{"id":255535,"date":"2026-01-21T04:34:06","date_gmt":"2026-01-21T04:34:06","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/255535\/"},"modified":"2026-01-21T04:34:06","modified_gmt":"2026-01-21T04:34:06","slug":"daily-caffeine-supplements-significantly-reduce-fatigue-in-ms-trial","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/255535\/","title":{"rendered":"Daily caffeine supplements significantly reduce fatigue in MS trial"},"content":{"rendered":"

Taking oral caffeine supplements may significantly reduce fatigue and improve quality of life and mood in people with multiple sclerosis<\/a> (MS), according to a recent clinical trial in Iran.<\/p>\n

Participants took 100 mg of caffeine tablets daily for 12 weeks, equivalent to about two shots of espresso, or a placebo. The caffeine group showed significant improvements in multiple domains, including energy and fatigue, social and physical functioning, emotional well-being, pain, and general health.<\/p>\n

\u201cThese results suggest that caffeine may be a practical, readily available, and cost-effective therapeutic option for fatigue associated with MS,\u201d researchers wrote.<\/p>\n

The study, \u201cEfficacy of Caffeine Supplementation on Fatigue in Patients with Multiple Sclerosis: A Randomized Double-Blind Placebo-Controlled Trial<\/a>,\u201d was published in Multiple Sclerosis and Related Disorders.<\/p>\n

Recommended Reading<\/p>\n

\"A<\/p>\n

Fatigue one of the most common MS symptoms<\/p>\n

Fatigue<\/a>, defined as an overwhelming feeling of mental or physical tiredness that significantly impacts daily activities, is one of the most common symptoms of MS<\/a>, affecting about 80% of people with the disease.\u00a0For many, it is considered the single most debilitating symptom of the disease.<\/p>\n

Despite its prevalence and significant impact on a person\u2019s well-being, there are still limited treatment options to ease MS-related fatigue.<\/p>\n

Caffeine, a compound found in coffee and cocoa, is known to act as a neuronal stimulant, helping people feel more alert, focused, and energetic. Due to its properties, it could represent a safer and more accessible alternative for easing fatigue in MS, but clinical trials testing this effect are still lacking.<\/p>\n

To address this, a team of Iranian researchers conducted a clinical trial (IRCT20241129063892N1)<\/a> to determine whether caffeine supplementation could reduce fatigue in MS patients.<\/p>\n

The trial enrolled 60 adults, most of whom (96.7%) had relapsing-remitting MS<\/a>, and randomly assigned them to receive 100 mg of caffeine per day in oral tablets or a placebo for about three months.<\/p>\n

After this period, both groups experienced a significant reduction in fatigue, but the decline was more than twice as large in the caffeine group as in the placebo group (16.5 points vs. 7.1 points, respectively).<\/p>\n

Oral caffeine supplementation appears to be a safe and well-tolerated intervention that may provide clinically relevant fatigue reduction and an additional, incremental benefit on top of the non-specific effects of care in patients with multiple sclerosis.<\/p>\n

The two groups also experienced improvements in health-related quality of life, as assessed with the 36-Item Short-Form Health Survey (SF-36). For those given caffeine supplements, significant gains were observed in several SF-36 domains, including energy and fatigue, social and physical functioning, emotional well-being, pain, and general health.<\/p>\n

The placebo group experienced a significant improvement in role limitations due to physical health, energy, fatigue, and social functioning.<\/p>\n

However, no significant differences emerged in total SF-36 scores or specific domains between the caffeine and placebo groups after three months.<\/p>\n

Caffeine was deemed safe and well tolerated, with only minor, temporary side effects reported. The most common side effect was mild indigestion, which occurred in two patients (6%) in the caffeine group and in one patient given the placebo (3%).<\/p>\n

\u201cOral caffeine supplementation appears to be a safe and well-tolerated intervention that may provide clinically relevant fatigue reduction and an additional, incremental benefit on top of the non-specific effects of care in patients with multiple sclerosis,\u201d the researchers concluded.<\/p>\n","protected":false},"excerpt":{"rendered":"Taking oral caffeine supplements may significantly reduce fatigue and improve quality of life and mood in people with…\n","protected":false},"author":2,"featured_media":255536,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[103,61,60,446],"class_list":{"0":"post-255535","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-nutrition","8":"tag-health","9":"tag-ie","10":"tag-ireland","11":"tag-nutrition"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/255535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=255535"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/255535\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/255536"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=255535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=255535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=255535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}