{"id":386541,"date":"2026-04-07T15:42:15","date_gmt":"2026-04-07T15:42:15","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/386541\/"},"modified":"2026-04-07T15:42:15","modified_gmt":"2026-04-07T15:42:15","slug":"benjamin-walbaum-breast-cancer-weekly-highlights","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/386541\/","title":{"rendered":"Benjamin Walbaum: Breast Cancer Weekly Highlights"},"content":{"rendered":"

Benjamin Walbaum, Medical Oncologist at Pontifical Catholic University of Chile, shared a post on\u00a0LinkedIn<\/a>:<\/p>\n

\u201cBreast Cancer Weekly Highlights | April 1\u20136, 2026
My take from last week\u2019s breast cancer publications.<\/p>\n

1.Second-line therapies after CDK4\/6i failure in HR+\/HER2\u2212 MBC: real-world data from the HERMIONE-13 study \u2013 ESMO Real World Data and Emerging Evidence<\/p>\n

Endocrine therapy \u00b1 targeted therapy may remain a valid post-CDK4\/6 option in selected patients, with survival outcomes that challenge the routine default to chemotherapy.<\/p>\n

2.ctDNA use in older women with ER+ breast cancer to facilitate surgical de-escalation: a prospective hybrid-decentralized trial \u2013 Clinical Cancer Research<\/p>\n

Pretreatment ctDNA negativity identified a subgroup of older women who may be candidates for surgery-free management with primary endocrine therapy.<\/p>\n

3.Integrating baseline ctDNA-derived tumor metrics enhances risk stratification in HR+\/HER2\u2212 advanced breast cancer: a real-world multicenter cohort from Austria \u2013 ESMO Open<\/p>\n

Baseline ctDNA tumor fraction metrics improved prognostic stratification beyond standard clinical variables, supporting broader use of liquid biopsy in HR+\/HER2\u2212 advanced disease.<\/p>\n

4.Datopotamab deruxtecan vs. chemotherapy in untreated advanced TNBC (TROPION-Breast02): a phase III randomized trial\u00a0\u2013 Annals of Oncology<\/p>\n

Dato-DXd delivered both PFS and OS benefit over chemotherapy, strengthening its role as a potential new first-line standard in advanced TNBC.<\/p>\n

5.Scalp cooling system vs. chemical cooling cap for prevention of chemotherapy-induced alopecia (COHAIR Study): a randomized trial \u2013 The Breast<\/p>\n

Both scalp cooling strategies were effective and oncologically safe, with efficacy and patient experience emerging as key differentiators.<\/p>\n

6.Clonal hematopoiesis of indeterminate potential (CHIP) and risk of trastuzumab-related cardiotoxic effects \u2013 JAMA Oncology<\/p>\n

CHIP may become a clinically relevant biomarker to identify patients at increased risk of trastuzumab-related cardiotoxicity before starting HER2-targeted therapy.<\/p>\n

7.Loss of luminal lineage identity drives resistance to next-generation ER\u03b1 antagonists in pretreated ER+\/HER2\u2212 metastatic breast cancer \u2013 Nature Communications<\/p>\n

Lineage plasticity, more than ESR1 mutation status alone, may be a central mechanism of resistance to next-generation SERDs.<\/p>\n

8.HER2 heterogeneous breast cancer models reveal novel therapeutic targets and subclonal dynamics during evolution to resistance to HER2-targeted therapies \u2013 Cancer Discovery<\/p>\n

HER2-low subclones appear to drive T-DXd resistance and recurrence in heterogeneous tumors, highlighting HER2 heterogeneity as a biologically relevant therapeutic challenge.<\/p>\n

BONUS TRACK
Clinical response to PARP inhibitor in metastatic breast cancer with a germline reduced-penetrance BRCA2 pathogenic variant: a Molecular Tumor Board discussion \u2013 JCO Precision Oncology<\/p>\n

This case illustrates that reduced-penetrance BRCA2 variants may still carry therapeutic relevance for PARP inhibition and deserve careful multidisciplinary interpretation.\u201d<\/p>\n

\"Benjamin<\/p>\n

Optimizing Dose Homogeneity in Whole Breast Irradiation<\/a>
\"Benjamin<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Benjamin Walbaum, Medical Oncologist at Pontifical Catholic University of Chile, shared a post on\u00a0LinkedIn: \u201cBreast Cancer Weekly Highlights…\n","protected":false},"author":2,"featured_media":386542,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[61,60,80],"class_list":{"0":"post-386541","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-technology","8":"tag-ie","9":"tag-ireland","10":"tag-technology"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/386541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=386541"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/386541\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/386542"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=386541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=386541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=386541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}