{"id":168696,"date":"2025-12-01T05:17:09","date_gmt":"2025-12-01T05:17:09","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/168696\/"},"modified":"2025-12-01T05:17:09","modified_gmt":"2025-12-01T05:17:09","slug":"tga-alerts-to-suicidal-thoughts-reduced-contraception-effectiveness-2","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/168696\/","title":{"rendered":"TGA alerts to suicidal thoughts, reduced contraception effectiveness"},"content":{"rendered":"<p>Australia\u2019s medicines regulator has issued a safety warning over the risk of suicidal thoughts and behaviour linked to drugs known as GLP-1 receptor agonists, including <a href=\"https:\/\/www.smh.com.au\/national\/what-is-ozempic-and-why-is-there-a-shortage-of-it-20221128-p5c1wb.html\" rel=\"noopener nofollow\" target=\"_blank\">Ozempic<\/a>.<\/p>\n<p>The Therapeutic Goods Administration (TGA) also warned that a link between GLP-1 receptor agonist medication Mounjaro (tirzepatide) and reduced effectiveness of oral contraception could not be ruled out.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"Eli Lilly GLP1 medicine Mounjaro will come with a new product warning.\" src=\"https:\/\/www.newsbeep.com\/ie\/wp-content\/uploads\/2025\/12\/6decaaf62b686963b04a9f83b41fb90f4f071306.jpeg\" height=\"349\" width=\"620\" \/><\/p>\n<p>Eli Lilly GLP1 medicine Mounjaro will come with a new product warning.Credit: Bloomberg<\/p>\n<p>The TGA\u2019s <a href=\"https:\/\/www.tga.gov.au\/safety\/safety-monitoring-and-information\/safety-alerts\/product-warnings-updated-glp-1-ra-class\" rel=\"noopener nofollow\" target=\"_blank\">safety alert published on Monday<\/a> said it had updated the product warnings for the class of high-profile drugs indicated for the treatment of type 2 diabetes and obesity (but known to be used for weight loss more broadly) following investigations by international regulators.<\/p>\n<p>The affected drugs are:<\/p>\n<p>Ozempic (semaglutide)Wegovy (semaglutide)Saxenda (liraglutide)Trulicity (dulaglutide)Mounjaro (tirzepatide)<\/p>\n<p>\u201cPatients taking these medicines should tell their health professional if they experience new or worsening depression, suicidal thoughts or any unusual changes in mood or behaviour,\u201d the alert read.<\/p>\n<p><img decoding=\"async\" alt=\"The updated wording that will appear in the product information for GLP-1 RAs.\" loading=\"lazy\" src=\"https:\/\/www.newsbeep.com\/ie\/wp-content\/uploads\/2025\/12\/f7f6b4f9570ec65c712b2c963d11671322b5ab1d1515a7f06cd91213e868f2b6.png\" height=\"390\" width=\"584\" \/><\/p>\n<p>The updated wording that will appear in the product information for GLP-1 RAs.Credit: TGA<\/p>\n<p>The TGA\u2019s search of its Database of Adverse Event Notifications for GLP-1 RA medicines on September 23 retrieved 85 reports, including 72 for suicidal ideation, six for depressional suicide, four for suicide attempt, two for suicide and one of self-injurious ideation.<\/p>\n<p>It\u2019s investigation included seeking advice from an independent expert group, the Advisory Committee on Medicines, which in <a href=\"https:\/\/www.tga.gov.au\/resources\/publication\/meeting-statements\/acm-meeting-statement-meeting-51-5-and-6-june-2025#glucagonlikepeptide1-receptor-agonists-and-suicidal-or-selfinjurious-ideation\" rel=\"noopener nofollow\" target=\"_blank\">June reported that there was insufficient evidence<\/a> of a causal link between the medicines and suicidal ideation or behaviours.<\/p>\n","protected":false},"excerpt":{"rendered":"Australia\u2019s medicines regulator has issued a safety warning over the risk of suicidal thoughts and behaviour linked to&hellip;\n","protected":false},"author":2,"featured_media":168657,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[33],"tags":[103,61,60,371],"class_list":{"0":"post-168696","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-medication","8":"tag-health","9":"tag-ie","10":"tag-ireland","11":"tag-medication"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/168696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=168696"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/168696\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/168657"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=168696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=168696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=168696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}