{"id":551268,"date":"2026-07-15T16:52:22","date_gmt":"2026-07-15T16:52:22","guid":{"rendered":"https:\/\/www.newsbeep.com\/ie\/551268\/"},"modified":"2026-07-15T16:52:22","modified_gmt":"2026-07-15T16:52:22","slug":"l-tartaric-acid-benefits-diabetic-cardiomyopathy-emj","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ie\/551268\/","title":{"rendered":"L-Tartaric Acid Benefits Diabetic Cardiomyopathy \u2013 EMJ"},"content":{"rendered":"<p>DIABETIC cardiomyopathy may be alleviated by L-tartaric acid, according to new pre-clinical findings.<\/p>\n<p>Researchers investigated the effects of L-tartaric acid in streptozotocin-induced diabetic mice, a commonly used model of <a href=\"https:\/\/www.emjreviews.com\/diabetes\/news\/new-study-identifies-potential-target-for-treating-diabetic-cardiomyopathy\/\" rel=\"nofollow noopener\" target=\"_blank\">diabetic cardiomyopathy<\/a>.<\/p>\n<p>Following diabetes induction, animals received oral L-tartaric acid at doses of 50 mg\/kg or 100 mg\/kg daily for 16 weeks.<\/p>\n<p>Cardiac function and a range of molecular markers associated with disease progression were subsequently evaluated.<\/p>\n<p>L-tartaric Acid Linked to Improved Cardiac Performance<\/p>\n<p>The diabetic control group demonstrated substantial metabolic and cardiac abnormalities, including elevated blood glucose, triglyceride, and cholesterol levels, together with impaired ventricular function.<\/p>\n<p><a href=\"https:\/\/www.emjreviews.com\/cardiology\/news\/ai-echocardiography-predicts-mortality-in-pulmonary-hypertension\/\" rel=\"nofollow noopener\" target=\"_blank\">Echocardiographic<\/a> assessment revealed increased left ventricular end-systolic and end-diastolic diameters and reduced left ventricular ejection fraction and fractional shortening.<\/p>\n<p>Treatment with L-tartaric acid was associated with improvements in these parameters.<\/p>\n<p>The higher 100 mg\/kg dose produced the greatest effect, with significant reductions in ventricular diameters and improvements in left ventricular ejection fraction and fractional shortening, suggesting partial restoration of cardiac performance.<\/p>\n<p>Metabolic measures also improved in treated animals, particularly in the higher dose group.<\/p>\n<p>Reduced Inflammation and Apoptosis<\/p>\n<p>Researchers observed that L-tartaric acid treatment reduced three key elevated inflammatory markers in the treated mice, with larger reductions observed at the 100 mg\/kg dose.<\/p>\n<p>The therapy was also associated with lower expression of proapoptotic markers and increased expression of antiapoptotic markers.<\/p>\n<p>These molecular changes were accompanied by evidence of reduced cardiac apoptosis, a process implicated in the development of diabetic cardiomyopathy.<\/p>\n<p>Analysis of cardiac tissue showed that diabetes reduced expression of autophagy related markers.<\/p>\n<p>L-tartaric acid increased expression of these markers, with statistically significant effects observed at the higher dose.<\/p>\n<p>Although the researchers noted that causal relationships between these pathways remain unconfirmed, the findings suggest that L-tartaric acid may have therapeutic potential in diabetic cardiomyopathy and warrant further investigation to clarify mechanisms and evaluate clinical relevance.<\/p>\n<p>Reference<\/p>\n<p>Chen W et al. l-Tartaric acid mitigates diabetic cardiac damage and is associated with changes in autophagy, apoptosis, and inflammatory markers. Sci Rep. 2026;DOI:10.1038\/s41598-026-58125-6<\/p>\n<p>Featured image: Semoga on Adobe Stock<\/p>\n","protected":false},"excerpt":{"rendered":"DIABETIC cardiomyopathy may be alleviated by L-tartaric acid, according to new pre-clinical findings. Researchers investigated the effects of&hellip;\n","protected":false},"author":2,"featured_media":551269,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[103,61,60],"class_list":["post-551268","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-health","tag-ie","tag-ireland"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/551268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/comments?post=551268"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/posts\/551268\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media\/551269"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/media?parent=551268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/categories?post=551268"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ie\/wp-json\/wp\/v2\/tags?post=551268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}