{"id":499409,"date":"2026-06-14T15:37:08","date_gmt":"2026-06-14T15:37:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/499409\/"},"modified":"2026-06-14T15:37:08","modified_gmt":"2026-06-14T15:37:08","slug":"testosterone-benefits-older-men-with-t2d-risk-when-combined-with-lifestyle-changes","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/499409\/","title":{"rendered":"Testosterone benefits older men with T2D risk when combined with lifestyle changes"},"content":{"rendered":"

Testosterone treatment may improve body composition, glucose metabolism and sexual desire in some older men at high risk of type 2 diabetes (T2D), but the benefits require engagement in a lifestyle program, according to a study being presented\u00a0Saturday\u00a0at ENDO 2026, the Endocrine Society’s annual meeting in Chicago, Ill.<\/p>\n

More than\u00a040 million people\u00a0in the U.S. and hundreds of millions worldwide have been diagnosed with T2D, and more than 115 million adults in the U.S. are estimated to have prediabetes. T2D is\u00a0diagnosed most commonly\u00a0in adults aged 45 and older. It is strongly linked to abdominal obesity and loss of muscle mass and strength. Early detection and treatment can decrease the risk of developing complications of T2D.<\/p>\n

<\/p>\n

Testosterone treatment alone is not a replacement for lifestyle intervention, weight management or standard diabetes prevention in older men with central obesity and prediabetes or early T2D.”<\/p>\n


\n <\/p>\n

Gary Wittert,\u00a0M.B.B.ch., M.D.,\u00a0study’s lead author, of\u00a0Adelaide University\u00a0and Royal Adelaide Hospital in Adelaide, Australia<\/p>\n

<\/p>\n

Results are based on a sub-study of the randomized, double-blind, placebo-controlled Testosterone for the Prevention of Type 2 Diabetes<\/a> Mellitus (T4DM) research published in 2021, which involved 1,007 men aged 50-74 who were either at\u00a0high risk\u00a0of developing or had newly diagnosed T2D. While the T4DM study showed that testosterone plus lifestyle intervention reduced the likelihood of diabetes being present after two years, the new research deepens insights related to a subset of 121 patients who were studied for an\u00a0additional\u00a0two years. Wittert led the T4DM study.<\/p>\n

The new research extended the T4DM study among a subgroup of 121 participants who\u00a0elected\u00a0to continue\u00a0blinded\u00a0treatment for two\u00a0additional\u00a0years without ongoing enrollment in the lifestyle program. The study\u00a0aimed to\u00a0determine\u00a0the longer-term effects of testosterone treatment on blood sugar, measures of obesity, skeletal muscle mass and strength, sexual function, and safety.<\/p>\n

Results show that most of the benefits\u00a0on\u00a0blood sugar control occurred in the first two years and diminished by the fourth year. Blood sugar control remained significantly better than the placebo treated group. The improvements in body composition (reduction in fat and increase in muscle) and sexual desire that occurred during the first two years were\u00a0maintained\u00a0at four years.<\/p>\n

Testosterone did not clearly improve overall quality of life compared with placebo at either two or four years.\u00a0Overall,\u00a0quality\u00a0of life was similar between both study groups over the four years. No new safety concerns were\u00a0identified.<\/p>\n

“Our data found that in the specific group of men 50 and older we studied, testosterone alone is not a replacement for changes in diet and exercise, and that it is most beneficial when paired with a lifestyle program. It also may encourage clinicians to look more carefully at men’s metabolic health, waist circumference, muscle health, sexual\u00a0symptoms\u00a0and testosterone status as connected issues rather than treating them in isolation,” Wittert explained.<\/p>\n","protected":false},"excerpt":{"rendered":"Testosterone treatment may improve body composition, glucose metabolism and sexual desire in some older men at high risk…\n","protected":false},"author":2,"featured_media":137163,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[2991,9383,1702,56129,3172,3173,103,9385,61,60,496,9124,4369,23256,38548,89,18342,9398],"class_list":["post-499409","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-blood","tag-blood-sugar","tag-diabetes","tag-endocrine","tag-glucose","tag-glucose-metabolism","tag-health","tag-hormone","tag-ie","tag-ireland","tag-metabolism","tag-muscle","tag-obesity","tag-placebo","tag-prediabetes","tag-research","tag-testosterone","tag-type-2-diabetes"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/499409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=499409"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/499409\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/137163"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=499409"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=499409"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=499409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}