We hope to inch closer toward a blood test that can make reliable diagnosis across disorders without aid from other clinical instruments<\/p>\n
Jacob Vogel<\/p>\n
Now, researchers Jacob Vogel and Lijun An, together with colleagues from the Swedish BioFINDER study and the Global Neurodegenerative Proteomics Consortium (GNPC, an international research consortium that has created the world\u2019s largest proteomics database for neurodegenerative diseases) have developed an AI model capable of detecting multiple diseases at once. The model is based on protein measurements from more than 17,000 patients and control participants, collected from several datasets within GNPC\u2019s proteomics database, the largest in the world for proteins related to neurodegenerative diseases.\u00a0<\/p>\n
\u201cOur hope is to be able to accurately diagnose several diseases at once with a single blood test in the future,\u201d says Jacob Vogel, who led the study. He is an assistant professor, head of a research group, and part of the strategic research area MultiPark at Lund University.\u00a0<\/p>\n
Using advanced statistical learning methods and a process known as \u201cjoint learning,\u201d the researchers\u2019 AI model was able to identify a specific set of proteins that form a general pattern for diseases involving brain degeneration. This learned pattern was then used to diagnose different neurodegenerative diseases. Vogel confirms that their AI model outperforms previous models, while also being able to diagnose five different dementia-related conditions: Alzheimer\u2019s disease, Parkinson\u2019s disease, ALS, frontotemporal dementia, and previous stroke.\u00a0<\/p>\n
The study stands out compared to similar research because the model\u2019s results were validated across multiple independent datasets, according to the researchers. \u201cWe also found that the protein profile predicted cognitive decline better than the clinical diagnosis did, and it seems like individuals with the same clinical diagnosis may have different underlying biological subtypes,\u201d says Lijun An, the study\u2019s first author.\u00a0<\/p>\n
Many individuals diagnosed with Alzheimer\u2019s disease showed a protein pattern more similar to other brain disorders. \u201cThis could mean they have more than one underlying disease, that Alzheimer\u2019s can develop in multiple ways, or that the clinical diagnosis is incorrect. However, I don\u2019t think current protein measurements from blood samples will be sufficient on their own to diagnose multiple diseases, we need to refine the method and combine it with other clinical diagnostic tools,\u201d says Jacob Vogel.\u00a0<\/p>\n
At the same time, he emphasizes that diagnostics is not the only application of their model. Many of the proteins that contributed to the AI model point to areas where follow-up studies could lead to a better understanding of the disease-driving processes behind these neurodegenerative conditions.\u00a0<\/p>\n
The next step is to include more proteomic markers using advanced methods such as mass spectrometry to identify patterns unique to each disease. \u201cWe hope to inch closer toward a blood test that can make reliable diagnosis across disorders without aid from other clinical instruments,\u201d says Jacob Vogel.\u00a0<\/p>\n
Source: Lund University; by Martina Svensson \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"We hope to inch closer toward a blood test that can make reliable diagnosis across disorders without aid…\n","protected":false},"author":2,"featured_media":382953,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[170791,103,61,60,170792],"class_list":{"0":"post-382952","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-lunduniversity-brjacob-vogel-amp-anlijuncn-bsky-social-from-lund-university-bsky-social","9":"tag-health","10":"tag-ie","11":"tag-ireland","12":"tag-with-colleagues-from-biofinder-bsky-social-and-neuroproteome-bsky-social"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/382952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=382952"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/382952\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/382953"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=382952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=382952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=382952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}