Understanding the extent of disease in patients who have initial negative PSMA PET scans provides valuable information for physicians as they create treatment plans<\/p>\n
Ur Metser<\/p>\n
\u201cThere is little information on the utility of repeating a PSMA PET after an initial negative scan,\u201d said Ur Metser, BSc, MD, FRCPC, professor of radiology at the University of Toronto and head of the Division of Molecular Imaging at the Joint Department of Medical Imaging at Princess Margaret Cancer Centre in Toronto. \u201cIn our study, my colleagues and I sought to determine the benefit of a second PSMA PET scan, as well as to assess predictors for positive PSMA PET scans.\u201d\u00a0<\/p>\n
The study included 210 patients from the Registry for Recurrent Prostate Cancer in Ontario who had more than one PSMA PET scan and whose initial scan was negative. The scan positivity rate, serum PSA, PSA doubling time, and management change after the second scan were compared with baseline data. Disease distribution was classified as local recurrence, locoregional, oligometastatic (fewer than five positive disease sites), or extensive metastatic (more than five positive disease sites).\u00a0<\/p>\n
A second PSMA PET scan revealed evidence of disease in 56% of recurrent prostate cancer patients who had an initial negative PSMA PET scan. A management change was necessary for nearly 50%\u00a0of patients, in particular those with oligometastatic disease. Researchers found that repeat imaging was most likely to detect disease in patients with higher PSA levels and a PSA doubling time of less than twelve months.\u00a0<\/p>\n
\u201cThe findings in this study further strengthen the pivotal role of PSMA PET in the management of men with recurrence of prostate cancer after first-line therapy,\u201d said Metser. \u201cUnderstanding the extent of disease in patients who have initial negative PSMA PET scans provides valuable information for physicians as they create treatment plans.\u201d\u00a0<\/p>\n
Source: Society of Nuclear Medicine and Molecular Imaging\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Understanding the extent of disease in patients who have initial negative PSMA PET scans provides valuable information for…\n","protected":false},"author":2,"featured_media":546995,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60,231858,231857,231856,231855],"class_list":["post-546994","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland","tag-published-by-snm-mi-bsky-social","tag-published-by-the-mysnmmi-brled-by-uoftmedicalimaging-bsky-social","tag-published-in-journalofnucmed-brled-by-medicalimaginguoft","tag-x-led-by-imagingtoronto"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/546994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=546994"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/546994\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/546995"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=546994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=546994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=546994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}