp;publication_year=2020&amp;author=Alessio%2CN&amp;author=Squillaro%2CT&amp;author=Di%20Bernardo%2CG&amp;author=Galano%2CG&amp;author=De%20Rosa%2CR&amp;author=Melone%2CMAB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Evans DS, Young D, Tanaka T, Basisty N, Bandinelli S, Ferrucci L, et al. Proteomic analysis of the senescence-associated secretory phenotype: GDF-15, IGFBP-2, and cystatin-C are associated with multiple aging traits. J Gerontol A Biol Sci Med Sci. 2024;79(3):glad265 <a href=\"https:\/\/doi.org\/10.1093\/gerona\/glad265\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1093\/gerona\/glad265\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1093\/gerona\/glad265<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/gerona\/glad265\" data-track-item_id=\"10.1093\/gerona\/glad265\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Fgerona%2Fglad265\" aria-label=\"Article reference 49\" data-doi=\"10.1093\/gerona\/glad265\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38367212\" aria-label=\"PubMed reference 49\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11648972\" aria-label=\"PubMed Central reference 49\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 49\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Proteomic%20analysis%20of%20the%20senescence-associated%20secretory%20phenotype%3A%20GDF-15%2C%20IGFBP-2%2C%20and%20cystatin-C%20are%20associated%20with%20multiple%20aging%20traits&amp;journal=J%20Gerontol%20A%20Biol%20Sci%20Med%20Sci&amp;doi=10.1093%2Fgerona%2Fglad265&amp;publication_year=2024&amp;author=Evans%2CDS&amp;author=Young%2CD&amp;author=Tanaka%2CT&amp;author=Basisty%2CN&amp;author=Bandinelli%2CS&amp;author=Ferrucci%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, et al. Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. Aging Cell. 2019;18:e13027.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhslajurzM\" aria-label=\"CAS reference 50\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31493351\" aria-label=\"PubMed reference 50\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6826133\" aria-label=\"PubMed Central reference 50\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20amphiregulin%20%28AREG%29%20derived%20from%20senescent%20stromal%20cells%20diminishes%20cancer%20resistance%20and%20averts%20programmed%20cell%20death%201%20ligand%20%28PD-L1%29-mediated%20immunosuppression&amp;journal=Aging%20Cell&amp;volume=18&amp;publication_year=2019&amp;author=Xu%2CQ&amp;author=Long%2CQ&amp;author=Zhu%2CD&amp;author=Fu%2CD&amp;author=Zhang%2CB&amp;author=Han%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Strzyz P. Senescent fibroblasts support lung repair. Nat Rev Mol Cell Biol. 2022;23:775.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36329214\" aria-label=\"PubMed reference 51\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 51\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20fibroblasts%20support%20lung%20repair&amp;journal=Nat%20Rev%20Mol%20Cell%20Biol&amp;volume=23&amp;publication_year=2022&amp;author=Strzyz%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR52\">Alexander PB, Yuan L, Yang P, Sun T, Chen R, Xiang H, et al. EGF promotes mammalian cell growth by suppressing cellular senescence. Cell Res. 2015;25:135\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhvVOntLbL\" aria-label=\"CAS reference 52\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25367123\" aria-label=\"PubMed reference 52\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 52\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=EGF%20promotes%20mammalian%20cell%20growth%20by%20suppressing%20cellular%20senescence&amp;journal=Cell%20Res&amp;volume=25&amp;pages=135-8&amp;publication_year=2015&amp;author=Alexander%2CPB&amp;author=Yuan%2CL&amp;author=Yang%2CP&amp;author=Sun%2CT&amp;author=Chen%2CR&amp;author=Xiang%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Shang D, Sun D, Shi C, Xu J, Shen M, Hu X, et al. Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. Aging Cell. 2020;19:e13145.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXns1Cgu7g%3D\" aria-label=\"CAS reference 53\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32323422\" aria-label=\"PubMed reference 53\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7253070\" aria-label=\"PubMed Central reference 53\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 53\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activation%20of%20epidermal%20growth%20factor%20receptor%20signaling%20mediates%20cellular%20senescence%20induced%20by%20certain%20pro-inflammatory%20cytokines&amp;journal=Aging%20Cell&amp;volume=19&amp;publication_year=2020&amp;author=Shang%2CD&amp;author=Sun%2CD&amp;author=Shi%2CC&amp;author=Xu%2CJ&amp;author=Shen%2CM&amp;author=Hu%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Vassilieva I, Kosheverova V, Vitte M, Kamentseva R, Shatrova A, Tsupkina N, et al. Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3. Aging (Albany NY). 2020;12(2):1987\u20132004.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhtFKqsbvF\" aria-label=\"CAS reference 54\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31951594\" aria-label=\"PubMed reference 54\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 54\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Paracrine%20senescence%20of%20human%20endometrial%20mesenchymal%20stem%20cells%3A%20a%20role%20for%20the%20insulin-like%20growth%20factor%20binding%20protein%203&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=12&amp;issue=2&amp;pages=1987-2004&amp;publication_year=2020&amp;author=Vassilieva%2CI&amp;author=Kosheverova%2CV&amp;author=Vitte%2CM&amp;author=Kamentseva%2CR&amp;author=Shatrova%2CA&amp;author=Tsupkina%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Hu D, Ge Y, Cui Y, Li K, Chen J, Zhang C, et al. Upregulated IGFBP3 with aging is involved in modulating apoptosis, oxidative stress, and fibrosis: a target of age-related erectile dysfunction. Oxid Med Cell Longev. 2022;2022:6831779.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35154570\" aria-label=\"PubMed reference 55\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8831074\" aria-label=\"PubMed Central reference 55\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 55\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Upregulated%20IGFBP3%20with%20aging%20is%20involved%20in%20modulating%20apoptosis%2C%20oxidative%20stress%2C%20and%20fibrosis%3A%20a%20target%20of%20age-related%20erectile%20dysfunction&amp;journal=Oxid%20Med%20Cell%20Longev&amp;volume=2022&amp;publication_year=2022&amp;author=Hu%2CD&amp;author=Ge%2CY&amp;author=Cui%2CY&amp;author=Li%2CK&amp;author=Chen%2CJ&amp;author=Zhang%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR56\">Chen Q, Tang L, Zhang Y, Wan C, Yu X, Dong Y, et al. STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-kappaB\/HIF-1alpha pathway. Life Sci. 2022;293:120089.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhslOktr8%3D\" aria-label=\"CAS reference 56\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35007563\" aria-label=\"PubMed reference 56\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 56\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=STING%20up-regulates%20VEGF%20expression%20in%20oxidative%20stress-induced%20senescence%20of%20retinal%20pigment%20epithelium%20via%20NF-kappaB%2FHIF-1alpha%20pathway&amp;journal=Life%20Sci&amp;volume=293&amp;publication_year=2022&amp;author=Chen%2CQ&amp;author=Tang%2CL&amp;author=Zhang%2CY&amp;author=Wan%2CC&amp;author=Yu%2CX&amp;author=Dong%2CY&amp;author=Chen%2CX&amp;author=Wang%2CX&amp;author=Li%2CN&amp;author=Xin%2CG&amp;author=Zhang%2CM&amp;author=Chen%2CZ&amp;author=Niu%2CH&amp;author=Huang%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Kut C, Mac Gabhann F, Popel AS. Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer. Br J Cancer. 2007;97(2):978\u201385.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXhtFSnurfE\" aria-label=\"CAS reference 57\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17912242\" aria-label=\"PubMed reference 57\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2360423\" aria-label=\"PubMed Central reference 57\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 57\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Where%20is%20VEGF%20in%20the%20body%3F%20A%20meta-analysis%20of%20VEGF%20distribution%20in%20cancer&amp;journal=Br%20J%20Cancer&amp;volume=97&amp;issue=2&amp;pages=978-85&amp;publication_year=2007&amp;author=Kut%2CC&amp;author=Mac%20Gabhann%2CF&amp;author=Popel%2CAS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Menicacci B, Laurenzana A, Chilla A, Margheri F, Peppicelli S, Tanganelli E, et al. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related protumoral effects on melanoma cells. J Gerontol A Biol Sci Med Sci. 2017;72:1187\u201395.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXjvVCjsLg%3D\" aria-label=\"CAS reference 58\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28329136\" aria-label=\"PubMed reference 58\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 58\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chronic%20resveratrol%20treatment%20inhibits%20MRC5%20fibroblast%20SASP-related%20protumoral%20effects%20on%20melanoma%20cells&amp;journal=J%20Gerontol%20A%20Biol%20Sci%20Med%20Sci&amp;volume=72&amp;pages=1187-95&amp;publication_year=2017&amp;author=Menicacci%2CB&amp;author=Laurenzana%2CA&amp;author=Chilla%2CA&amp;author=Margheri%2CF&amp;author=Peppicelli%2CS&amp;author=Tanganelli%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Hasan MR, Ho SH, Owen DA, Tai IT. Inhibition of VEGF induces cellular senescence in colorectal cancer cells. Int J Cancer. 2011;129(2011):2115\u201323.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhtFSjsb%2FM\" aria-label=\"CAS reference 59\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21618508\" aria-label=\"PubMed reference 59\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 59\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20VEGF%20induces%20cellular%20senescence%20in%20colorectal%20cancer%20cells&amp;journal=Int%20J%20Cancer&amp;volume=129&amp;issue=2011&amp;pages=2115-2123&amp;publication_year=2011&amp;author=Hasan%2CMR&amp;author=Ho%2CSH&amp;author=Owen%2CDA&amp;author=Tai%2CIT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR60\">Alqahtani S, Alqahtani T, Venkatesan K, Sivadasan D, Ahmed R, Sirag N, Elfadil H, Abdullah Mohamed H, T A H, Elsayed Ahmed R, Muralidharan P, Paulsamy P. SASP modulation for cellular rejuvenation and tissue homeostasis: therapeutic strategies and molecular insights. Cells. 2025;14.(8):608. <a href=\"https:\/\/doi.org\/10.3390\/cells14080608\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cells14080608\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cells14080608<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Jiang B, Zhang W, Zhang X, Sun Y. Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy. Semin Cancer Biol. 2024;101:58\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXht1GjsrfF\" aria-label=\"CAS reference 61\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38810814\" aria-label=\"PubMed reference 61\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 61\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20senescent%20cells%20to%20reshape%20the%20tumor%20microenvironment%20and%20improve%20anticancer%20efficacy&amp;journal=Semin%20Cancer%20Biol&amp;volume=101&amp;pages=58-73&amp;publication_year=2024&amp;author=Jiang%2CB&amp;author=Zhang%2CW&amp;author=Zhang%2CX&amp;author=Sun%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Zhao S, Qiao Z, Pfeifer R, Pape HC, Mao K, Tang H, et al. Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature. Eur J Med Res. 2024;29:38.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38195489\" aria-label=\"PubMed reference 62\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10775505\" aria-label=\"PubMed Central reference 62\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 62\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Modulation%20of%20fracture%20healing%20by%20senescence-associated%20secretory%20phenotype%20%28SASP%29%3A%20a%20narrative%20review%20of%20the%20current%20literature&amp;journal=Eur%20J%20Med%20Res&amp;volume=29&amp;publication_year=2024&amp;author=Zhao%2CS&amp;author=Qiao%2CZ&amp;author=Pfeifer%2CR&amp;author=Pape%2CHC&amp;author=Mao%2CK&amp;author=Tang%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR63\">Jakhar R, Crasta K. Exosomes as emerging pro-tumorigenic mediators of the senescence-associated secretory phenotype. Int J Mol Sci. 2019;20(10):2547. <a href=\"https:\/\/doi.org\/10.3390\/ijms20102547\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms20102547\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms20102547<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms20102547\" data-track-item_id=\"10.3390\/ijms20102547\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms20102547\" aria-label=\"Article reference 63\" data-doi=\"10.3390\/ijms20102547\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31137607\" aria-label=\"PubMed reference 63\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6566274\" aria-label=\"PubMed Central reference 63\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 63\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Exosomes%20as%20emerging%20pro-tumorigenic%20mediators%20of%20the%20senescence-associated%20secretory%20phenotype&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms20102547&amp;publication_year=2019&amp;author=Jakhar%2CR&amp;author=Crasta%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR64\">DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, et al. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol. 2004;164:1131\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXjsFemur4%3D\" aria-label=\"CAS reference 64\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15039201\" aria-label=\"PubMed reference 64\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1615345\" aria-label=\"PubMed Central reference 64\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 64\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Proteases%2C%20extracellular%20matrix%2C%20and%20cancer%3A%20a%20workshop%20of%20the%20path%20B%20study%20section&amp;journal=Am%20J%20Pathol&amp;volume=164&amp;pages=1131-1139&amp;publication_year=2004&amp;author=DeClerck%2CYA&amp;author=Mercurio%2CAM&amp;author=Stack%2CMS&amp;author=Chapman%2CHA&amp;author=Zutter%2CMM&amp;author=Muschel%2CRJ&amp;author=Raz%2CA&amp;author=Matrisian%2CLM&amp;author=Sloane%2CBF&amp;author=Noel%2CA&amp;author=Hendrix%2CMJ&amp;author=Coussens%2CL&amp;author=Padarathsingh%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR65\">Mebratu YA, Soni S, Rosas L, Rojas M, Horowitz JC, Nho R. The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype. Am J Physiol Cell Physiol. 2023;325:C565-79.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitFKisr%2FE\" aria-label=\"CAS reference 65\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37486065\" aria-label=\"PubMed reference 65\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10511170\" aria-label=\"PubMed Central reference 65\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 65\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20aged%20extracellular%20matrix%20and%20the%20profibrotic%20role%20of%20senescence-associated%20secretory%20phenotype&amp;journal=Am%20J%20Physiol%20Cell%20Physiol&amp;volume=325&amp;pages=C565-79&amp;publication_year=2023&amp;author=Mebratu%2CYA&amp;author=Soni%2CS&amp;author=Rosas%2CL&amp;author=Rojas%2CM&amp;author=Horowitz%2CJC&amp;author=Nho%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR66\">Hassona Y, Cirillo N, Heesom K, Parkinson EK, Prime SS. Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer. 2014;111:1230\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhtlKktrzP\" aria-label=\"CAS reference 66\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25117810\" aria-label=\"PubMed reference 66\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4453858\" aria-label=\"PubMed Central reference 66\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 66\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20cancer-associated%20fibroblasts%20secrete%20active%20MMP-2%20that%20promotes%20keratinocyte%20dis-cohesion%20and%20invasion&amp;journal=Br%20J%20Cancer&amp;volume=111&amp;pages=1230-7&amp;publication_year=2014&amp;author=Hassona%2CY&amp;author=Cirillo%2CN&amp;author=Heesom%2CK&amp;author=Parkinson%2CEK&amp;author=Prime%2CSS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR67\">Lan YY, Chang FH, Tsai JH, Chang Y. Epstein-barr virus Rta promotes invasion of bystander tumor cells through paracrine of matrix metalloproteinase 9. Biochem Biophys Res Commun. 2018;503:2160\u20136.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhsVGjt7zF\" aria-label=\"CAS reference 67\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30082032\" aria-label=\"PubMed reference 67\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 67\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epstein-barr%20virus%20Rta%20promotes%20invasion%20of%20bystander%20tumor%20cells%20through%20paracrine%20of%20matrix%20metalloproteinase%209&amp;journal=Biochem%20Biophys%20Res%20Commun&amp;volume=503&amp;pages=2160-6&amp;publication_year=2018&amp;author=Lan%2CYY&amp;author=Chang%2CFH&amp;author=Tsai%2CJH&amp;author=Chang%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR68\">Ozcan S, Alessio N, Acar MB, Mert E, Omerli F, Peluso G, et al. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. Aging (Albany NY). 2016;8:1316\u201329.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27288264\" aria-label=\"PubMed reference 68\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 68\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unbiased%20analysis%20of%20senescence%20associated%20secretory%20phenotype%20%28SASP%29%20to%20identify%20common%20components%20following%20different%20genotoxic%20stresses&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=8&amp;pages=1316-29&amp;publication_year=2016&amp;author=Ozcan%2CS&amp;author=Alessio%2CN&amp;author=Acar%2CMB&amp;author=Mert%2CE&amp;author=Omerli%2CF&amp;author=Peluso%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR69\">Ries C, Egea V, Karow M, Kolb H, Jochum M, Neth P. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood. 2007;109:4055\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXkvFCiu7s%3D\" aria-label=\"CAS reference 69\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17197427\" aria-label=\"PubMed reference 69\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 69\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=MMP-2%2C%20MT1-MMP%2C%20and%20TIMP-2%20are%20essential%20for%20the%20invasive%20capacity%20of%20human%20mesenchymal%20stem%20cells%3A%20differential%20regulation%20by%20inflammatory%20cytokines&amp;journal=Blood&amp;volume=109&amp;pages=4055-4063&amp;publication_year=2007&amp;author=Ries%2CC&amp;author=Egea%2CV&amp;author=Karow%2CM&amp;author=Kolb%2CH&amp;author=Jochum%2CM&amp;author=Neth%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR70\">Rana T, Jiang C, Liu G, Miyata T, Antony V, Thannickal VJ, et al. PAI-1 regulation of TGF-beta1-induced alveolar type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages. Am J Respir Cell Mol Biol. 2020;62(319):319\u201330.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXpvVOks7Y%3D\" aria-label=\"CAS reference 70\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31513752\" aria-label=\"PubMed reference 70\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7055702\" aria-label=\"PubMed Central reference 70\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 70\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=PAI-1%20regulation%20of%20TGF-beta1-induced%20alveolar%20type%20II%20cell%20senescence%2C%20SASP%20secretion%2C%20and%20SASP-mediated%20activation%20of%20alveolar%20macrophages&amp;journal=Am%20J%20Respir%20Cell%20Mol%20Biol&amp;volume=62&amp;issue=319&amp;pages=319-330&amp;publication_year=2020&amp;author=Rana%2CT&amp;author=Jiang%2CC&amp;author=Liu%2CG&amp;author=Miyata%2CT&amp;author=Antony%2CV&amp;author=Thannickal%2CVJ&amp;author=Liu%2CRM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR71\">Wu J, Wang J, Pei Z, Zhu Y, Zhang X, Zhou Z, et al. Endothelial senescence induced by PAI-1 promotes endometrial fibrosis. Cell Death Discov. 2025;11:89.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXlslWht7g%3D\" aria-label=\"CAS reference 71\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40050610\" aria-label=\"PubMed reference 71\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11885584\" aria-label=\"PubMed Central reference 71\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 71\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Endothelial%20senescence%20induced%20by%20PAI-1%20promotes%20endometrial%20fibrosis&amp;journal=Cell%20Death%20Discov&amp;volume=11&amp;publication_year=2025&amp;author=Wu%2CJ&amp;author=Wang%2CJ&amp;author=Pei%2CZ&amp;author=Zhu%2CY&amp;author=Zhang%2CX&amp;author=Zhou%2CZ&amp;author=Ye%2CC&amp;author=Song%2CM&amp;author=Hu%2CY&amp;author=Xue%2CP&amp;author=Zhao%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR72\">Oh CK, Ariue B, Alban RF, Shaw B, Cho SH. PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model. Biochem Biophys Res Commun. 2002;294:1155\u201360.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38Xks1Gnt7c%3D\" aria-label=\"CAS reference 72\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12074598\" aria-label=\"PubMed reference 72\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 72\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=PAI-1%20promotes%20extracellular%20matrix%20deposition%20in%20the%20airways%20of%20a%20murine%20asthma%20model&amp;journal=Biochem%20Biophys%20Res%20Commun&amp;volume=294&amp;pages=1155-60&amp;publication_year=2002&amp;author=Oh%2CCK&amp;author=Ariue%2CB&amp;author=Alban%2CRF&amp;author=Shaw%2CB&amp;author=Cho%2CSH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR73\">Giroud J, Bouriez I, Paulus H, Pourtier A, Debacq-Chainiaux F, Pluquet O. Exploring the communication of the SASP: dynamic, interactive, and adaptive effects on the microenvironment. Int J Mol Sci. 2023;24(13):10788. <a href=\"https:\/\/doi.org\/10.3390\/ijms241310788\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms241310788\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms241310788<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms241310788\" data-track-item_id=\"10.3390\/ijms241310788\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms241310788\" aria-label=\"Article reference 73\" data-doi=\"10.3390\/ijms241310788\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37445973\" aria-label=\"PubMed reference 73\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10341516\" aria-label=\"PubMed Central reference 73\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 73\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Exploring%20the%20communication%20of%20the%20SASP%3A%20dynamic%2C%20interactive%2C%20and%20adaptive%20effects%20on%20the%20microenvironment&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms241310788&amp;publication_year=2023&amp;author=Giroud%2CJ&amp;author=Bouriez%2CI&amp;author=Paulus%2CH&amp;author=Pourtier%2CA&amp;author=Debacq-Chainiaux%2CF&amp;author=Pluquet%2CO\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR74\">Dasgupta N, Arnold R, Equey A, Gandhi A, Adams PD. The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression. NPJ Aging. 2024;10:48.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39448585\" aria-label=\"PubMed reference 74\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11502686\" aria-label=\"PubMed Central reference 74\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 74\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20the%20dynamic%20epigenetic%20landscape%20in%20senescence%3A%20orchestrating%20SASP%20expression&amp;journal=NPJ%20Aging&amp;volume=10&amp;publication_year=2024&amp;author=Dasgupta%2CN&amp;author=Arnold%2CR&amp;author=Equey%2CA&amp;author=Gandhi%2CA&amp;author=Adams%2CPD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR75\">Ou HL, Schumacher B. DNA damage responses and p53 in the aging process. Blood. 2018;131:488\u201395.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhs1CqtrnJ\" aria-label=\"CAS reference 75\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29141944\" aria-label=\"PubMed reference 75\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 75\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=DNA%20damage%20responses%20and%20p53%20in%20the%20aging%20process&amp;journal=Blood&amp;volume=131&amp;pages=488-95&amp;publication_year=2018&amp;author=Ou%2CHL&amp;author=Schumacher%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR76\">Lopez AR, Jorgensen MH, Havelund JF, Arendrup FS, Kolapalli SP, Nielsen TM, et al. Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence. Cell Rep. 2023;42:113381.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitlWrsrvJ\" aria-label=\"CAS reference 76\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37930887\" aria-label=\"PubMed reference 76\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 76\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autophagy-mediated%20control%20of%20ribosome%20homeostasis%20in%20oncogene-induced%20senescence&amp;journal=Cell%20Rep&amp;volume=42&amp;publication_year=2023&amp;author=Lopez%2CAR&amp;author=Jorgensen%2CMH&amp;author=Havelund%2CJF&amp;author=Arendrup%2CFS&amp;author=Kolapalli%2CSP&amp;author=Nielsen%2CTM&amp;author=Pais%2CE&amp;author=Beese%2CCJ&amp;author=Abdul-Al%2CA&amp;author=Vind%2CAC&amp;author=Bartek%2CJ&amp;author=Bekker-Jensen%2CS&amp;author=Montes%2CM&amp;author=Galanos%2CP&amp;author=Faergeman%2CN&amp;author=Happonen%2CL&amp;author=Frankel%2CLB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR77\">Faheem MM, Seligson ND, Ahmad SM, Rasool RU, Gandhi SG, Bhagat M, et al. Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives. Cell Death Discov. 2020;6:51.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32566256\" aria-label=\"PubMed reference 77\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7295779\" aria-label=\"PubMed Central reference 77\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 77\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Convergence%20of%20therapy-induced%20senescence%20%28TIS%29%20and%20EMT%20in%20multistep%20carcinogenesis%3A%20current%20opinions%20and%20emerging%20perspectives&amp;journal=Cell%20Death%20Discov&amp;volume=6&amp;publication_year=2020&amp;author=Faheem%2CMM&amp;author=Seligson%2CND&amp;author=Ahmad%2CSM&amp;author=Rasool%2CRU&amp;author=Gandhi%2CSG&amp;author=Bhagat%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR78\">Ye T, Gao H, Zhang ZR, Ge Y, Liu YK, Yan JY, et al. Epigenetic regulation of cellular senescence in gastrointestinal cancer. Mol Cancer Ther. 2025. <a href=\"https:\/\/doi.org\/10.1158\/1535-7163.MCT-24-0949\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1158\/1535-7163.MCT-24-0949\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1158\/1535-7163.MCT-24-0949<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1158\/1535-7163.MCT-24-0949\" data-track-item_id=\"10.1158\/1535-7163.MCT-24-0949\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1158%2F1535-7163.MCT-24-0949\" aria-label=\"Article reference 78\" data-doi=\"10.1158\/1535-7163.MCT-24-0949\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=41184204\" aria-label=\"PubMed reference 78\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12307273\" aria-label=\"PubMed Central reference 78\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 78\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epigenetic%20regulation%20of%20cellular%20senescence%20in%20gastrointestinal%20cancer&amp;journal=Mol%20Cancer%20Ther&amp;doi=10.1158%2F1535-7163.MCT-24-0949&amp;publication_year=2025&amp;author=Ye%2CT&amp;author=Gao%2CH&amp;author=Zhang%2CZR&amp;author=Ge%2CY&amp;author=Liu%2CYK&amp;author=Yan%2CJY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR79\">Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006;444:633\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28Xht1KjurvE\" aria-label=\"CAS reference 79\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17136093\" aria-label=\"PubMed reference 79\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 79\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Oncogene-induced%20senescence%20is%20part%20of%20the%20tumorigenesis%20barrier%20imposed%20by%20DNA%20damage%20checkpoints&amp;journal=Nature&amp;volume=444&amp;pages=633-7&amp;publication_year=2006&amp;author=Bartkova%2CJ&amp;author=Rezaei%2CN&amp;author=Liontos%2CM&amp;author=Karakaidos%2CP&amp;author=Kletsas%2CD&amp;author=Issaeva%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR80\">Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C, et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature. 2006;444:638\u201342.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28Xht1KjurjF\" aria-label=\"CAS reference 80\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17136094\" aria-label=\"PubMed reference 80\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 80\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Oncogene-induced%20senescence%20is%20a%20DNA%20damage%20response%20triggered%20by%20DNA%20hyper-replication&amp;journal=Nature&amp;volume=444&amp;pages=638-42&amp;publication_year=2006&amp;author=Di%20Micco%2CR&amp;author=Fumagalli%2CM&amp;author=Cicalese%2CA&amp;author=Piccinin%2CS&amp;author=Gasparini%2CP&amp;author=Luise%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR81\">Sheekey E, Narita M. P53 in senescence &#8211; it\u2019s a marathon, not a sprint. FEBS J. 2023;290(3):1212\u201320.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xhs1OnsA%3D%3D\" aria-label=\"CAS reference 81\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34921507\" aria-label=\"PubMed reference 81\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 81\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=P53%20in%20senescence%20-%20it%E2%80%99s%20a%20marathon%2C%20not%20a%20sprint&amp;journal=FEBS%20J&amp;volume=290&amp;issue=3&amp;pages=1212-20&amp;publication_year=2023&amp;author=Sheekey%2CE&amp;author=Narita%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR82\">Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, et al. ATM is a key driver of NF-kappaB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging (Albany NY). 2020;12:4688\u2013710.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXitlantr%2FM\" aria-label=\"CAS reference 82\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32201398\" aria-label=\"PubMed reference 82\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 82\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=ATM%20is%20a%20key%20driver%20of%20NF-kappaB-dependent%20DNA-damage-induced%20senescence%2C%20stem%20cell%20dysfunction%20and%20aging&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=12&amp;pages=4688-4710&amp;publication_year=2020&amp;author=Zhao%2CJ&amp;author=Zhang%2CL&amp;author=Lu%2CA&amp;author=Han%2CY&amp;author=Colangelo%2CD&amp;author=Bukata%2CC&amp;author=Scibetta%2CA&amp;author=Yousefzadeh%2CMJ&amp;author=Li%2CX&amp;author=Gurkar%2CAU&amp;author=McGowan%2CSJ&amp;author=Angelini%2CL&amp;author=O%27Kelly%2CR&amp;author=Li%2CH&amp;author=Corbo%2CL&amp;author=Sano%2CT&amp;author=Nick%2CH&amp;author=Pola%2CE&amp;author=Pilla%2CSPS&amp;author=Ladiges%2CWC&amp;author=Vo%2CN&amp;author=Huard%2CJ&amp;author=Niedernhofer%2CLJ&amp;author=Robbins%2CPD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR83\">Rufini A, Tucci P, Celardo I, Melino G. Senescence and aging: the critical roles of p53. Oncogene. 2013;32:5129\u201343.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXis1Wqs70%3D\" aria-label=\"CAS reference 83\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23416979\" aria-label=\"PubMed reference 83\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 83\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence%20and%20aging%3A%20the%20critical%20roles%20of%20p53&amp;journal=Oncogene&amp;volume=32&amp;pages=5129-5143&amp;publication_year=2013&amp;author=Rufini%2CA&amp;author=Tucci%2CP&amp;author=Celardo%2CI&amp;author=Melino%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR84\">Cheng Q, Chen J. Mechanism of p53 stabilization by ATM after DNA damage. Cell Cycle. 2010;9:472\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXot1Cgsr0%3D\" aria-label=\"CAS reference 84\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20081365\" aria-label=\"PubMed reference 84\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 84\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mechanism%20of%20p53%20stabilization%20by%20ATM%20after%20DNA%20damage&amp;journal=Cell%20Cycle&amp;volume=9&amp;pages=472-8&amp;publication_year=2010&amp;author=Cheng%2CQ&amp;author=Chen%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR85\">Manic G, Obrist F, Sistigu A, Vitale I. Trial watch: targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy. Mol Cell Oncol. 2015;2:e1012976.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27308506\" aria-label=\"PubMed reference 85\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4905354\" aria-label=\"PubMed Central reference 85\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 85\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Trial%20watch%3A%20targeting%20ATM-CHK2%20and%20ATR-CHK1%20pathways%20for%20anticancer%20therapy&amp;journal=Mol%20Cell%20Oncol&amp;volume=2&amp;publication_year=2015&amp;author=Manic%2CG&amp;author=Obrist%2CF&amp;author=Sistigu%2CA&amp;author=Vitale%2CI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR86\">Engeland K. Cell cycle regulation: p53\u2013p21-RB signaling. Cell Death Differ. 2022;29:946\u201360.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XovF2qtb0%3D\" aria-label=\"CAS reference 86\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35361964\" aria-label=\"PubMed reference 86\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9090780\" aria-label=\"PubMed Central reference 86\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 86\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cell%20cycle%20regulation%3A%20p53%E2%80%93p21-RB%20signaling&amp;journal=Cell%20Death%20Differ&amp;volume=29&amp;pages=946-60&amp;publication_year=2022&amp;author=Engeland%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR87\">Kim YY, Jee HJ, Um JH, Kim YM, Bae SS, Yun J. Cooperation between p21 and Akt is required for p53-dependent cellular senescence. Aging Cell. 2017;16(2017):1094\u2013103.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtFelsbnE\" aria-label=\"CAS reference 87\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28691365\" aria-label=\"PubMed reference 87\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5595696\" aria-label=\"PubMed Central reference 87\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 87\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cooperation%20between%20p21%20and%20Akt%20is%20required%20for%20p53-dependent%20cellular%20senescence&amp;journal=Aging%20Cell&amp;volume=16&amp;issue=2017&amp;pages=1094-1103&amp;publication_year=2017&amp;author=Kim%2CYY&amp;author=Jee%2CHJ&amp;author=Um%2CJH&amp;author=Kim%2CYM&amp;author=Bae%2CSS&amp;author=Yun%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR88\">Yan J, Chen S, Yi Z, Zhao R, Zhu J, Ding S, et al. The role of p21 in cellular senescence and aging-related diseases. Mol Cells. 2024;47:100113.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39304134\" aria-label=\"PubMed reference 88\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11564947\" aria-label=\"PubMed Central reference 88\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 88\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20p21%20in%20cellular%20senescence%20and%20aging-related%20diseases&amp;journal=Mol%20Cells&amp;volume=47&amp;publication_year=2024&amp;author=Yan%2CJ&amp;author=Chen%2CS&amp;author=Yi%2CZ&amp;author=Zhao%2CR&amp;author=Zhu%2CJ&amp;author=Ding%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR89\">Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J. 2004;23:2554\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXlsVWgtLs%3D\" aria-label=\"CAS reference 89\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15192702\" aria-label=\"PubMed reference 89\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC449769\" aria-label=\"PubMed Central reference 89\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 89\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=DNA%20damage%20checkpoint%20kinase%20Chk2%20triggers%20replicative%20senescence&amp;journal=EMBO%20J&amp;volume=23&amp;pages=2554-63&amp;publication_year=2004&amp;author=Gire%2CV&amp;author=Roux%2CP&amp;author=Wynford-Thomas%2CD&amp;author=Brondello%2CJM&amp;author=Dulic%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR90\">Aasland D, Gotzinger L, Hauck L, Berte N, Meyer J, Effenberger M, et al. Temozolomide induces senescence and repression of DNA repair pathways in glioblastoma cells via activation of ATR-CHK1, p21, and NF-kappaB. Cancer Res. 2019;79:99\u2013113.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXotFGgs7g%3D\" aria-label=\"CAS reference 90\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30361254\" aria-label=\"PubMed reference 90\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 90\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Temozolomide%20induces%20senescence%20and%20repression%20of%20DNA%20repair%20pathways%20in%20glioblastoma%20cells%20via%20activation%20of%20ATR-CHK1%2C%20p21%2C%20and%20NF-kappaB&amp;journal=Cancer%20Res&amp;volume=79&amp;pages=99-113&amp;publication_year=2019&amp;author=Aasland%2CD&amp;author=Gotzinger%2CL&amp;author=Hauck%2CL&amp;author=Berte%2CN&amp;author=Meyer%2CJ&amp;author=Effenberger%2CM&amp;author=Schneider%2CS&amp;author=Reuber%2CEE&amp;author=Roos%2CWP&amp;author=Tomicic%2CMT&amp;author=Kaina%2CB&amp;author=Christmann%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR91\">Safwan-Zaiter H, Wagner KD, Wagner N. P16INK4A-more than a senescence marker. Life. 2022;12(9):1332. <a href=\"https:\/\/doi.org\/10.3390\/life12091332\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/life12091332\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/life12091332<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/life12091332\" data-track-item_id=\"10.3390\/life12091332\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Flife12091332\" aria-label=\"Article reference 91\" data-doi=\"10.3390\/life12091332\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36143369\" aria-label=\"PubMed reference 91\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9501954\" aria-label=\"PubMed Central reference 91\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 91\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=P16INK4A-more%20than%20a%20senescence%20marker&amp;journal=Life&amp;doi=10.3390%2Flife12091332&amp;publication_year=2022&amp;author=Safwan-Zaiter%2CH&amp;author=Wagner%2CKD&amp;author=Wagner%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR92\">Ohtani N, Yamakoshi K, Takahashi A, Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest. 2004;51:146\u201353.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15460900\" aria-label=\"PubMed reference 92\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 92\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20p16INK4a-RB%20pathway%3A%20molecular%20link%20between%20cellular%20senescence%20and%20tumor%20suppression&amp;journal=J%20Med%20Invest&amp;volume=51&amp;pages=146-53&amp;publication_year=2004&amp;author=Ohtani%2CN&amp;author=Yamakoshi%2CK&amp;author=Takahashi%2CA&amp;author=Hara%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR93\">Gimenez-Bastida JA, Avila-Galvez MA, Espin JC, Gonzalez-Sarrias A. Conjugated physiological resveratrol metabolites induce senescence in breast cancer cells: role of p53\/p21 and p16\/Rb pathways, and ABC transporters. Mol Nutr Food Res. 2019;63:e1900629.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31441212\" aria-label=\"PubMed reference 93\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 93\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Conjugated%20physiological%20resveratrol%20metabolites%20induce%20senescence%20in%20breast%20cancer%20cells%3A%20role%20of%20p53%2Fp21%20and%20p16%2FRb%20pathways%2C%20and%20ABC%20transporters&amp;journal=Mol%20Nutr%20Food%20Res&amp;volume=63&amp;publication_year=2019&amp;author=Gimenez-Bastida%2CJA&amp;author=Avila-Galvez%2CMA&amp;author=Espin%2CJC&amp;author=Gonzalez-Sarrias%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR94\">Chen J, Huang X, Halicka D, Brodsky S, Avram A, Eskander J, et al. Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53. Am J Physiol Heart Circ Physiol. 2006;290:H1575-1586.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28Xks1Snsb4%3D\" aria-label=\"CAS reference 94\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16243918\" aria-label=\"PubMed reference 94\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 94\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Contribution%20of%20p16INK4a%20and%20p21CIP1%20pathways%20to%20induction%20of%20premature%20senescence%20of%20human%20endothelial%20cells%3A%20permissive%20role%20of%20p53&amp;journal=Am%20J%20Physiol%20Heart%20Circ%20Physiol&amp;volume=290&amp;pages=H1575-1586&amp;publication_year=2006&amp;author=Chen%2CJ&amp;author=Huang%2CX&amp;author=Halicka%2CD&amp;author=Brodsky%2CS&amp;author=Avram%2CA&amp;author=Eskander%2CJ&amp;author=Bloomgarden%2CNA&amp;author=Darzynkiewicz%2CZ&amp;author=Goligorsky%2CMS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR95\">Rezatabar S, Karimian A, Rameshknia V, Parsian H, Majidinia M, Kopi TA, et al. RAS\/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression. J Cell Physiol. 2019;234:14951\u201365.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXjslOnsbs%3D\" aria-label=\"CAS reference 95\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30811039\" aria-label=\"PubMed reference 95\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 95\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=RAS%2FMAPK%20signaling%20functions%20in%20oxidative%20stress%2C%20DNA%20damage%20response%20and%20cancer%20progression&amp;journal=J%20Cell%20Physiol&amp;volume=234&amp;pages=14951-65&amp;publication_year=2019&amp;author=Rezatabar%2CS&amp;author=Karimian%2CA&amp;author=Rameshknia%2CV&amp;author=Parsian%2CH&amp;author=Majidinia%2CM&amp;author=Kopi%2CTA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR96\">Roy S, Roy S, Rana A, Akhter Y, Hande MP, Banerjee B. The role of p38 MAPK pathway in p53 compromised state and telomere mediated DNA damage response. Mutat Res-Genet Toxicol Environ Mutagen. 2018;836:89\u201397.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhtVCntbrO\" aria-label=\"CAS reference 96\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30389168\" aria-label=\"PubMed reference 96\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 96\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20p38%20MAPK%20pathway%20in%20p53%20compromised%20state%20and%20telomere%20mediated%20DNA%20damage%20response&amp;journal=Mutat%20Res-Genet%20Toxicol%20Environ%20Mutagen&amp;volume=836&amp;pages=89-97&amp;publication_year=2018&amp;author=Roy%2CS&amp;author=Roy%2CS&amp;author=Rana%2CA&amp;author=Akhter%2CY&amp;author=Hande%2CMP&amp;author=Banerjee%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR97\">Xu L, Ma Y, Ji Y, Ma Y, Wang Y, Zhao X, et al. Obesity exacerbates postoperative cognitive dysfunction by activating the PARP1\/NAD(+)\/SIRT1 axis through oxidative stress. Exp Gerontol. 2023:112320. <a href=\"https:\/\/doi.org\/10.1016\/j.exger.2023.112320\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1016\/j.exger.2023.112320\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.exger.2023.112320<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.exger.2023.112320\" data-track-item_id=\"10.1016\/j.exger.2023.112320\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.exger.2023.112320\" aria-label=\"Article reference 97\" data-doi=\"10.1016\/j.exger.2023.112320\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39492487\" aria-label=\"PubMed reference 97\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 97\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Obesity%20exacerbates%20postoperative%20cognitive%20dysfunction%20by%20activating%20the%20PARP1%2FNAD%28%2B%29%2FSIRT1%20axis%20through%20oxidative%20stress&amp;journal=Exp%20Gerontol&amp;doi=10.1016%2Fj.exger.2023.112320&amp;publication_year=2023&amp;author=Xu%2CL&amp;author=Ma%2CY&amp;author=Ji%2CY&amp;author=Ma%2CY&amp;author=Wang%2CY&amp;author=Zhao%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR98\">Murata MM, Kong X, Moncada E, Chen Y, Imamura H, Wang P, et al. NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival. Mol Biol Cell. 2019;30:2584\u201397.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXisVOmu73K\" aria-label=\"CAS reference 98\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31390283\" aria-label=\"PubMed reference 98\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6740200\" aria-label=\"PubMed Central reference 98\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 98\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=NAD%2B%20consumption%20by%20PARP1%20in%20response%20to%20DNA%20damage%20triggers%20metabolic%20shift%20critical%20for%20damaged%20cell%20survival&amp;journal=Mol%20Biol%20Cell&amp;volume=30&amp;pages=2584-97&amp;publication_year=2019&amp;author=Murata%2CMM&amp;author=Kong%2CX&amp;author=Moncada%2CE&amp;author=Chen%2CY&amp;author=Imamura%2CH&amp;author=Wang%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR99\">Mendelsohn AR, Larrick JW. The NAD+\/PARP1\/SIRT1 axis in aging. Rejuvenation Res. 2017;20:244\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtVKit73M\" aria-label=\"CAS reference 99\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28537485\" aria-label=\"PubMed reference 99\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 99\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20NAD%2B%2FPARP1%2FSIRT1%20axis%20in%20aging&amp;journal=Rejuvenation%20Res&amp;volume=20&amp;pages=244-7&amp;publication_year=2017&amp;author=Mendelsohn%2CAR&amp;author=Larrick%2CJW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR100\">Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, et al. The canonical NF-kappaB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage. Cell Signal. 2012;24:2007\u201323.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XhtlSgurnO\" aria-label=\"CAS reference 100\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22750558\" aria-label=\"PubMed reference 100\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3432746\" aria-label=\"PubMed Central reference 100\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 100\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20canonical%20NF-kappaB%20pathway%20differentially%20protects%20normal%20and%20human%20tumor%20cells%20from%20ROS-induced%20DNA%20damage&amp;journal=Cell%20Signal&amp;volume=24&amp;pages=2007-2023&amp;publication_year=2012&amp;author=Sfikas%2CA&amp;author=Batsi%2CC&amp;author=Tselikou%2CE&amp;author=Vartholomatos%2CG&amp;author=Monokrousos%2CN&amp;author=Pappas%2CP&amp;author=Christoforidis%2CS&amp;author=Tzavaras%2CT&amp;author=Kanavaros%2CP&amp;author=Gorgoulis%2CVG&amp;author=Marcu%2CKB&amp;author=Kolettas%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR101\">Jing H, Lee S. NF-kappaB in cellular senescence and cancer treatment. Mol Cells. 2014;37:189\u201395.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24608805\" aria-label=\"PubMed reference 101\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3969038\" aria-label=\"PubMed Central reference 101\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 101\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=NF-kappaB%20in%20cellular%20senescence%20and%20cancer%20treatment&amp;journal=Mol%20Cells&amp;volume=37&amp;pages=189-95&amp;publication_year=2014&amp;author=Jing%2CH&amp;author=Lee%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR102\">Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal. 2012;24:835\u201345.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XhsVeksLo%3D\" aria-label=\"CAS reference 102\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22182507\" aria-label=\"PubMed reference 102\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 102\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Emerging%20role%20of%20NF-kappaB%20signaling%20in%20the%20induction%20of%20senescence-associated%20secretory%20phenotype%20%28SASP%29&amp;journal=Cell%20Signal&amp;volume=24&amp;pages=835-45&amp;publication_year=2012&amp;author=Salminen%2CA&amp;author=Kauppinen%2CA&amp;author=Kaarniranta%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR103\">Sebastian T, Malik R, Thomas S, Sage J, Johnson PF. C\/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence. EMBO J. 2005;24:3301\u201312.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXhtVajsrjM\" aria-label=\"CAS reference 103\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16107878\" aria-label=\"PubMed reference 103\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1224679\" aria-label=\"PubMed Central reference 103\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 103\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=C%2FEBPbeta%20cooperates%20with%20RB%3AE2F%20to%20implement%20Ras%28V12%29-induced%20cellular%20senescence&amp;journal=EMBO%20J&amp;volume=24&amp;pages=3301-12&amp;publication_year=2005&amp;author=Sebastian%2CT&amp;author=Malik%2CR&amp;author=Thomas%2CS&amp;author=Sage%2CJ&amp;author=Johnson%2CPF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR104\">Liu X, Huang Z, Zhang Y, Shui X, Liu F, Wu Z, et al. Lacidipine ameliorates the endothelial senescence and inflammatory injury through CXCR7\/P38\/C\/EBP-beta signaling pathway. Front Cardiovasc Med. 2021;8:692540.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXisVOjtbvI\" aria-label=\"CAS reference 104\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34295928\" aria-label=\"PubMed reference 104\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8290057\" aria-label=\"PubMed Central reference 104\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 104\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Lacidipine%20ameliorates%20the%20endothelial%20senescence%20and%20inflammatory%20injury%20through%20CXCR7%2FP38%2FC%2FEBP-beta%20signaling%20pathway&amp;journal=Front%20Cardiovasc%20Med&amp;volume=8&amp;publication_year=2021&amp;author=Liu%2CX&amp;author=Huang%2CZ&amp;author=Zhang%2CY&amp;author=Shui%2CX&amp;author=Liu%2CF&amp;author=Wu%2CZ&amp;author=Xu%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR105\">Ahmad A, Biersack B, Li Y, Kong D, Bao B, Schobert R, et al. Targeted regulation of PI3K\/Akt\/mTOR\/NF-kappaB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy. Anticancer Agents Med Chem. 2013;13:1002\u201313.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXht1GmurzO\" aria-label=\"CAS reference 105\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23272910\" aria-label=\"PubMed reference 105\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3901097\" aria-label=\"PubMed Central reference 105\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 105\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeted%20regulation%20of%20PI3K%2FAkt%2FmTOR%2FNF-kappaB%20signaling%20by%20indole%20compounds%20and%20their%20derivatives%3A%20mechanistic%20details%20and%20biological%20implications%20for%20cancer%20therapy&amp;journal=Anticancer%20Agents%20Med%20Chem&amp;volume=13&amp;pages=1002-1013&amp;publication_year=2013&amp;author=Ahmad%2CA&amp;author=Biersack%2CB&amp;author=Li%2CY&amp;author=Kong%2CD&amp;author=Bao%2CB&amp;author=Schobert%2CR&amp;author=Padhye%2CSB&amp;author=Sarkar%2CFH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR106\">Shi T, Dansen TB. Reactive oxygen species induced p53 activation: DNA damage, redox signaling, or both? Antioxid Redox Signal. 2020;33(2020):839\u201359.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhvVSnt77M\" aria-label=\"CAS reference 106\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32151151\" aria-label=\"PubMed reference 106\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 106\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reactive%20oxygen%20species%20induced%20p53%20activation%3A%20DNA%20damage%2C%20redox%20signaling%2C%20or%20both%3F&amp;journal=Antioxid%20Redox%20Signal&amp;volume=33&amp;issue=2020&amp;pages=839-859&amp;publication_year=2020&amp;author=Shi%2CT&amp;author=Dansen%2CTB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR107\">Guterres FA, Martinez GR, Rocha ME, Winnischofer SM. Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53\/p21 pathway. Exp Cell Res. 2013;319(2013):2977\u201388.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23933099\" aria-label=\"PubMed reference 107\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 107\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Simvastatin%20rises%20reactive%20oxygen%20species%20levels%20and%20induces%20senescence%20in%20human%20melanoma%20cells%20by%20activation%20of%20p53%2Fp21%20pathway&amp;journal=Exp%20Cell%20Res&amp;volume=319&amp;issue=2013&amp;pages=2977-2988&amp;publication_year=2013&amp;author=Guterres%2CFA&amp;author=Martinez%2CGR&amp;author=Rocha%2CME&amp;author=Winnischofer%2CSM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR108\">Zhou Z, Yin Y, Chang Q, Sun G, Lin J, Dai Y. Downregulation of B-myb promotes senescence via the ROS-mediated p53\/p21 pathway, in vascular endothelial cells. Cell Prolif. 2017;50(2):e12319. <a href=\"https:\/\/doi.org\/10.1111\/cpr.12319\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1111\/cpr.12319\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1111\/cpr.12319<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1111\/cpr.12319\" data-track-item_id=\"10.1111\/cpr.12319\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1111%2Fcpr.12319\" aria-label=\"Article reference 108\" data-doi=\"10.1111\/cpr.12319\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29131440\" aria-label=\"PubMed reference 108\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6528931\" aria-label=\"PubMed Central reference 108\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 108\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Downregulation%20of%20B-myb%20promotes%20senescence%20via%20the%20ROS-mediated%20p53%2Fp21%20pathway%2C%20in%20vascular%20endothelial%20cells&amp;journal=Cell%20Prolif&amp;doi=10.1111%2Fcpr.12319&amp;publication_year=2017&amp;author=Zhou%2CZ&amp;author=Yin%2CY&amp;author=Chang%2CQ&amp;author=Sun%2CG&amp;author=Lin%2CJ&amp;author=Dai%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR109\">Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, et al. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol. 2006;8:1291\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XhtFCqu7jE\" aria-label=\"CAS reference 109\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17028578\" aria-label=\"PubMed reference 109\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 109\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mitogenic%20signalling%20and%20the%20p16INK4a-Rb%20pathway%20cooperate%20to%20enforce%20irreversible%20cellular%20senescence&amp;journal=Nat%20Cell%20Biol&amp;volume=8&amp;pages=1291-7&amp;publication_year=2006&amp;author=Takahashi%2CA&amp;author=Ohtani%2CN&amp;author=Yamakoshi%2CK&amp;author=Iida%2CS&amp;author=Tahara%2CH&amp;author=Nakayama%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR110\">Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 2003;22:4212\u201322.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3sXmvVaqt7o%3D\" aria-label=\"CAS reference 110\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12912919\" aria-label=\"PubMed reference 110\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC175806\" aria-label=\"PubMed Central reference 110\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 110\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reversal%20of%20human%20cellular%20senescence%3A%20roles%20of%20the%20p53%20and%20p16%20pathways&amp;journal=EMBO%20J&amp;volume=22&amp;pages=4212-4222&amp;publication_year=2003&amp;author=Beausejour%2CCM&amp;author=Krtolica%2CA&amp;author=Galimi%2CF&amp;author=Narita%2CM&amp;author=Lowe%2CSW&amp;author=Yaswen%2CP&amp;author=Campisi%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR111\">Zhang L, Fang Y, Xu XF, Jin DY. Moscatilin induces apoptosis of pancreatic cancer cells via reactive oxygen species and the JNK\/SAPK pathway. Mol Med Rep. 2017;15:1195\u2013203.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXpsl2ls7k%3D\" aria-label=\"CAS reference 111\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28138710\" aria-label=\"PubMed reference 111\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5367346\" aria-label=\"PubMed Central reference 111\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 111\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Moscatilin%20induces%20apoptosis%20of%20pancreatic%20cancer%20cells%20via%20reactive%20oxygen%20species%20and%20the%20JNK%2FSAPK%20pathway&amp;journal=Mol%20Med%20Rep&amp;volume=15&amp;pages=1195-203&amp;publication_year=2017&amp;author=Zhang%2CL&amp;author=Fang%2CY&amp;author=Xu%2CXF&amp;author=Jin%2CDY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR112\">Wagner KD, Wagner N. The senescence markers p16INK4A, p14ARF\/p19ARF, and p21 in organ development and homeostasis. Cells. 2022;11(12):1966. <a href=\"https:\/\/doi.org\/10.3390\/cells11121966\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cells11121966\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cells11121966<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/cells11121966\" data-track-item_id=\"10.3390\/cells11121966\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fcells11121966\" aria-label=\"Article reference 112\" data-doi=\"10.3390\/cells11121966\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36552794\" aria-label=\"PubMed reference 112\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9776765\" aria-label=\"PubMed Central reference 112\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 112\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20senescence%20markers%20p16INK4A%2C%20p14ARF%2Fp19ARF%2C%20and%20p21%20in%20organ%20development%20and%20homeostasis&amp;journal=Cells&amp;doi=10.3390%2Fcells11121966&amp;publication_year=2022&amp;author=Wagner%2CKD&amp;author=Wagner%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR113\">Hsieh CC, Kuro-o M, Rosenblatt KP, Brobey R, Papaconstantinou J. The ASK1-signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging (Albany NY). 2010;2:597\u2013611.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXht1KlsLvI\" aria-label=\"CAS reference 113\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20844314\" aria-label=\"PubMed reference 113\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 113\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20ASK1-signalosome%20regulates%20p38%20MAPK%20activity%20in%20response%20to%20levels%20of%20endogenous%20oxidative%20stress%20in%20the%20Klotho%20mouse%20models%20of%20aging&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=2&amp;pages=597-611&amp;publication_year=2010&amp;author=Hsieh%2CCC&amp;author=Kuro-o%2CM&amp;author=Rosenblatt%2CKP&amp;author=Brobey%2CR&amp;author=Papaconstantinou%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR114\">Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science. 2008;319:1352\u20135.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXislSkt7c%3D\" aria-label=\"CAS reference 114\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18323444\" aria-label=\"PubMed reference 114\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 114\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20oncogene-induced%20DNA%20damage%20model%20for%20cancer%20development&amp;journal=Science&amp;volume=319&amp;pages=1352-5&amp;publication_year=2008&amp;author=Halazonetis%2CTD&amp;author=Gorgoulis%2CVG&amp;author=Bartek%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR115\">Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, et al. Tumour biology: senescence in premalignant tumours. Nature. 2005;436:642.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXmvFentLc%3D\" aria-label=\"CAS reference 115\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16079833\" aria-label=\"PubMed reference 115\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 115\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumour%20biology%3A%20senescence%20in%20premalignant%20tumours&amp;journal=Nature&amp;volume=436&amp;publication_year=2005&amp;author=Collado%2CM&amp;author=Gil%2CJ&amp;author=Efeyan%2CA&amp;author=Guerra%2CC&amp;author=Schuhmacher%2CAJ&amp;author=Barradas%2CM&amp;author=Benguria%2CA&amp;author=Zaballos%2CA&amp;author=Flores%2CJM&amp;author=Barbacid%2CM&amp;author=Beach%2CD&amp;author=Serrano%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR116\">Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature. 2005;436:720\u20134.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXmvFenuro%3D\" aria-label=\"CAS reference 116\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16079850\" aria-label=\"PubMed reference 116\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 116\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BRAFE600-associated%20senescence-like%20cell%20cycle%20arrest%20of%20human%20naevi&amp;journal=Nature&amp;volume=436&amp;pages=720-724&amp;publication_year=2005&amp;author=Michaloglou%2CC&amp;author=Vredeveld%2CLC&amp;author=Soengas%2CMS&amp;author=Denoyelle%2CC&amp;author=Kuilman%2CT&amp;author=Horst%2CCM&amp;author=Majoor%2CDM&amp;author=Shay%2CJW&amp;author=Mooi%2CWJ&amp;author=Peeper%2CDS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR117\">Mallette FA, Ferbeyre G. The DNA damage signaling pathway connects oncogenic stress to cellular senescence. Cell Cycle. 2007;6:1831\u20136.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXhtFWmurbF\" aria-label=\"CAS reference 117\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17671427\" aria-label=\"PubMed reference 117\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 117\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20DNA%20damage%20signaling%20pathway%20connects%20oncogenic%20stress%20to%20cellular%20senescence&amp;journal=Cell%20Cycle&amp;volume=6&amp;pages=1831-1836&amp;publication_year=2007&amp;author=Mallette%2CFA&amp;author=Ferbeyre%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR118\">Maya-Mendoza A, Ostrakova J, Kosar M, Hall A, Duskova P, Mistrik M, et al. Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress. Mol Oncol. 2015;9:601\u201316.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhvF2jtLnM\" aria-label=\"CAS reference 118\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25435281\" aria-label=\"PubMed reference 118\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 118\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Myc%20and%20Ras%20oncogenes%20engage%20different%20energy%20metabolism%20programs%20and%20evoke%20distinct%20patterns%20of%20oxidative%20and%20DNA%20replication%20stress&amp;journal=Mol%20Oncol&amp;volume=9&amp;pages=601-16&amp;publication_year=2015&amp;author=Maya-Mendoza%2CA&amp;author=Ostrakova%2CJ&amp;author=Kosar%2CM&amp;author=Hall%2CA&amp;author=Duskova%2CP&amp;author=Mistrik%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR119\">Shtutman M, Chang BD, Schools GP, Broude EV. Cellular model of p21-induced senescence. Methods Mol Biol. 2017;1534:31\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXntlGju7s%3D\" aria-label=\"CAS reference 119\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27812865\" aria-label=\"PubMed reference 119\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6764449\" aria-label=\"PubMed Central reference 119\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 119\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20model%20of%20p21-induced%20senescence&amp;journal=Methods%20Mol%20Biol&amp;volume=1534&amp;pages=31-39&amp;publication_year=2017&amp;author=Shtutman%2CM&amp;author=Chang%2CBD&amp;author=Schools%2CGP&amp;author=Broude%2CEV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR120\">Xu Y, Li N, Xiang R, Sun P. Emerging roles of the p38 MAPK and PI3K\/AKT\/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci. 2014;39:268\u201376.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXnvFSlsLk%3D\" aria-label=\"CAS reference 120\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24818748\" aria-label=\"PubMed reference 120\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4358807\" aria-label=\"PubMed Central reference 120\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 120\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Emerging%20roles%20of%20the%20p38%20MAPK%20and%20PI3K%2FAKT%2FmTOR%20pathways%20in%20oncogene-induced%20senescence&amp;journal=Trends%20Biochem%20Sci&amp;volume=39&amp;pages=268-76&amp;publication_year=2014&amp;author=Xu%2CY&amp;author=Li%2CN&amp;author=Xiang%2CR&amp;author=Sun%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR121\">Freund A, Patil CK, Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J. 2011;30:1536\u201348.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXjtVGmsr4%3D\" aria-label=\"CAS reference 121\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21399611\" aria-label=\"PubMed reference 121\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3102277\" aria-label=\"PubMed Central reference 121\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 121\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=p38MAPK%20is%20a%20novel%20DNA%20damage%20response-independent%20regulator%20of%20the%20senescence-associated%20secretory%20phenotype&amp;journal=EMBO%20J&amp;volume=30&amp;pages=1536-48&amp;publication_year=2011&amp;author=Freund%2CA&amp;author=Patil%2CCK&amp;author=Campisi%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR122\">Ruiz L, Traskine M, Ferrer I, Castro E, Leal JF, Kaufman M, et al. Characterization of the p53 response to oncogene-induced senescence. PLoS One. 2008;3:e3230.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18800172\" aria-label=\"PubMed reference 122\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2535567\" aria-label=\"PubMed Central reference 122\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 122\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Characterization%20of%20the%20p53%20response%20to%20oncogene-induced%20senescence&amp;journal=PLoS%20One&amp;volume=3&amp;publication_year=2008&amp;author=Ruiz%2CL&amp;author=Traskine%2CM&amp;author=Ferrer%2CI&amp;author=Castro%2CE&amp;author=Leal%2CJF&amp;author=Kaufman%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR123\">Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Proc Natl Acad Sci U S A. 2016;113:E5024-5033.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28Xht12lu7zI\" aria-label=\"CAS reference 123\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27503890\" aria-label=\"PubMed reference 123\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5003242\" aria-label=\"PubMed Central reference 123\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 123\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Derepression%20of%20hTERT%20gene%20expression%20promotes%20escape%20from%20oncogene-induced%20cellular%20senescence&amp;journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&amp;volume=113&amp;pages=E5024-5033&amp;publication_year=2016&amp;author=Patel%2CPL&amp;author=Suram%2CA&amp;author=Mirani%2CN&amp;author=Bischof%2CO&amp;author=Herbig%2CU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR124\">Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, et al. Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma. Cancer Cell. 2018;33:322\u201336 e328.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXislSgtrg%3D\" aria-label=\"CAS reference 124\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29438700\" aria-label=\"PubMed reference 124\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5977991\" aria-label=\"PubMed Central reference 124\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 124\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20the%20senescence-overriding%20cooperative%20activity%20of%20structurally%20unrelated%20H3K9%20demethylases%20in%20melanoma&amp;journal=Cancer%20Cell.&amp;volume=33&amp;pages=322-336&amp;publication_year=2018&amp;author=Yu%2CY&amp;author=Schleich%2CK&amp;author=Yue%2CB&amp;author=Ji%2CS&amp;author=Lohneis%2CP&amp;author=Kemper%2CK&amp;author=Silvis%2CMR&amp;author=Qutob%2CN&amp;author=Rooijen%2CE&amp;author=Werner-Klein%2CM&amp;author=Li%2CL&amp;author=Dhawan%2CD&amp;author=Meierjohann%2CS&amp;author=Reimann%2CM&amp;author=Elkahloun%2CA&amp;author=Treitschke%2CS&amp;author=D%C3%B6rken%2CB&amp;author=Speck%2CC&amp;author=Mallette%2CFA&amp;author=Zon%2CLI&amp;author=Holmen%2CSL&amp;author=Peeper%2CDS&amp;author=Samuels%2CY&amp;author=Schmitt%2CCA&amp;author=Lee%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR125\">Laberge RM, Awad P, Campisi J, Desprez PY. Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron. 2012;5:39\u201344.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xms1Wns70%3D\" aria-label=\"CAS reference 125\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21706180\" aria-label=\"PubMed reference 125\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 125\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epithelial-mesenchymal%20transition%20induced%20by%20senescent%20fibroblasts&amp;journal=Cancer%20Microenviron&amp;volume=5&amp;pages=39-44&amp;publication_year=2012&amp;author=Laberge%2CRM&amp;author=Awad%2CP&amp;author=Campisi%2CJ&amp;author=Desprez%2CPY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR126\">Burns TF, Dobromilskaya I, Murphy SC, Gajula RP, Thiyagarajan S, Chatley SN, et al. Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer. Mol Cancer Res. 2013;11:329\u201338.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXlvFyjur4%3D\" aria-label=\"CAS reference 126\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23364532\" aria-label=\"PubMed reference 126\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3631276\" aria-label=\"PubMed Central reference 126\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 126\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20TWIST1%20leads%20to%20activation%20of%20oncogene-induced%20senescence%20in%20oncogene-driven%20non-small%20cell%20lung%20cancer&amp;journal=Mol%20Cancer%20Res&amp;volume=11&amp;pages=329-38&amp;publication_year=2013&amp;author=Burns%2CTF&amp;author=Dobromilskaya%2CI&amp;author=Murphy%2CSC&amp;author=Gajula%2CRP&amp;author=Thiyagarajan%2CS&amp;author=Chatley%2CSN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR127\">Cuollo L, Antonangeli F, Santoni A, Soriani A. The senescence-associated secretory phenotype (SASP) in the challenging future of cancer therapy and age-related diseases. Biology. 2020;9(12):485. <a href=\"https:\/\/doi.org\/10.3390\/biology9120485\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/biology9120485\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/biology9120485<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/biology9120485\" data-track-item_id=\"10.3390\/biology9120485\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fbiology9120485\" aria-label=\"Article reference 127\" data-doi=\"10.3390\/biology9120485\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33371508\" aria-label=\"PubMed reference 127\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7767554\" aria-label=\"PubMed Central reference 127\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 127\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20senescence-associated%20secretory%20phenotype%20%28SASP%29%20in%20the%20challenging%20future%20of%20cancer%20therapy%20and%20age-related%20diseases&amp;journal=Biology&amp;doi=10.3390%2Fbiology9120485&amp;publication_year=2020&amp;author=Cuollo%2CL&amp;author=Antonangeli%2CF&amp;author=Santoni%2CA&amp;author=Soriani%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR128\">Gewirtz DA, Holt SE, Elmore LW. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol. 2008;76:947\u201357.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXht1Sms7jE\" aria-label=\"CAS reference 128\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18657518\" aria-label=\"PubMed reference 128\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 128\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Accelerated%20senescence%3A%20an%20emerging%20role%20in%20tumor%20cell%20response%20to%20chemotherapy%20and%20radiation&amp;journal=Biochem%20Pharmacol&amp;volume=76&amp;pages=947-57&amp;publication_year=2008&amp;author=Gewirtz%2CDA&amp;author=Holt%2CSE&amp;author=Elmore%2CLW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR129\">Saleh T, Bloukh S, Carpenter VJ, Alwohoush E, Bakeer J, Darwish S, et al. Therapy-induced senescence: an \u201cOld\u201d friend becomes the enemy. Cancers (Basel). 2020;12(4):822. <a href=\"https:\/\/doi.org\/10.3390\/cancers12040822\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cancers12040822\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cancers12040822<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR130\">Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, et al. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol. 2015;17:1205\u201317.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhtlCksbzL\" aria-label=\"CAS reference 130\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26280535\" aria-label=\"PubMed reference 130\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4589897\" aria-label=\"PubMed Central reference 130\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 130\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=mTOR%20regulates%20MAPKAPK2%20translation%20to%20control%20the%20senescence-associated%20secretory%20phenotype&amp;journal=Nat%20Cell%20Biol&amp;volume=17&amp;pages=1205-17&amp;publication_year=2015&amp;author=Herranz%2CN&amp;author=Gallage%2CS&amp;author=Mellone%2CM&amp;author=Wuestefeld%2CT&amp;author=Klotz%2CS&amp;author=Hanley%2CCJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR131\">Loo TM, Miyata K, Tanaka Y, Takahashi A. Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer. Cancer Sci. 2020;111:304\u201311.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXisVyqurrI\" aria-label=\"CAS reference 131\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31799772\" aria-label=\"PubMed reference 131\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 131\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20senescence%20and%20senescence-associated%20secretory%20phenotype%20via%20the%20cGAS-STING%20signaling%20pathway%20in%20cancer&amp;journal=Cancer%20Sci&amp;volume=111&amp;pages=304-11&amp;publication_year=2020&amp;author=Loo%2CTM&amp;author=Miyata%2CK&amp;author=Tanaka%2CY&amp;author=Takahashi%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR132\">Yu L, Liu P. cGAS\/STING signalling pathway in senescence and oncogenesis. Semin Cancer Biol. 2024;106\u2013107:87\u2013102.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39222763\" aria-label=\"PubMed reference 132\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11625615\" aria-label=\"PubMed Central reference 132\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 132\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=cGAS%2FSTING%20signalling%20pathway%20in%20senescence%20and%20oncogenesis&amp;journal=Semin%20Cancer%20Biol&amp;volume=106%E2%80%93107&amp;pages=87-102&amp;publication_year=2024&amp;author=Yu%2CL&amp;author=Liu%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR133\">Zeng PH, Yin WJ. The cGAS\/STING signaling pathway: a cross-talk of infection, senescence and tumors. Cell Cycle. 2023;22:38\u201356.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XitV2kt7jP\" aria-label=\"CAS reference 133\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35946607\" aria-label=\"PubMed reference 133\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 133\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20cGAS%2FSTING%20signaling%20pathway%3A%20a%20cross-talk%20of%20infection%2C%20senescence%20and%20tumors&amp;journal=Cell%20Cycle&amp;volume=22&amp;pages=38-56&amp;publication_year=2023&amp;author=Zeng%2CPH&amp;author=Yin%2CWJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR134\">Muela-Zarzuela I, Suarez-Rivero JM, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, et al. Nlrp1 inflammasome promotes senescence and senescence-associated secretory phenotype. Inflamm Res. 2024;73:1253\u201366.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhtlyqsL%2FE\" aria-label=\"CAS reference 134\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38907167\" aria-label=\"PubMed reference 134\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11281979\" aria-label=\"PubMed Central reference 134\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 134\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Nlrp1%20inflammasome%20promotes%20senescence%20and%20senescence-associated%20secretory%20phenotype&amp;journal=Inflamm%20Res&amp;volume=73&amp;pages=1253-66&amp;publication_year=2024&amp;author=Muela-Zarzuela%2CI&amp;author=Suarez-Rivero%2CJM&amp;author=Gallardo-Orihuela%2CA&amp;author=Wang%2CC&amp;author=Izawa%2CK&amp;author=Gregorio-Procopio%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR135\">Vaissiere T, Sawan C, Herceg Z. Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res. 2008;659:40\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXpsVams7o%3D\" aria-label=\"CAS reference 135\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18407786\" aria-label=\"PubMed reference 135\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 135\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epigenetic%20interplay%20between%20histone%20modifications%20and%20DNA%20methylation%20in%20gene%20silencing&amp;journal=Mutat%20Res&amp;volume=659&amp;pages=40-8&amp;publication_year=2008&amp;author=Vaissiere%2CT&amp;author=Sawan%2CC&amp;author=Herceg%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR136\">Rodr\u00edguez S, Berm\u00fadez LG, Gonz\u00e1lez D, Bernal C, Ca\u00f1as A, Morales-Ru\u00edz T, et al. Transcriptional regulation of CDKN2A\/p16 by sirtuin 7 in senescence. Mol Med Rep. 2022;26(5):345. <a href=\"https:\/\/doi.org\/10.3892\/mmr.2022.12861\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3892\/mmr.2022.12861\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3892\/mmr.2022.12861<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR137\">Ito T, Teo YV, Evans SA, Neretti N, Sedivy JM. Regulation of cellular senescence by polycomb chromatin modifiers through distinct DNA damage- and histone methylation-dependent pathways. Cell Rep. 2018;22:3480\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXmsVegsLc%3D\" aria-label=\"CAS reference 137\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29590617\" aria-label=\"PubMed reference 137\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5915310\" aria-label=\"PubMed Central reference 137\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 137\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Regulation%20of%20cellular%20senescence%20by%20polycomb%20chromatin%20modifiers%20through%20distinct%20DNA%20damage-%20and%20histone%20methylation-dependent%20pathways&amp;journal=Cell%20Rep&amp;volume=22&amp;pages=3480-92&amp;publication_year=2018&amp;author=Ito%2CT&amp;author=Teo%2CYV&amp;author=Evans%2CSA&amp;author=Neretti%2CN&amp;author=Sedivy%2CJM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR138\">Zhang N, Shang M, Li H, Wu L, Dong M, Huang B, et al. Dual inhibition of H3K9me2 and H3K27me3 promotes tumor cell senescence without triggering the secretion of SASP. Int J Mol Sci. 2022;23(7):3911. <a href=\"https:\/\/doi.org\/10.3390\/ijms23073911\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms23073911\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms23073911<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms23073911\" data-track-item_id=\"10.3390\/ijms23073911\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms23073911\" aria-label=\"Article reference 138\" data-doi=\"10.3390\/ijms23073911\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36614339\" aria-label=\"PubMed reference 138\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9821249\" aria-label=\"PubMed Central reference 138\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 138\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dual%20inhibition%20of%20H3K9me2%20and%20H3K27me3%20promotes%20tumor%20cell%20senescence%20without%20triggering%20the%20secretion%20of%20SASP&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms23073911&amp;publication_year=2022&amp;author=Zhang%2CN&amp;author=Shang%2CM&amp;author=Li%2CH&amp;author=Wu%2CL&amp;author=Dong%2CM&amp;author=Huang%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR139\">Shvedunova M, Akhtar A. Modulation of cellular processes by histone and non-histone protein acetylation. Nat Rev Mol Cell Biol. 2022;23:329\u201349.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhsFSmu7Y%3D\" aria-label=\"CAS reference 139\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35042977\" aria-label=\"PubMed reference 139\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 139\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Modulation%20of%20cellular%20processes%20by%20histone%20and%20non-histone%20protein%20acetylation&amp;journal=Nat%20Rev%20Mol%20Cell%20Biol&amp;volume=23&amp;pages=329-49&amp;publication_year=2022&amp;author=Shvedunova%2CM&amp;author=Akhtar%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR140\">Gadecka A, Koblowska M, Kossowska H, Iwanicka-Nowicka R, Janiszewska D, Mosieniak G, et al. Senescence-associated alterations in histone H3 modifications, HP1 alpha levels and distribution, and in the transcriptome of vascular smooth muscle cells in different types of senescence. Cell Commun Signal. 2025;23(1):321.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXitlOktL%2FN\" aria-label=\"CAS reference 140\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40597225\" aria-label=\"PubMed reference 140\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12220758\" aria-label=\"PubMed Central reference 140\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 140\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20alterations%20in%20histone%20H3%20modifications%2C%20HP1%20alpha%20levels%20and%20distribution%2C%20and%20in%20the%20transcriptome%20of%20vascular%20smooth%20muscle%20cells%20in%20different%20types%20of%20senescence&amp;journal=Cell%20Commun%20Signal&amp;volume=23&amp;issue=1&amp;publication_year=2025&amp;author=Gadecka%2CA&amp;author=Koblowska%2CM&amp;author=Kossowska%2CH&amp;author=Iwanicka-Nowicka%2CR&amp;author=Janiszewska%2CD&amp;author=Mosieniak%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR141\">Kaneda A, Fujita T, Anai M, Yamamoto S, Nagae G, Morikawa M, et al. Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence. PLoS Genet. 2011;7:e1002359.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXhsFSrtL7J\" aria-label=\"CAS reference 141\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22072987\" aria-label=\"PubMed reference 141\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3207904\" aria-label=\"PubMed Central reference 141\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 141\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activation%20of%20Bmp2-Smad1%20signal%20and%20its%20regulation%20by%20coordinated%20alteration%20of%20H3K27%20trimethylation%20in%20Ras-induced%20senescence&amp;journal=PLoS%20Genet&amp;volume=7&amp;publication_year=2011&amp;author=Kaneda%2CA&amp;author=Fujita%2CT&amp;author=Anai%2CM&amp;author=Yamamoto%2CS&amp;author=Nagae%2CG&amp;author=Morikawa%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR142\">Warnon C, Bouhjar K, Ninane N, Verhoyen M, Fattaccioli A, Fransolet M, et al. Hdac2 and 7 down-regulation induces senescence in dermal fibroblasts. Aging (Albany NY). 2021;13:17978\u20138005.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xhs1Ojurk%3D\" aria-label=\"CAS reference 142\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34253688\" aria-label=\"PubMed reference 142\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 142\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hdac2%20and%207%20down-regulation%20induces%20senescence%20in%20dermal%20fibroblasts&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=13&amp;pages=17978-8005&amp;publication_year=2021&amp;author=Warnon%2CC&amp;author=Bouhjar%2CK&amp;author=Ninane%2CN&amp;author=Verhoyen%2CM&amp;author=Fattaccioli%2CA&amp;author=Fransolet%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR143\">Di Giorgio E, Paluvai H, Dalla E, Ranzino L, Renzini A, Moresi V, et al. Hdac4 degradation during senescence unleashes an epigenetic program driven by AP-1\/p300 at selected enhancers and super-enhancers. Genome Biol. 2021;22:129.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXht1Krt7nJ\" aria-label=\"CAS reference 143\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33966634\" aria-label=\"PubMed reference 143\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8108360\" aria-label=\"PubMed Central reference 143\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 143\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hdac4%20degradation%20during%20senescence%20unleashes%20an%20epigenetic%20program%20driven%20by%20AP-1%2Fp300%20at%20selected%20enhancers%20and%20super-enhancers&amp;journal=Genome%20Biol&amp;volume=22&amp;publication_year=2021&amp;author=Di%20Giorgio%2CE&amp;author=Paluvai%2CH&amp;author=Dalla%2CE&amp;author=Ranzino%2CL&amp;author=Renzini%2CA&amp;author=Moresi%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR144\">Willis-Martinez D, Richards HW, Timchenko NA, Medrano EE. Role of HDAC1 in senescence, aging, and cancer. Exp Gerontol. 2010;45(2010):279\u201385.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXjtFyns7Y%3D\" aria-label=\"CAS reference 144\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19818845\" aria-label=\"PubMed reference 144\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 144\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Role%20of%20HDAC1%20in%20senescence%2C%20aging%2C%20and%20cancer&amp;journal=Exp%20Gerontol&amp;volume=45&amp;issue=2010&amp;pages=279-85&amp;publication_year=2010&amp;author=Willis-Martinez%2CD&amp;author=Richards%2CHW&amp;author=Timchenko%2CNA&amp;author=Medrano%2CEE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR145\">Kupis W, Palyga J, Tomal E, Niewiadomska E. The role of sirtuins in cellular homeostasis. J Physiol Biochem. 2016;72:371\u201380.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XnvVGgtbg%3D\" aria-label=\"CAS reference 145\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27154583\" aria-label=\"PubMed reference 145\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4992043\" aria-label=\"PubMed Central reference 145\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 145\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20sirtuins%20in%20cellular%20homeostasis&amp;journal=J%20Physiol%20Biochem&amp;volume=72&amp;pages=371-80&amp;publication_year=2016&amp;author=Kupis%2CW&amp;author=Palyga%2CJ&amp;author=Tomal%2CE&amp;author=Niewiadomska%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR146\">Schiedel M, Robaa D, Rumpf T, Sippl W, Jung M. The current state of NAD(+) -dependent histone deacetylases (Sirtuins) as novel therapeutic targets. Med Res Rev. 2018;38:147\u2013200.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhvFKitbrO\" aria-label=\"CAS reference 146\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28094444\" aria-label=\"PubMed reference 146\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 146\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20current%20state%20of%20NAD%28%2B%29%20-dependent%20histone%20deacetylases%20%28Sirtuins%29%20as%20novel%20therapeutic%20targets&amp;journal=Med%20Res%20Rev&amp;volume=38&amp;pages=147-200&amp;publication_year=2018&amp;author=Schiedel%2CM&amp;author=Robaa%2CD&amp;author=Rumpf%2CT&amp;author=Sippl%2CW&amp;author=Jung%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR147\">Tasselli L, Zheng W, Chua KF. SIRT6: novel mechanisms and links to aging and disease. Trends Endocrinol Metab. 2017;28:168\u201385.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhslSit7rE\" aria-label=\"CAS reference 147\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27836583\" aria-label=\"PubMed reference 147\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 147\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=SIRT6%3A%20novel%20mechanisms%20and%20links%20to%20aging%20and%20disease&amp;journal=Trends%20Endocrinol%20Metab&amp;volume=28&amp;pages=168-85&amp;publication_year=2017&amp;author=Tasselli%2CL&amp;author=Zheng%2CW&amp;author=Chua%2CKF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR148\">Tang L, Nogales E, Ciferri C. Structure and function of SWI\/SNF chromatin remodeling complexes and mechanistic implications for transcription. Prog Biophys Mol Biol. 2010;102(2010):122\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXosVGmsr8%3D\" aria-label=\"CAS reference 148\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20493208\" aria-label=\"PubMed reference 148\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2924208\" aria-label=\"PubMed Central reference 148\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 148\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Structure%20and%20function%20of%20SWI%2FSNF%20chromatin%20remodeling%20complexes%20and%20mechanistic%20implications%20for%20transcription&amp;journal=Prog%20Biophys%20Mol%20Biol&amp;volume=102&amp;issue=2010&amp;pages=122-128&amp;publication_year=2010&amp;author=Tang%2CL&amp;author=Nogales%2CE&amp;author=Ciferri%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR149\">Hao F, Zhang Y, Hou J, Zhao B. Chromatin remodeling and cancer: the critical influence of the SWI\/SNF complex. Epigenetics Chromatin. 2025;18:22.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXpvVCqu7o%3D\" aria-label=\"CAS reference 149\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40269969\" aria-label=\"PubMed reference 149\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12016160\" aria-label=\"PubMed Central reference 149\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 149\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chromatin%20remodeling%20and%20cancer%3A%20the%20critical%20influence%20of%20the%20SWI%2FSNF%20complex&amp;journal=Epigenetics%20Chromatin&amp;volume=18&amp;publication_year=2025&amp;author=Hao%2CF&amp;author=Zhang%2CY&amp;author=Hou%2CJ&amp;author=Zhao%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR150\">Tu Z, Zhuang X, Yao YG, Zhang R. BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. Mol Cell Biol. 2013;33:1819\u201329.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXmsVGktLY%3D\" aria-label=\"CAS reference 150\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23438604\" aria-label=\"PubMed reference 150\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3624184\" aria-label=\"PubMed Central reference 150\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 150\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BRG1%20is%20required%20for%20formation%20of%20senescence-associated%20heterochromatin%20foci%20induced%20by%20oncogenic%20RAS%20or%20BRCA1%20loss&amp;journal=Mol%20Cell%20Biol&amp;volume=33&amp;pages=1819-29&amp;publication_year=2013&amp;author=Tu%2CZ&amp;author=Zhuang%2CX&amp;author=Yao%2CYG&amp;author=Zhang%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR151\">Corpet A, Stucki M. Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells. Chromosoma. 2014;123:423\u201336.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24861957\" aria-label=\"PubMed reference 151\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 151\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chromatin%20maintenance%20and%20dynamics%20in%20senescence%3A%20a%20spotlight%20on%20SAHF%20formation%20and%20the%20epigenome%20of%20senescent%20cells&amp;journal=Chromosoma&amp;volume=123&amp;pages=423-36&amp;publication_year=2014&amp;author=Corpet%2CA&amp;author=Stucki%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR152\">Olan I, Handa T, Narita M. Beyond SAHF: an integrative view of chromatin compartmentalization during senescence. Curr Opin Cell Biol. 2023;83:102206.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhsVeit7%2FE\" aria-label=\"CAS reference 152\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37451177\" aria-label=\"PubMed reference 152\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 152\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Beyond%20SAHF%3A%20an%20integrative%20view%20of%20chromatin%20compartmentalization%20during%20senescence&amp;journal=Curr%20Opin%20Cell%20Biol&amp;volume=83&amp;publication_year=2023&amp;author=Olan%2CI&amp;author=Handa%2CT&amp;author=Narita%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR153\">Yamakuchi M, Lowenstein CJ. Mir-34, SIRT1 and p53: the feedback loop. Cell Cycle. 2009;8:712\u20135.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXlvFWju78%3D\" aria-label=\"CAS reference 153\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19221490\" aria-label=\"PubMed reference 153\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 153\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mir-34%2C%20SIRT1%20and%20p53%3A%20the%20feedback%20loop&amp;journal=Cell%20Cycle&amp;volume=8&amp;pages=712-5&amp;publication_year=2009&amp;author=Yamakuchi%2CM&amp;author=Lowenstein%2CCJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR154\">Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, et al. MiR-34 mirnas regulate cellular senescence in type II alveolar epithelial cells of patients with idiopathic pulmonary fibrosis. PLoS One. 2016;11:e0158367.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27362652\" aria-label=\"PubMed reference 154\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4928999\" aria-label=\"PubMed Central reference 154\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 154\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=MiR-34%20mirnas%20regulate%20cellular%20senescence%20in%20type%20II%20alveolar%20epithelial%20cells%20of%20patients%20with%20idiopathic%20pulmonary%20fibrosis&amp;journal=PLoS%20One&amp;volume=11&amp;publication_year=2016&amp;author=Disayabutr%2CS&amp;author=Kim%2CEK&amp;author=Cha%2CSI&amp;author=Green%2CG&amp;author=Naikawadi%2CRP&amp;author=Jones%2CKD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR155\">Wang Y, Chen J, Chen X, Jiang F, Sun Y, Pan Y, et al. Mir-34a suppresses HNSCC growth through modulating cell cycle arrest and senescence. Neoplasma. 2017;64:543\u201353.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28485160\" aria-label=\"PubMed reference 155\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 155\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mir-34a%20suppresses%20HNSCC%20growth%20through%20modulating%20cell%20cycle%20arrest%20and%20senescence&amp;journal=Neoplasma&amp;volume=64&amp;pages=543-53&amp;publication_year=2017&amp;author=Wang%2CY&amp;author=Chen%2CJ&amp;author=Chen%2CX&amp;author=Jiang%2CF&amp;author=Sun%2CY&amp;author=Pan%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR156\">Song Y, Wang R, Li LW, Liu X, Wang YF, Wang QX, et al. Long non-coding RNA HOTAIR mediates the switching of histone H3 lysine 27 acetylation to methylation to promote epithelial-to-mesenchymal transition in gastric cancer. Int J Oncol. 2019;54:77\u201386.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtVKlsb7K\" aria-label=\"CAS reference 156\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30431069\" aria-label=\"PubMed reference 156\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 156\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Long%20non-coding%20RNA%20HOTAIR%20mediates%20the%20switching%20of%20histone%20H3%20lysine%2027%20acetylation%20to%20methylation%20to%20promote%20epithelial-to-mesenchymal%20transition%20in%20gastric%20cancer&amp;journal=Int%20J%20Oncol&amp;volume=54&amp;pages=77-86&amp;publication_year=2019&amp;author=Song%2CY&amp;author=Wang%2CR&amp;author=Li%2CLW&amp;author=Liu%2CX&amp;author=Wang%2CYF&amp;author=Wang%2CQX&amp;author=Zhang%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR157\">LaPak KM, Burd CE. The molecular balancing act of p16(INK4a) in cancer and aging. Mol Cancer Res. 2014;12:167\u201383.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXivFeks74%3D\" aria-label=\"CAS reference 157\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24136988\" aria-label=\"PubMed reference 157\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 157\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20molecular%20balancing%20act%20of%20p16%28INK4a%29%20in%20cancer%20and%20aging&amp;journal=Mol%20Cancer%20Res&amp;volume=12&amp;pages=167-83&amp;publication_year=2014&amp;author=LaPak%2CKM&amp;author=Burd%2CCE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR158\">Wang K, Liu H, Hu Q, Wang L, Liu J, Zheng Z, et al. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduct Target Ther. 2022;7:374.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XivVaqsLnK\" aria-label=\"CAS reference 158\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36336680\" aria-label=\"PubMed reference 158\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9637765\" aria-label=\"PubMed Central reference 158\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 158\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Epigenetic%20regulation%20of%20aging%3A%20implications%20for%20interventions%20of%20aging%20and%20diseases&amp;journal=Signal%20Transduct%20Target%20Ther&amp;volume=7&amp;publication_year=2022&amp;author=Wang%2CK&amp;author=Liu%2CH&amp;author=Hu%2CQ&amp;author=Wang%2CL&amp;author=Liu%2CJ&amp;author=Zheng%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR159\">Salminen A, Kaarniranta K, Kauppinen A. Insulin\/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases. Inflamm Res. 2021;70:1043\u201361.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhvFGmtbnO\" aria-label=\"CAS reference 159\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34476533\" aria-label=\"PubMed reference 159\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8572812\" aria-label=\"PubMed Central reference 159\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 159\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Insulin%2FIGF-1%20signaling%20promotes%20immunosuppression%20via%20the%20STAT3%20pathway%3A%20impact%20on%20the%20aging%20process%20and%20age-related%20diseases&amp;journal=Inflamm%20Res&amp;volume=70&amp;pages=1043-61&amp;publication_year=2021&amp;author=Salminen%2CA&amp;author=Kaarniranta%2CK&amp;author=Kauppinen%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR160\">Salminen A, Kaarniranta K. Insulin\/IGF-1 paradox of aging: regulation via AKT\/IKK\/NF-kappaB signaling. Cell Signal. 2010;22(2):573\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXhtVaktLw%3D\" aria-label=\"CAS reference 160\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19861158\" aria-label=\"PubMed reference 160\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 160\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Insulin%2FIGF-1%20paradox%20of%20aging%3A%20regulation%20via%20AKT%2FIKK%2FNF-kappaB%20signaling&amp;journal=Cell%20Signal&amp;volume=22&amp;issue=2&amp;pages=573-7&amp;publication_year=2010&amp;author=Salminen%2CA&amp;author=Kaarniranta%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR161\">Yan H, Lu W, Wang F. The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers. Signal Transduct Target Ther. 2023;8:45.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36717545\" aria-label=\"PubMed reference 161\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9886966\" aria-label=\"PubMed Central reference 161\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 161\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20cGAS-STING%20pathway%3A%20a%20therapeutic%20target%20in%20chromosomally%20unstable%20cancers&amp;journal=Signal%20Transduct%20Target%20Ther&amp;volume=8&amp;publication_year=2023&amp;author=Yan%2CH&amp;author=Lu%2CW&amp;author=Wang%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR162\">Samson N, Ablasser A. The cGAS-STING pathway and cancer. Nat Cancer. 2022;3:1452\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XjtFSlsLrI\" aria-label=\"CAS reference 162\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36510011\" aria-label=\"PubMed reference 162\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 162\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20cGAS-STING%20pathway%20and%20cancer&amp;journal=Nat%20Cancer&amp;volume=3&amp;pages=1452-63&amp;publication_year=2022&amp;author=Samson%2CN&amp;author=Ablasser%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR163\">Decout A, Katz JD, Venkatraman S, Ablasser A. The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol. 2021;21:548\u201369.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXosVCrsLg%3D\" aria-label=\"CAS reference 163\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33833439\" aria-label=\"PubMed reference 163\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8029610\" aria-label=\"PubMed Central reference 163\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 163\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20cGAS-STING%20pathway%20as%20a%20therapeutic%20target%20in%20inflammatory%20diseases&amp;journal=Nat%20Rev%20Immunol&amp;volume=21&amp;pages=548-69&amp;publication_year=2021&amp;author=Decout%2CA&amp;author=Katz%2CJD&amp;author=Venkatraman%2CS&amp;author=Ablasser%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR164\">Coombes MM, Briggs KL, Bone JR, Clayman GL, El-Naggar AK, Dent SY. Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. Oncogene. 2003;22:8902\u201311.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3sXpsVGhtr4%3D\" aria-label=\"CAS reference 164\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=14654786\" aria-label=\"PubMed reference 164\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 164\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Resetting%20the%20histone%20code%20at%20CDKN2A%20in%20HNSCC%20by%20inhibition%20of%20DNA%20methylation&amp;journal=Oncogene&amp;volume=22&amp;pages=8902-11&amp;publication_year=2003&amp;author=Coombes%2CMM&amp;author=Briggs%2CKL&amp;author=Bone%2CJR&amp;author=Clayman%2CGL&amp;author=El-Naggar%2CAK&amp;author=Dent%2CSY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR165\">Juengel E, Dauselt A, Makarevic J, Wiesner C, Tsaur I, Bartsch G, et al. Acetylation of histone H3 prevents resistance development caused by chronic mTOR inhibition in renal cell carcinoma cells. Cancer Lett. 2012;324:83\u201390.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xns1CisLs%3D\" aria-label=\"CAS reference 165\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22579787\" aria-label=\"PubMed reference 165\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 165\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Acetylation%20of%20histone%20H3%20prevents%20resistance%20development%20caused%20by%20chronic%20mTOR%20inhibition%20in%20renal%20cell%20carcinoma%20cells&amp;journal=Cancer%20Lett&amp;volume=324&amp;pages=83-90&amp;publication_year=2012&amp;author=Juengel%2CE&amp;author=Dauselt%2CA&amp;author=Makarevic%2CJ&amp;author=Wiesner%2CC&amp;author=Tsaur%2CI&amp;author=Bartsch%2CG&amp;author=Haferkamp%2CA&amp;author=Blaheta%2CRA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR166\">Chen M, Fang Y, Liang M, Zhang N, Zhang X, Xu L, et al. The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma. J Transl Med. 2023;21:276.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXosFWgs7Y%3D\" aria-label=\"CAS reference 166\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37088830\" aria-label=\"PubMed reference 166\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10124003\" aria-label=\"PubMed Central reference 166\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 166\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20activation%20of%20mTOR%20signalling%20modulates%20DNA%20methylation%20by%20enhancing%20DNMT1%20translation%20in%20hepatocellular%20carcinoma&amp;journal=J%20Transl%20Med&amp;volume=21&amp;publication_year=2023&amp;author=Chen%2CM&amp;author=Fang%2CY&amp;author=Liang%2CM&amp;author=Zhang%2CN&amp;author=Zhang%2CX&amp;author=Xu%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR167\">Sergi C, Shen F, Liu SM. Insulin\/IGF-1R, SIRT1, and FOXOs pathways-an intriguing interaction platform for bone and osteosarcoma. Front Endocrinol (Lausanne). 2019;10:93.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30881341\" aria-label=\"PubMed reference 167\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 167\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Insulin%2FIGF-1R%2C%20SIRT1%2C%20and%20FOXOs%20pathways-an%20intriguing%20interaction%20platform%20for%20bone%20and%20osteosarcoma&amp;journal=Front%20Endocrinol%20%28Lausanne%29&amp;volume=10&amp;publication_year=2019&amp;author=Sergi%2CC&amp;author=Shen%2CF&amp;author=Liu%2CSM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR168\">Zhang X, Zhuang M, Zhang H, Zhu Y, Yang J, Wu X, et al. Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP. J Biol Chem. 2025;301:108438.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXpvFKmur4%3D\" aria-label=\"CAS reference 168\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40127867\" aria-label=\"PubMed reference 168\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12147179\" aria-label=\"PubMed Central reference 168\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 168\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Melatonin-mediated%20cGAS-STING%20signal%20in%20senescent%20macrophages%20promote%20TNBC%20chemotherapy%20resistance%20and%20drive%20the%20SASP&amp;journal=J%20Biol%20Chem&amp;volume=301&amp;publication_year=2025&amp;author=Zhang%2CX&amp;author=Zhuang%2CM&amp;author=Zhang%2CH&amp;author=Zhu%2CY&amp;author=Yang%2CJ&amp;author=Wu%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR169\">Ji Y, Li B, Lin R, Yuan J, Han Y, Du Y, et al. Super-enhancers in tumors: unraveling recent advances in their role in oncogenesis and the emergence of targeted therapies. J Transl Med. 2025;23:98.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhvVSitb3P\" aria-label=\"CAS reference 169\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39838405\" aria-label=\"PubMed reference 169\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11753147\" aria-label=\"PubMed Central reference 169\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 169\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Super-enhancers%20in%20tumors%3A%20unraveling%20recent%20advances%20in%20their%20role%20in%20oncogenesis%20and%20the%20emergence%20of%20targeted%20therapies&amp;journal=J%20Transl%20Med&amp;volume=23&amp;publication_year=2025&amp;author=Ji%2CY&amp;author=Li%2CB&amp;author=Lin%2CR&amp;author=Yuan%2CJ&amp;author=Han%2CY&amp;author=Du%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR170\">Tasdemir N, Banito A, Roe JS, Alonso-Curbelo D, Camiolo M, Tschaharganeh DF, et al. BRD4 connects enhancer remodeling to senescence immune surveillance. Cancer Discov. 2016;6(6):612\u201329.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28Xpt1Ggurc%3D\" aria-label=\"CAS reference 170\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27099234\" aria-label=\"PubMed reference 170\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4893996\" aria-label=\"PubMed Central reference 170\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 170\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=BRD4%20connects%20enhancer%20remodeling%20to%20senescence%20immune%20surveillance&amp;journal=Cancer%20Discov&amp;volume=6&amp;issue=6&amp;pages=612-29&amp;publication_year=2016&amp;author=Tasdemir%2CN&amp;author=Banito%2CA&amp;author=Roe%2CJS&amp;author=Alonso-Curbelo%2CD&amp;author=Camiolo%2CM&amp;author=Tschaharganeh%2CDF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR171\">Basisty N, Kale A, Jeon OH, Kuehnemann C, Payne T, Rao C, et al. A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biol. 2020;18:e3000599.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31945054\" aria-label=\"PubMed reference 171\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6964821\" aria-label=\"PubMed Central reference 171\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 171\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20proteomic%20atlas%20of%20senescence-associated%20secretomes%20for%20aging%20biomarker%20development&amp;journal=PLoS%20Biol&amp;volume=18&amp;publication_year=2020&amp;author=Basisty%2CN&amp;author=Kale%2CA&amp;author=Jeon%2COH&amp;author=Kuehnemann%2CC&amp;author=Payne%2CT&amp;author=Rao%2CC&amp;author=Holtz%2CA&amp;author=Shah%2CS&amp;author=Sharma%2CV&amp;author=Ferrucci%2CL&amp;author=Campisi%2CJ&amp;author=Schilling%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR172\">Valerio HP, Ravagnani FG, Ronsein GE, Di Mascio P. A single dose of Ultraviolet-A induces proteome remodeling and senescence in primary human keratinocytes. Sci Rep. 2021;11:23355.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXis1GjtrnI\" aria-label=\"CAS reference 172\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34857819\" aria-label=\"PubMed reference 172\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8639817\" aria-label=\"PubMed Central reference 172\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 172\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20single%20dose%20of%20Ultraviolet-A%20induces%20proteome%20remodeling%20and%20senescence%20in%20primary%20human%20keratinocytes&amp;journal=Sci%20Rep&amp;volume=11&amp;publication_year=2021&amp;author=Valerio%2CHP&amp;author=Ravagnani%2CFG&amp;author=Ronsein%2CGE&amp;author=Mascio%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR173\">WalderaLupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, et al. Characterization of skin aging-associated secreted proteins (SAASP) produced by dermal fibroblasts isolated from intrinsically aged human skin. J Invest Dermatol. 2015;135:1954\u201368.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhtFyksrrE\" aria-label=\"CAS reference 173\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 173\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Characterization%20of%20skin%20aging-associated%20secreted%20proteins%20%28SAASP%29%20produced%20by%20dermal%20fibroblasts%20isolated%20from%20intrinsically%20aged%20human%20skin&amp;journal=J%20Invest%20Dermatol&amp;volume=135&amp;pages=1954-68&amp;publication_year=2015&amp;author=WalderaLupa%2CDM&amp;author=Kalfalah%2CF&amp;author=Safferling%2CK&amp;author=Boukamp%2CP&amp;author=Poschmann%2CG&amp;author=Volpi%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR174\">Okamura K, Sato M, Suzuki T, Nohara K. Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells. Toxicol Appl Pharmacol. 2022;454:116231.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XitlKrtLnN\" aria-label=\"CAS reference 174\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36089002\" aria-label=\"PubMed reference 174\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 174\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inorganic%20arsenic%20exposure-induced%20premature%20senescence%20and%20senescence-associated%20secretory%20phenotype%20%28SASP%29%20in%20human%20hepatic%20stellate%20cells&amp;journal=Toxicol%20Appl%20Pharmacol&amp;volume=454&amp;publication_year=2022&amp;author=Okamura%2CK&amp;author=Sato%2CM&amp;author=Suzuki%2CT&amp;author=Nohara%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR175\">Cohn RL, Gasek NS, Kuchel GA, Xu M. The heterogeneity of cellular senescence: insights at the single-cell level. Trends Cell Biol. 2023;33:9\u201317.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhvVeiurjO\" aria-label=\"CAS reference 175\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35599179\" aria-label=\"PubMed reference 175\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 175\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20heterogeneity%20of%20cellular%20senescence%3A%20insights%20at%20the%20single-cell%20level&amp;journal=Trends%20Cell%20Biol&amp;volume=33&amp;pages=9-17&amp;publication_year=2023&amp;author=Cohn%2CRL&amp;author=Gasek%2CNS&amp;author=Kuchel%2CGA&amp;author=Xu%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR176\">Gao X, Wang X, Yang Q, Zhao X, Wen W, Li G, et al. Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells. J Immunol. 2015;194:438\u201345.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXitFWls73O\" aria-label=\"CAS reference 176\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25429071\" aria-label=\"PubMed reference 176\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 176\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tumoral%20expression%20of%20IL-33%20inhibits%20tumor%20growth%20and%20modifies%20the%20tumor%20microenvironment%20through%20CD8%2B%20T%20and%20NK%20cells&amp;journal=J%20Immunol&amp;volume=194&amp;pages=438-45&amp;publication_year=2015&amp;author=Gao%2CX&amp;author=Wang%2CX&amp;author=Yang%2CQ&amp;author=Zhao%2CX&amp;author=Wen%2CW&amp;author=Li%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR177\">Xiao L, Li X, Cao P, Fei W, Zhou H, Tang N, et al. Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2\/STAT3\/Sox4\/NLRP3 signaling pathway. J Exp Clin Cancer Res. 2022;41(1):166.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhvVSmt77J\" aria-label=\"CAS reference 177\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35513871\" aria-label=\"PubMed reference 177\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9069786\" aria-label=\"PubMed Central reference 177\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 177\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin-6%20mediated%20inflammasome%20activation%20promotes%20oral%20squamous%20cell%20carcinoma%20progression%20via%20JAK2%2FSTAT3%2FSox4%2FNLRP3%20signaling%20pathway&amp;journal=J%20Exp%20Clin%20Cancer%20Res&amp;volume=41&amp;issue=1&amp;publication_year=2022&amp;author=Xiao%2CL&amp;author=Li%2CX&amp;author=Cao%2CP&amp;author=Fei%2CW&amp;author=Zhou%2CH&amp;author=Tang%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR178\">Weng YS, Tseng HY, Chen YA, Shen PC, Al Haq AT, Chen LM, et al. MCT-1\/miR-34a\/IL-6\/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer. Mol Cancer. 2019;18:42.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30885232\" aria-label=\"PubMed reference 178\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6421700\" aria-label=\"PubMed Central reference 178\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 178\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=MCT-1%2FmiR-34a%2FIL-6%2FIL-6R%20signaling%20axis%20promotes%20EMT%20progression%2C%20cancer%20stemness%20and%20M2%20macrophage%20polarization%20in%20triple-negative%20breast%20cancer&amp;journal=Mol%20Cancer&amp;volume=18&amp;publication_year=2019&amp;author=Weng%2CYS&amp;author=Tseng%2CHY&amp;author=Chen%2CYA&amp;author=Shen%2CPC&amp;author=Al%20Haq%2CAT&amp;author=Chen%2CLM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR179\">Fu XL, Duan W, Su CY, Mao FY, Lv YP, Teng YS, et al. Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression. Cancer Immunol Immunother. 2017;66:1597\u2013608.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtlKmsbvO\" aria-label=\"CAS reference 179\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28828629\" aria-label=\"PubMed reference 179\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11028627\" aria-label=\"PubMed Central reference 179\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 179\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin%206%20induces%20M2%20macrophage%20differentiation%20by%20STAT3%20activation%20that%20correlates%20with%20gastric%20cancer%20progression&amp;journal=Cancer%20Immunol%20Immunother&amp;volume=66&amp;pages=1597-608&amp;publication_year=2017&amp;author=Fu%2CXL&amp;author=Duan%2CW&amp;author=Su%2CCY&amp;author=Mao%2CFY&amp;author=Lv%2CYP&amp;author=Teng%2CYS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR180\">Du H, Rose JP, Bons J, Guo L, Valentino TR, Wu F, et al. Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts. Geroscience. 2025;47:3941\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXitVehs7w%3D\" aria-label=\"CAS reference 180\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39826027\" aria-label=\"PubMed reference 180\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12181613\" aria-label=\"PubMed Central reference 180\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 180\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Substrate%20stiffness%20dictates%20unique%20doxorubicin-induced%20senescence-associated%20secretory%20phenotypes%20and%20transcriptomic%20signatures%20in%20human%20pulmonary%20fibroblasts&amp;journal=Geroscience&amp;volume=47&amp;pages=3941-63&amp;publication_year=2025&amp;author=Du%2CH&amp;author=Rose%2CJP&amp;author=Bons%2CJ&amp;author=Guo%2CL&amp;author=Valentino%2CTR&amp;author=Wu%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR181\">Felisbino MB, Rubino M, Travers JG, Schuetze KB, Lemieux ME, Anseth KS, et al. Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype. Am J Physiol Heart Circ Physiol. 2024;326:H61\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37889253\" aria-label=\"PubMed reference 181\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 181\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Substrate%20stiffness%20modulates%20cardiac%20fibroblast%20activation%2C%20senescence%2C%20and%20proinflammatory%20secretory%20phenotype&amp;journal=Am%20J%20Physiol%20Heart%20Circ%20Physiol&amp;volume=326&amp;pages=H61-H73&amp;publication_year=2024&amp;author=Felisbino%2CMB&amp;author=Rubino%2CM&amp;author=Travers%2CJG&amp;author=Schuetze%2CKB&amp;author=Lemieux%2CME&amp;author=Anseth%2CKS&amp;author=Aguado%2CBA&amp;author=McKinsey%2CTA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR182\">Toutfaire M, Dumortier E, Fattaccioli A, Van Steenbrugge M, Proby CM, Debacq-Chainiaux F. Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis. Int J Biochem Cell Biol. 2018;98:113\u201326.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXltlSgur4%3D\" aria-label=\"CAS reference 182\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29550586\" aria-label=\"PubMed reference 182\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 182\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unraveling%20the%20interplay%20between%20senescent%20dermal%20fibroblasts%20and%20cutaneous%20squamous%20cell%20carcinoma%20cell%20lines%20at%20different%20stages%20of%20tumorigenesis&amp;journal=Int%20J%20Biochem%20Cell%20Biol&amp;volume=98&amp;pages=113-26&amp;publication_year=2018&amp;author=Toutfaire%2CM&amp;author=Dumortier%2CE&amp;author=Fattaccioli%2CA&amp;author=Van%20Steenbrugge%2CM&amp;author=Proby%2CCM&amp;author=Debacq-Chainiaux%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR183\">Nishimura J, Morita Y, Tobe-Nishimoto A, Kitahira Y, Takayama S, Kishimoto S, et al. CDDP-induced desmoplasia-like changes in oral cancer tissues are related to SASP-related factors induced by the senescence of cancer cells. Int Immunopharmacol. 2024;136:112377.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXht1ehs77K\" aria-label=\"CAS reference 183\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38838554\" aria-label=\"PubMed reference 183\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 183\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CDDP-induced%20desmoplasia-like%20changes%20in%20oral%20cancer%20tissues%20are%20related%20to%20SASP-related%20factors%20induced%20by%20the%20senescence%20of%20cancer%20cells&amp;journal=Int%20Immunopharmacol&amp;volume=136&amp;publication_year=2024&amp;author=Nishimura%2CJ&amp;author=Morita%2CY&amp;author=Tobe-Nishimoto%2CA&amp;author=Kitahira%2CY&amp;author=Takayama%2CS&amp;author=Kishimoto%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR184\">Bai J, Wang Y, Wang J, Zhai J, He F, Zhu G. Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. Am J Physiol Cell Physiol. 2020;318:C1005-17.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhtFyisL7I\" aria-label=\"CAS reference 184\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32233952\" aria-label=\"PubMed reference 184\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 184\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Irradiation-induced%20senescence%20of%20bone%20marrow%20mesenchymal%20stem%20cells%20aggravates%20osteogenic%20differentiation%20dysfunction%20via%20paracrine%20signaling&amp;journal=Am%20J%20Physiol%20Cell%20Physiol&amp;volume=318&amp;pages=C1005-17&amp;publication_year=2020&amp;author=Bai%2CJ&amp;author=Wang%2CY&amp;author=Wang%2CJ&amp;author=Zhai%2CJ&amp;author=He%2CF&amp;author=Zhu%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR185\">Najafi M, Farhood B, Mortezaee K. Extracellular matrix (ECM) stiffness and degradation as cancer drivers. J Cell Biochem. 2019;120:2782\u201390.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhvFSqtrjJ\" aria-label=\"CAS reference 185\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30321449\" aria-label=\"PubMed reference 185\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 185\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Extracellular%20matrix%20%28ECM%29%20stiffness%20and%20degradation%20as%20cancer%20drivers&amp;journal=J%20Cell%20Biochem&amp;volume=120&amp;pages=2782-90&amp;publication_year=2019&amp;author=Najafi%2CM&amp;author=Farhood%2CB&amp;author=Mortezaee%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR186\">Chaudhuri O, Koshy ST, da Branco Cunha C, Shin JW, Verbeke CS, Allison KH, et al. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat Mater. 2014;13:970\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXpslGisr0%3D\" aria-label=\"CAS reference 186\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24930031\" aria-label=\"PubMed reference 186\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 186\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Extracellular%20matrix%20stiffness%20and%20composition%20jointly%20regulate%20the%20induction%20of%20malignant%20phenotypes%20in%20mammary%20epithelium&amp;journal=Nat%20Mater&amp;volume=13&amp;pages=970-8&amp;publication_year=2014&amp;author=Chaudhuri%2CO&amp;author=Koshy%2CST&amp;author=Branco%20Cunha%2CC&amp;author=Shin%2CJW&amp;author=Verbeke%2CCS&amp;author=Allison%2CKH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR187\">Gkretsi V, Stylianopoulos T. Cell adhesion and matrix stiffness: coordinating cancer cell invasion and metastasis. Front Oncol. 2018;8:145.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29780748\" aria-label=\"PubMed reference 187\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5945811\" aria-label=\"PubMed Central reference 187\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 187\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cell%20adhesion%20and%20matrix%20stiffness%3A%20coordinating%20cancer%20cell%20invasion%20and%20metastasis&amp;journal=Front%20Oncol&amp;volume=8&amp;publication_year=2018&amp;author=Gkretsi%2CV&amp;author=Stylianopoulos%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR188\">Cirillo N, Vicidomini A, McCullough M, Gambardella A, Hassona Y, Prime SS, et al. A hyaluronic acid-based compound inhibits fibroblast senescence induced by oxidative stress in vitro and prevents oral mucositis in vivo. J Cell Physiol. 2015;230:1421\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXlsVGrtbc%3D\" aria-label=\"CAS reference 188\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25536474\" aria-label=\"PubMed reference 188\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 188\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20hyaluronic%20acid-based%20compound%20inhibits%20fibroblast%20senescence%20induced%20by%20oxidative%20stress%20in%20vitro%20and%20prevents%20oral%20mucositis%20in%20vivo&amp;journal=J%20Cell%20Physiol&amp;volume=230&amp;pages=1421-9&amp;publication_year=2015&amp;author=Cirillo%2CN&amp;author=Vicidomini%2CA&amp;author=McCullough%2CM&amp;author=Gambardella%2CA&amp;author=Hassona%2CY&amp;author=Prime%2CSS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR189\">Yao X, Li H, Chen L, Tan LP. Uv-induced senescence of human dermal fibroblasts restrained by low-stiffness matrix by inhibiting NF-\u03baB activation. Engineered Regeneration. 2022;3:365\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhs1Ggu7zN\" aria-label=\"CAS reference 189\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 189\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Uv-induced%20senescence%20of%20human%20dermal%20fibroblasts%20restrained%20by%20low-stiffness%20matrix%20by%20inhibiting%20NF-%CE%BAB%20activation&amp;journal=Engineered%20Regeneration&amp;volume=3&amp;pages=365-73&amp;publication_year=2022&amp;author=Yao%2CX&amp;author=Li%2CH&amp;author=Chen%2CL&amp;author=Tan%2CLP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR190\">Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, et al. SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells. Cell Rep. 2019;28:3329\u201337 (e3325).<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhvVKks7rJ\" aria-label=\"CAS reference 190\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31553904\" aria-label=\"PubMed reference 190\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6907691\" aria-label=\"PubMed Central reference 190\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 190\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=SILAC%20Analysis%20Reveals%20Increased%20Secretion%20of%20Hemostasis-Related%20Factors%20by%20Senescent%20Cells&amp;journal=Cell%20Rep&amp;volume=28&amp;pages=3329-3337&amp;publication_year=2019&amp;author=Wiley%2CCD&amp;author=Liu%2CS&amp;author=Limbad%2CC&amp;author=Zawadzka%2CAM&amp;author=Beck%2CJ&amp;author=Demaria%2CM&amp;author=Artwood%2CR&amp;author=Alimirah%2CF&amp;author=Lopez-Dominguez%2CJA&amp;author=Kuehnemann%2CC&amp;author=Danielson%2CSR&amp;author=Basisty%2CN&amp;author=Kasler%2CHG&amp;author=Oron%2CTR&amp;author=Desprez%2CPY&amp;author=Mooney%2CSD&amp;author=Gibson%2CBW&amp;author=Schilling%2CB&amp;author=Campisi%2CJ&amp;author=Kapahi%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR191\">Kim H, Jang J, Song MJ, Park CH, Lee DH, Lee SH, et al. Inhibition of matrix metalloproteinase expression by selective clearing of senescent dermal fibroblasts attenuates ultraviolet-induced photoaging. Biomed Pharmacother. 2022;150:113034.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xht1OmsL7E\" aria-label=\"CAS reference 191\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35489284\" aria-label=\"PubMed reference 191\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 191\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20matrix%20metalloproteinase%20expression%20by%20selective%20clearing%20of%20senescent%20dermal%20fibroblasts%20attenuates%20ultraviolet-induced%20photoaging&amp;journal=Biomed%20Pharmacother&amp;volume=150&amp;publication_year=2022&amp;author=Kim%2CH&amp;author=Jang%2CJ&amp;author=Song%2CMJ&amp;author=Park%2CCH&amp;author=Lee%2CDH&amp;author=Lee%2CSH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR192\">Gwak H, Hong S, Lee SH, Kim IW, Kim Y, Kim H, et al. Low-intensity pulsed ultrasound treatment selectively stimulates senescent cells to promote SASP factors for immune cell recruitment. Aging Cell. 2025;24:e14486.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhsFyisrY%3D\" aria-label=\"CAS reference 192\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39821933\" aria-label=\"PubMed reference 192\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12073891\" aria-label=\"PubMed Central reference 192\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 192\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Low-intensity%20pulsed%20ultrasound%20treatment%20selectively%20stimulates%20senescent%20cells%20to%20promote%20SASP%20factors%20for%20immune%20cell%20recruitment&amp;journal=Aging%20Cell&amp;volume=24&amp;publication_year=2025&amp;author=Gwak%2CH&amp;author=Hong%2CS&amp;author=Lee%2CSH&amp;author=Kim%2CIW&amp;author=Kim%2CY&amp;author=Kim%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR193\">Tian YT, Ma LP, Ding CY, Liu MM, Wang SN, Tian M, et al. Autophagy regulates X-ray radiation-induced premature senescence through STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells. Int J Radiat Biol. 2022;98:1432\u201341.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhtVeit7jL\" aria-label=\"CAS reference 193\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35426771\" aria-label=\"PubMed reference 193\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 193\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Autophagy%20regulates%20X-ray%20radiation-induced%20premature%20senescence%20through%20STAT3-Beclin1-p62%20pathway%20in%20lung%20adenocarcinoma%20cells&amp;journal=Int%20J%20Radiat%20Biol&amp;volume=98&amp;pages=1432-41&amp;publication_year=2022&amp;author=Tian%2CYT&amp;author=Ma%2CLP&amp;author=Ding%2CCY&amp;author=Liu%2CMM&amp;author=Wang%2CSN&amp;author=Tian%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR194\">Huart C, Fransolet M, Demazy C, Le Calv\u00e9 B, Lucas S, Michiels C, et al. Taking advantage of the senescence-promoting effect of olaparib after X-ray and proton irradiation using the senolytic drug, ABT-263. Cancers (Basel). 202;14(6):1460. <a href=\"https:\/\/doi.org\/10.3390\/cancers14061460\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cancers14061460\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cancers14061460<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/cancers14061460\" data-track-item_id=\"10.3390\/cancers14061460\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fcancers14061460\" aria-label=\"Article reference 194\" data-doi=\"10.3390\/cancers14061460\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35326611\" aria-label=\"PubMed reference 194\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 194\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Taking%20advantage%20of%20the%20senescence-promoting%20effect%20of%20olaparib%20after%20X-ray%20and%20proton%20irradiation%20using%20the%20senolytic%20drug%2C%20ABT-263&amp;journal=Cancers%20%28Basel%29&amp;doi=10.3390%2Fcancers14061460&amp;publication_year=2022&amp;author=Huart%2CC&amp;author=Fransolet%2CM&amp;author=Demazy%2CC&amp;author=Le%20Calv%C3%A9%2CB&amp;author=Lucas%2CS&amp;author=Michiels%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR195\">Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M. Unmasking Transcriptional Heterogeneity in Senescent Cells. Curr Biol. 2017;27:2652\u201360 e2654.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtlylsbzN\" aria-label=\"CAS reference 195\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28844647\" aria-label=\"PubMed reference 195\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5788810\" aria-label=\"PubMed Central reference 195\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 195\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Unmasking%20Transcriptional%20Heterogeneity%20in%20Senescent%20Cells&amp;journal=Curr%20Biol&amp;volume=27&amp;pages=2652-2660&amp;publication_year=2017&amp;author=Hernandez-Segura%2CA&amp;author=Jong%2CTV&amp;author=Melov%2CS&amp;author=Guryev%2CV&amp;author=Campisi%2CJ&amp;author=Demaria%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR196\">Alessio N, Acar MB, Squillaro T, Aprile D, Ayaz-Guner S, Di Bernardo G, et al. Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti-tumour properties. Cell Prolif. 2023;56:e13401.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXmtFWitrs%3D\" aria-label=\"CAS reference 196\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36949664\" aria-label=\"PubMed reference 196\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10280137\" aria-label=\"PubMed Central reference 196\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 196\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Progression%20of%20irradiated%20mesenchymal%20stromal%20cells%20from%20early%20to%20late%20senescence%3A%20Changes%20in%20SASP%20composition%20and%20anti-tumour%20properties&amp;journal=Cell%20Prolif&amp;volume=56&amp;publication_year=2023&amp;author=Alessio%2CN&amp;author=Acar%2CMB&amp;author=Squillaro%2CT&amp;author=Aprile%2CD&amp;author=Ayaz-Guner%2CS&amp;author=Bernardo%2CG&amp;author=Peluso%2CG&amp;author=Ozcan%2CS&amp;author=Galderisi%2CU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR197\">Crespo J, Sun H, Welling TH, Tian Z, Zou W. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment. Curr Opin Immunol. 2013;25(2):214\u201321.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXkvFOgsg%3D%3D\" aria-label=\"CAS reference 197\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23298609\" aria-label=\"PubMed reference 197\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3636159\" aria-label=\"PubMed Central reference 197\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 197\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=T%20cell%20anergy%2C%20exhaustion%2C%20senescence%2C%20and%20stemness%20in%20the%20tumor%20microenvironment&amp;journal=Curr%20Opin%20Immunol&amp;volume=25&amp;issue=2&amp;pages=214-21&amp;publication_year=2013&amp;author=Crespo%2CJ&amp;author=Sun%2CH&amp;author=Welling%2CTH&amp;author=Tian%2CZ&amp;author=Zou%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR198\">Magkouta S, Markaki E, Evangelou K, Petty R, Verginis P, Gorgoulis V. Decoding T cell senescence in cancer: is revisiting required? Semin Cancer Biol. 2025;108:33\u201347.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXkt1Cmtg%3D%3D\" aria-label=\"CAS reference 198\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39615809\" aria-label=\"PubMed reference 198\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 198\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Decoding%20T%20cell%20senescence%20in%20cancer%3A%20is%20revisiting%20required%3F&amp;journal=Semin%20Cancer%20Biol&amp;volume=108&amp;pages=33-47&amp;publication_year=2025&amp;author=Magkouta%2CS&amp;author=Markaki%2CE&amp;author=Evangelou%2CK&amp;author=Petty%2CR&amp;author=Verginis%2CP&amp;author=Gorgoulis%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR199\">Ge Z, Wu S, Zhang Z, Ding S. Mechanism of tumor cells escaping from immune surveillance of NK cells. Immunopharmacol Immunotoxicol. 2020;42:187\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXlvVyiu78%3D\" aria-label=\"CAS reference 199\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32223464\" aria-label=\"PubMed reference 199\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 199\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mechanism%20of%20tumor%20cells%20escaping%20from%20immune%20surveillance%20of%20NK%20cells&amp;journal=Immunopharmacol%20Immunotoxicol&amp;volume=42&amp;pages=187-98&amp;publication_year=2020&amp;author=Ge%2CZ&amp;author=Wu%2CS&amp;author=Zhang%2CZ&amp;author=Ding%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR200\">Lin D, Lei L, Liu Y, Zhang Y, Hu B, Bao G, et al. Membrane IL1alpha inhibits the development of hepatocellular carcinoma via promoting T- and NK-cell activation. Cancer Res. 2016;76:3179\u201388.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XovVykt70%3D\" aria-label=\"CAS reference 200\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27206848\" aria-label=\"PubMed reference 200\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 200\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Membrane%20IL1alpha%20inhibits%20the%20development%20of%20hepatocellular%20carcinoma%20via%20promoting%20T-%20and%20NK-cell%20activation&amp;journal=Cancer%20Res&amp;volume=76&amp;pages=3179-3188&amp;publication_year=2016&amp;author=Lin%2CD&amp;author=Lei%2CL&amp;author=Liu%2CY&amp;author=Zhang%2CY&amp;author=Hu%2CB&amp;author=Bao%2CG&amp;author=Song%2CY&amp;author=Jin%2CZ&amp;author=Liu%2CC&amp;author=Mei%2CY&amp;author=Sandikin%2CD&amp;author=Wu%2CY&amp;author=Zhao%2CL&amp;author=Yu%2CX&amp;author=Liu%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR201\">Oka N, Markova T, Tsuzuki K, Li W, El-Darawish Y, Pencheva-Demireva M, et al. IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18. Cancer Immunol Immunother. 2020;69:1699\u2013712.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXotlShtLg%3D\" aria-label=\"CAS reference 201\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32333080\" aria-label=\"PubMed reference 201\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11027610\" aria-label=\"PubMed Central reference 201\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 201\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-12%20regulates%20the%20expansion%2C%20phenotype%2C%20and%20function%20of%20murine%20NK%20cells%20activated%20by%20IL-15%20and%20IL-18&amp;journal=Cancer%20Immunol%20Immunother&amp;volume=69&amp;pages=1699-712&amp;publication_year=2020&amp;author=Oka%2CN&amp;author=Markova%2CT&amp;author=Tsuzuki%2CK&amp;author=Li%2CW&amp;author=El-Darawish%2CY&amp;author=Pencheva-Demireva%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR202\">Gotthardt D, Trifinopoulos J, Sexl V, Putz EM. JAK\/STAT cytokine signaling at the crossroad of NK cell development and maturation. Front Immunol. 2019;10:2590.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhsVeqtbnO\" aria-label=\"CAS reference 202\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31781102\" aria-label=\"PubMed reference 202\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6861185\" aria-label=\"PubMed Central reference 202\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 202\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=JAK%2FSTAT%20cytokine%20signaling%20at%20the%20crossroad%20of%20NK%20cell%20development%20and%20maturation&amp;journal=Front%20Immunol&amp;volume=10&amp;publication_year=2019&amp;author=Gotthardt%2CD&amp;author=Trifinopoulos%2CJ&amp;author=Sexl%2CV&amp;author=Putz%2CEM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR203\">Kim J, Kim JS, Lee HK, Kim HS, Park EJ, Choi JE, et al. Cxcr3-deficient natural killer cells fail to migrate to B16F10 melanoma cells. Int Immunopharmacol. 2018;63:66\u201373.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhsVags77I\" aria-label=\"CAS reference 203\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30075430\" aria-label=\"PubMed reference 203\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 203\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cxcr3-deficient%20natural%20killer%20cells%20fail%20to%20migrate%20to%20B16F10%20melanoma%20cells&amp;journal=Int%20Immunopharmacol&amp;volume=63&amp;pages=66-73&amp;publication_year=2018&amp;author=Kim%2CJ&amp;author=Kim%2CJS&amp;author=Lee%2CHK&amp;author=Kim%2CHS&amp;author=Park%2CEJ&amp;author=Choi%2CJE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR204\">Benigni G, Dimitrova P, Antonangeli F, Sanseviero E, Milanova V, Blom A, et al. CXCR3\/CXCL10 axis regulates neutrophil-NK cell cross-talk determining the severity of experimental osteoarthritis. J Immunol. 2017;198:2115\u201324.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXjtVamsb0%3D\" aria-label=\"CAS reference 204\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28108560\" aria-label=\"PubMed reference 204\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 204\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CXCR3%2FCXCL10%20axis%20regulates%20neutrophil-NK%20cell%20cross-talk%20determining%20the%20severity%20of%20experimental%20osteoarthritis&amp;journal=J%20Immunol&amp;volume=198&amp;pages=2115-24&amp;publication_year=2017&amp;author=Benigni%2CG&amp;author=Dimitrova%2CP&amp;author=Antonangeli%2CF&amp;author=Sanseviero%2CE&amp;author=Milanova%2CV&amp;author=Blom%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR205\">Gagnon J, Ramanathan S, Leblanc C, Cloutier A, McDonald PP, Ilangumaran S. IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes. J Immunol. 2008;180:7958\u201368.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXntVemu74%3D\" aria-label=\"CAS reference 205\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18523259\" aria-label=\"PubMed reference 205\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 205\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%2C%20in%20synergy%20with%20IL-7%20or%20IL-15%2C%20stimulates%20TCR-independent%20proliferation%20and%20functional%20differentiation%20of%20CD8%2B%20T%20lymphocytes&amp;journal=J%20Immunol&amp;volume=180&amp;pages=7958-68&amp;publication_year=2008&amp;author=Gagnon%2CJ&amp;author=Ramanathan%2CS&amp;author=Leblanc%2CC&amp;author=Cloutier%2CA&amp;author=McDonald%2CPP&amp;author=Ilangumaran%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR206\">Yang Y, Ochando J, Yopp A, Bromberg JS, Ding Y. IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J Immunol. 2005;174:2720\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXhsFeqs70%3D\" aria-label=\"CAS reference 206\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15728480\" aria-label=\"PubMed reference 206\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 206\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%20plays%20a%20unique%20role%20in%20initiating%20c-Maf%20expression%20during%20early%20stage%20of%20CD4%20T%20cell%20activation&amp;journal=J%20Immunol&amp;volume=174&amp;pages=2720-9&amp;publication_year=2005&amp;author=Yang%2CY&amp;author=Ochando%2CJ&amp;author=Yopp%2CA&amp;author=Bromberg%2CJS&amp;author=Ding%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR207\">Rincon M, Anguita J, Nakamura T, Fikrig E, Flavell RA. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med. 1997;185:461\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DyaK2s7ovVOkuw%3D%3D\" aria-label=\"CAS reference 207\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=9053446\" aria-label=\"PubMed reference 207\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2196041\" aria-label=\"PubMed Central reference 207\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 207\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin%20%28IL%29-6%20directs%20the%20differentiation%20of%20IL-4-producing%20CD4%2B%20T%20cells&amp;journal=J%20Exp%20Med&amp;volume=185&amp;pages=461-9&amp;publication_year=1997&amp;author=Rincon%2CM&amp;author=Anguita%2CJ&amp;author=Nakamura%2CT&amp;author=Fikrig%2CE&amp;author=Flavell%2CRA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR208\">Gesser B, Lund M, Lohse N, Vestergaad C, Matsushima K, Sindet-Pedersen S, et al. IL-8 induces T cell chemotaxis, suppresses IL-4, and up-regulates IL-8 production by CD4+ T cells. J Leukoc Biol. 1996;59:407\u201311.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK28XitFGgs7c%3D\" aria-label=\"CAS reference 208\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8604020\" aria-label=\"PubMed reference 208\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 208\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-8%20induces%20T%20cell%20chemotaxis%2C%20suppresses%20IL-4%2C%20and%20up-regulates%20IL-8%20production%20by%20CD4%2B%20T%20cells&amp;journal=J%20Leukoc%20Biol&amp;volume=59&amp;pages=407-411&amp;publication_year=1996&amp;author=Gesser%2CB&amp;author=Lund%2CM&amp;author=Lohse%2CN&amp;author=Vestergaad%2CC&amp;author=Matsushima%2CK&amp;author=Sindet-Pedersen%2CS&amp;author=Jensen%2CSL&amp;author=Thestrup-Pedersen%2CK&amp;author=Larsen%2CCG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR209\">Zhang H, Yan D, Shi X, Liang H, Pang Y, Qin N, et al. Transmembrane TNF-alpha mediates \u201cforward\u201d and \u201creverse\u201d signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cells. J Leukoc Biol. 2008;84:789\u201397.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1cXhtV2itbnF\" aria-label=\"CAS reference 209\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18550789\" aria-label=\"PubMed reference 209\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2516903\" aria-label=\"PubMed Central reference 209\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 209\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Transmembrane%20TNF-alpha%20mediates%20%E2%80%9Cforward%E2%80%9D%20and%20%E2%80%9Creverse%E2%80%9D%20signaling%2C%20inducing%20cell%20death%20or%20survival%20via%20the%20NF-kappaB%20pathway%20in%20Raji%20Burkitt%20lymphoma%20cells&amp;journal=J%20Leukoc%20Biol&amp;volume=84&amp;pages=789-97&amp;publication_year=2008&amp;author=Zhang%2CH&amp;author=Yan%2CD&amp;author=Shi%2CX&amp;author=Liang%2CH&amp;author=Pang%2CY&amp;author=Qin%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR210\">Karki R, Sharma BR, Tuladhar S, Williams EP, Zalduondo L, Samir P, et al. Synergism of TNF-alpha and IFN-gamma triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell. 2021;184:149\u201368 e117.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXisV2ntbvE\" aria-label=\"CAS reference 210\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33278357\" aria-label=\"PubMed reference 210\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 210\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Synergism%20of%20TNF-alpha%20and%20IFN-gamma%20triggers%20inflammatory%20cell%20death%2C%20tissue%20damage%2C%20and%20mortality%20in%20SARS-CoV-2%20infection%20and%20cytokine%20shock%20syndromes&amp;journal=Cell.&amp;volume=184&amp;pages=149-168&amp;publication_year=2021&amp;author=Karki%2CR&amp;author=Sharma%2CBR&amp;author=Tuladhar%2CS&amp;author=Williams%2CEP&amp;author=Zalduondo%2CL&amp;author=Samir%2CP&amp;author=Zheng%2CM&amp;author=Sundaram%2CB&amp;author=Banoth%2CB&amp;author=Malireddi%2CRKS&amp;author=Schreiner%2CP&amp;author=Neale%2CG&amp;author=Vogel%2CP&amp;author=Webby%2CR&amp;author=Jonsson%2CCB&amp;author=Kanneganti%2CTD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR211\">Haabeth OA, Lorvik KB, Yagita H, Bogen B, Corthay A. Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology. 2016;5:e1039763.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26942052\" aria-label=\"PubMed reference 211\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 211\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin-1%20is%20required%20for%20cancer%20eradication%20mediated%20by%20tumor-specific%20Th1%20cells&amp;journal=Oncoimmunology&amp;volume=5&amp;publication_year=2016&amp;author=Haabeth%2COA&amp;author=Lorvik%2CKB&amp;author=Yagita%2CH&amp;author=Bogen%2CB&amp;author=Corthay%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR212\">Lekan AA, Weiner LM. The role of chemokines in orchestrating the immune response to pancreatic ductal adenocarcinoma. Cancers (Basel). 2024;16(3):559. <a href=\"https:\/\/doi.org\/10.3390\/cancers16030559\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cancers16030559\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cancers16030559<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/cancers16030559\" data-track-item_id=\"10.3390\/cancers16030559\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fcancers16030559\" aria-label=\"Article reference 212\" data-doi=\"10.3390\/cancers16030559\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38339310\" aria-label=\"PubMed reference 212\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 212\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20chemokines%20in%20orchestrating%20the%20immune%20response%20to%20pancreatic%20ductal%20adenocarcinoma&amp;journal=Cancers%20%28Basel%29&amp;doi=10.3390%2Fcancers16030559&amp;publication_year=2024&amp;author=Lekan%2CAA&amp;author=Weiner%2CLM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR213\">Freeman P, Bellomo G, Ireland L, Abudula M, Luckett T, Oberst M, et al. Inhibition of insulin-like growth factors increases production of CXCL9\/10 by macrophages and fibroblasts and facilitates CD8(+) cytotoxic T cell recruitment to pancreatic tumours. Front Immunol. 2024;15:1382538.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXisF2mtbbO\" aria-label=\"CAS reference 213\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39165364\" aria-label=\"PubMed reference 213\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11334161\" aria-label=\"PubMed Central reference 213\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 213\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inhibition%20of%20insulin-like%20growth%20factors%20increases%20production%20of%20CXCL9%2F10%20by%20macrophages%20and%20fibroblasts%20and%20facilitates%20CD8%28%2B%29%20cytotoxic%20T%20cell%20recruitment%20to%20pancreatic%20tumours&amp;journal=Front%20Immunol&amp;volume=15&amp;publication_year=2024&amp;author=Freeman%2CP&amp;author=Bellomo%2CG&amp;author=Ireland%2CL&amp;author=Abudula%2CM&amp;author=Luckett%2CT&amp;author=Oberst%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR214\">Gunassekaran GR, PoongkavithaiVadevoo SM, Baek MC, Lee B. M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages. Biomaterials. 2021;278:121137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXitVOgt7vJ\" aria-label=\"CAS reference 214\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34560422\" aria-label=\"PubMed reference 214\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 214\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=M1%20macrophage%20exosomes%20engineered%20to%20foster%20M1%20polarization%20and%20target%20the%20IL-4%20receptor%20inhibit%20tumor%20growth%20by%20reprogramming%20tumor-associated%20macrophages%20into%20M1-like%20macrophages&amp;journal=Biomaterials&amp;volume=278&amp;publication_year=2021&amp;author=Gunassekaran%2CGR&amp;author=PoongkavithaiVadevoo%2CSM&amp;author=Baek%2CMC&amp;author=Lee%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR215\">Choo YW, Kang M, Kim HY, Han J, Kang S, Lee JR, et al. M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors. ACS Nano. 2018;12:8977\u201393.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhsFGqsrzJ\" aria-label=\"CAS reference 215\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30133260\" aria-label=\"PubMed reference 215\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 215\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=M1%20macrophage-derived%20nanovesicles%20potentiate%20the%20anticancer%20efficacy%20of%20immune%20checkpoint%20inhibitors&amp;journal=ACS%20Nano&amp;volume=12&amp;pages=8977-93&amp;publication_year=2018&amp;author=Choo%2CYW&amp;author=Kang%2CM&amp;author=Kim%2CHY&amp;author=Han%2CJ&amp;author=Kang%2CS&amp;author=Lee%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR216\">Ren F, Fan M, Mei J, Wu Y, Liu C, Pu Q, et al. Interferon-gamma and celecoxib inhibit lung-tumor growth through modulating M2\/M1 macrophage ratio in the tumor microenvironment. Drug Des Devel Ther. 2014;8:1527\u201338.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25284985\" aria-label=\"PubMed reference 216\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4181549\" aria-label=\"PubMed Central reference 216\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 216\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon-gamma%20and%20celecoxib%20inhibit%20lung-tumor%20growth%20through%20modulating%20M2%2FM1%20macrophage%20ratio%20in%20the%20tumor%20microenvironment&amp;journal=Drug%20Des%20Devel%20Ther&amp;volume=8&amp;pages=1527-1538&amp;publication_year=2014&amp;author=Ren%2CF&amp;author=Fan%2CM&amp;author=Mei%2CJ&amp;author=Wu%2CY&amp;author=Liu%2CC&amp;author=Pu%2CQ&amp;author=You%2CZ&amp;author=Liu%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR217\">Wang Q, Cheng F, Ma TT, Xiong HY, Li ZW, Xie CL, et al. Interleukin-12 inhibits the hepatocellular carcinoma growth by inducing macrophage polarization to the M1-like phenotype through downregulation of Stat-3. Mol Cell Biochem. 2016;415:157\u201368.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28Xks1CrtLc%3D\" aria-label=\"CAS reference 217\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27003285\" aria-label=\"PubMed reference 217\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 217\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin-12%20inhibits%20the%20hepatocellular%20carcinoma%20growth%20by%20inducing%20macrophage%20polarization%20to%20the%20M1-like%20phenotype%20through%20downregulation%20of%20Stat-3&amp;journal=Mol%20Cell%20Biochem&amp;volume=415&amp;pages=157-68&amp;publication_year=2016&amp;author=Wang%2CQ&amp;author=Cheng%2CF&amp;author=Ma%2CTT&amp;author=Xiong%2CHY&amp;author=Li%2CZW&amp;author=Xie%2CCL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR218\">Watkins SK, Egilmez NK, Suttles J, Stout RD. IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J Immunol. 2007;178:1357\u201362.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2sXntVGhsg%3D%3D\" aria-label=\"CAS reference 218\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17237382\" aria-label=\"PubMed reference 218\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 218\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-12%20rapidly%20alters%20the%20functional%20profile%20of%20tumor-associated%20and%20tumor-infiltrating%20macrophages%20in%20vitro%20and%20in%20vivo&amp;journal=J%20Immunol&amp;volume=178&amp;pages=1357-62&amp;publication_year=2007&amp;author=Watkins%2CSK&amp;author=Egilmez%2CNK&amp;author=Suttles%2CJ&amp;author=Stout%2CRD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR219\">Tekin C, Aberson HL, Bijlsma MF, Spek CA. Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-alpha secretion. BMC Cancer. 2020;20:1183.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXkt1eltg%3D%3D\" aria-label=\"CAS reference 219\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33267818\" aria-label=\"PubMed reference 219\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7709323\" aria-label=\"PubMed Central reference 219\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 219\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Early%20macrophage%20infiltrates%20impair%20pancreatic%20cancer%20cell%20growth%20by%20TNF-alpha%20secretion&amp;journal=BMC%20Cancer&amp;volume=20&amp;publication_year=2020&amp;author=Tekin%2CC&amp;author=Aberson%2CHL&amp;author=Bijlsma%2CMF&amp;author=Spek%2CCA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR220\">Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med. 2009;15:1170\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhtFGjt7rK\" aria-label=\"CAS reference 220\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19767732\" aria-label=\"PubMed reference 220\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 220\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activation%20of%20the%20NLRP3%20inflammasome%20in%20dendritic%20cells%20induces%20IL-1beta-dependent%20adaptive%20immunity%20against%20tumors&amp;journal=Nat%20Med&amp;volume=15&amp;pages=1170-1178&amp;publication_year=2009&amp;author=Ghiringhelli%2CF&amp;author=Apetoh%2CL&amp;author=Tesniere%2CA&amp;author=Aymeric%2CL&amp;author=Ma%2CY&amp;author=Ortiz%2CC&amp;author=Vermaelen%2CK&amp;author=Panaretakis%2CT&amp;author=Mignot%2CG&amp;author=Ullrich%2CE&amp;author=Perfettini%2CJL&amp;author=Schlemmer%2CF&amp;author=Tasdemir%2CE&amp;author=Uhl%2CM&amp;author=Genin%2CP&amp;author=Civas%2CA&amp;author=Ryffel%2CB&amp;author=Kanellopoulos%2CJ&amp;author=Tschopp%2CJ&amp;author=Andre%2CF&amp;author=Lidereau%2CR&amp;author=McLaughlin%2CNM&amp;author=Haynes%2CNM&amp;author=Smyth%2CMJ&amp;author=Kroemer%2CG&amp;author=Zitvogel%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR221\">Dominguez D, Ye C, Geng Z, Chen S, Fan J, Qin L, et al. Exogenous IL-33 restores dendritic cell activation and maturation in established cancer. J Immunol. 2017;198:1365\u201375.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtlaitL0%3D\" aria-label=\"CAS reference 221\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28011934\" aria-label=\"PubMed reference 221\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 221\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Exogenous%20IL-33%20restores%20dendritic%20cell%20activation%20and%20maturation%20in%20established%20cancer&amp;journal=J%20Immunol&amp;volume=198&amp;pages=1365-75&amp;publication_year=2017&amp;author=Dominguez%2CD&amp;author=Ye%2CC&amp;author=Geng%2CZ&amp;author=Chen%2CS&amp;author=Fan%2CJ&amp;author=Qin%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR222\">Liu S, Yu Y, Zhang M, Wang W, Cao X. The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells. J Immunol. 2001;166:5407\u201315.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3MXjtFyrtLo%3D\" aria-label=\"CAS reference 222\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11313377\" aria-label=\"PubMed reference 222\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 222\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20involvement%20of%20TNF-alpha-related%20apoptosis-inducing%20ligand%20in%20the%20enhanced%20cytotoxicity%20of%20IFN-beta-stimulated%20human%20dendritic%20cells%20to%20tumor%20cells&amp;journal=J%20Immunol&amp;volume=166&amp;pages=5407-15&amp;publication_year=2001&amp;author=Liu%2CS&amp;author=Yu%2CY&amp;author=Zhang%2CM&amp;author=Wang%2CW&amp;author=Cao%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR223\">Li H, Wang C, Yu J, Cao S, Wei F, Zhang W, et al. Dendritic cell-activated cytokine-induced killer cells enhance the anti-tumor effect of chemotherapy on non-small cell lung cancer in patients after surgery. Cytotherapy. 2009;11:1076\u201383.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhsVyitbrL\" aria-label=\"CAS reference 223\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19929470\" aria-label=\"PubMed reference 223\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 223\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dendritic%20cell-activated%20cytokine-induced%20killer%20cells%20enhance%20the%20anti-tumor%20effect%20of%20chemotherapy%20on%20non-small%20cell%20lung%20cancer%20in%20patients%20after%20surgery&amp;journal=Cytotherapy&amp;volume=11&amp;pages=1076-83&amp;publication_year=2009&amp;author=Li%2CH&amp;author=Wang%2CC&amp;author=Yu%2CJ&amp;author=Cao%2CS&amp;author=Wei%2CF&amp;author=Zhang%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR224\">Yang T, Zhang W, Wang L, Xiao C, Wang L, Gong Y, et al. Co-culture of dendritic cells and cytokine-induced killer cells effectively suppresses liver cancer stem cell growth by inhibiting pathways in the immune system. BMC Cancer. 2018;18:984.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXht1yls7jL\" aria-label=\"CAS reference 224\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30326865\" aria-label=\"PubMed reference 224\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6192155\" aria-label=\"PubMed Central reference 224\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 224\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Co-culture%20of%20dendritic%20cells%20and%20cytokine-induced%20killer%20cells%20effectively%20suppresses%20liver%20cancer%20stem%20cell%20growth%20by%20inhibiting%20pathways%20in%20the%20immune%20system&amp;journal=BMC%20Cancer&amp;volume=18&amp;publication_year=2018&amp;author=Yang%2CT&amp;author=Zhang%2CW&amp;author=Wang%2CL&amp;author=Xiao%2CC&amp;author=Wang%2CL&amp;author=Gong%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR225\">Chaudhry UI, Kingham TP, Plitas G, Katz SC, Raab JR, DeMatteo RP. Combined stimulation with interleukin-18 and CpG induces murine natural killer dendritic cells to produce IFN-gamma and inhibit tumor growth. Cancer Res. 2006;66:10497\u2013504.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD28XhtFGjsrbI\" aria-label=\"CAS reference 225\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=17079471\" aria-label=\"PubMed reference 225\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 225\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Combined%20stimulation%20with%20interleukin-18%20and%20CpG%20induces%20murine%20natural%20killer%20dendritic%20cells%20to%20produce%20IFN-gamma%20and%20inhibit%20tumor%20growth&amp;journal=Cancer%20Res&amp;volume=66&amp;pages=10497-504&amp;publication_year=2006&amp;author=Chaudhry%2CUI&amp;author=Kingham%2CTP&amp;author=Plitas%2CG&amp;author=Katz%2CSC&amp;author=Raab%2CJR&amp;author=DeMatteo%2CRP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR226\">Chen Y, Ma L, Cheng Z, Hu Z, Xu Y, Wu J, et al. Senescent fibroblast facilitates re-epithelization and collagen deposition in radiation-induced skin injury through IL-33-mediated macrophage polarization. J Transl Med. 2024;22:176.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38369466\" aria-label=\"PubMed reference 226\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10874572\" aria-label=\"PubMed Central reference 226\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 226\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20fibroblast%20facilitates%20re-epithelization%20and%20collagen%20deposition%20in%20radiation-induced%20skin%20injury%20through%20IL-33-mediated%20macrophage%20polarization&amp;journal=J%20Transl%20Med&amp;volume=22&amp;publication_year=2024&amp;author=Chen%2CY&amp;author=Ma%2CL&amp;author=Cheng%2CZ&amp;author=Hu%2CZ&amp;author=Xu%2CY&amp;author=Wu%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR227\">Lim HX, Choi S, Cho D, Kim TS. IL-33 inhibits the differentiation and immunosuppressive activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. Immunol Cell Biol. 2017;95:99\u2013107.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhsVChu7nM\" aria-label=\"CAS reference 227\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27507556\" aria-label=\"PubMed reference 227\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 227\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-33%20inhibits%20the%20differentiation%20and%20immunosuppressive%20activity%20of%20granulocytic%20myeloid-derived%20suppressor%20cells%20in%20tumor-bearing%20mice&amp;journal=Immunol%20Cell%20Biol&amp;volume=95&amp;pages=99-107&amp;publication_year=2017&amp;author=Lim%2CHX&amp;author=Choi%2CS&amp;author=Cho%2CD&amp;author=Kim%2CTS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR228\">Choi JN, Sun EG, Cho SH. IL-12 enhances immune response by modulation of myeloid derived suppressor cells in tumor microenvironment. Chonnam Med J. 2019;55(2):31\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XovFKhtr8%3D\" aria-label=\"CAS reference 228\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30740338\" aria-label=\"PubMed reference 228\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6351325\" aria-label=\"PubMed Central reference 228\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 228\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-12%20enhances%20immune%20response%20by%20modulation%20of%20myeloid%20derived%20suppressor%20cells%20in%20tumor%20microenvironment&amp;journal=Chonnam%20Med%20J&amp;volume=55&amp;issue=2&amp;pages=31-9&amp;publication_year=2019&amp;author=Choi%2CJN&amp;author=Sun%2CEG&amp;author=Cho%2CSH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR229\">Steding CE, Wu ST, Zhang Y, Jeng MH, Elzey BD, Kao C. The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis. Immunology. 2011;133:221\u201338.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXlvFyrt7Y%3D\" aria-label=\"CAS reference 229\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21453419\" aria-label=\"PubMed reference 229\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3088984\" aria-label=\"PubMed Central reference 229\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 229\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20interleukin-12%20on%20modulating%20myeloid-derived%20suppressor%20cells%2C%20increasing%20overall%20survival%20and%20reducing%20metastasis&amp;journal=Immunology&amp;volume=133&amp;pages=221-38&amp;publication_year=2011&amp;author=Steding%2CCE&amp;author=Wu%2CST&amp;author=Zhang%2CY&amp;author=Jeng%2CMH&amp;author=Elzey%2CBD&amp;author=Kao%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR230\">Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, et al. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Res. 2009;69:8700\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXhtl2rsbfE\" aria-label=\"CAS reference 230\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19843867\" aria-label=\"PubMed reference 230\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2783758\" aria-label=\"PubMed Central reference 230\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 230\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin%2012%20stimulates%20IFN-gamma-mediated%20inhibition%20of%20tumor-induced%20regulatory%20T-cell%20proliferation%20and%20enhances%20tumor%20clearance&amp;journal=Cancer%20Res&amp;volume=69&amp;pages=8700-9&amp;publication_year=2009&amp;author=Cao%2CX&amp;author=Leonard%2CK&amp;author=Collins%2CLI&amp;author=Cai%2CSF&amp;author=Mayer%2CJC&amp;author=Payton%2CJE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR231\">Tian Y, Yuan C, Ma D, Zhang Y, Liu Y, Zhang W, et al. IL-21 and IL-12 inhibit differentiation of Treg and TH17 cells and enhance cytotoxicity of peripheral blood mononuclear cells in patients with cervical cancer. Int J Gynecol Cancer. 2011;21(2011):1672\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22080897\" aria-label=\"PubMed reference 231\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 231\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-21%20and%20IL-12%20inhibit%20differentiation%20of%20Treg%20and%20TH17%20cells%20and%20enhance%20cytotoxicity%20of%20peripheral%20blood%20mononuclear%20cells%20in%20patients%20with%20cervical%20cancer&amp;journal=Int%20J%20Gynecol%20Cancer&amp;volume=21&amp;issue=2011&amp;pages=1672-1678&amp;publication_year=2011&amp;author=Tian%2CY&amp;author=Yuan%2CC&amp;author=Ma%2CD&amp;author=Zhang%2CY&amp;author=Liu%2CY&amp;author=Zhang%2CW&amp;author=Hou%2CF&amp;author=Cui%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR232\">Takasugi M, Yoshida Y, Ohtani N. Cellular senescence and the tumour microenvironment. Mol Oncol. 2022;16(2):3333\u201351.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XitFSjs7zL\" aria-label=\"CAS reference 232\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35674109\" aria-label=\"PubMed reference 232\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9490140\" aria-label=\"PubMed Central reference 232\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 232\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20senescence%20and%20the%20tumour%20microenvironment&amp;journal=Mol%20Oncol&amp;volume=16&amp;issue=2&amp;pages=3333-51&amp;publication_year=2022&amp;author=Takasugi%2CM&amp;author=Yoshida%2CY&amp;author=Ohtani%2CN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR233\">Gonzalez-Meljem JM, Apps JR, Fraser HC. Paracrine roles of cellular senescence in promoting tumourigenesis. Br J Cancer. 2018;118:1283\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXoslSjsr4%3D\" aria-label=\"CAS reference 233\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29670296\" aria-label=\"PubMed reference 233\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5959857\" aria-label=\"PubMed Central reference 233\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 233\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Paracrine%20roles%20of%20cellular%20senescence%20in%20promoting%20tumourigenesis&amp;journal=Br%20J%20Cancer&amp;volume=118&amp;pages=1283-8&amp;publication_year=2018&amp;author=Gonzalez-Meljem%2CJM&amp;author=Apps%2CJR&amp;author=Fraser%2CHC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR234\">Chen C, Chen J, Zhang Y, Zhang Q, Shi H. Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression. Front Oncol. 2025;15:1605085.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40510156\" aria-label=\"PubMed reference 234\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12159025\" aria-label=\"PubMed Central reference 234\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 234\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20secretory%20phenotype%20in%20lung%20cancer%3A%20remodeling%20the%20tumor%20microenvironment%20for%20metastasis%20and%20immune%20suppression&amp;journal=Front%20Oncol&amp;volume=15&amp;publication_year=2025&amp;author=Chen%2CC&amp;author=Chen%2CJ&amp;author=Zhang%2CY&amp;author=Zhang%2CQ&amp;author=Shi%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR235\">Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone MA, et al. The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. Aging (Albany NY). 2019;11:5817\u201328.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXlt1yhtrg%3D\" aria-label=\"CAS reference 235\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31412320\" aria-label=\"PubMed reference 235\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 235\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20senescence-associated%20secretory%20phenotype%20%28SASP%29%20from%20mesenchymal%20stromal%20cells%20impairs%20growth%20of%20immortalized%20prostate%20cells%20but%20has%20no%20effect%20on%20metastatic%20prostatic%20cancer%20cells&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=11&amp;pages=5817-28&amp;publication_year=2019&amp;author=Alessio%2CN&amp;author=Aprile%2CD&amp;author=Squillaro%2CT&amp;author=Di%20Bernardo%2CG&amp;author=Finicelli%2CM&amp;author=Melone%2CMA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR236\">Ioannidou A, Goulielmaki E, Garinis GA. DNA damage: from chronic inflammation to age-related deterioration. Front Genet. 2016;7:187.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27826317\" aria-label=\"PubMed reference 236\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5078321\" aria-label=\"PubMed Central reference 236\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 236\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=DNA%20damage%3A%20from%20chronic%20inflammation%20to%20age-related%20deterioration&amp;journal=Front%20Genet&amp;volume=7&amp;publication_year=2016&amp;author=Ioannidou%2CA&amp;author=Goulielmaki%2CE&amp;author=Garinis%2CGA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR237\">Alspach E, Flanagan KC, Luo X, Ruhland MK, Huang H, Pazolli E, et al. P38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov. 2014;4:716\u201329.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXpsVGgsL8%3D\" aria-label=\"CAS reference 237\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24670723\" aria-label=\"PubMed reference 237\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4049323\" aria-label=\"PubMed Central reference 237\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 237\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=P38MAPK%20plays%20a%20crucial%20role%20in%20stromal-mediated%20tumorigenesis&amp;journal=Cancer%20Discov&amp;volume=4&amp;pages=716-29&amp;publication_year=2014&amp;author=Alspach%2CE&amp;author=Flanagan%2CKC&amp;author=Luo%2CX&amp;author=Ruhland%2CMK&amp;author=Huang%2CH&amp;author=Pazolli%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR238\">Kojima H, Inoue T, Kunimoto H, Nakajima K. IL-6-STAT3 signaling and premature senescence. JAKSTAT. 2013;2(2):e25763.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24416650\" aria-label=\"PubMed reference 238\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3876432\" aria-label=\"PubMed Central reference 238\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 238\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6-STAT3%20signaling%20and%20premature%20senescence&amp;journal=JAKSTAT&amp;volume=2&amp;issue=2&amp;publication_year=2013&amp;author=Kojima%2CH&amp;author=Inoue%2CT&amp;author=Kunimoto%2CH&amp;author=Nakajima%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR239\">Hu X, Li J, Fu M, Zhao X, Wang W. The JAK\/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021;6:402.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34824210\" aria-label=\"PubMed reference 239\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8617206\" aria-label=\"PubMed Central reference 239\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 239\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20JAK%2FSTAT%20signaling%20pathway%3A%20from%20bench%20to%20clinic&amp;journal=Signal%20Transduct%20Target%20Ther&amp;volume=6&amp;publication_year=2021&amp;author=Hu%2CX&amp;author=Li%2CJ&amp;author=Fu%2CM&amp;author=Zhao%2CX&amp;author=Wang%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR240\">Wan D, Jiang W, Hao J. Research advances in how the cGAS-STING pathway controls the cellular inflammatory response. Front Immunol. 2020;11:615.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXitVWntr%2FJ\" aria-label=\"CAS reference 240\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32411126\" aria-label=\"PubMed reference 240\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7198750\" aria-label=\"PubMed Central reference 240\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 240\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Research%20advances%20in%20how%20the%20cGAS-STING%20pathway%20controls%20the%20cellular%20inflammatory%20response&amp;journal=Front%20Immunol&amp;volume=11&amp;publication_year=2020&amp;author=Wan%2CD&amp;author=Jiang%2CW&amp;author=Hao%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR241\">Kawakami S, Johmura Y, Nakanishi M. Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells. J Biochem. 2024;176:97\u2013108.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXislOlsLfL\" aria-label=\"CAS reference 241\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38564227\" aria-label=\"PubMed reference 241\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11289320\" aria-label=\"PubMed Central reference 241\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 241\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Intracellular%20acidification%20and%20glycolysis%20modulate%20inflammatory%20pathway%20in%20senescent%20cells&amp;journal=J%20Biochem&amp;volume=176&amp;pages=97-108&amp;publication_year=2024&amp;author=Kawakami%2CS&amp;author=Johmura%2CY&amp;author=Nakanishi%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR242\">Yasuda T, Baba H, Ishimoto T. Cellular senescence in the tumor microenvironment and context-specific cancer treatment strategies. FEBS J. 2023;290(2023):1290\u2013302.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXitlCntbvJ\" aria-label=\"CAS reference 242\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34653317\" aria-label=\"PubMed reference 242\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 242\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20senescence%20in%20the%20tumor%20microenvironment%20and%20context-specific%20cancer%20treatment%20strategies&amp;journal=FEBS%20J&amp;volume=290&amp;issue=2023&amp;pages=1290-302&amp;publication_year=2023&amp;author=Yasuda%2CT&amp;author=Baba%2CH&amp;author=Ishimoto%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR243\">Bogdanova DA, Kolosova ED, Pukhalskaia TV, Levchuk KA, Demidov ON, Belotserkovskaya EV. The differential effect of senolytics on SASP cytokine secretion and regulation of EMT by CAFs. Int J Mol Sci. 2024;25(7):4031. <a href=\"https:\/\/doi.org\/10.3390\/ijms25074031\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms25074031\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms25074031<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms25074031\" data-track-item_id=\"10.3390\/ijms25074031\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms25074031\" aria-label=\"Article reference 243\" data-doi=\"10.3390\/ijms25074031\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39769021\" aria-label=\"PubMed reference 243\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11678009\" aria-label=\"PubMed Central reference 243\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 243\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20differential%20effect%20of%20senolytics%20on%20SASP%20cytokine%20secretion%20and%20regulation%20of%20EMT%20by%20CAFs&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms25074031&amp;publication_year=2024&amp;author=Bogdanova%2CDA&amp;author=Kolosova%2CED&amp;author=Pukhalskaia%2CTV&amp;author=Levchuk%2CKA&amp;author=Demidov%2CON&amp;author=Belotserkovskaya%2CEV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR244\">Yu Y, Xiao CH, Tan LD, Wang QS, Li XQ, Feng YM. Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-beta signalling. Br J Cancer. 2014;110:724\u201332.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhvFCqtLjL\" aria-label=\"CAS reference 244\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24335925\" aria-label=\"PubMed reference 244\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 244\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cancer-associated%20fibroblasts%20induce%20epithelial-mesenchymal%20transition%20of%20breast%20cancer%20cells%20through%20paracrine%20TGF-beta%20signalling&amp;journal=Br%20J%20Cancer&amp;volume=110&amp;pages=724-32&amp;publication_year=2014&amp;author=Yu%2CY&amp;author=Xiao%2CCH&amp;author=Tan%2CLD&amp;author=Wang%2CQS&amp;author=Li%2CXQ&amp;author=Feng%2CYM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR245\">Saitoh M. Transcriptional regulation of EMT transcription factors in cancer. Semin Cancer Biol. 2023;97:21\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXisVansrvN\" aria-label=\"CAS reference 245\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37802266\" aria-label=\"PubMed reference 245\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 245\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Transcriptional%20regulation%20of%20EMT%20transcription%20factors%20in%20cancer&amp;journal=Semin%20Cancer%20Biol&amp;volume=97&amp;pages=21-9&amp;publication_year=2023&amp;author=Saitoh%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR246\">Xiang H, Ramil CP, Hai J, Zhang C, Wang H, Watkins AA, et al. Cancer-associated fibroblasts promote immunosuppression by inducing ROS-Generating Monocytic MDSCs in lung squamous cell carcinoma, cancer. Immunol Res. 2020;8:436\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXit12qu7rF\" aria-label=\"CAS reference 246\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 246\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cancer-associated%20fibroblasts%20promote%20immunosuppression%20by%20inducing%20ROS-Generating%20Monocytic%20MDSCs%20in%20lung%20squamous%20cell%20carcinoma%2C%20cancer&amp;journal=Immunol%20Res&amp;volume=8&amp;pages=436-450&amp;publication_year=2020&amp;author=Xiang%2CH&amp;author=Ramil%2CCP&amp;author=Hai%2CJ&amp;author=Zhang%2CC&amp;author=Wang%2CH&amp;author=Watkins%2CAA&amp;author=Afshar%2CR&amp;author=Georgiev%2CP&amp;author=Sze%2CMA&amp;author=Song%2CXS&amp;author=Curran%2CPJ&amp;author=Cheng%2CM&amp;author=Miller%2CJR&amp;author=Sun%2CD&amp;author=Loboda%2CA&amp;author=Jia%2CY&amp;author=Moy%2CLY&amp;author=Chi%2CA&amp;author=Brandish%2CPE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR247\">Oo MW, Kawai H, Takabatake K, Tomida S, Eguchi T, Ono K, et al. Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment. JCI Insight. 2022;7(1):e148960. <a href=\"https:\/\/doi.org\/10.1172\/jci.insight.148960\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1172\/jci.insight.148960\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1172\/jci.insight.148960<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1172\/jci.insight.148960\" data-track-item_id=\"10.1172\/jci.insight.148960\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1172%2Fjci.insight.148960\" aria-label=\"Article reference 247\" data-doi=\"10.1172\/jci.insight.148960\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34874922\" aria-label=\"PubMed reference 247\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8765046\" aria-label=\"PubMed Central reference 247\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 247\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Resident%20stroma-secreted%20chemokine%20CCL2%20governs%20myeloid-derived%20suppressor%20cells%20in%20the%20tumor%20microenvironment&amp;journal=JCI%20Insight&amp;doi=10.1172%2Fjci.insight.148960&amp;publication_year=2022&amp;author=Oo%2CMW&amp;author=Kawai%2CH&amp;author=Takabatake%2CK&amp;author=Tomida%2CS&amp;author=Eguchi%2CT&amp;author=Ono%2CK&amp;author=Shan%2CQ&amp;author=Ohara%2CT&amp;author=Yoshida%2CS&amp;author=Omori%2CH&amp;author=Sukegawa%2CS&amp;author=Nakano%2CK&amp;author=Okamoto%2CK&amp;author=Sasaki%2CA&amp;author=Nagatsuka%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR248\">Ye J, Baer JM, Faget DV, Morikis VA, Ren Q, Melam A, et al. Senescent CAFs mediate immunosuppression and drive breast cancer progression. Cancer Discov. 2024;14:1302\u201323.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXjslyrsrk%3D\" aria-label=\"CAS reference 248\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38683161\" aria-label=\"PubMed reference 248\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11216870\" aria-label=\"PubMed Central reference 248\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 248\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20CAFs%20mediate%20immunosuppression%20and%20drive%20breast%20cancer%20progression&amp;journal=Cancer%20Discov&amp;volume=14&amp;pages=1302-23&amp;publication_year=2024&amp;author=Ye%2CJ&amp;author=Baer%2CJM&amp;author=Faget%2CDV&amp;author=Morikis%2CVA&amp;author=Ren%2CQ&amp;author=Melam%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR249\">Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E, et al. Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8(+) T cell activation and limit responsiveness to immunotherapy in mice. Nat Commun. 2024;15:6162.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhslKhs7fK\" aria-label=\"CAS reference 249\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39039076\" aria-label=\"PubMed reference 249\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11263607\" aria-label=\"PubMed Central reference 249\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 249\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20cancer-associated%20fibroblasts%20in%20pancreatic%20adenocarcinoma%20restrict%20CD8%28%2B%29%20T%20cell%20activation%20and%20limit%20responsiveness%20to%20immunotherapy%20in%20mice&amp;journal=Nat%20Commun&amp;volume=15&amp;publication_year=2024&amp;author=Assouline%2CB&amp;author=Kahn%2CR&amp;author=Hodali%2CL&amp;author=Condiotti%2CR&amp;author=Engel%2CY&amp;author=Elyada%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR250\">Parrinello S, Coppe JP, Krtolica A, Campisi J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci. 2005;118:485\u201396.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXhvFKntb0%3D\" aria-label=\"CAS reference 250\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15657080\" aria-label=\"PubMed reference 250\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 250\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Stromal-epithelial%20interactions%20in%20aging%20and%20cancer%3A%20senescent%20fibroblasts%20alter%20epithelial%20cell%20differentiation&amp;journal=J%20Cell%20Sci&amp;volume=118&amp;pages=485-96&amp;publication_year=2005&amp;author=Parrinello%2CS&amp;author=Coppe%2CJP&amp;author=Krtolica%2CA&amp;author=Campisi%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR251\">Lawrenson K, Grun B, Benjamin E, Jacobs IJ, Dafou D, Gayther SA. Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia. 2010;12:317\u201325.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXksFegsL8%3D\" aria-label=\"CAS reference 251\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20360942\" aria-label=\"PubMed reference 251\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2847739\" aria-label=\"PubMed Central reference 251\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 251\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20fibroblasts%20promote%20neoplastic%20transformation%20of%20partially%20transformed%20ovarian%20epithelial%20cells%20in%20a%20three-dimensional%20model%20of%20early%20stage%20ovarian%20cancer&amp;journal=Neoplasia&amp;volume=12&amp;pages=317-25&amp;publication_year=2010&amp;author=Lawrenson%2CK&amp;author=Grun%2CB&amp;author=Benjamin%2CE&amp;author=Jacobs%2CIJ&amp;author=Dafou%2CD&amp;author=Gayther%2CSA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR252\">Johnson DE, O\u2019Keefe RA, Grandis JR. Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15:234\u201348.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXit12nsbc%3D\" aria-label=\"CAS reference 252\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29405201\" aria-label=\"PubMed reference 252\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5858971\" aria-label=\"PubMed Central reference 252\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 252\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20the%20IL-6%2FJAK%2FSTAT3%20signalling%20axis%20in%20cancer&amp;journal=Nat%20Rev%20Clin%20Oncol&amp;volume=15&amp;pages=234-48&amp;publication_year=2018&amp;author=Johnson%2CDE&amp;author=O%E2%80%99Keefe%2CRA&amp;author=Grandis%2CJR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR253\">Huang B, Lang X, Li X. The role of IL-6\/JAK2\/STAT3 signaling pathway in cancers. Front Oncol. 2022;12:1023177.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhsVChurjK\" aria-label=\"CAS reference 253\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36591515\" aria-label=\"PubMed reference 253\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9800921\" aria-label=\"PubMed Central reference 253\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 253\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20IL-6%2FJAK2%2FSTAT3%20signaling%20pathway%20in%20cancers&amp;journal=Front%20Oncol&amp;volume=12&amp;publication_year=2022&amp;author=Huang%2CB&amp;author=Lang%2CX&amp;author=Li%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR254\">Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, et al. The IL-6\/JAK\/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia. 2013;15:848\u201362.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhtFGjsbfK\" aria-label=\"CAS reference 254\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23814496\" aria-label=\"PubMed reference 254\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3689247\" aria-label=\"PubMed Central reference 254\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 254\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20IL-6%2FJAK%2FStat3%20feed-forward%20loop%20drives%20tumorigenesis%20and%20metastasis&amp;journal=Neoplasia&amp;volume=15&amp;pages=848-862&amp;publication_year=2013&amp;author=Chang%2CQ&amp;author=Bournazou%2CE&amp;author=Sansone%2CP&amp;author=Berishaj%2CM&amp;author=Gao%2CSP&amp;author=Daly%2CL&amp;author=Wels%2CJ&amp;author=Theilen%2CT&amp;author=Granitto%2CS&amp;author=Zhang%2CX&amp;author=Cotari%2CJ&amp;author=Alpaugh%2CML&amp;author=Stanchina%2CE&amp;author=Manova%2CK&amp;author=Li%2CM&amp;author=Bonafe%2CM&amp;author=Ceccarelli%2CC&amp;author=Taffurelli%2CM&amp;author=Santini%2CD&amp;author=Altan-Bonnet%2CG&amp;author=Kaplan%2CR&amp;author=Norton%2CL&amp;author=Nishimoto%2CN&amp;author=Huszar%2CD&amp;author=Lyden%2CD&amp;author=Bromberg%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR255\">Zhao J, Wang Z, Tian Y, Ning J, Ye H. T cell exhaustion and senescence for ovarian cancer immunotherapy. Semin Cancer Biol. 2024;104\u2013105:1\u201315.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39032717\" aria-label=\"PubMed reference 255\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 255\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=T%20cell%20exhaustion%20and%20senescence%20for%20ovarian%20cancer%20immunotherapy&amp;journal=Semin%20Cancer%20Biol&amp;volume=104%E2%80%93105&amp;pages=1-15&amp;publication_year=2024&amp;author=Zhao%2CJ&amp;author=Wang%2CZ&amp;author=Tian%2CY&amp;author=Ning%2CJ&amp;author=Ye%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR256\">Gao HF, Cheng CS, Tang J, Li Y, Chen H, Meng ZQ, et al. CXCL9 chemokine promotes the progression of human pancreatic adenocarcinoma through STAT3-dependent cytotoxic T lymphocyte suppression. Aging (Albany NY). 2020;12(2):502\u201317.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhtVOht7zF\" aria-label=\"CAS reference 256\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31913856\" aria-label=\"PubMed reference 256\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 256\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=CXCL9%20chemokine%20promotes%20the%20progression%20of%20human%20pancreatic%20adenocarcinoma%20through%20STAT3-dependent%20cytotoxic%20T%20lymphocyte%20suppression&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=12&amp;issue=2&amp;pages=502-517&amp;publication_year=2020&amp;author=Gao%2CHF&amp;author=Cheng%2CCS&amp;author=Tang%2CJ&amp;author=Li%2CY&amp;author=Chen%2CH&amp;author=Meng%2CZQ&amp;author=Chen%2CZ&amp;author=Chen%2CLY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR257\">Chibaya L, Snyder J, Ruscetti M. Senescence and the tumor-immune landscape: implications for cancer immunotherapy. Semin Cancer Biol. 2022;86:827\u201345.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xht1CnsbbE\" aria-label=\"CAS reference 257\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35143990\" aria-label=\"PubMed reference 257\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9357237\" aria-label=\"PubMed Central reference 257\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 257\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence%20and%20the%20tumor-immune%20landscape%3A%20implications%20for%20cancer%20immunotherapy&amp;journal=Semin%20Cancer%20Biol&amp;volume=86&amp;pages=827-45&amp;publication_year=2022&amp;author=Chibaya%2CL&amp;author=Snyder%2CJ&amp;author=Ruscetti%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR258\">Nakagami H. Cellular senescence and senescence-associated T cells as a potential therapeutic target. Geriatr Gerontol Int. 2020;20:97\u2013100.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31837250\" aria-label=\"PubMed reference 258\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 258\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20senescence%20and%20senescence-associated%20T%20cells%20as%20a%20potential%20therapeutic%20target&amp;journal=Geriatr%20Gerontol%20Int&amp;volume=20&amp;pages=97-100&amp;publication_year=2020&amp;author=Nakagami%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR259\">Du M, Sun L, Guo J, Lv H. Macrophages and tumor-associated macrophages in the senescent microenvironment: from immunosuppressive TME to targeted tumor therapy. Pharmacol Res. 2024;204:107198.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhtVKrsbrN\" aria-label=\"CAS reference 259\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38692466\" aria-label=\"PubMed reference 259\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 259\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Macrophages%20and%20tumor-associated%20macrophages%20in%20the%20senescent%20microenvironment%3A%20from%20immunosuppressive%20TME%20to%20targeted%20tumor%20therapy&amp;journal=Pharmacol%20Res&amp;volume=204&amp;publication_year=2024&amp;author=Du%2CM&amp;author=Sun%2CL&amp;author=Guo%2CJ&amp;author=Lv%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR260\">Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233:6425\u201340.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXjsFWqs7s%3D\" aria-label=\"CAS reference 260\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29319160\" aria-label=\"PubMed reference 260\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 260\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Macrophage%20plasticity%2C%20polarization%2C%20and%20function%20in%20health%20and%20disease&amp;journal=J%20Cell%20Physiol&amp;volume=233&amp;pages=6425-6440&amp;publication_year=2018&amp;author=Shapouri-Moghaddam%2CA&amp;author=Mohammadian%2CS&amp;author=Vazini%2CH&amp;author=Taghadosi%2CM&amp;author=Esmaeili%2CSA&amp;author=Mardani%2CF&amp;author=Seifi%2CB&amp;author=Mohammadi%2CA&amp;author=Afshari%2CJT&amp;author=Sahebkar%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR261\">Zhou J, Zheng S, Liu T, Liu Q, Chen Y, Tan D, et al. IL-1beta from M2 macrophages promotes migration and invasion of ESCC cells enhancing epithelial-mesenchymal transition and activating NF-kappaB signaling pathway. J Cell Biochem. 2018;119:7040\u201352.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXpt1amsrg%3D\" aria-label=\"CAS reference 261\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29737564\" aria-label=\"PubMed reference 261\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 261\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-1beta%20from%20M2%20macrophages%20promotes%20migration%20and%20invasion%20of%20ESCC%20cells%20enhancing%20epithelial-mesenchymal%20transition%20and%20activating%20NF-kappaB%20signaling%20pathway&amp;journal=J%20Cell%20Biochem&amp;volume=119&amp;pages=7040-7052&amp;publication_year=2018&amp;author=Zhou%2CJ&amp;author=Zheng%2CS&amp;author=Liu%2CT&amp;author=Liu%2CQ&amp;author=Chen%2CY&amp;author=Tan%2CD&amp;author=Ma%2CR&amp;author=Lu%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR262\">Cho U, Kim B, Kim S, Han Y, Song YS. Pro-inflammatory M1 macrophage enhances metastatic potential of ovarian cancer cells through NF-kappaB activation. Mol Carcinog. 2018;57:235\u201342.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhvVSit7rN\" aria-label=\"CAS reference 262\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29024042\" aria-label=\"PubMed reference 262\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 262\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Pro-inflammatory%20M1%20macrophage%20enhances%20metastatic%20potential%20of%20ovarian%20cancer%20cells%20through%20NF-kappaB%20activation&amp;journal=Mol%20Carcinog&amp;volume=57&amp;pages=235-42&amp;publication_year=2018&amp;author=Cho%2CU&amp;author=Kim%2CB&amp;author=Kim%2CS&amp;author=Han%2CY&amp;author=Song%2CYS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR263\">Xu YD, Cheng M, Shang PP, Yang YQ. Role of IL-6 in dendritic cell functions. J Leukoc Biol. 2022;111:695\u2013709.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhvVWiu73I\" aria-label=\"CAS reference 263\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34405445\" aria-label=\"PubMed reference 263\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 263\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Role%20of%20IL-6%20in%20dendritic%20cell%20functions&amp;journal=J%20Leukoc%20Biol&amp;volume=111&amp;pages=695-709&amp;publication_year=2022&amp;author=Xu%2CYD&amp;author=Cheng%2CM&amp;author=Shang%2CPP&amp;author=Yang%2CYQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR264\">Park SJ, Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, et al. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol. 2004;173:3844\u201354.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2cXnsVWksrc%3D\" aria-label=\"CAS reference 264\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15356132\" aria-label=\"PubMed reference 264\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 264\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%20regulates%20in%20vivo%20dendritic%20cell%20differentiation%20through%20STAT3%20activation&amp;journal=J%20Immunol&amp;volume=173&amp;pages=3844-54&amp;publication_year=2004&amp;author=Park%2CSJ&amp;author=Nakagawa%2CT&amp;author=Kitamura%2CH&amp;author=Atsumi%2CT&amp;author=Kamon%2CH&amp;author=Sawa%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR265\">Shi H, Han X, Sun Y, Shang C, Wei M, Ba X, et al. Chemokine (C-X-C motif) ligand 1 and CXCL2 produced by tumor promote the generation of monocytic myeloid-derived suppressor cells. Cancer Sci. 2018;109:3826\u201339.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXitFams73M\" aria-label=\"CAS reference 265\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30259595\" aria-label=\"PubMed reference 265\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6272093\" aria-label=\"PubMed Central reference 265\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 265\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chemokine%20%28C-X-C%20motif%29%20ligand%201%20and%20CXCL2%20produced%20by%20tumor%20promote%20the%20generation%20of%20monocytic%20myeloid-derived%20suppressor%20cells&amp;journal=Cancer%20Sci&amp;volume=109&amp;pages=3826-39&amp;publication_year=2018&amp;author=Shi%2CH&amp;author=Han%2CX&amp;author=Sun%2CY&amp;author=Shang%2CC&amp;author=Wei%2CM&amp;author=Ba%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR266\">Highfill SL, Cui Y, Giles AJ, Smith JP, Zhang H, Morse E, et al. Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy. Sci Transl Med. 2014;6(237):ra267.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 266\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Disruption%20of%20CXCR2-mediated%20MDSC%20tumor%20trafficking%20enhances%20anti-PD1%20efficacy&amp;journal=Sci%20Transl%20Med&amp;volume=6&amp;issue=237&amp;publication_year=2014&amp;author=Highfill%2CSL&amp;author=Cui%2CY&amp;author=Giles%2CAJ&amp;author=Smith%2CJP&amp;author=Zhang%2CH&amp;author=Morse%2CE\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR267\">Bullock K, Richmond A. Suppressing MDSC recruitment to the tumor microenvironment by antagonizing CXCR2 to enhance the efficacy of immunotherapy. Cancers (Basel). 2021;13(24):6293. <a href=\"https:\/\/doi.org\/10.3390\/cancers13246293\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cancers13246293\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cancers13246293<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/cancers13246293\" data-track-item_id=\"10.3390\/cancers13246293\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fcancers13246293\" aria-label=\"Article reference 267\" data-doi=\"10.3390\/cancers13246293\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34944914\" aria-label=\"PubMed reference 267\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 267\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Suppressing%20MDSC%20recruitment%20to%20the%20tumor%20microenvironment%20by%20antagonizing%20CXCR2%20to%20enhance%20the%20efficacy%20of%20immunotherapy&amp;journal=Cancers%20%28Basel%29&amp;doi=10.3390%2Fcancers13246293&amp;publication_year=2021&amp;author=Bullock%2CK&amp;author=Richmond%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR268\">Stewart CA, Metheny H, Iida N, Smith L, Hanson M, Steinhagen F, et al. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest. 2013;123:4859\u201374.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhslKksbzE\" aria-label=\"CAS reference 268\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24216477\" aria-label=\"PubMed reference 268\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3809773\" aria-label=\"PubMed Central reference 268\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 268\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interferon-dependent%20IL-10%20production%20by%20Tregs%20limits%20tumor%20Th17%20inflammation&amp;journal=J%20Clin%20Invest&amp;volume=123&amp;pages=4859-74&amp;publication_year=2013&amp;author=Stewart%2CCA&amp;author=Metheny%2CH&amp;author=Iida%2CN&amp;author=Smith%2CL&amp;author=Hanson%2CM&amp;author=Steinhagen%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR269\">Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, et al. IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. J Immunol. 2012;189:5638\u201348.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xhsl2jtLnJ\" aria-label=\"CAS reference 269\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23125413\" aria-label=\"PubMed reference 269\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 269\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-10%20produced%20by%20induced%20regulatory%20T%20cells%20%28iTregs%29%20controls%20colitis%20and%20pathogenic%20ex-iTregs%20during%20immunotherapy&amp;journal=J%20Immunol&amp;volume=189&amp;pages=5638-48&amp;publication_year=2012&amp;author=Schmitt%2CEG&amp;author=Haribhai%2CD&amp;author=Williams%2CJB&amp;author=Aggarwal%2CP&amp;author=Jia%2CS&amp;author=Charbonnier%2CLM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR270\">Davidson TS, Shevach EM. Polyclonal treg cells modulate T effector cell trafficking. Eur J Immunol. 2011;41(2011):2862\u201370.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXht1SrsrfK\" aria-label=\"CAS reference 270\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21728170\" aria-label=\"PubMed reference 270\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 270\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Polyclonal%20treg%20cells%20modulate%20T%20effector%20cell%20trafficking&amp;journal=Eur%20J%20Immunol&amp;volume=41&amp;issue=2011&amp;pages=2862-2870&amp;publication_year=2011&amp;author=Davidson%2CTS&amp;author=Shevach%2CEM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR271\">Budhu S, Schaer DA, Li Y, Toledo-Crow R, Panageas K, Yang X, Zhong H, Houghton AN, Silverstein SC, Merghoub T, Wolchok JD. Blockade of surface-bound TGF-beta on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment. Sci Signal. 2017;10.(494):eaak9702.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR272\">Borodkina AV, Deryabin PI, Giukova AA, Nikolsky NN. \u201cSocial Life\u201d of Senescent Cells: What Is SASP and Why Study It? Acta Naturae. 2018;10(2):4\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DC%2BC1MjosFSntg%3D%3D\" aria-label=\"CAS reference 272\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29713514\" aria-label=\"PubMed reference 272\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5916729\" aria-label=\"PubMed Central reference 272\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 272\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=%E2%80%9CSocial%20Life%E2%80%9D%20of%20Senescent%20Cells%3A%20What%20Is%20SASP%20and%20Why%20Study%20It%3F&amp;journal=Acta%20Naturae&amp;volume=10&amp;issue=2&amp;pages=4-14&amp;publication_year=2018&amp;author=Borodkina%2CAV&amp;author=Deryabin%2CPI&amp;author=Giukova%2CAA&amp;author=Nikolsky%2CNN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR273\">Levi N, Papismadov N, Solomonov I, Sagi I, Krizhanovsky V. The ECM path of senescence in aging: components and modifiers. FEBS J. 2020;287:2636\u201346.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXlt1Wgs7s%3D\" aria-label=\"CAS reference 273\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32145148\" aria-label=\"PubMed reference 273\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 273\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20ECM%20path%20of%20senescence%20in%20aging%3A%20components%20and%20modifiers&amp;journal=FEBS%20J&amp;volume=287&amp;pages=2636-46&amp;publication_year=2020&amp;author=Levi%2CN&amp;author=Papismadov%2CN&amp;author=Solomonov%2CI&amp;author=Sagi%2CI&amp;author=Krizhanovsky%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR274\">Higashiguchi M, Murakami H, Akita H, Kobayashi S, Takahama S, Iwagami Y, Yamada D, Tomimaru Y, Noda T, Gotoh K, Doki Y, Yamamoto T, Eguchi H. The impact of cellular senescence and senescence\u2011associated secretory phenotype in cancer\u2011associated fibroblasts on the malignancy of pancreatic cancer. Oncol Rep. 2023;49(5):98.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR275\">Wang T, Notta F, Navab R, Joseph J, Ibrahimov E, Xu J, et al. Senescent carcinoma-associated fibroblasts upregulate IL8 to enhance prometastatic phenotypes. Mol Cancer Res. 2017;15:3\u201314.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhs1Wmsw%3D%3D\" aria-label=\"CAS reference 275\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27678171\" aria-label=\"PubMed reference 275\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 275\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescent%20carcinoma-associated%20fibroblasts%20upregulate%20IL8%20to%20enhance%20prometastatic%20phenotypes&amp;journal=Mol%20Cancer%20Res&amp;volume=15&amp;pages=3-14&amp;publication_year=2017&amp;author=Wang%2CT&amp;author=Notta%2CF&amp;author=Navab%2CR&amp;author=Joseph%2CJ&amp;author=Ibrahimov%2CE&amp;author=Xu%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR276\">Yamao T, Yamashita YI, Yamamura K, Nakao Y, Tsukamoto M, Nakagawa S, et al. Cellular senescence, represented by expression of Caveolin-1, in cancer-associated fibroblasts promotes tumor invasion in pancreatic cancer. Ann Surg Oncol. 2019;26:1552\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30805811\" aria-label=\"PubMed reference 276\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 276\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cellular%20senescence%2C%20represented%20by%20expression%20of%20Caveolin-1%2C%20in%20cancer-associated%20fibroblasts%20promotes%20tumor%20invasion%20in%20pancreatic%20cancer&amp;journal=Ann%20Surg%20Oncol&amp;volume=26&amp;pages=1552-9&amp;publication_year=2019&amp;author=Yamao%2CT&amp;author=Yamashita%2CYI&amp;author=Yamamura%2CK&amp;author=Nakao%2CY&amp;author=Tsukamoto%2CM&amp;author=Nakagawa%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR277\">Chowdhury SR, Murphy KC, Parikh CN, DeMarco KD, Zhou L, Ruscetti M. Measuring the impact of therapy-induced senescence on NK cell phenotypes in cancer. Methods Cell Biol. 2024;190:171\u2013201.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhtFCgu7rM\" aria-label=\"CAS reference 277\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39515879\" aria-label=\"PubMed reference 277\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 277\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Measuring%20the%20impact%20of%20therapy-induced%20senescence%20on%20NK%20cell%20phenotypes%20in%20cancer&amp;journal=Methods%20Cell%20Biol&amp;volume=190&amp;pages=171-201&amp;publication_year=2024&amp;author=Chowdhury%2CSR&amp;author=Murphy%2CKC&amp;author=Parikh%2CCN&amp;author=DeMarco%2CKD&amp;author=Zhou%2CL&amp;author=Ruscetti%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR278\">Rautela J, Huntington ND. IL-15 signaling in NK cell cancer immunotherapy. Curr Opin Immunol. 2017;44:1\u20136.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28Xhsl2htrvF\" aria-label=\"CAS reference 278\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27835762\" aria-label=\"PubMed reference 278\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 278\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-15%20signaling%20in%20NK%20cell%20cancer%20immunotherapy&amp;journal=Curr%20Opin%20Immunol&amp;volume=44&amp;pages=1-6&amp;publication_year=2017&amp;author=Rautela%2CJ&amp;author=Huntington%2CND\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR279\">Ma S, Caligiuri MA, Yu J. Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy. Trends Immunol. 2022;43:833\u201347.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XitF2htrnF\" aria-label=\"CAS reference 279\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36058806\" aria-label=\"PubMed reference 279\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9612852\" aria-label=\"PubMed Central reference 279\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 279\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Harnessing%20IL-15%20signaling%20to%20potentiate%20NK%20cell-mediated%20cancer%20immunotherapy&amp;journal=Trends%20Immunol&amp;volume=43&amp;pages=833-47&amp;publication_year=2022&amp;author=Ma%2CS&amp;author=Caligiuri%2CMA&amp;author=Yu%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR280\">Admasu TD, Yu JS. Harnessing immune rejuvenation: advances in overcoming T cell senescence and exhaustion in cancer immunotherapy. Aging Cell. 2025;24:e70055.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXotFartLY%3D\" aria-label=\"CAS reference 280\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40178455\" aria-label=\"PubMed reference 280\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12073907\" aria-label=\"PubMed Central reference 280\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 280\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Harnessing%20immune%20rejuvenation%3A%20advances%20in%20overcoming%20T%20cell%20senescence%20and%20exhaustion%20in%20cancer%20immunotherapy&amp;journal=Aging%20Cell&amp;volume=24&amp;publication_year=2025&amp;author=Admasu%2CTD&amp;author=Yu%2CJS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR281\">Nizzoli G, Krietsch J, Weick A, Steinfelder S, Facciotti F, Gruarin P, et al. Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses. Blood. 2013;122:932\u201342.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhtlWltLbF\" aria-label=\"CAS reference 281\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23794066\" aria-label=\"PubMed reference 281\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 281\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Human%20CD1c%2B%20dendritic%20cells%20secrete%20high%20levels%20of%20IL-12%20and%20potently%20prime%20cytotoxic%20T-cell%20responses&amp;journal=Blood&amp;volume=122&amp;pages=932-42&amp;publication_year=2013&amp;author=Nizzoli%2CG&amp;author=Krietsch%2CJ&amp;author=Weick%2CA&amp;author=Steinfelder%2CS&amp;author=Facciotti%2CF&amp;author=Gruarin%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR282\">Mehrotra PT, Wu D, Crim JA, Mostowski HS, Siegel JP. Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes. J Immunol. 1993;151:2444\u201352.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK2cXivFSmsw%3D%3D\" aria-label=\"CAS reference 282\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8103066\" aria-label=\"PubMed reference 282\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 282\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20IL-12%20on%20the%20generation%20of%20cytotoxic%20activity%20in%20human%20CD8%2B%20T%20lymphocytes&amp;journal=J%20Immunol&amp;volume=151&amp;pages=2444-52&amp;publication_year=1993&amp;author=Mehrotra%2CPT&amp;author=Wu%2CD&amp;author=Crim%2CJA&amp;author=Mostowski%2CHS&amp;author=Siegel%2CJP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR283\">Thomas DA, Massague J. Tgf-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell. 2005;8:369\u201380.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD2MXht12gsbvK\" aria-label=\"CAS reference 283\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16286245\" aria-label=\"PubMed reference 283\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 283\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tgf-beta%20directly%20targets%20cytotoxic%20T%20cell%20functions%20during%20tumor%20evasion%20of%20immune%20surveillance&amp;journal=Cancer%20Cell&amp;volume=8&amp;pages=369-80&amp;publication_year=2005&amp;author=Thomas%2CDA&amp;author=Massague%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR284\">Sharma S, Stolina M, Lin Y, Gardner B, Miller PW, Kronenberg M, et al. T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function. J Immunol. 1999;163:5020\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DyaK1MXmvFajtbs%3D\" aria-label=\"CAS reference 284\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=10528207\" aria-label=\"PubMed reference 284\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 284\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=T%20cell-derived%20IL-10%20promotes%20lung%20cancer%20growth%20by%20suppressing%20both%20T%20cell%20and%20APC%20function&amp;journal=J%20Immunol&amp;volume=163&amp;pages=5020-8&amp;publication_year=1999&amp;author=Sharma%2CS&amp;author=Stolina%2CM&amp;author=Lin%2CY&amp;author=Gardner%2CB&amp;author=Miller%2CPW&amp;author=Kronenberg%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR285\">Ruffell B, Chang-Strachan D, Chan V, Rosenbusch A, Ho CM, Pryer N, et al. Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Cancer Cell. 2014;26:623\u201337.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhslOrtLzK\" aria-label=\"CAS reference 285\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25446896\" aria-label=\"PubMed reference 285\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4254570\" aria-label=\"PubMed Central reference 285\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 285\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Macrophage%20IL-10%20blocks%20CD8%2B%20T%20cell-dependent%20responses%20to%20chemotherapy%20by%20suppressing%20IL-12%20expression%20in%20intratumoral%20dendritic%20cells&amp;journal=Cancer%20Cell&amp;volume=26&amp;pages=623-637&amp;publication_year=2014&amp;author=Ruffell%2CB&amp;author=Chang-Strachan%2CD&amp;author=Chan%2CV&amp;author=Rosenbusch%2CA&amp;author=Ho%2CCM&amp;author=Pryer%2CN&amp;author=Daniel%2CD&amp;author=Hwang%2CES&amp;author=Rugo%2CHS&amp;author=Coussens%2CLM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR286\">Chomarat P, Banchereau J, Davoust J, Palucka AK. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol. 2000;1:510\u20134.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3cXoslyru70%3D\" aria-label=\"CAS reference 286\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11101873\" aria-label=\"PubMed reference 286\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 286\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%20switches%20the%20differentiation%20of%20monocytes%20from%20dendritic%20cells%20to%20macrophages&amp;journal=Nat%20Immunol&amp;volume=1&amp;pages=510-4&amp;publication_year=2000&amp;author=Chomarat%2CP&amp;author=Banchereau%2CJ&amp;author=Davoust%2CJ&amp;author=Palucka%2CAK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR287\">Zhang F, Wang H, Wang X, Jiang G, Liu H, Zhang G, et al. TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype. Oncotarget. 2016;7:52294\u2013306.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27418133\" aria-label=\"PubMed reference 287\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5239552\" aria-label=\"PubMed Central reference 287\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 287\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=TGF-beta%20induces%20M2-like%20macrophage%20polarization%20via%20SNAIL-mediated%20suppression%20of%20a%20pro-inflammatory%20phenotype&amp;journal=Oncotarget&amp;volume=7&amp;pages=52294-52306&amp;publication_year=2016&amp;author=Zhang%2CF&amp;author=Wang%2CH&amp;author=Wang%2CX&amp;author=Jiang%2CG&amp;author=Liu%2CH&amp;author=Zhang%2CG&amp;author=Wang%2CH&amp;author=Fang%2CR&amp;author=Bu%2CX&amp;author=Cai%2CS&amp;author=Du%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR288\">Zhu L, Fu X, Chen X, Han X, Dong P. M2 macrophages induce EMT through the TGF-beta\/Smad2 signaling pathway. Cell Biol Int. 2017;41:960\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtlemtr%2FF\" aria-label=\"CAS reference 288\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28493530\" aria-label=\"PubMed reference 288\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 288\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=M2%20macrophages%20induce%20EMT%20through%20the%20TGF-beta%2FSmad2%20signaling%20pathway&amp;journal=Cell%20Biol%20Int&amp;volume=41&amp;pages=960-8&amp;publication_year=2017&amp;author=Zhu%2CL&amp;author=Fu%2CX&amp;author=Chen%2CX&amp;author=Han%2CX&amp;author=Dong%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR289\">Ma X, Gao Y, Chen Y, Liu J, Yang C, Bao C, et al. M2-type macrophages induce Tregs generation by activating the TGF-beta\/Smad signalling pathway to promote colorectal cancer development. Onco Targets Ther. 2021;14:5391\u2013402.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34908844\" aria-label=\"PubMed reference 289\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8665883\" aria-label=\"PubMed Central reference 289\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 289\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=M2-type%20macrophages%20induce%20Tregs%20generation%20by%20activating%20the%20TGF-beta%2FSmad%20signalling%20pathway%20to%20promote%20colorectal%20cancer%20development&amp;journal=Onco%20Targets%20Ther&amp;volume=14&amp;pages=5391-5402&amp;publication_year=2021&amp;author=Ma%2CX&amp;author=Gao%2CY&amp;author=Chen%2CY&amp;author=Liu%2CJ&amp;author=Yang%2CC&amp;author=Bao%2CC&amp;author=Wang%2CY&amp;author=Feng%2CY&amp;author=Song%2CX&amp;author=Qiao%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR290\">McBride JM, Jung T, de Vries JE, Aversa G. IL-10 alters DC function via modulation of cell surface molecules resulting in impaired T-cell responses. Cell Immunol. 2002;215:162\u201372.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XmsV2ktLo%3D\" aria-label=\"CAS reference 290\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12202153\" aria-label=\"PubMed reference 290\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 290\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-10%20alters%20DC%20function%20via%20modulation%20of%20cell%20surface%20molecules%20resulting%20in%20impaired%20T-cell%20responses&amp;journal=Cell%20Immunol&amp;volume=215&amp;pages=162-72&amp;publication_year=2002&amp;author=McBride%2CJM&amp;author=Jung%2CT&amp;author=Vries%2CJE&amp;author=Aversa%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR291\">Weber R, Groth C, Lasser S, Arkhypov I, Petrova V, Altevogt P, et al. IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy. Cell Immunol. 2021;359:104254.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXisFWrs77M\" aria-label=\"CAS reference 291\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33296753\" aria-label=\"PubMed reference 291\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 291\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%20as%20a%20major%20regulator%20of%20MDSC%20activity%20and%20possible%20target%20for%20cancer%20immunotherapy&amp;journal=Cell%20Immunol&amp;volume=359&amp;publication_year=2021&amp;author=Weber%2CR&amp;author=Groth%2CC&amp;author=Lasser%2CS&amp;author=Arkhypov%2CI&amp;author=Petrova%2CV&amp;author=Altevogt%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR292\">Weber R, Riester Z, H\u00fcser L, Sticht C, Siebenmorgen A, Groth C, et al. IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma. J Immunother Cancer. 2020;8(2):e000949. <a href=\"https:\/\/doi.org\/10.1136\/jitc-2020-000949\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.1136\/jitc-2020-000949\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.1136\/jitc-2020-000949<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1136\/jitc-2020-000949\" data-track-item_id=\"10.1136\/jitc-2020-000949\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1136%2Fjitc-2020-000949\" aria-label=\"Article reference 292\" data-doi=\"10.1136\/jitc-2020-000949\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33199511\" aria-label=\"PubMed reference 292\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7670944\" aria-label=\"PubMed Central reference 292\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 292\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%20regulates%20CCR5%20expression%20and%20immunosuppressive%20capacity%20of%20MDSC%20in%20murine%20melanoma&amp;journal=J%20Immunother%20Cancer&amp;doi=10.1136%2Fjitc-2020-000949&amp;publication_year=2020&amp;author=Weber%2CR&amp;author=Riester%2CZ&amp;author=H%C3%BCser%2CL&amp;author=Sticht%2CC&amp;author=Siebenmorgen%2CA&amp;author=Groth%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR293\">Tobin RP, Jordan KR, Kapoor P, Spongberg E, Davis D, Vorwald VM, et al. IL-6 and IL-8 are linked with myeloid-derived suppressor cell accumulation and correlate with poor clinical outcomes in melanoma patients. Front Oncol. 2019;9:1223.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31781510\" aria-label=\"PubMed reference 293\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6857649\" aria-label=\"PubMed Central reference 293\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 293\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%20and%20IL-8%20are%20linked%20with%20myeloid-derived%20suppressor%20cell%20accumulation%20and%20correlate%20with%20poor%20clinical%20outcomes%20in%20melanoma%20patients&amp;journal=Front%20Oncol&amp;volume=9&amp;publication_year=2019&amp;author=Tobin%2CRP&amp;author=Jordan%2CKR&amp;author=Kapoor%2CP&amp;author=Spongberg%2CE&amp;author=Davis%2CD&amp;author=Vorwald%2CVM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR294\">Lee CS, Baek J, Han SY. The role of kinase modulators in cellular senescence for use in cancer treatment. Molecules. 2017;22(9):1411. <a href=\"https:\/\/doi.org\/10.3390\/molecules22091411\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/molecules22091411\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/molecules22091411<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/molecules22091411\" data-track-item_id=\"10.3390\/molecules22091411\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fmolecules22091411\" aria-label=\"Article reference 294\" data-doi=\"10.3390\/molecules22091411\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29295560\" aria-label=\"PubMed reference 294\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5943942\" aria-label=\"PubMed Central reference 294\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 294\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20kinase%20modulators%20in%20cellular%20senescence%20for%20use%20in%20cancer%20treatment&amp;journal=Molecules&amp;doi=10.3390%2Fmolecules22091411&amp;publication_year=2017&amp;author=Lee%2CCS&amp;author=Baek%2CJ&amp;author=Han%2CSY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR295\">Peng S, Sen B, Mazumdar T, Byers LA, Diao L, Wang J, et al. Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations. Oncotarget. 2016;7:565\u201379.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26623721\" aria-label=\"PubMed reference 295\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 295\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dasatinib%20induces%20DNA%20damage%20and%20activates%20DNA%20repair%20pathways%20leading%20to%20senescence%20in%20non-small%20cell%20lung%20cancer%20cell%20lines%20with%20kinase-inactivating%20BRAF%20mutations&amp;journal=Oncotarget&amp;volume=7&amp;pages=565-79&amp;publication_year=2016&amp;author=Peng%2CS&amp;author=Sen%2CB&amp;author=Mazumdar%2CT&amp;author=Byers%2CLA&amp;author=Diao%2CL&amp;author=Wang%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR296\">Rahimifard M, Baeeri M, Bahadar H, Moini-Nodeh S, Khalid M, Haghi-Aminjan H, Mohammadian H, Abdollahi M. Molecular and biochemical evidence of edaravone&#8217;s impact on Dasatinib-induced AGS cell senescence: a promising strategy for gastric cancer therapy. Curr Med Chem. 2025. Feb 24 (online ahead of print). <a href=\"https:\/\/doi.org\/10.2174\/0109298673338322250211111422\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.2174\/0109298673338322250211111422\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.2174\/0109298673338322250211111422<\/a>.<\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR297\">Ozsoy S, Becer E, Kabadayi H, Vatansever HS, Yucecan S. Quercetin-mediated apoptosis and cellular senescence in human colon cancer. Anticancer Agents Med Chem. 2020;20:1387\u201396.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhvFajt7fN\" aria-label=\"CAS reference 297\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32268873\" aria-label=\"PubMed reference 297\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 297\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Quercetin-mediated%20apoptosis%20and%20cellular%20senescence%20in%20human%20colon%20cancer&amp;journal=Anticancer%20Agents%20Med%20Chem&amp;volume=20&amp;pages=1387-96&amp;publication_year=2020&amp;author=Ozsoy%2CS&amp;author=Becer%2CE&amp;author=Kabadayi%2CH&amp;author=Vatansever%2CHS&amp;author=Yucecan%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR298\">Wang L, Xiong B, Lu W, Cheng Y, Zhu J, Ai G, et al. Senolytic drugs dasatinib and quercetin combined with carboplatin or olaparib reduced the peritoneal and adipose tissue metastasis of ovarian cancer. Biomed Pharmacother. 2024;174:116474.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXms1Wmt7k%3D\" aria-label=\"CAS reference 298\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38518604\" aria-label=\"PubMed reference 298\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 298\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senolytic%20drugs%20dasatinib%20and%20quercetin%20combined%20with%20carboplatin%20or%20olaparib%20reduced%20the%20peritoneal%20and%20adipose%20tissue%20metastasis%20of%20ovarian%20cancer&amp;journal=Biomed%20Pharmacother&amp;volume=174&amp;publication_year=2024&amp;author=Wang%2CL&amp;author=Xiong%2CB&amp;author=Lu%2CW&amp;author=Cheng%2CY&amp;author=Zhu%2CJ&amp;author=Ai%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR299\">Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, et al. Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age. Aging Cell. 2023;22:e13767.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhtV2ku7k%3D\" aria-label=\"CAS reference 299\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36637079\" aria-label=\"PubMed reference 299\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9924942\" aria-label=\"PubMed Central reference 299\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 299\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senolytic%20drugs%2C%20dasatinib%20and%20quercetin%2C%20attenuate%20adipose%20tissue%20inflammation%2C%20and%20ameliorate%20metabolic%20function%20in%20old%20age&amp;journal=Aging%20Cell&amp;volume=22&amp;publication_year=2023&amp;author=Islam%2CMT&amp;author=Tuday%2CE&amp;author=Allen%2CS&amp;author=Kim%2CJ&amp;author=Trott%2CDW&amp;author=Holland%2CWL&amp;author=Donato%2CAJ&amp;author=Lesniewski%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR300\">Novais EJ, Tran VA, Johnston SN, Darris KR, Roupas AJ, Sessions GA, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12:5213.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhvF2qurbO\" aria-label=\"CAS reference 300\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34480023\" aria-label=\"PubMed reference 300\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8417260\" aria-label=\"PubMed Central reference 300\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 300\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Long-term%20treatment%20with%20senolytic%20drugs%20Dasatinib%20and%20Quercetin%20ameliorates%20age-dependent%20intervertebral%20disc%20degeneration%20in%20mice&amp;journal=Nat%20Commun&amp;volume=12&amp;publication_year=2021&amp;author=Novais%2CEJ&amp;author=Tran%2CVA&amp;author=Johnston%2CSN&amp;author=Darris%2CKR&amp;author=Roupas%2CAJ&amp;author=Sessions%2CGA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR301\">Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18\u201328.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30279143\" aria-label=\"PubMed reference 301\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6197652\" aria-label=\"PubMed Central reference 301\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 301\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Fisetin%20is%20a%20senotherapeutic%20that%20extends%20health%20and%20lifespan&amp;journal=EBioMedicine&amp;volume=36&amp;pages=18-28&amp;publication_year=2018&amp;author=Yousefzadeh%2CMJ&amp;author=Zhu%2CY&amp;author=McGowan%2CSJ&amp;author=Angelini%2CL&amp;author=Fuhrmann-Stroissnigg%2CH&amp;author=Xu%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR302\">Rzeszutek I, Cybularczyk-Cecotka M, Deregowska A, Stec P, Wnuk M, Kolodziej O, et al. New mitochondria-targeted fisetin derivative compromises mitophagy and limits survival of drug-induced senescent breast cancer cells. J Med Chem. 2024;67:17676\u201389.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXitVCgtbnL\" aria-label=\"CAS reference 302\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39322603\" aria-label=\"PubMed reference 302\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11472315\" aria-label=\"PubMed Central reference 302\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 302\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=New%20mitochondria-targeted%20fisetin%20derivative%20compromises%20mitophagy%20and%20limits%20survival%20of%20drug-induced%20senescent%20breast%20cancer%20cells&amp;journal=J%20Med%20Chem&amp;volume=67&amp;pages=17676-17689&amp;publication_year=2024&amp;author=Rzeszutek%2CI&amp;author=Cybularczyk-Cecotka%2CM&amp;author=Deregowska%2CA&amp;author=Stec%2CP&amp;author=Wnuk%2CM&amp;author=Kolodziej%2CO&amp;author=Kalafut%2CJ&amp;author=Wawruszak%2CA&amp;author=Witkowski%2CW&amp;author=Litwinienko%2CG&amp;author=Lewinska%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR303\">Mullen M, Nelson AL, Goff A, Billings J, Kloser H, Huard C, et al. Fisetin attenuates cellular senescence accumulation during culture expansion of human adipose-derived stem cells. Stem Cells. 2023;41:698\u2013710.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXhvVWrur%2FF\" aria-label=\"CAS reference 303\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37279940\" aria-label=\"PubMed reference 303\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10346405\" aria-label=\"PubMed Central reference 303\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 303\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Fisetin%20attenuates%20cellular%20senescence%20accumulation%20during%20culture%20expansion%20of%20human%20adipose-derived%20stem%20cells&amp;journal=Stem%20Cells&amp;volume=41&amp;pages=698-710&amp;publication_year=2023&amp;author=Mullen%2CM&amp;author=Nelson%2CAL&amp;author=Goff%2CA&amp;author=Billings%2CJ&amp;author=Kloser%2CH&amp;author=Huard%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR304\">Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, et al. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024;23:e14060.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXis1aksL%2FK\" aria-label=\"CAS reference 304\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38062873\" aria-label=\"PubMed reference 304\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 304\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Intermittent%20supplementation%20with%20fisetin%20improves%20arterial%20function%20in%20old%20mice%20by%20decreasing%20cellular%20senescence&amp;journal=Aging%20Cell&amp;volume=23&amp;publication_year=2024&amp;author=Mahoney%2CSA&amp;author=Venkatasubramanian%2CR&amp;author=Darrah%2CMA&amp;author=Ludwig%2CKR&amp;author=VanDongen%2CNS&amp;author=Greenberg%2CNT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR305\">Jochems F, Baltira C, MacDonald JA, Daniels V, Mathur A, de Gooijer MC, et al. Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state. Cell Death Differ. 2025;32:855\u201365.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXivVClt77L\" aria-label=\"CAS reference 305\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39706991\" aria-label=\"PubMed reference 305\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 305\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senolysis%20by%20ABT-263%20is%20associated%20with%20inherent%20apoptotic%20dependence%20of%20cancer%20cells%20derived%20from%20the%20non-senescent%20state&amp;journal=Cell%20Death%20Differ&amp;volume=32&amp;pages=855-65&amp;publication_year=2025&amp;author=Jochems%2CF&amp;author=Baltira%2CC&amp;author=MacDonald%2CJA&amp;author=Daniels%2CV&amp;author=Mathur%2CA&amp;author=Gooijer%2CMC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR306\">Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med. 2016;22:78\u201383.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXitVWqtrrM\" aria-label=\"CAS reference 306\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26657143\" aria-label=\"PubMed reference 306\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 306\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Clearance%20of%20senescent%20cells%20by%20ABT263%20rejuvenates%20aged%20hematopoietic%20stem%20cells%20in%20mice&amp;journal=Nat%20Med&amp;volume=22&amp;pages=78-83&amp;publication_year=2016&amp;author=Chang%2CJ&amp;author=Wang%2CY&amp;author=Shao%2CL&amp;author=Laberge%2CRM&amp;author=Demaria%2CM&amp;author=Campisi%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR307\">Zhu RZ, Li BS, Gao SS, Seo JH, Choi BM. Luteolin inhibits H2O2-induced cellular senescence via modulation of SIRT1 and p53. Korean J Physiol Pharmacol. 2021;25:297\u2013305.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXitlGgu7jJ\" aria-label=\"CAS reference 307\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34187948\" aria-label=\"PubMed reference 307\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8255127\" aria-label=\"PubMed Central reference 307\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 307\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Luteolin%20inhibits%20H2O2-induced%20cellular%20senescence%20via%20modulation%20of%20SIRT1%20and%20p53&amp;journal=Korean%20J%20Physiol%20Pharmacol&amp;volume=25&amp;pages=297-305&amp;publication_year=2021&amp;author=Zhu%2CRZ&amp;author=Li%2CBS&amp;author=Gao%2CSS&amp;author=Seo%2CJH&amp;author=Choi%2CBM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR308\">Yan Y, Huang H, Su T, Huang W, Wu X, Chen X, et al. Luteolin mitigates photoaging caused by UVA-induced fibroblast senescence by modulating oxidative stress pathways. Int J Mol Sci. 2025;26(5):1809. <a href=\"https:\/\/doi.org\/10.3390\/ijms26051809\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/ijms26051809\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/ijms26051809<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms26051809\" data-track-item_id=\"10.3390\/ijms26051809\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms26051809\" aria-label=\"Article reference 308\" data-doi=\"10.3390\/ijms26051809\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=41155476\" aria-label=\"PubMed reference 308\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC12563792\" aria-label=\"PubMed Central reference 308\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 308\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Luteolin%20mitigates%20photoaging%20caused%20by%20UVA-induced%20fibroblast%20senescence%20by%20modulating%20oxidative%20stress%20pathways&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms26051809&amp;publication_year=2025&amp;author=Yan%2CY&amp;author=Huang%2CH&amp;author=Su%2CT&amp;author=Huang%2CW&amp;author=Wu%2CX&amp;author=Chen%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR309\">Sun Y, Hu X, Hu G, Xu C, Jiang H. Curcumin attenuates hydrogen peroxide-induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells. Biol Pharm Bull. 2015;38(2):1134\u201341.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28Xis1KitLs%3D\" aria-label=\"CAS reference 309\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26235577\" aria-label=\"PubMed reference 309\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 309\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Curcumin%20attenuates%20hydrogen%20peroxide-induced%20premature%20senescence%20via%20the%20activation%20of%20SIRT1%20in%20human%20umbilical%20vein%20endothelial%20cells&amp;journal=Biol%20Pharm%20Bull&amp;volume=38&amp;issue=2&amp;pages=1134-41&amp;publication_year=2015&amp;author=Sun%2CY&amp;author=Hu%2CX&amp;author=Hu%2CG&amp;author=Xu%2CC&amp;author=Jiang%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR310\">Jin H, Lian N, Zhang F, Chen L, Chen Q, Lu C, et al. Activation of PPARgamma\/P53 signaling is required for curcumin to induce hepatic stellate cell senescence. Cell Death Dis. 2016;7:e2189.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28Xmt1ejs7c%3D\" aria-label=\"CAS reference 310\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27077805\" aria-label=\"PubMed reference 310\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4855671\" aria-label=\"PubMed Central reference 310\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 310\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Activation%20of%20PPARgamma%2FP53%20signaling%20is%20required%20for%20curcumin%20to%20induce%20hepatic%20stellate%20cell%20senescence&amp;journal=Cell%20Death%20Dis&amp;volume=7&amp;publication_year=2016&amp;author=Jin%2CH&amp;author=Lian%2CN&amp;author=Zhang%2CF&amp;author=Chen%2CL&amp;author=Chen%2CQ&amp;author=Lu%2CC&amp;author=Bian%2CM&amp;author=Shao%2CJ&amp;author=Wu%2CL&amp;author=Zheng%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR311\">Grabowska W, Mosieniak G, Achtabowska N, Czochara R, Litwinienko G, Bojko A, et al. Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence. Biogerontology. 2019;20:783\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31372798\" aria-label=\"PubMed reference 311\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6790191\" aria-label=\"PubMed Central reference 311\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 311\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Curcumin%20induces%20multiple%20signaling%20pathways%20leading%20to%20vascular%20smooth%20muscle%20cell%20senescence&amp;journal=Biogerontology&amp;volume=20&amp;pages=783-98&amp;publication_year=2019&amp;author=Grabowska%2CW&amp;author=Mosieniak%2CG&amp;author=Achtabowska%2CN&amp;author=Czochara%2CR&amp;author=Litwinienko%2CG&amp;author=Bojko%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR312\">Li W, He Y, Zhang R, Zheng G, Zhou D. The curcumin analog EF24 is a novel senolytic agent. Aging (Albany NY). 2019;11(2):771\u201382.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXitlagtL%2FP\" aria-label=\"CAS reference 312\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30694217\" aria-label=\"PubMed reference 312\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 312\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20curcumin%20analog%20EF24%20is%20a%20novel%20senolytic%20agent&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=11&amp;issue=2&amp;pages=771-82&amp;publication_year=2019&amp;author=Li%2CW&amp;author=He%2CY&amp;author=Zhang%2CR&amp;author=Zheng%2CG&amp;author=Zhou%2CD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR313\">Zhang Y, Liu J, Zheng R, Hou K, Zhang Y, Jia T, et al. Curcumin analogue EF24 prevents alveolar epithelial cell senescence to ameliorate idiopathic pulmonary fibrosis via activation of PTEN. Phytomedicine. 2024;133:155882.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhs1yqsb7J\" aria-label=\"CAS reference 313\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39096545\" aria-label=\"PubMed reference 313\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 313\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Curcumin%20analogue%20EF24%20prevents%20alveolar%20epithelial%20cell%20senescence%20to%20ameliorate%20idiopathic%20pulmonary%20fibrosis%20via%20activation%20of%20PTEN&amp;journal=Phytomedicine&amp;volume=133&amp;publication_year=2024&amp;author=Zhang%2CY&amp;author=Liu%2CJ&amp;author=Zheng%2CR&amp;author=Hou%2CK&amp;author=Zhang%2CY&amp;author=Jia%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR314\">Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, et al. Identification of HSP90 inhibitors as a novel class of senolytics. Nat Commun. 2017;8:422.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28871086\" aria-label=\"PubMed reference 314\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5583353\" aria-label=\"PubMed Central reference 314\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 314\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Identification%20of%20HSP90%20inhibitors%20as%20a%20novel%20class%20of%20senolytics&amp;journal=Nat%20Commun&amp;volume=8&amp;publication_year=2017&amp;author=Fuhrmann-Stroissnigg%2CH&amp;author=Ling%2CYY&amp;author=Zhao%2CJ&amp;author=McGowan%2CSJ&amp;author=Zhu%2CY&amp;author=Brooks%2CRW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR315\">Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD. Hsp90 inhibitors as senolytic drugs to extend healthy aging. Cell Cycle. 2018;17:1048\u201355.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhtlyrtrfM\" aria-label=\"CAS reference 315\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29886783\" aria-label=\"PubMed reference 315\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6110594\" aria-label=\"PubMed Central reference 315\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 315\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Hsp90%20inhibitors%20as%20senolytic%20drugs%20to%20extend%20healthy%20aging&amp;journal=Cell%20Cycle&amp;volume=17&amp;pages=1048-55&amp;publication_year=2018&amp;author=Fuhrmann-Stroissnigg%2CH&amp;author=Niedernhofer%2CLJ&amp;author=Robbins%2CPD\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR316\">Wang Y, Chang J, Liu X, Zhang X, Zhang S, Zhang X, et al. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging (Albany NY). 2016;8:2915\u201326.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhtVyis7%2FK\" aria-label=\"CAS reference 316\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27913811\" aria-label=\"PubMed reference 316\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 316\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Discovery%20of%20piperlongumine%20as%20a%20potential%20novel%20lead%20for%20the%20development%20of%20senolytic%20agents&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=8&amp;pages=2915-26&amp;publication_year=2016&amp;author=Wang%2CY&amp;author=Chang%2CJ&amp;author=Liu%2CX&amp;author=Zhang%2CX&amp;author=Zhang%2CS&amp;author=Zhang%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR317\">Kapoor N, Bhattacharjee A, Chakraborty S, Katti DS. Piperlongumine mediates amelioration of osteoarthritis via inhibition of chondrocyte senescence and inflammation in a goat ex vivo model. Eur J Pharmacol. 2023;961:176136.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitlOnsrbM\" aria-label=\"CAS reference 317\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37944845\" aria-label=\"PubMed reference 317\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 317\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Piperlongumine%20mediates%20amelioration%20of%20osteoarthritis%20via%20inhibition%20of%20chondrocyte%20senescence%20and%20inflammation%20in%20a%20goat%20ex%20vivo%20model&amp;journal=Eur%20J%20Pharmacol&amp;volume=961&amp;publication_year=2023&amp;author=Kapoor%2CN&amp;author=Bhattacharjee%2CA&amp;author=Chakraborty%2CS&amp;author=Katti%2CDS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR318\">Bode-Boger SM, Martens-Lobenhoffer J, Tager M, Schroder H, Scalera F. Aspirin reduces endothelial cell senescence. Biochem Biophys Res Commun. 2005;334:1226\u201332.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=16039999\" aria-label=\"PubMed reference 318\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 318\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Aspirin%20reduces%20endothelial%20cell%20senescence&amp;journal=Biochem%20Biophys%20Res%20Commun&amp;volume=334&amp;pages=1226-32&amp;publication_year=2005&amp;author=Bode-Boger%2CSM&amp;author=Martens-Lobenhoffer%2CJ&amp;author=Tager%2CM&amp;author=Schroder%2CH&amp;author=Scalera%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR319\">Feng M, Kim J, Field K, Reid C, Chatzistamou I, Shim M. Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence. FASEB Bioadv. 2019;1:579\u201390.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhslKitr%2FO\" aria-label=\"CAS reference 319\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32123852\" aria-label=\"PubMed reference 319\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6996307\" aria-label=\"PubMed Central reference 319\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 319\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Aspirin%20ameliorates%20the%20long-term%20adverse%20effects%20of%20doxorubicin%20through%20suppression%20of%20cellular%20senescence&amp;journal=FASEB%20Bioadv&amp;volume=1&amp;pages=579-90&amp;publication_year=2019&amp;author=Feng%2CM&amp;author=Kim%2CJ&amp;author=Field%2CK&amp;author=Reid%2CC&amp;author=Chatzistamou%2CI&amp;author=Shim%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR320\">Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell. 2016;15:428\u201335.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XksVKqsbw%3D\" aria-label=\"CAS reference 320\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26711051\" aria-label=\"PubMed reference 320\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4854923\" aria-label=\"PubMed Central reference 320\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 320\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Identification%20of%20a%20novel%20senolytic%20agent%2C%20navitoclax%2C%20targeting%20the%20Bcl-2%20family%20of%20anti-apoptotic%20factors&amp;journal=Aging%20Cell&amp;volume=15&amp;pages=428-35&amp;publication_year=2016&amp;author=Zhu%2CY&amp;author=Tchkonia%2CT&amp;author=Fuhrmann-Stroissnigg%2CH&amp;author=Dai%2CHM&amp;author=Ling%2CYY&amp;author=Stout%2CMB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR321\">Mohamad Anuar NN, Nor Hisam NS, Liew SL, Ugusman A. Clinical review: Navitoclax as a pro-apoptotic and anti-fibrotic agent. Front Pharmacol. 2020;11:564108.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33381025\" aria-label=\"PubMed reference 321\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7768911\" aria-label=\"PubMed Central reference 321\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 321\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Clinical%20review%3A%20Navitoclax%20as%20a%20pro-apoptotic%20and%20anti-fibrotic%20agent&amp;journal=Front%20Pharmacol&amp;volume=11&amp;publication_year=2020&amp;author=Mohamad%20Anuar%2CNN&amp;author=Nor%20Hisam%2CNS&amp;author=Liew%2CSL&amp;author=Ugusman%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR322\">Wong M, Tan N, Zha J, Peale FV, Yue P, Fairbrother WJ, et al. Navitoclax (ABT-263) reduces Bcl-x(L)-mediated chemoresistance in ovarian cancer models. Mol Cancer Ther. 2012;11:1026\u201335.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38Xltl2ntLg%3D\" aria-label=\"CAS reference 322\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22302098\" aria-label=\"PubMed reference 322\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 322\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Navitoclax%20%28ABT-263%29%20reduces%20Bcl-x%28L%29-mediated%20chemoresistance%20in%20ovarian%20cancer%20models&amp;journal=Mol%20Cancer%20Ther&amp;volume=11&amp;pages=1026-35&amp;publication_year=2012&amp;author=Wong%2CM&amp;author=Tan%2CN&amp;author=Zha%2CJ&amp;author=Peale%2CFV&amp;author=Yue%2CP&amp;author=Fairbrother%2CWJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR323\">Nor Hisam NS, Ugusman A, Rajab NF, Ahmad MF, Fenech M, Liew SL, et al. Combination therapy of navitoclax with chemotherapeutic agents in solid tumors and blood cancer: a review of current evidence. Pharmaceutics. 2021;13(9):1353. <a href=\"https:\/\/doi.org\/10.3390\/pharmaceutics13091353\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/pharmaceutics13091353\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/pharmaceutics13091353<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/pharmaceutics13091353\" data-track-item_id=\"10.3390\/pharmaceutics13091353\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fpharmaceutics13091353\" aria-label=\"Article reference 323\" data-doi=\"10.3390\/pharmaceutics13091353\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34575429\" aria-label=\"PubMed reference 323\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8468743\" aria-label=\"PubMed Central reference 323\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 323\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Combination%20therapy%20of%20navitoclax%20with%20chemotherapeutic%20agents%20in%20solid%20tumors%20and%20blood%20cancer%3A%20a%20review%20of%20current%20evidence&amp;journal=Pharmaceutics&amp;doi=10.3390%2Fpharmaceutics13091353&amp;publication_year=2021&amp;author=Nor%20Hisam%2CNS&amp;author=Ugusman%2CA&amp;author=Rajab%2CNF&amp;author=Ahmad%2CMF&amp;author=Fenech%2CM&amp;author=Liew%2CSL&amp;author=Mohamad%20Anuar%2CNN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR324\">Angelopoulou A, Theocharous G, Valakos D, Polyzou A, Magkouta S, Myrianthopoulos V, et al. Loss of the tumour suppressor LKB1\/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy. Mol Cancer. 2024;23:147.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhs1egtrrF\" aria-label=\"CAS reference 324\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39048991\" aria-label=\"PubMed reference 324\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11270803\" aria-label=\"PubMed Central reference 324\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 324\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Loss%20of%20the%20tumour%20suppressor%20LKB1%2FSTK11%20uncovers%20a%20leptin-mediated%20sensitivity%20mechanism%20to%20mitochondrial%20uncouplers%20for%20targeted%20cancer%20therapy&amp;journal=Mol%20Cancer&amp;volume=23&amp;publication_year=2024&amp;author=Angelopoulou%2CA&amp;author=Theocharous%2CG&amp;author=Valakos%2CD&amp;author=Polyzou%2CA&amp;author=Magkouta%2CS&amp;author=Myrianthopoulos%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR325\">Russo GL, Russo M, Spagnuolo C, Tedesco I, Bilotto S, Iannitti R, et al. Quercetin: a pleiotropic kinase inhibitor against cancer. Cancer Treat Res. 2014;159:185\u2013205.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXlvVWhsbk%3D\" aria-label=\"CAS reference 325\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24114481\" aria-label=\"PubMed reference 325\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 325\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Quercetin%3A%20a%20pleiotropic%20kinase%20inhibitor%20against%20cancer&amp;journal=Cancer%20Treat%20Res&amp;volume=159&amp;pages=185-205&amp;publication_year=2014&amp;author=Russo%2CGL&amp;author=Russo%2CM&amp;author=Spagnuolo%2CC&amp;author=Tedesco%2CI&amp;author=Bilotto%2CS&amp;author=Iannitti%2CR&amp;author=Palumbo%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR326\">Russo GL, Russo M, Spagnuolo C. The pleiotropic flavonoid quercetin: from its metabolism to the inhibition of protein kinases in chronic lymphocytic leukemia. Food Funct. 2014;5:2393\u2013401.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXhtFOjt7bI\" aria-label=\"CAS reference 326\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=25096193\" aria-label=\"PubMed reference 326\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 326\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20pleiotropic%20flavonoid%20quercetin%3A%20from%20its%20metabolism%20to%20the%20inhibition%20of%20protein%20kinases%20in%20chronic%20lymphocytic%20leukemia&amp;journal=Food%20Funct&amp;volume=5&amp;pages=2393-401&amp;publication_year=2014&amp;author=Russo%2CGL&amp;author=Russo%2CM&amp;author=Spagnuolo%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR327\">Imran M, Saeed F, Gilani SA, Shariati MA, Imran A, Afzaal M, et al. Fisetin: an anticancer perspective. Food Sci Nutr. 2021;9:3\u201316.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXlt1amsrw%3D\" aria-label=\"CAS reference 327\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33473265\" aria-label=\"PubMed reference 327\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 327\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Fisetin%3A%20an%20anticancer%20perspective&amp;journal=Food%20Sci%20Nutr&amp;volume=9&amp;pages=3-16&amp;publication_year=2021&amp;author=Imran%2CM&amp;author=Saeed%2CF&amp;author=Gilani%2CSA&amp;author=Shariati%2CMA&amp;author=Imran%2CA&amp;author=Afzaal%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR328\">Rahmani AH, Almatroudi A, Allemailem KS, Khan AA, Almatroodi SA. The potential role of fisetin, a flavonoid in cancer prevention and treatment. Molecules. 2022;27(24):9009. <a href=\"https:\/\/doi.org\/10.3390\/molecules27249009\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/molecules27249009\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/molecules27249009<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/molecules27249009\" data-track-item_id=\"10.3390\/molecules27249009\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fmolecules27249009\" aria-label=\"Article reference 328\" data-doi=\"10.3390\/molecules27249009\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36558146\" aria-label=\"PubMed reference 328\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9782831\" aria-label=\"PubMed Central reference 328\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 328\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20potential%20role%20of%20fisetin%2C%20a%20flavonoid%20in%20cancer%20prevention%20and%20treatment&amp;journal=Molecules&amp;doi=10.3390%2Fmolecules27249009&amp;publication_year=2022&amp;author=Rahmani%2CAH&amp;author=Almatroudi%2CA&amp;author=Allemailem%2CKS&amp;author=Khan%2CAA&amp;author=Almatroodi%2CSA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR329\">Samaraweera L, Adomako A, Rodriguez-Gabin A, McDaid HM. A novel indication for panobinostat as a senolytic drug in NSCLC and HNSCC. Sci Rep. 2017;7:1900.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28507307\" aria-label=\"PubMed reference 329\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5432488\" aria-label=\"PubMed Central reference 329\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 329\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20novel%20indication%20for%20panobinostat%20as%20a%20senolytic%20drug%20in%20NSCLC%20and%20HNSCC&amp;journal=Sci%20Rep&amp;volume=7&amp;publication_year=2017&amp;author=Samaraweera%2CL&amp;author=Adomako%2CA&amp;author=Rodriguez-Gabin%2CA&amp;author=McDaid%2CHM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR330\">Ibrahim N, Buchbinder EI, Granter SR, Rodig SJ, Giobbie-Hurder A, Becerra C, et al. A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma. Cancer Med. 2016;5:3041\u201350.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XhvFemu7nK\" aria-label=\"CAS reference 330\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27748045\" aria-label=\"PubMed reference 330\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5119958\" aria-label=\"PubMed Central reference 330\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 330\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20phase%20I%20trial%20of%20panobinostat%20%28LBH589%29%20in%20patients%20with%20metastatic%20melanoma&amp;journal=Cancer%20Med&amp;volume=5&amp;pages=3041-50&amp;publication_year=2016&amp;author=Ibrahim%2CN&amp;author=Buchbinder%2CEI&amp;author=Granter%2CSR&amp;author=Rodig%2CSJ&amp;author=Giobbie-Hurder%2CA&amp;author=Becerra%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR331\">Wakita M, Takahashi A, Sano O, Loo TM, Imai Y, Narukawa M, et al. A bet family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells. Nat Commun. 2020;11:1935.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXnvVCis7g%3D\" aria-label=\"CAS reference 331\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32321921\" aria-label=\"PubMed reference 331\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7176673\" aria-label=\"PubMed Central reference 331\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 331\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20bet%20family%20protein%20degrader%20provokes%20senolysis%20by%20targeting%20NHEJ%20and%20autophagy%20in%20senescent%20cells&amp;journal=Nat%20Commun&amp;volume=11&amp;publication_year=2020&amp;author=Wakita%2CM&amp;author=Takahashi%2CA&amp;author=Sano%2CO&amp;author=Loo%2CTM&amp;author=Imai%2CY&amp;author=Narukawa%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR332\">Wilson WH, O\u2019Connor OA, Czuczman MS, LaCasce AS, Gerecitano JF, Leonard JP, et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol. 2010;11:1149\u201359.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXhsVyhsLbN\" aria-label=\"CAS reference 332\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21094089\" aria-label=\"PubMed reference 332\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3025495\" aria-label=\"PubMed Central reference 332\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 332\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Navitoclax%2C%20a%20targeted%20high-affinity%20inhibitor%20of%20BCL-2%2C%20in%20lymphoid%20malignancies%3A%20a%20phase%201%20dose-escalation%20study%20of%20safety%2C%20pharmacokinetics%2C%20pharmacodynamics%2C%20and%20antitumour%20activity&amp;journal=Lancet%20Oncol&amp;volume=11&amp;pages=1149-1159&amp;publication_year=2010&amp;author=Wilson%2CWH&amp;author=O%27Connor%2COA&amp;author=Czuczman%2CMS&amp;author=LaCasce%2CAS&amp;author=Gerecitano%2CJF&amp;author=Leonard%2CJP&amp;author=Tulpule%2CA&amp;author=Dunleavy%2CK&amp;author=Xiong%2CH&amp;author=Chiu%2CYL&amp;author=Cui%2CY&amp;author=Busman%2CT&amp;author=Elmore%2CSW&amp;author=Rosenberg%2CSH&amp;author=Krivoshik%2CAP&amp;author=Enschede%2CSH&amp;author=Humerickhouse%2CRA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR333\">Yu L, Liu J, Huang X, Jiang Q. Adverse effects of dasatinib on glucose-lipid metabolism in patients with chronic myeloid leukaemia in the chronic phase. Sci Rep. 2019;9:17601.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31772301\" aria-label=\"PubMed reference 333\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6879732\" aria-label=\"PubMed Central reference 333\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 333\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Adverse%20effects%20of%20dasatinib%20on%20glucose-lipid%20metabolism%20in%20patients%20with%20chronic%20myeloid%20leukaemia%20in%20the%20chronic%20phase&amp;journal=Sci%20Rep&amp;volume=9&amp;publication_year=2019&amp;author=Yu%2CL&amp;author=Liu%2CJ&amp;author=Huang%2CX&amp;author=Jiang%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR334\">Gandhi L, Camidge DR, Ribeiro de Oliveira M, Bonomi P, Gandara D, Khaira D, et al. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J Clin Oncol. 2011;29:909\u201316.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXktlelsbw%3D\" aria-label=\"CAS reference 334\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21282543\" aria-label=\"PubMed reference 334\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4668282\" aria-label=\"PubMed Central reference 334\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 334\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Phase%20I%20study%20of%20Navitoclax%20%28ABT-263%29%2C%20a%20novel%20Bcl-2%20family%20inhibitor%2C%20in%20patients%20with%20small-cell%20lung%20cancer%20and%20other%20solid%20tumors&amp;journal=J%20Clin%20Oncol&amp;volume=29&amp;pages=909-916&amp;publication_year=2011&amp;author=Gandhi%2CL&amp;author=Camidge%2CDR&amp;author=Ribeiro%20de%20Oliveira%2CM&amp;author=Bonomi%2CP&amp;author=Gandara%2CD&amp;author=Khaira%2CD&amp;author=Hann%2CCL&amp;author=McKeegan%2CEM&amp;author=Litvinovich%2CE&amp;author=Hemken%2CPM&amp;author=Dive%2CC&amp;author=Enschede%2CSH&amp;author=Nolan%2CC&amp;author=Chiu%2CYL&amp;author=Busman%2CT&amp;author=Xiong%2CH&amp;author=Krivoshik%2CAP&amp;author=Humerickhouse%2CR&amp;author=Shapiro%2CGI&amp;author=Rudin%2CCM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR335\">Mu\u00f1oz-Esp\u00edn D, Rovira M, Galiana I, Gim\u00e9nez C, Lozano-Torres B, Paez-Ribes M, et al. A versatile drug delivery system targeting senescent cells. EMBO Mol Med. 2018;10(9):e9355. <a href=\"https:\/\/doi.org\/10.15252\/emmm.201809355\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.15252\/emmm.201809355\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.15252\/emmm.201809355<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.15252\/emmm.201809355\" data-track-item_id=\"10.15252\/emmm.201809355\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.15252%2Femmm.201809355\" aria-label=\"Article reference 335\" data-doi=\"10.15252\/emmm.201809355\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30012580\" aria-label=\"PubMed reference 335\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6127887\" aria-label=\"PubMed Central reference 335\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 335\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20versatile%20drug%20delivery%20system%20targeting%20senescent%20cells&amp;journal=EMBO%20Mol%20Med&amp;doi=10.15252%2Femmm.201809355&amp;publication_year=2018&amp;author=Mu%C3%B1oz-Esp%C3%ADn%2CD&amp;author=Rovira%2CM&amp;author=Galiana%2CI&amp;author=Gim%C3%A9nez%2CC&amp;author=Lozano-Torres%2CB&amp;author=Paez-Ribes%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR336\">Magkouta S, Veroutis D, Papaspyropoulos A, Georgiou M, Lougiakis N, Pippa N, et al. Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog. Nat Aging. 2025;5:162\u201375.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXktlaktw%3D%3D\" aria-label=\"CAS reference 336\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39730824\" aria-label=\"PubMed reference 336\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 336\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Generation%20of%20a%20selective%20senolytic%20platform%20using%20a%20micelle-encapsulated%20Sudan%20Black%20B%20conjugated%20analog&amp;journal=Nat%20Aging&amp;volume=5&amp;pages=162-175&amp;publication_year=2025&amp;author=Magkouta%2CS&amp;author=Veroutis%2CD&amp;author=Papaspyropoulos%2CA&amp;author=Georgiou%2CM&amp;author=Lougiakis%2CN&amp;author=Pippa%2CN&amp;author=Havaki%2CS&amp;author=Palaiologou%2CA&amp;author=Thanos%2CDF&amp;author=Kambas%2CK&amp;author=Lagopati%2CN&amp;author=Boukos%2CN&amp;author=Pouli%2CN&amp;author=Marakos%2CP&amp;author=Kotsinas%2CA&amp;author=Thanos%2CD&amp;author=Evangelou%2CK&amp;author=Sampaziotis%2CF&amp;author=Tamvakopoulos%2CC&amp;author=Pispas%2CS&amp;author=Petty%2CR&amp;author=Kotopoulos%2CN&amp;author=Gorgoulis%2CVG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR337\">Admasu TD, Kim K, Rae M, Avelar R, Gonciarz RL, Rebbaa A, et al. Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis. Cell Rep. 2023;42:112058.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXisFSjsrk%3D\" aria-label=\"CAS reference 337\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36753419\" aria-label=\"PubMed reference 337\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 337\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Selective%20ablation%20of%20primary%20and%20paracrine%20senescent%20cells%20by%20targeting%20iron%20dyshomeostasis&amp;journal=Cell%20Rep&amp;volume=42&amp;publication_year=2023&amp;author=Admasu%2CTD&amp;author=Kim%2CK&amp;author=Rae%2CM&amp;author=Avelar%2CR&amp;author=Gonciarz%2CRL&amp;author=Rebbaa%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR338\">Wang R, Sunchu B, Perez VI. Rapamycin and the inhibition of the secretory phenotype. Exp Gerontol. 2017;94:89\u201392.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXivVymu74%3D\" aria-label=\"CAS reference 338\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28167236\" aria-label=\"PubMed reference 338\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 338\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Rapamycin%20and%20the%20inhibition%20of%20the%20secretory%20phenotype&amp;journal=Exp%20Gerontol&amp;volume=94&amp;pages=89-92&amp;publication_year=2017&amp;author=Wang%2CR&amp;author=Sunchu%2CB&amp;author=Perez%2CVI\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR339\">Turgut S, Atasever E, Cebe T, Andican G, Cakatay U. Senotherapeutic repurposing of metformin for age-related diseases and their signaling pathways. Mol Biol Rep. 2025;52:410.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXpsFKns7c%3D\" aria-label=\"CAS reference 339\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40261556\" aria-label=\"PubMed reference 339\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 339\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senotherapeutic%20repurposing%20of%20metformin%20for%20age-related%20diseases%20and%20their%20signaling%20pathways&amp;journal=Mol%20Biol%20Rep&amp;volume=52&amp;publication_year=2025&amp;author=Turgut%2CS&amp;author=Atasever%2CE&amp;author=Cebe%2CT&amp;author=Andican%2CG&amp;author=Cakatay%2CU\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR340\">Hu Q, Peng J, Jiang L, Li W, Su Q, Zhang J, et al. Metformin as a senostatic drug enhances the anticancer efficacy of CDK4\/6 inhibitor in head and neck squamous cell carcinoma. Cell Death Dis. 2020;11:925.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXitlCqurvM\" aria-label=\"CAS reference 340\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33116117\" aria-label=\"PubMed reference 340\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7595194\" aria-label=\"PubMed Central reference 340\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 340\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Metformin%20as%20a%20senostatic%20drug%20enhances%20the%20anticancer%20efficacy%20of%20CDK4%2F6%20inhibitor%20in%20head%20and%20neck%20squamous%20cell%20carcinoma&amp;journal=Cell%20Death%20Dis&amp;volume=11&amp;publication_year=2020&amp;author=Hu%2CQ&amp;author=Peng%2CJ&amp;author=Jiang%2CL&amp;author=Li%2CW&amp;author=Su%2CQ&amp;author=Zhang%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR341\">Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, et al. Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Sci Transl Med. 2016;8:362ra144.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27797960\" aria-label=\"PubMed reference 341\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 341\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Senescence-associated%20secretory%20phenotype%20contributes%20to%20pathological%20angiogenesis%20in%20retinopathy&amp;journal=Sci%20Transl%20Med&amp;volume=8&amp;publication_year=2016&amp;author=Oubaha%2CM&amp;author=Miloudi%2CK&amp;author=Dejda%2CA&amp;author=Guber%2CV&amp;author=Mawambo%2CG&amp;author=Germain%2CMA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR342\">Pemmaraju N, Garcia JS, Potluri J, Harb JG, Sun Y, Jung P, et al. Addition of navitoclax to ongoing ruxolitinib treatment in patients with myelofibrosis (REFINE): a post-hoc analysis of molecular biomarkers in a phase 2 study. Lancet Haematol. 2022;9:e434\u201344.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXis1Ort7g%3D\" aria-label=\"CAS reference 342\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35576960\" aria-label=\"PubMed reference 342\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 342\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Addition%20of%20navitoclax%20to%20ongoing%20ruxolitinib%20treatment%20in%20patients%20with%20myelofibrosis%20%28REFINE%29%3A%20a%20post-hoc%20analysis%20of%20molecular%20biomarkers%20in%20a%20phase%202%20study&amp;journal=Lancet%20Haematol&amp;volume=9&amp;pages=e434-e444&amp;publication_year=2022&amp;author=Pemmaraju%2CN&amp;author=Garcia%2CJS&amp;author=Potluri%2CJ&amp;author=Harb%2CJG&amp;author=Sun%2CY&amp;author=Jung%2CP&amp;author=Qin%2CQQ&amp;author=Tantravahi%2CSK&amp;author=Verstovsek%2CS&amp;author=Harrison%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR343\">Ge H, Ke J, Xu N, Li H, Gong J, Li X, et al. Dexamethasone alleviates pemetrexed-induced senescence in non-small-cell lung cancer. Food Chem Toxicol. 2018;119:86\u201397.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXps1Kqtbk%3D\" aria-label=\"CAS reference 343\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29753869\" aria-label=\"PubMed reference 343\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 343\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dexamethasone%20alleviates%20pemetrexed-induced%20senescence%20in%20non-small-cell%20lung%20cancer&amp;journal=Food%20Chem%20Toxicol&amp;volume=119&amp;pages=86-97&amp;publication_year=2018&amp;author=Ge%2CH&amp;author=Ke%2CJ&amp;author=Xu%2CN&amp;author=Li%2CH&amp;author=Gong%2CJ&amp;author=Li%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR344\">Jiang H, Wang GT, Wang Z, Ma QY, Ma ZH. Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts. World J Gastrointest Oncol. 2024;16(2024):3980\u201393.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39350997\" aria-label=\"PubMed reference 344\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11438786\" aria-label=\"PubMed Central reference 344\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 344\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Resveratrol%20inhibits%20pancreatic%20cancer%20proliferation%20and%20metastasis%20by%20depleting%20senescent%20tumor-associated%20fibroblasts&amp;journal=World%20J%20Gastrointest%20Oncol&amp;volume=16&amp;issue=2024&amp;pages=3980-3993&amp;publication_year=2024&amp;author=Jiang%2CH&amp;author=Wang%2CGT&amp;author=Wang%2CZ&amp;author=Ma%2CQY&amp;author=Ma%2CZH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR345\">Luan FL, Ding R, Sharma VK, Chon WJ, Lagman M, Suthanthiran M. Rapamycin is an effective inhibitor of human renal cancer metastasis. Kidney Int. 2003;63:917\u201326.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD3sXivV2jsb8%3D\" aria-label=\"CAS reference 345\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12631072\" aria-label=\"PubMed reference 345\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 345\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Rapamycin%20is%20an%20effective%20inhibitor%20of%20human%20renal%20cancer%20metastasis&amp;journal=Kidney%20Int&amp;volume=63&amp;pages=917-26&amp;publication_year=2003&amp;author=Luan%2CFL&amp;author=Ding%2CR&amp;author=Sharma%2CVK&amp;author=Chon%2CWJ&amp;author=Lagman%2CM&amp;author=Suthanthiran%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR346\">Jin P, Li X, Xia Y, Li H, Li X, Yang ZY, et al. Bepotastine sensitizes ovarian cancer to PARP inhibitors through suppressing NF-kappaB-triggered SASP in cancer-associated fibroblasts. Mol Cancer Ther. 2023;22:447\u201358.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXoslSku78%3D\" aria-label=\"CAS reference 346\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36780236\" aria-label=\"PubMed reference 346\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 346\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Bepotastine%20sensitizes%20ovarian%20cancer%20to%20PARP%20inhibitors%20through%20suppressing%20NF-kappaB-triggered%20SASP%20in%20cancer-associated%20fibroblasts&amp;journal=Mol%20Cancer%20Ther&amp;volume=22&amp;pages=447-458&amp;publication_year=2023&amp;author=Jin%2CP&amp;author=Li%2CX&amp;author=Xia%2CY&amp;author=Li%2CH&amp;author=Li%2CX&amp;author=Yang%2CZY&amp;author=Wang%2CZ&amp;author=Xu%2CC&amp;author=Fang%2CT&amp;author=Zhou%2CD&amp;author=Xiong%2CX&amp;author=Wang%2CSY&amp;author=Xu%2CS&amp;author=Gao%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR347\">Beppu M, Ikebe T, Shirasuna K. The inhibitory effects of immunosuppressive factors, dexamethasone and interleukin-4, on NF-kappaB-mediated protease production by oral cancer. Biochim Biophys Acta. 2002;1586:11\u201322.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD38XitlSktQ%3D%3D\" aria-label=\"CAS reference 347\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11781145\" aria-label=\"PubMed reference 347\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 347\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20inhibitory%20effects%20of%20immunosuppressive%20factors%2C%20dexamethasone%20and%20interleukin-4%2C%20on%20NF-kappaB-mediated%20protease%20production%20by%20oral%20cancer&amp;journal=Biochim%20Biophys%20Acta&amp;volume=1586&amp;pages=11-22&amp;publication_year=2002&amp;author=Beppu%2CM&amp;author=Ikebe%2CT&amp;author=Shirasuna%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR348\">Al-Mansour F, Alraddadi A, He B, Saleh A, Poblocka M, Alzahrani W, et al. Characterization of the HDAC\/PI3K inhibitor CUDC-907 as a novel senolytic. Aging (Albany NY). 2023;15:2373\u201394.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitlWiur7I\" aria-label=\"CAS reference 348\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36988504\" aria-label=\"PubMed reference 348\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 348\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Characterization%20of%20the%20HDAC%2FPI3K%20inhibitor%20CUDC-907%20as%20a%20novel%20senolytic&amp;journal=Aging%20%28Albany%20NY%29&amp;volume=15&amp;pages=2373-94&amp;publication_year=2023&amp;author=Al-Mansour%2CF&amp;author=Alraddadi%2CA&amp;author=He%2CB&amp;author=Saleh%2CA&amp;author=Poblocka%2CM&amp;author=Alzahrani%2CW\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR349\">Feldmeyer L, Hofbauer GF, Boni T, French LE, Hafner J. Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing. Br J Dermatol. 2012;166:422\u20134.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XkvVSjtb0%3D\" aria-label=\"CAS reference 349\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21895616\" aria-label=\"PubMed reference 349\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 349\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mammalian%20target%20of%20rapamycin%20%28mTOR%29%20inhibitors%20slow%20skin%20carcinogenesis%2C%20but%20impair%20wound%20healing&amp;journal=Br%20J%20Dermatol&amp;volume=166&amp;pages=422-4&amp;publication_year=2012&amp;author=Feldmeyer%2CL&amp;author=Hofbauer%2CGF&amp;author=Boni%2CT&amp;author=French%2CLE&amp;author=Hafner%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR350\">Nguyen VN, Abagyan R, Tsunoda SM. Mtor inhibitors associated with higher cardiovascular adverse events-a large population database analysis. Clin Transplant. 2021;35:e14228.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXptFKrsbo%3D\" aria-label=\"CAS reference 350\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33476406\" aria-label=\"PubMed reference 350\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 350\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mtor%20inhibitors%20associated%20with%20higher%20cardiovascular%20adverse%20events-a%20large%20population%20database%20analysis&amp;journal=Clin%20Transplant&amp;volume=35&amp;publication_year=2021&amp;author=Nguyen%2CVN&amp;author=Abagyan%2CR&amp;author=Tsunoda%2CSM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR351\">Giles AJ, Hutchinson MND, Sonnemann HM, Jung J, Fecci PE, Ratnam NM, et al. Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy. J Immunother Cancer. 2018;6:51.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29891009\" aria-label=\"PubMed reference 351\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5996496\" aria-label=\"PubMed Central reference 351\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 351\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Dexamethasone-induced%20immunosuppression%3A%20mechanisms%20and%20implications%20for%20immunotherapy&amp;journal=J%20Immunother%20Cancer&amp;volume=6&amp;publication_year=2018&amp;author=Giles%2CAJ&amp;author=Hutchinson%2CMND&amp;author=Sonnemann%2CHM&amp;author=Jung%2CJ&amp;author=Fecci%2CPE&amp;author=Ratnam%2CNM&amp;author=Zhang%2CW&amp;author=Song%2CH&amp;author=Bailey%2CR&amp;author=Davis%2CD&amp;author=Reid%2CCM&amp;author=Park%2CDM&amp;author=Gilbert%2CMR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR352\">Yokoyama T, Kohn EC, Brill E, Lee JM. Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2\/Bcl-xL and PARP. Int J Oncol. 2017;50:1064\u201374.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXjs1yju7k%3D\" aria-label=\"CAS reference 352\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28350129\" aria-label=\"PubMed reference 352\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5363883\" aria-label=\"PubMed Central reference 352\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 352\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Apoptosis%20is%20augmented%20in%20high-grade%20serous%20ovarian%20cancer%20by%20the%20combined%20inhibition%20of%20Bcl-2%2FBcl-xL%20and%20PARP&amp;journal=Int%20J%20Oncol&amp;volume=50&amp;pages=1064-74&amp;publication_year=2017&amp;author=Yokoyama%2CT&amp;author=Kohn%2CEC&amp;author=Brill%2CE&amp;author=Lee%2CJM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR353\">Wang T, Liu W, Shen Q, Tao R, Li C, Shen Q, et al. Combination of PARP inhibitor and CDK4\/6 inhibitor modulates cGAS\/STING-dependent therapy-induced senescence and provides \u201cone-two punch\u201d opportunity with anti-PD-L1 therapy in colorectal cancer. Cancer Sci. 2023;114:4184\u2013201.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXhvFWmt7bF\" aria-label=\"CAS reference 353\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37702298\" aria-label=\"PubMed reference 353\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10637067\" aria-label=\"PubMed Central reference 353\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 353\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Combination%20of%20PARP%20inhibitor%20and%20CDK4%2F6%20inhibitor%20modulates%20cGAS%2FSTING-dependent%20therapy-induced%20senescence%20and%20provides%20%E2%80%9Cone-two%20punch%E2%80%9D%20opportunity%20with%20anti-PD-L1%20therapy%20in%20colorectal%20cancer&amp;journal=Cancer%20Sci&amp;volume=114&amp;pages=4184-201&amp;publication_year=2023&amp;author=Wang%2CT&amp;author=Liu%2CW&amp;author=Shen%2CQ&amp;author=Tao%2CR&amp;author=Li%2CC&amp;author=Shen%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR354\">Squarzoni S, Schena E, Sabatelli P, Mattioli E, Capanni C, Cenni V, et al. Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice. Aging Cell. 2021;20:e13285.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXitVGqsA%3D%3D\" aria-label=\"CAS reference 354\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33393189\" aria-label=\"PubMed reference 354\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7811841\" aria-label=\"PubMed Central reference 354\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 354\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interleukin-6%20neutralization%20ameliorates%20symptoms%20in%20prematurely%20aged%20mice&amp;journal=Aging%20Cell&amp;volume=20&amp;publication_year=2021&amp;author=Squarzoni%2CS&amp;author=Schena%2CE&amp;author=Sabatelli%2CP&amp;author=Mattioli%2CE&amp;author=Capanni%2CC&amp;author=Cenni%2CV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR355\">Su H, Lin X, Paredong A, Yao C, Zhang Y, Geng M, et al. IL-6\/GATA2\/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury. Front Mol Biosci. 2025;12:1538526.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2MXmtFKls70%3D\" aria-label=\"CAS reference 355\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=40007559\" aria-label=\"PubMed reference 355\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11850272\" aria-label=\"PubMed Central reference 355\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 355\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=IL-6%2FGATA2%2FSERPINE1%20pathway%20is%20implicated%20in%20regulating%20cellular%20senescence%20after%20acute%20kidney%20injury&amp;journal=Front%20Mol%20Biosci&amp;volume=12&amp;publication_year=2025&amp;author=Su%2CH&amp;author=Lin%2CX&amp;author=Paredong%2CA&amp;author=Yao%2CC&amp;author=Zhang%2CY&amp;author=Geng%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR356\">Xiong J, Dong L, Lv Q, Yin Y, Zhao J, Ke Y, et al. Targeting senescence-associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes. Clin Transl Med. 2024;14:e1772.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39270064\" aria-label=\"PubMed reference 356\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11398298\" aria-label=\"PubMed Central reference 356\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 356\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Targeting%20senescence-associated%20secretory%20phenotypes%20to%20remodel%20the%20tumour%20microenvironment%20and%20modulate%20tumour%20outcomes&amp;journal=Clin%20Transl%20Med&amp;volume=14&amp;publication_year=2024&amp;author=Xiong%2CJ&amp;author=Dong%2CL&amp;author=Lv%2CQ&amp;author=Yin%2CY&amp;author=Zhao%2CJ&amp;author=Ke%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR357\">Al-Jomah N, Al-Mohanna FH, Aboussekhra A. Tocilizumab suppresses the pro-carcinogenic effects of breast cancer-associated fibroblasts through inhibition of the STAT3\/AUF1 pathway. Carcinogenesis. 2021;42:1439\u201348.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xmt1ansrg%3D\" aria-label=\"CAS reference 357\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34718441\" aria-label=\"PubMed reference 357\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 357\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Tocilizumab%20suppresses%20the%20pro-carcinogenic%20effects%20of%20breast%20cancer-associated%20fibroblasts%20through%20inhibition%20of%20the%20STAT3%2FAUF1%20pathway&amp;journal=Carcinogenesis&amp;volume=42&amp;pages=1439-48&amp;publication_year=2021&amp;author=Al-Jomah%2CN&amp;author=Al-Mohanna%2CFH&amp;author=Aboussekhra%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR358\">Blay JY, Brahmi M, Dufresne A, Swalduz A, Avrillon V, Assaad S, et al. Anti-IL-6R ab tocilizumab to treat paraneoplastic inflammatory syndrome of solid cancers. ESMO Open. 2025;10(1):104088.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39754984\" aria-label=\"PubMed reference 358\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11758126\" aria-label=\"PubMed Central reference 358\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 358\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Anti-IL-6R%20ab%20tocilizumab%20to%20treat%20paraneoplastic%20inflammatory%20syndrome%20of%20solid%20cancers&amp;journal=ESMO%20Open&amp;volume=10&amp;issue=1&amp;publication_year=2025&amp;author=Blay%2CJY&amp;author=Brahmi%2CM&amp;author=Dufresne%2CA&amp;author=Swalduz%2CA&amp;author=Avrillon%2CV&amp;author=Assaad%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR359\">Guo Y, Nemeth J, O\u2019Brien C, Susa M, Liu X, Zhang Z, et al. Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer. Clin Cancer Res. 2010;16:5759\u201369.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3cXhsFamtLrL\" aria-label=\"CAS reference 359\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=20699329\" aria-label=\"PubMed reference 359\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 359\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Effects%20of%20siltuximab%20on%20the%20IL-6-induced%20signaling%20pathway%20in%20ovarian%20cancer&amp;journal=Clin%20Cancer%20Res&amp;volume=16&amp;pages=5759-5769&amp;publication_year=2010&amp;author=Guo%2CY&amp;author=Nemeth%2CJ&amp;author=O%27Brien%2CC&amp;author=Susa%2CM&amp;author=Liu%2CX&amp;author=Zhang%2CZ&amp;author=Choy%2CE&amp;author=Mankin%2CH&amp;author=Hornicek%2CF&amp;author=Duan%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR360\">Najjary S, Mohammadzadeh R, Mokhtarzadeh A, Mohammadi A, Kojabad AB, Baradaran B. Role of miR-21 as an authentic oncogene in mediating drug resistance in breast cancer. Gene. 2020;738:144453.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXjt12rsrk%3D\" aria-label=\"CAS reference 360\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32035242\" aria-label=\"PubMed reference 360\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 360\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Role%20of%20miR-21%20as%20an%20authentic%20oncogene%20in%20mediating%20drug%20resistance%20in%20breast%20cancer&amp;journal=Gene&amp;volume=738&amp;publication_year=2020&amp;author=Najjary%2CS&amp;author=Mohammadzadeh%2CR&amp;author=Mokhtarzadeh%2CA&amp;author=Mohammadi%2CA&amp;author=Kojabad%2CAB&amp;author=Baradaran%2CB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR361\">Nguyen HT, Kacimi SEO, Nguyen TL, Suman KH, Lemus-Martin R, Saleem H, et al. Mir-21 in the cancers of the digestive system and its potential role as a diagnostic, predictive, and therapeutic biomarker. Biology. 2021;10(5):417. <a href=\"https:\/\/doi.org\/10.3390\/biology10050417\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/biology10050417\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/biology10050417<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/biology10050417\" data-track-item_id=\"10.3390\/biology10050417\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fbiology10050417\" aria-label=\"Article reference 361\" data-doi=\"10.3390\/biology10050417\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34943253\" aria-label=\"PubMed reference 361\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8698713\" aria-label=\"PubMed Central reference 361\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 361\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mir-21%20in%20the%20cancers%20of%20the%20digestive%20system%20and%20its%20potential%20role%20as%20a%20diagnostic%2C%20predictive%2C%20and%20therapeutic%20biomarker&amp;journal=Biology&amp;doi=10.3390%2Fbiology10050417&amp;publication_year=2021&amp;author=Nguyen%2CHT&amp;author=Kacimi%2CSEO&amp;author=Nguyen%2CTL&amp;author=Suman%2CKH&amp;author=Lemus-Martin%2CR&amp;author=Saleem%2CH&amp;author=Do%2CDN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR362\">Chen JC, Hsieh YY, Lo HL, Li A, Chou CJ, Yang PM. In vitro and in silico mechanistic insights into miR-21\u20135p-mediated topoisomerase drug resistance in human colorectal cancer cells. Biomolecules. 2019;9(9):467. <a href=\"https:\/\/doi.org\/10.3390\/biom9090467\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/biom9090467\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/biom9090467<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/biom9090467\" data-track-item_id=\"10.3390\/biom9090467\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fbiom9090467\" aria-label=\"Article reference 362\" data-doi=\"10.3390\/biom9090467\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31906046\" aria-label=\"PubMed reference 362\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7023197\" aria-label=\"PubMed Central reference 362\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 362\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=In%20vitro%20and%20in%20silico%20mechanistic%20insights%20into%20miR-21%E2%80%935p-mediated%20topoisomerase%20drug%20resistance%20in%20human%20colorectal%20cancer%20cells&amp;journal=Biomolecules&amp;doi=10.3390%2Fbiom9090467&amp;publication_year=2019&amp;author=Chen%2CJC&amp;author=Hsieh%2CYY&amp;author=Lo%2CHL&amp;author=Li%2CA&amp;author=Chou%2CCJ&amp;author=Yang%2CPM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR363\">Wang T, Wu J, Liu X, Li S. Serum miR-34a is a potential diagnostic and prognostic marker for osteosarcoma. Int J Clin Exp Pathol. 2017;10:9683\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31966849\" aria-label=\"PubMed reference 363\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6965930\" aria-label=\"PubMed Central reference 363\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 363\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Serum%20miR-34a%20is%20a%20potential%20diagnostic%20and%20prognostic%20marker%20for%20osteosarcoma&amp;journal=Int%20J%20Clin%20Exp%20Pathol&amp;volume=10&amp;pages=9683-9&amp;publication_year=2017&amp;author=Wang%2CT&amp;author=Wu%2CJ&amp;author=Liu%2CX&amp;author=Li%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR364\">Lian H, Zhou Y, Sun Z, Liu K. Microrna34a is associated with chemotherapy resistance, metastasis, recurrence, survival, and prognosis in patient with osteosarcoma. Medicine (Baltimore). 2022;101:e30722.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XislShs7%2FL\" aria-label=\"CAS reference 364\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36197268\" aria-label=\"PubMed reference 364\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 364\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microrna34a%20is%20associated%20with%20chemotherapy%20resistance%2C%20metastasis%2C%20recurrence%2C%20survival%2C%20and%20prognosis%20in%20patient%20with%20osteosarcoma&amp;journal=Medicine%20%28Baltimore%29&amp;volume=101&amp;publication_year=2022&amp;author=Lian%2CH&amp;author=Zhou%2CY&amp;author=Sun%2CZ&amp;author=Liu%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR365\">Yang S, Li A, Lv L, Zheng Z, Liu P, Min J, et al. Exosomal miRNA-146a-5p derived from senescent hepatocellular carcinoma cells promotes aging and inhibits aerobic glycolysis in liver cells via targeting IRF7. J Cancer. 2024;15:4448\u201366.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXitl2ls7%2FM\" aria-label=\"CAS reference 365\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39006088\" aria-label=\"PubMed reference 365\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11242348\" aria-label=\"PubMed Central reference 365\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 365\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Exosomal%20miRNA-146a-5p%20derived%20from%20senescent%20hepatocellular%20carcinoma%20cells%20promotes%20aging%20and%20inhibits%20aerobic%20glycolysis%20in%20liver%20cells%20via%20targeting%20IRF7&amp;journal=J%20Cancer&amp;volume=15&amp;pages=4448-66&amp;publication_year=2024&amp;author=Yang%2CS&amp;author=Li%2CA&amp;author=Lv%2CL&amp;author=Zheng%2CZ&amp;author=Liu%2CP&amp;author=Min%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR366\">Iguchi T, Nambara S, Masuda T, Komatsu H, Ueda M, Kidogami S, et al. Mir-146a polymorphism (rs2910164) predicts colorectal cancer patients\u2019 susceptibility to liver metastasis. PLoS One. 2016;11:e0165912.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27824903\" aria-label=\"PubMed reference 366\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5100922\" aria-label=\"PubMed Central reference 366\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 366\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Mir-146a%20polymorphism%20%28rs2910164%29%20predicts%20colorectal%20cancer%20patients%E2%80%99%20susceptibility%20to%20liver%20metastasis&amp;journal=PLoS%20One&amp;volume=11&amp;publication_year=2016&amp;author=Iguchi%2CT&amp;author=Nambara%2CS&amp;author=Masuda%2CT&amp;author=Komatsu%2CH&amp;author=Ueda%2CM&amp;author=Kidogami%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR367\">Sun X, Thorne RF, Zhang XD, He M, Li J, Feng S, et al. LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1alpha-FOXO4-p21-dependent signaling axis. EMBO Rep. 2020;21:e48796.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXksVaisL4%3D\" aria-label=\"CAS reference 367\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32149459\" aria-label=\"PubMed reference 367\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7132339\" aria-label=\"PubMed Central reference 367\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 367\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=LncRNA%20GUARDIN%20suppresses%20cellular%20senescence%20through%20a%20LRP130-PGC1alpha-FOXO4-p21-dependent%20signaling%20axis&amp;journal=EMBO%20Rep&amp;volume=21&amp;publication_year=2020&amp;author=Sun%2CX&amp;author=Thorne%2CRF&amp;author=Zhang%2CXD&amp;author=He%2CM&amp;author=Li%2CJ&amp;author=Feng%2CS&amp;author=Liu%2CX&amp;author=Wu%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR368\">Yang W, Du WW, Li X, Yee AJ, Yang BB. Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis. Oncogene. 2016;35:3919\u201331.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXitVShs77O\" aria-label=\"CAS reference 368\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26657152\" aria-label=\"PubMed reference 368\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 368\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Foxo3%20activity%20promoted%20by%20non-coding%20effects%20of%20circular%20RNA%20and%20Foxo3%20pseudogene%20in%20the%20inhibition%20of%20tumor%20growth%20and%20angiogenesis&amp;journal=Oncogene&amp;volume=35&amp;pages=3919-31&amp;publication_year=2016&amp;author=Yang%2CW&amp;author=Du%2CWW&amp;author=Li%2CX&amp;author=Yee%2CAJ&amp;author=Yang%2CBB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR369\">Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, et al. Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Res. 2017;45:4021\u201335.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1cXhsVyrtrw%3D\" aria-label=\"CAS reference 369\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27928058\" aria-label=\"PubMed reference 369\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 369\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Identification%20of%20senescence-associated%20circular%20RNAs%20%28SAC-RNAs%29%20reveals%20senescence%20suppressor%20CircPVT1&amp;journal=Nucleic%20Acids%20Res&amp;volume=45&amp;pages=4021-35&amp;publication_year=2017&amp;author=Panda%2CAC&amp;author=Grammatikakis%2CI&amp;author=Kim%2CKM&amp;author=De%2CS&amp;author=Martindale%2CJL&amp;author=Munk%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR370\">Min X, Cai MY, Shao T, Xu ZY, Liao Z, Liu DL, et al. A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR-24-3p\/CDK4\/pRb axis. Aging Cell. 2022;21:e13529.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXislejt77E\" aria-label=\"CAS reference 370\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34902213\" aria-label=\"PubMed reference 370\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 370\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=A%20circular%20intronic%20RNA%20ciPVT1%20delays%20endothelial%20cell%20senescence%20by%20regulating%20the%20miR-24-3p%2FCDK4%2FpRb%20axis&amp;journal=Aging%20Cell&amp;volume=21&amp;publication_year=2022&amp;author=Min%2CX&amp;author=Cai%2CMY&amp;author=Shao%2CT&amp;author=Xu%2CZY&amp;author=Liao%2CZ&amp;author=Liu%2CDL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR371\">Li MF, Zhang DH, Wang LS, Yue CF, Pang LJ, Guo YM, et al. Construction and validation of a SASP-related prognostic signature in patients with acute myeloid leukaemia. J Cell Mol Med. 2024;28:e70017.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhvVSlt73I\" aria-label=\"CAS reference 371\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39159071\" aria-label=\"PubMed reference 371\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11332597\" aria-label=\"PubMed Central reference 371\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 371\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Construction%20and%20validation%20of%20a%20SASP-related%20prognostic%20signature%20in%20patients%20with%20acute%20myeloid%20leukaemia&amp;journal=J%20Cell%20Mol%20Med&amp;volume=28&amp;publication_year=2024&amp;author=Li%2CMF&amp;author=Zhang%2CDH&amp;author=Wang%2CLS&amp;author=Yue%2CCF&amp;author=Pang%2CLJ&amp;author=Guo%2CYM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR372\">Bhatiya M, Pathak S, Banerjee A. Oxidative stress and cellular senescence: the key tumor-promoting factors in colon cancer and beneficial effects of polyphenols in colon cancer prevention. Curr Cancer Ther Rev. 2021;17:292\u2013303.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/molecular-cancer.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXis1Kmur3F\" aria-label=\"CAS reference 372\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 372\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Oxidative%20stress%20and%20cellular%20senescence%3A%20the%20key%20tumor-promoting%20factors%20in%20colon%20cancer%20and%20beneficial%20effects%20of%20polyphenols%20in%20colon%20cancer%20prevention&amp;journal=Curr%20Cancer%20Ther%20Rev&amp;volume=17&amp;pages=292-303&amp;publication_year=2021&amp;author=Bhatiya%2CM&amp;author=Pathak%2CS&amp;author=Banerjee%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Bernadotte A, Mikhelson VM, Spivak IM. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence.&hellip;\n","protected":false},"author":2,"featured_media":126894,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[4731,22004,42494,61,60,3063,74686,74687,80,46596],"class_list":{"0":"post-126893","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-technology","8":"tag-cancer-research","9":"tag-cancer-therapy","10":"tag-cellular-senescence","11":"tag-ie","12":"tag-ireland","13":"tag-oncology","14":"tag-senescence-associated-secretory-phenotype-sasp","15":"tag-senolytic-therapies","16":"tag-technology","17":"tag-tumor-microenvironment"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/126893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=126893"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/126893\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/126894"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=126893"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=126893"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=126893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}