{"id":314426,"date":"2026-02-24T08:52:06","date_gmt":"2026-02-24T08:52:06","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/314426\/"},"modified":"2026-02-24T08:52:06","modified_gmt":"2026-02-24T08:52:06","slug":"miradx-launches-new-prostox-genetic-test-for-prostate-cancer-patients","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/314426\/","title":{"rendered":"MiraDx launches new PROSTOX genetic test for prostate cancer patients"},"content":{"rendered":"

MiraDx<\/a>, a molecular diagnostics company focused on genetic testing to personalise cancer treatment, today announced the U.S. commercial launch of PROSTOX Standard, a new, clinically validated genetic test that expands access to personalised radiation therapy for patients with localised prostate cancer.<\/p>\n

The test identifies those at increased risk of developing long-term urinary side effects following conventionally fractionated or moderately hypofractionated radiation therapy (CFRT or MHFRT), and complements the company\u2019s existing PROSTOX Ultra offering, for patientsbeing considered for stereotactic body radiation therapy (SBRT).<\/p>\n

By offering both tests, MiraDx is expanding access to toxicity risk assessment testing to a broader group of prostate cancer patients at risk for genitourinary (GU) toxicity following external beam radiation therapy (EBRT).<\/p>\n

While EBRT is an effective and widely used treatment for localised prostate cancer, more than 20% of patients treated with radiation therapy experience persistent urinary side effects, referred to as late GU toxicity.<\/a><\/p>\n

PROSTOX tests help predict late-onset genitourinary (GU) toxicity\u2014side effects such as urinary urgency, leakage, or discomfort\u2014that can appear months or years after radiation treatment and significantly impact quality of life.<\/p>\n

Localised prostate cancer has an excellent prognosis with a five-year survival rate of over 99%.<\/a> Although SBRT, CFRT, and MHFRT have similar efficacy in this population, individual responses to each treatment method can vary due to a patient\u2019s genetics. Until now, clinicians have lacked a biology-driven tool to identify which patients are most at risk for GU toxicity from each EBRT method.<\/p>\n

PROSTOX tests address this gap by analysing inherited genetic variants in microRNAs and their pathways that influence how individual patients tolerate radiation. Using a simple cheek swab, PROSTOX delivers actionable results in 5-7 days, enabling physicians and patients to make more personalised radiation treatment decisions based upon each patient\u2019s individual side effect risk profile.<\/p>\n

\u201cPROSTOX tests bring precision medicine to radiation oncology by shifting the focus from the tumor alone to determining the most effective treatment approach for each patient based upon their unique biology and resulting treatment risks,\u201d said Melissa C. Stoppler, MD, Executive Vice President of Medical Affairs at MiraDx. \u201cHaving information about which type of radiation each patient will tolerate best allows clinicians to better tailor radiation treatments to patients, helping them avoid future long-term side effects.\u201d<\/p>\n

Each PROSTOX test evaluates genetic risk across a different radiation therapy regimen. A result that a patient is at high risk with PROSTOX Standard does not imply a high-risk result for PROSTOX Ultra, and vice versa. In rare cases (less than 2% of patients), PROSTOX tests will identify that a patient has a high risk for late GU side effects with both SBRT and CFRT\/MHFRT. For these patients, other interventions may be available.<\/p>\n

\u201cBeing diagnosed with prostate cancer is life altering and comes with many decisions and so much uncertainty,\u201d said Ron Stewart, a patient who received PROSTOX testing. \u201cThe PROSTOX test helped me feel more confident about my treatment plan and more optimistic that my cancer treatment would not hamper my quality of life down the road.\u201d<\/p>\n

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