{"id":518408,"date":"2026-06-25T21:50:14","date_gmt":"2026-06-25T21:50:14","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/518408\/"},"modified":"2026-06-25T21:50:14","modified_gmt":"2026-06-25T21:50:14","slug":"study-uncovers-chain-reaction-that-connects-smoking-to-heart-disease","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/518408\/","title":{"rendered":"Study Uncovers Chain Reaction That Connects Smoking to Heart Disease"},"content":{"rendered":"

OKLAHOMA CITY \u2013 Scientists at the University of Oklahoma have identified a previously unrecognized immune system pathway that helps explain how cigarette smoking increases the risk of cardiovascular disease. The findings, published<\/a> in Circulation Research, show that cigarette smoke activates immune cells that trigger widespread inflammation throughout the body, accelerating the buildup of plaque in arteries.<\/p>\n

Cigarette smoking is a major risk factor for cardiovascular disease and is linked to heart attacks, strokes and other life-threatening conditions. While smoking\u2019s harmful effects on the lungs are well established, the biological processes that connect cigarette smoke exposure to cardiovascular disease have been less well understood.<\/p>\n

The new study, conducted in a mouse model of atherosclerosis, centers on neutrophils, the most abundant white blood cell in the body, whose job is to find and vanquish invading pathogens. When cigarette smoke is breathed into the lungs, researchers found that the chemicals agitate the neutrophils, which then rapidly increase in number. They make their way into the blood vessels, where they encounter macrophages, another type of white blood cell. As a result of that interaction, the neutrophils die.<\/p>\n

Upon the neutrophils\u2019 death, they release a number of proteins \u2013 notably Interleukin 1-alpha and Interleukin-1 beta. In turn, the macrophages become dysfunctional. When the macrophages cannot perform their function, which is to remove dead cells and bad cholesterol, the arteries become susceptible to plaque dislodging, forming a clot, and causing a heart attack or stroke. Additional risk factors, like high blood pressure, increase vulnerability.<\/p>\n

\u201cSmoking essentially reprograms some of our \u2018first responder\u2019 immune cells,\u201d said the paper\u2019s senior author, Prabhakara Nagareddy, Ph.D., a professor of medicine at the OU College of Medicine. \u201cInstead of helping protect us, they become overactive and drive chronic inflammation inside the arteries.\u201d<\/p>\n

The study also had a surprising finding: The chemicals in cigarette smoke could trigger these inflammatory effects even when administered orally rather than inhaled.<\/p>\n

\u201cThis suggests that tobacco-related chemicals can directly activate immune cells after they are absorbed into the body,\u201d he said. \u201cThe cardiovascular effects of tobacco exposure may extend beyond inflammation that begins in the lungs.\u201d<\/p>\n

While the best treatment is not smoking or quitting smoking, Nagareddy said, understanding what drives chronic inflammation in the arteries is crucial. One day, that knowledge could point the way toward new therapies that reduce some of the cardiovascular damage.<\/p>\n

\u201cMost therapies today focus on lowering cholesterol. That\u2019s incredibly important, but inflammation is the other half of the story,\u201d he said. \u201cUnderstanding how smoking activates inflammation could eventually help us identify new treatments that protect people who are at high cardiovascular risk.\u201d<\/p>\n

The research team plans to continue the work by investigating which cigarette compounds cause the most damage.<\/p>\n

\u201cCigarette smoke contains more than 7,000 chemical compounds. Our next goal is to identify which ones are actually driving this harmful inflammatory response,\u201d said the paper\u2019s first author, Dipanjan Chattopadhyay, Ph.D., a postdoctoral researcher in Nagareddy\u2019s laboratory.<\/p>\n

The researchers plan to study other nicotine delivery systems, such as vaping and nicotine pouches, to see if the neutrophils react in the same way. They also plan to conduct the same studies in humans.<\/p>\n

About the project<\/p>\n

The paper, \u201cInflammasome-Primed Neutrophils Aggravate Atherosclerosis in Cigarette Smoking,\u201d can be found at https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.125.327714<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"OKLAHOMA CITY \u2013 Scientists at the University of Oklahoma have identified a previously unrecognized immune system pathway that…\n","protected":false},"author":2,"featured_media":518409,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[123476,55588,1058,103,5851,61,60,15146,89],"class_list":["post-518408","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-april-wilkerson","tag-college-of-medicine","tag-feature","tag-health","tag-homepage","tag-ie","tag-ireland","tag-press-release","tag-research"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/518408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=518408"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/518408\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/518409"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=518408"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=518408"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=518408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}