{"id":264198,"date":"2026-01-26T04:14:32","date_gmt":"2026-01-26T04:14:32","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/264198\/"},"modified":"2026-01-26T04:14:32","modified_gmt":"2026-01-26T04:14:32","slug":"night-owls-who-dont-respond-to-ssris-circadian-rhythm-core-to-atypical-depression-mystery","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/264198\/","title":{"rendered":"Night owls who don&#8217;t respond to SSRIs: circadian rhythm core to &#8216;atypical&#8217; depression mystery"},"content":{"rendered":"<p>About 21% of patients with depression have an atypical form that is less likely to respond\u00a0to common antidepressants, an Australian study suggests.<\/p>\n<p>New research, published in\u00a0Biological Psychiatry, suggests\u00a0a genetic link between circadian rhythm and atypical depression, which the researchers said was related to traits such as weight gain and hypersomnia, and mainly affected women.<\/p>\n<p>\u201cWhat Australian doctors have been taught mostly is the notion of one exogenous, environmental type of depression versus one biological type of depression,\u201d said co-author Professor Ian Hickie, the co-director of the University of Sydney\u2019s Brain and Mind Centre.<\/p>\n<p>\u201cBut here there\u2019s a different biology completely.<\/p>\n<p>\t\t\u00d7<\/p>\n<p>\n\t\t\t\tSign in\n\t\t\t<\/p>\n<p class=\"d-none message adg-password-reset\">\n\t\t\t\tIf this is your first visit to the new AusDoc website, reset your password<br \/>\n\t\t\t\t<a class=\"adg-reset_password_link\" href=\"https:\/\/www.ausdoc.com.au\/wp-login.php?action=lostpassword\" target=\"_blank\" rel=\"nofollow noopener\">here.<\/a>\n\t\t\t<\/p>\n","protected":false},"excerpt":{"rendered":"About 21% of patients with depression have an atypical form that is less likely to respond\u00a0to common antidepressants,&hellip;\n","protected":false},"author":2,"featured_media":264199,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[1853,1701,103,61,60,410,411,43,1703,413],"class_list":{"0":"post-264198","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-mental-health","8":"tag-depression","9":"tag-endocrinology","10":"tag-health","11":"tag-ie","12":"tag-ireland","13":"tag-mental-health","14":"tag-mentalhealth","15":"tag-news","16":"tag-psychiatry","17":"tag-psychology"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/264198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=264198"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/264198\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/264199"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=264198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=264198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=264198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}